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The map label for this gene is gcvR [H]

Identifier: 152971344

GI number: 152971344

Start: 3084488

End: 3085054

Strand: Direct

Name: gcvR [H]

Synonym: KPN_02813

Alternate gene names: 152971344

Gene position: 3084488-3085054 (Clockwise)

Preceding gene: 152971337

Following gene: 152971345

Centisome position: 58.03

GC content: 52.73

Gene sequence:

>567_bases
TTGACAGCCTCATTACAACACTATCTGGTTATTACCGCCCTGGGGGCTGACCGTCCCGGCATCGTGAATACGATCACTCG
CCACGTCAGCAGCTGCGGTTGTAATATCGAAGACAGCCGGCTGGCCATGCTCGGTGATGAGTTTACGTTTATCATGCTGC
TTTCCGGGTCGTGGAATGCGATTAACCTGATCGAATCAACTCTGCCGCTGAAAGGCGCGGAGCTGGAGCTGTTGATCGTG
ATGAAACGCACCACTGCGCGCCCGCCGCAGGCCATGCCAAACACCGTTTGGGTCCAGGTTGAGGTGCCGGACTCACCGCA
TATCATCGAGCGCTTTACTGCCCTGTGCGATACATGGAATATGAATATTGCGGAGCTGGTGTCCCGCACGCAGCCGGGAG
ACGGCGATTCCGCGCAGCTTTTTATTCAGATAACTGCCCACAGTCCTGCGACGCAAAATGCAGCAAATATCGAACAAGCG
TTCAAAGCCCTATGTACAGAACTGAACGCACAAGGCAGTATTAACATCGTTAATTATTCACAGCATGATGAACAGGATGG
AGTTTAA

Upstream 100 bases:

>100_bases
TGTAATAAAAGCAAGAGACCCGACGCCATCAGGGATGTTGTATGGCGGTTTTTTTTATGCTTTCCTAATGTTACCTCACC
TTTTTAAAGGAAGAACAGGT

Downstream 100 bases:

>100_bases
CCCATGACCCCACTGAAAGCCGGTGATATCGCACCGAAATTTAGCTTACCGGACCAGGACGGCGAGGAAGTAAATTTAAC
CGACTTCCAGGGACAACGTG

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MTASLQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNAINLIESTLPLKGAELELLIV
MKRTTARPPQAMPNTVWVQVEVPDSPHIIERFTALCDTWNMNIAELVSRTQPGDGDSAQLFIQITAHSPATQNAANIEQA
FKALCTELNAQGSINIVNYSQHDEQDGV

Sequences:

>Translated_188_residues
MTASLQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNAINLIESTLPLKGAELELLIV
MKRTTARPPQAMPNTVWVQVEVPDSPHIIERFTALCDTWNMNIAELVSRTQPGDGDSAQLFIQITAHSPATQNAANIEQA
FKALCTELNAQGSINIVNYSQHDEQDGV
>Mature_187_residues
TASLQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNAINLIESTLPLKGAELELLIVM
KRTTARPPQAMPNTVWVQVEVPDSPHIIERFTALCDTWNMNIAELVSRTQPGDGDSAQLFIQITAHSPATQNAANIEQAF
KALCTELNAQGSINIVNYSQHDEQDGV

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=189, Percent_Identity=85.1851851851852, Blast_Score=328, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 20548; Mature: 20416

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASLQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNA
CCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCE
INLIESTLPLKGAELELLIVMKRTTARPPQAMPNTVWVQVEVPDSPHIIERFTALCDTWN
EEHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
MNIAELVSRTQPGDGDSAQLFIQITAHSPATQNAANIEQAFKALCTELNAQGSINIVNYS
CCHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECC
QHDEQDGV
CCCCCCCC
>Mature Secondary Structure 
TASLQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGSWNA
CCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCE
INLIESTLPLKGAELELLIVMKRTTARPPQAMPNTVWVQVEVPDSPHIIERFTALCDTWN
EEHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCC
MNIAELVSRTQPGDGDSAQLFIQITAHSPATQNAANIEQAFKALCTELNAQGSINIVNYS
CCHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECC
QHDEQDGV
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]