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The map label for this gene is ahcY [H]

Identifier: 152971001

GI number: 152971001

Start: 2684538

End: 2685647

Strand: Direct

Name: ahcY [H]

Synonym: KPN_02462

Alternate gene names: 152971001

Gene position: 2684538-2685647 (Clockwise)

Preceding gene: 152971000

Following gene: 152971008

Centisome position: 50.51

GC content: 61.8

Gene sequence:

>1110_bases
GTGAATAATAAAATCTCTTTAGCGAAAGAAGTGGCATGGGCCAGCCAGAATATGCCGCGTACCCTGCGTCAGGTCGCCGC
GCTGCCCGACCTCAGCGGCGTGCGTCTGGCCTGCTGTATGCACCTCGACATGAAAATGATCCCGCTGGTGCAGGGGATCC
TCGACAAGGGCGCTCAGGTCTTTTTAACCACCTGTAACCCCACCACCGTGCAGGACGACGTGGTGGCCTGGCTGGTGGAG
CGCGGCGCCGAGGCCTGCGCGTGGCGCAATATGAGCGATGCCGACTGGCAACAGTCATGGGAAAAAGCGATTGCCTGGCA
GCCCACTCACCTGTGCGAGATGGGCGCCGATATCACCACCCTGCTCCACCAGCGCGGCGAGTTTGGGAACATCGTGGCGG
GTCTGGAAGCCACCGGCTCGGGCGTCAATCGGCTGGGGGATATTCAGCCAGGCTATCCGATCTTTAACTGGGACGATCTG
CCGGTCAAAGAGGGACTGCACAACCGCCATATGGTCGGTCTCACCGCCTGGCACACCTTCTTCCAGACCACTCACCTCAC
TCTGCATGAGAAAAAAGTGCTGGTGATCGGCTACGGCCTGGTCGGCCAGGGCGTCGCGGCGGCGGCAAAAGCTTTTGGCG
GTCAGGTGATGGTGGCGGAGATCGATCCTGCCCGCCGTCTGCAGGCGGCCTACGACGGCTGGCACGTGGTGGACCTCCAG
GAGGCAATCGCCTCGGCGGACGTGGTGGCCACAGCGACAGGCGGTAAAAACGTGGTTAATCGCCAGGCGCTGGACCGGGC
GAAAGCGGGAGTATTTATCCTTAACGTCGGCCACGTGGCGGAAGAGATCGACGGCGAGTACCTGCGCCAGTACCCCCAGG
AAGAGGTGATGCCGTATATCAACGCCTACCGCATGGCCGACAAAACCGTCTATCTGCTGGCCAATGGTTCAATGCTCAAT
CTGACCGCTGGCTTCGGCGACAGCCTGAACGCCTTTGACGTCACCCTCGCGGTGATGGCCAGCGGCATCCGCCATATTGT
CACCGACGGCATGCGCGCCCCGGCGAAGGTTTATCTCCTGCCCCAGGCGGTCTGGCAGCAGGCCCTGTAA

Upstream 100 bases:

>100_bases
CGATGTCCGACGGCATTGTGCTGTGAATTCTCGCGGGGGCTGATAGAATCCCTTTTCGGTCAGGGGGATACCCCTTTTGC
GAATTGAAGGTCATAACCCA

Downstream 100 bases:

>100_bases
ACCCGGCGCATCGCCCCCATCGCGGGACGATGCGCTTTACCATCAGGACGACGGCGCGCTATCGGGCAACACAATATTGC
TCTGCGCCAGCGTTCCCATC

Product: putative S-adenosylhomocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQGILDKGAQVFLTTCNPTTVQDDVVAWLVE
RGAEACAWRNMSDADWQQSWEKAIAWQPTHLCEMGADITTLLHQRGEFGNIVAGLEATGSGVNRLGDIQPGYPIFNWDDL
PVKEGLHNRHMVGLTAWHTFFQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYDGWHVVDLQ
EAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYPQEEVMPYINAYRMADKTVYLLANGSMLN
LTAGFGDSLNAFDVTLAVMASGIRHIVTDGMRAPAKVYLLPQAVWQQAL

Sequences:

>Translated_369_residues
MNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQGILDKGAQVFLTTCNPTTVQDDVVAWLVE
RGAEACAWRNMSDADWQQSWEKAIAWQPTHLCEMGADITTLLHQRGEFGNIVAGLEATGSGVNRLGDIQPGYPIFNWDDL
PVKEGLHNRHMVGLTAWHTFFQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYDGWHVVDLQ
EAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYPQEEVMPYINAYRMADKTVYLLANGSMLN
LTAGFGDSLNAFDVTLAVMASGIRHIVTDGMRAPAKVYLLPQAVWQQAL
>Mature_369_residues
MNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQGILDKGAQVFLTTCNPTTVQDDVVAWLVE
RGAEACAWRNMSDADWQQSWEKAIAWQPTHLCEMGADITTLLHQRGEFGNIVAGLEATGSGVNRLGDIQPGYPIFNWDDL
PVKEGLHNRHMVGLTAWHTFFQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYDGWHVVDLQ
EAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYPQEEVMPYINAYRMADKTVYLLANGSMLN
LTAGFGDSLNAFDVTLAVMASGIRHIVTDGMRAPAKVYLLPQAVWQQAL

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI298286489, Length=376, Percent_Identity=31.6489361702128, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI195539349, Length=375, Percent_Identity=31.4666666666667, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI195539337, Length=376, Percent_Identity=31.6489361702128, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI24308043, Length=376, Percent_Identity=31.6489361702128, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI21361647, Length=376, Percent_Identity=32.7127659574468, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI9951915, Length=373, Percent_Identity=26.0053619302949, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI239937451, Length=364, Percent_Identity=26.0989010989011, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17506425, Length=338, Percent_Identity=30.1775147928994, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320882, Length=345, Percent_Identity=29.8550724637681, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24656245, Length=371, Percent_Identity=31.5363881401617, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45553387, Length=371, Percent_Identity=31.5363881401617, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI45553385, Length=371, Percent_Identity=31.5363881401617, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24642172, Length=342, Percent_Identity=29.5321637426901, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 40318; Mature: 40318

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQGILDKGAQV
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEHHHHCCHHHHHHHHHHHCCCCEE
FLTTCNPTTVQDDVVAWLVERGAEACAWRNMSDADWQQSWEKAIAWQPTHLCEMGADITT
EEEECCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHH
LLHQRGEFGNIVAGLEATGSGVNRLGDIQPGYPIFNWDDLPVKEGLHNRHMVGLTAWHTF
HHHCCCCCCCEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCCCCCEEEEHHHHHHH
FQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYDGWHVVDLQ
HHHHEEEEECCEEEEEECCHHHCHHHHHHHHCCCEEEEEECCHHHHHHHHCCCEEEEEHH
EAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYPQEEVMPYI
HHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCHHHHHCCHHHHHHCCHHHHHHHH
NAYRMADKTVYLLANGSMLNLTAGFGDSLNAFDVTLAVMASGIRHIVTDGMRAPAKVYLL
HHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
PQAVWQQAL
CHHHHHHCC
>Mature Secondary Structure
MNNKISLAKEVAWASQNMPRTLRQVAALPDLSGVRLACCMHLDMKMIPLVQGILDKGAQV
CCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEHHHHCCHHHHHHHHHHHCCCCEE
FLTTCNPTTVQDDVVAWLVERGAEACAWRNMSDADWQQSWEKAIAWQPTHLCEMGADITT
EEEECCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHH
LLHQRGEFGNIVAGLEATGSGVNRLGDIQPGYPIFNWDDLPVKEGLHNRHMVGLTAWHTF
HHHCCCCCCCEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHCCCCCEEEEHHHHHHH
FQTTHLTLHEKKVLVIGYGLVGQGVAAAAKAFGGQVMVAEIDPARRLQAAYDGWHVVDLQ
HHHHEEEEECCEEEEEECCHHHCHHHHHHHHCCCEEEEEECCHHHHHHHHCCCEEEEEHH
EAIASADVVATATGGKNVVNRQALDRAKAGVFILNVGHVAEEIDGEYLRQYPQEEVMPYI
HHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCHHHHHCCHHHHHHCCHHHHHHHH
NAYRMADKTVYLLANGSMLNLTAGFGDSLNAFDVTLAVMASGIRHIVTDGMRAPAKVYLL
HHHHHCCCEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
PQAVWQQAL
CHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]