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The map label for this gene is nhaB [H]

Identifier: 152970859

GI number: 152970859

Start: 2535843

End: 2537435

Strand: Direct

Name: nhaB [H]

Synonym: KPN_02312

Alternate gene names: 152970859

Gene position: 2535843-2537435 (Clockwise)

Preceding gene: 152970857

Following gene: 152970860

Centisome position: 47.71

GC content: 60.83

Gene sequence:

>1593_bases
ATGCACAAAACCATGCACTCATTGACGGGGAAGGATTCTGTCGTGGAAATTTCTTATGGCCGCGCGCTGTGGCGCAATTT
TCTTGGCCAGTCGCCGGACTGGTACAAGCTGGCATTAATCATTTTCTTAATCGTAAATCCGCTGGTGTTCGCCGTGGCGC
CGTTTGTCGCCGGCTGGCTGCTGGTGGTTGAGTTTATCTTTACCCTCGCCATGGCGCTGAAGTGCTATCCGCTGCTGCCG
GGGGGTCTGCTGGCTATCGAGGCGCTGCTGATCGGCATGACCAGCCCGGCGCACGTCCGGGAAGAGATCGCCGGCAATCT
GGAGGTGCTGCTCCTGCTGATGTTCATGGTGGCGGGTATCTACTTTATGAAACAGCTTTTGCTGTTCGTGTTTACGCGCC
TGCTGCTGGGGATCCGTAGCAAAATGCTGCTATCGCTGGCCTTCTGCCTGGCGGCAGCCTTCCTCTCGGCCTTTCTCGAT
GCGCTGACGGTGGTGGCGGTAGTGATCAGCGTCGCCGTCGGGTTCTACGGCATCTATCACCGCGTCGCCTCGGCGCGCCC
GGACGATAGCGACCTGCTCAATGACAGCCATATCGAGCAGCACTACCGTGAGGTGCTGGAGCAGTTCCGCGGCTTTCTGC
GCAGCCTGATGATGCACGCCGGCGTCGGGACCGCGCTCGGCGGCGTCATGACCATGGTCGGCGAGCCGCAAAACCTGATT
ATCGCCAAAGCCGCGGGCTGGCATTTTGGCGAGTTCTTTCTTCGCATGGCGCCCGTGACCCTGCCGGTGATGGTCTGCGG
TCTGTTAACCTGTCTGCTGGTCGAAAAGTATCGCCTGTTTGGCTACGGCGAACCGCTACCGCCGACGGTGCGCAAGGTGC
TGCAGGAGTTTGACGATCGCAGCCGCGCCCAGCGCAGCCGTCAGGAGCGACTGCGGCTGATTGCCCAGGCGCTCATTGGC
GTTTGGCTGATCGTGGCCCTGGCTTTTCACCTGGCTGAGGTCGGCCTGATTGGCCTGTCGGTGATCATCCTCGCCACCAC
CTTTACCGGCGTTACCGATGAGCACGCCATTGGCAAGGCGTTCACCGAGGCGCTGCCCTTTACCGCGCTGCTGACGGTCT
TCTTCTCCATCGTCGCGGTTATCATCGATCAGCAGCTGTTCACGCCGGTGATCGAGTTTGTCCTGCAGGCCTCGCCGCAC
GCGCAGCTGTCGCTGTTTTATCTGTTCAACGGCCTGCTGTCGTCCATTTCGGATAACGTGTTTGTCGGCACGGTCTACAT
CAACGAAGCGAAAGCGGCGCTCGAACATGGCGCCATCAGCCTGCCCCAGTTTGAGATGCTGGCGGTAGCGATCAACACCG
GCACCAACCTGCCCTCGGTGGCTACCCCGAACGGCCAGGCGGCGTTTCTCTTCCTGCTGACTTCCGCCCTGGCGCCGCTT
ATTAGGCTCTCCTATGGCCGTATGGTGTGGATGGCGCTGCCCTACACCATCGTACTGACGCTGGTCGGCCTGTTATGCGT
CGAGTTCACCCTGATGCCAGTCACCGACTGGCTGCTGGCGCACGGCTGGCTGGTGACGCCCACCTTGCCCTGA

Upstream 100 bases:

>100_bases
CCGCTTTTACTTTGCGCTTTTCCTTATCTTCACAAACCGCCAGCGCGGCGCGAAGAAAGTTGCTTCTCATTTTGCTCAAC
TGGTACTCTTGCCAATCGTT

Downstream 100 bases:

>100_bases
GTCAGTTTTTGCCCGGGTTCGCCCGGGCGCATCAATAACCCGTTACGGAATATTTTCCGCCGCGCCTCTGGCGTCGGTTC
GGTTTTCGTTTACACTGCCA

Product: sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaB [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MHKTMHSLTGKDSVVEISYGRALWRNFLGQSPDWYKLALIIFLIVNPLVFAVAPFVAGWLLVVEFIFTLAMALKCYPLLP
GGLLAIEALLIGMTSPAHVREEIAGNLEVLLLLMFMVAGIYFMKQLLLFVFTRLLLGIRSKMLLSLAFCLAAAFLSAFLD
ALTVVAVVISVAVGFYGIYHRVASARPDDSDLLNDSHIEQHYREVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLI
IAKAAGWHFGEFFLRMAPVTLPVMVCGLLTCLLVEKYRLFGYGEPLPPTVRKVLQEFDDRSRAQRSRQERLRLIAQALIG
VWLIVALAFHLAEVGLIGLSVIILATTFTGVTDEHAIGKAFTEALPFTALLTVFFSIVAVIIDQQLFTPVIEFVLQASPH
AQLSLFYLFNGLLSSISDNVFVGTVYINEAKAALEHGAISLPQFEMLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPL
IRLSYGRMVWMALPYTIVLTLVGLLCVEFTLMPVTDWLLAHGWLVTPTLP

Sequences:

>Translated_530_residues
MHKTMHSLTGKDSVVEISYGRALWRNFLGQSPDWYKLALIIFLIVNPLVFAVAPFVAGWLLVVEFIFTLAMALKCYPLLP
GGLLAIEALLIGMTSPAHVREEIAGNLEVLLLLMFMVAGIYFMKQLLLFVFTRLLLGIRSKMLLSLAFCLAAAFLSAFLD
ALTVVAVVISVAVGFYGIYHRVASARPDDSDLLNDSHIEQHYREVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLI
IAKAAGWHFGEFFLRMAPVTLPVMVCGLLTCLLVEKYRLFGYGEPLPPTVRKVLQEFDDRSRAQRSRQERLRLIAQALIG
VWLIVALAFHLAEVGLIGLSVIILATTFTGVTDEHAIGKAFTEALPFTALLTVFFSIVAVIIDQQLFTPVIEFVLQASPH
AQLSLFYLFNGLLSSISDNVFVGTVYINEAKAALEHGAISLPQFEMLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPL
IRLSYGRMVWMALPYTIVLTLVGLLCVEFTLMPVTDWLLAHGWLVTPTLP
>Mature_530_residues
MHKTMHSLTGKDSVVEISYGRALWRNFLGQSPDWYKLALIIFLIVNPLVFAVAPFVAGWLLVVEFIFTLAMALKCYPLLP
GGLLAIEALLIGMTSPAHVREEIAGNLEVLLLLMFMVAGIYFMKQLLLFVFTRLLLGIRSKMLLSLAFCLAAAFLSAFLD
ALTVVAVVISVAVGFYGIYHRVASARPDDSDLLNDSHIEQHYREVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLI
IAKAAGWHFGEFFLRMAPVTLPVMVCGLLTCLLVEKYRLFGYGEPLPPTVRKVLQEFDDRSRAQRSRQERLRLIAQALIG
VWLIVALAFHLAEVGLIGLSVIILATTFTGVTDEHAIGKAFTEALPFTALLTVFFSIVAVIIDQQLFTPVIEFVLQASPH
AQLSLFYLFNGLLSSISDNVFVGTVYINEAKAALEHGAISLPQFEMLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPL
IRLSYGRMVWMALPYTIVLTLVGLLCVEFTLMPVTDWLLAHGWLVTPTLP

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3067

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaB Na(+)/H(+) (TC 2.A.34) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1787435, Length=512, Percent_Identity=85.3515625, Blast_Score=869, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004671 [H]

Pfam domain/function: PF06450 NhaB [H]

EC number: NA

Molecular weight: Translated: 58274; Mature: 58274

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3 Proton [Periplasm]; Na (I) [Cytoplasm] [C]

Specific reaction: 3 Proton [Periplasm] + 2 Na (I) [Cytoplasm] = 2 Na (I) [Periplasm] + 3 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA