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The map label for this gene is treA [H]

Identifier: 152970850

GI number: 152970850

Start: 2522905

End: 2524650

Strand: Direct

Name: treA [H]

Synonym: KPN_02303

Alternate gene names: 152970850

Gene position: 2522905-2524650 (Clockwise)

Preceding gene: 152970844

Following gene: 152970851

Centisome position: 47.47

GC content: 62.31

Gene sequence:

>1746_bases
ATGACGAGTACTGATGCACGTCGTCCCGCTGCTTTGCCCTGTTCCCTGCGCCTGGCGATCGGCGGCGCTCTGATCGCCCT
GATGAGCCTGAACGCTCAGGCGGAAGACGGCAAAACCGCGCCGCCCCCCTCGCCGGATATTCTGCTGGGCCCGCTGTTCA
ATGATGTCCAGAGCGCGAAGCTGTTTGCCGATCAGAAAACCTTCGCCGACGCTATCCCTAACAGCGATCCGCTGATGATC
CTTGCCGATTACCGGATGCAAAAAAACCAGGCCAGCTTCGACCTGCGCCACTTCGTCGAACTGAACTTCACGCTGCCGAA
AGAGAACGACACCTATGTGCCGCCCAAAGGGCAAACTCTGCGTCAACATATCGATGGCCTGTGGCCGGTCCTGACCCGCA
GCACCGTCGAGGTGGAAAAATGGGACTCGCTGCTGCCGCTGCCTAAGCCCTACGTGGTGCCCGGAGGACGTTTCCGCGAA
GTCTATTACTGGGACAGCTATTTCACGATGCTGGGTCTTGCCGAAAGCGGTCACTGGGATAAAGTCGAGGATATGGTCGC
CAACTTCGCCGCAGAAATTGACGCCTGGGGCCATATCCCCAACGGCAACCGCACCTATTATCTCAGCCGTTCGCAGCCCC
CCTTCTTCTCCTTTATGGTGAGCCTGCTGGCGACGCACGATGGCGACCAGGTGCTGAAAACCTACCAGCCGCAGCTGGAG
AAAGAGTATCGCTACTGGATGGCCGGAGCGGACGCGCTGCCTCCCGGCAGCGCCGACAAACGGGCGGTGCGGATGGCGGA
CGGCGCGCTGCTCAACCGCTACTGGGACGATAGCGACACCCCGCGTCCCGAGTCCTGGCTTGACGACGTCAAAACCGCCA
AAAGCAACCCGAATCGTCCGGCAACCGAGATCTATCGCGACCTGCGCTCCGCCGCCGCCTCCGGCTGGGATTTCAGCTCC
CGCTGGATGGACAATCCGCAGCAGCTCGCCACCATTCGCACCACCTCGATTGTCCCGGTCGATCTCAATGCCCTGATGTT
CCATCTGGAGAAAACCCTCGCCCGCGCCAGCAAGGCATCCGGGGACAGCGCTGGCGCTACGCAGTACGATGCGCTGGCTA
ACGCCCGCCAGCAGGCCATCGAGAAATACCTGTGGAATGATAAAGAGGGATGGTACGCCGACTACGATCTGAAAAGCCAC
AAGGTGCGCAATCAGTTGACCGCGGCGGCGCTGTTCCCCCTGTACGTCAATGCCGCGTCACGCGAGCGGGCGACGAAAGT
GGCCGCCGCCGCCGAGTCGCGCCTGCTTAAACCCGGCGGGCTGACCACCACCACCGTCAACAGCGGCCAGCAGTGGGACG
CCCCCAACGGCTGGGCGCCGCTGCAGTGGGTGGCGGTCGAGGGGCTGCAAAACTATGGTCAGCAGAAGATCGCCATGGAG
GTCACCTGGCGCTTCCTGACCAACGTGCAGCATACCTATGACAGTAAGCAAAAGCTGGTGGAGAAGTATGACGTGAGCTC
GACCGGCACCGGCGGCGGCGGCGGGGAATATCCGCTGCAGGACGGCTTTGGCTGGACCAACGGCGTCACCCTGAAGATGT
TGGATCTGATCTGCCCGCAGGAGAAACCCTGCGATGCGCTGCCCGCTACCCGTCCGGCGACAACCCCTTCACCGCAGGAC
AAACCTGTTGCGGCGCCCGCGGCTAACGACCCCGCCCCTGCGGAACCGCAAAAGACTGGCTCCTGA

Upstream 100 bases:

>100_bases
AAATGTTACCCCTGACACGCGCAGCGGCAGATATTCGTCTAAGGTTTTTGGATGGCCAAACGTCGTGGCCCGCAGTCGAT
AATGATAAGGAGAACTCCCC

Downstream 100 bases:

>100_bases
CGCTTTGCCGCCCCCCCTACCAAAATCGGTAGGGGGAAGCGGTCTCCCTGGTCACTACCGTCCCGTGCAGACCCATTCTG
CGGCTCGCGGGAAACACTTC

Product: trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAKLFADQKTFADAIPNSDPLMI
LADYRMQKNQASFDLRHFVELNFTLPKENDTYVPPKGQTLRQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFRE
VYYWDSYFTMLGLAESGHWDKVEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLE
KEYRYWMAGADALPPGSADKRAVRMADGALLNRYWDDSDTPRPESWLDDVKTAKSNPNRPATEIYRDLRSAAASGWDFSS
RWMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKASGDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSH
KVRNQLTAAALFPLYVNAASRERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAME
VTWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDALPATRPATTPSPQD
KPVAAPAANDPAPAEPQKTGS

Sequences:

>Translated_581_residues
MTSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAKLFADQKTFADAIPNSDPLMI
LADYRMQKNQASFDLRHFVELNFTLPKENDTYVPPKGQTLRQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFRE
VYYWDSYFTMLGLAESGHWDKVEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLE
KEYRYWMAGADALPPGSADKRAVRMADGALLNRYWDDSDTPRPESWLDDVKTAKSNPNRPATEIYRDLRSAAASGWDFSS
RWMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKASGDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSH
KVRNQLTAAALFPLYVNAASRERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAME
VTWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDALPATRPATTPSPQD
KPVAAPAANDPAPAEPQKTGS
>Mature_580_residues
TSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAKLFADQKTFADAIPNSDPLMIL
ADYRMQKNQASFDLRHFVELNFTLPKENDTYVPPKGQTLRQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFREV
YYWDSYFTMLGLAESGHWDKVEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLEK
EYRYWMAGADALPPGSADKRAVRMADGALLNRYWDDSDTPRPESWLDDVKTAKSNPNRPATEIYRDLRSAAASGWDFSSR
WMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKASGDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSHK
VRNQLTAAALFPLYVNAASRERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAMEV
TWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDALPATRPATTPSPQDK
PVAAPAANDPAPAEPQKTGS

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=551, Percent_Identity=34.4827586206897, Blast_Score=261, Evalue=1e-69,
Organism=Escherichia coli, GI1787447, Length=542, Percent_Identity=76.7527675276753, Blast_Score=879, Evalue=0.0,
Organism=Escherichia coli, GI1789936, Length=487, Percent_Identity=51.9507186858316, Blast_Score=508, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17542196, Length=527, Percent_Identity=33.5863377609108, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI25148109, Length=560, Percent_Identity=30.5357142857143, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17565078, Length=515, Percent_Identity=31.2621359223301, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI25141398, Length=528, Percent_Identity=30.8712121212121, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71987755, Length=408, Percent_Identity=29.1666666666667, Blast_Score=188, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6320204, Length=425, Percent_Identity=30.3529411764706, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6319473, Length=455, Percent_Identity=30.989010989011, Blast_Score=160, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24656680, Length=528, Percent_Identity=35.4166666666667, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24656675, Length=528, Percent_Identity=35.4166666666667, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24656661, Length=528, Percent_Identity=35.4166666666667, Blast_Score=275, Evalue=6e-74,
Organism=Drosophila melanogaster, GI17933716, Length=528, Percent_Identity=35.4166666666667, Blast_Score=275, Evalue=6e-74,
Organism=Drosophila melanogaster, GI24656670, Length=528, Percent_Identity=35.4166666666667, Blast_Score=275, Evalue=6e-74,
Organism=Drosophila melanogaster, GI24656685, Length=502, Percent_Identity=34.6613545816733, Blast_Score=255, Evalue=6e-68,
Organism=Drosophila melanogaster, GI22024178, Length=528, Percent_Identity=31.0606060606061, Blast_Score=225, Evalue=6e-59,
Organism=Drosophila melanogaster, GI45551104, Length=368, Percent_Identity=31.25, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI28573474, Length=314, Percent_Identity=28.6624203821656, Blast_Score=115, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 64295; Mature: 64164

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAK
CCCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHH
LFADQKTFADAIPNSDPLMILADYRMQKNQASFDLRHFVELNFTLPKENDTYVPPKGQTL
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHH
RQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFREVYYWDSYFTMLGLAESGHWD
HHHHHHHHHHHHCCEEEHHHHHCCCCCCCCEECCCCCEEEEEEECHHHHHHHCCCCCCCH
KVEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLE
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCHHHH
KEYRYWMAGADALPPGSADKRAVRMADGALLNRYWDDSDTPRPESWLDDVKTAKSNPNRP
HHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCC
ATEIYRDLRSAAASGWDFSSRWMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKAS
HHHHHHHHHHHHCCCCCCHHHHCCCHHHEEEEEECEEEEECHHHHHHHHHHHHHHHHHCC
GDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSHKVRNQLTAAALFPLYVNAAS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHH
RERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAME
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHH
VTWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
EKPCDALPATRPATTPSPQDKPVAAPAANDPAPAEPQKTGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TSTDARRPAALPCSLRLAIGGALIALMSLNAQAEDGKTAPPPSPDILLGPLFNDVQSAK
CCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHH
LFADQKTFADAIPNSDPLMILADYRMQKNQASFDLRHFVELNFTLPKENDTYVPPKGQTL
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHH
RQHIDGLWPVLTRSTVEVEKWDSLLPLPKPYVVPGGRFREVYYWDSYFTMLGLAESGHWD
HHHHHHHHHHHHCCEEEHHHHHCCCCCCCCEECCCCCEEEEEEECHHHHHHHCCCCCCCH
KVEDMVANFAAEIDAWGHIPNGNRTYYLSRSQPPFFSFMVSLLATHDGDQVLKTYQPQLE
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCHHHH
KEYRYWMAGADALPPGSADKRAVRMADGALLNRYWDDSDTPRPESWLDDVKTAKSNPNRP
HHHHHHHCCCCCCCCCCCCCHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCC
ATEIYRDLRSAAASGWDFSSRWMDNPQQLATIRTTSIVPVDLNALMFHLEKTLARASKAS
HHHHHHHHHHHHCCCCCCHHHHCCCHHHEEEEEECEEEEECHHHHHHHHHHHHHHHHHCC
GDSAGATQYDALANARQQAIEKYLWNDKEGWYADYDLKSHKVRNQLTAAALFPLYVNAAS
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHH
RERATKVAAAAESRLLKPGGLTTTTVNSGQQWDAPNGWAPLQWVAVEGLQNYGQQKIAME
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEHHH
VTWRFLTNVQHTYDSKQKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
EKPCDALPATRPATTPSPQDKPVAAPAANDPAPAEPQKTGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA