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The map label for this gene is lysR [H]

Identifier: 152970720

GI number: 152970720

Start: 2380127

End: 2381041

Strand: Direct

Name: lysR [H]

Synonym: KPN_02171

Alternate gene names: 152970720

Gene position: 2380127-2381041 (Clockwise)

Preceding gene: 152970717

Following gene: 152970721

Centisome position: 44.78

GC content: 57.81

Gene sequence:

>915_bases
ATGAAACTGCGTCATCTGGAAATCTTCTATGCCGTCATGACCTGCGGCTCTTTATCGCGAGCGGCGGAAGCGCTCAATAT
CTCCCAGCCCGCGGCCAGCAAAGCGTTAAAAAGCGCCGAAATGAAGCTGGGTTTTACCCTGTTTCAGCGGGTGCGCGGCA
AGCTGCTGCCGACCAGCGAGGCGATCACACTTTTCGAAAAAGCGCAGAGCATTTATCAGGACCTGGACAACCTGCGCCTG
CTGGCCGACAACCTGGCTCGCGATCCGCGCGCCAAGATCACTTTAGGCTGTCTGCCAAGCCTGGGGTTAAGCCTGGTGCC
GGAGCTGGTGACCGACTTTTATCAGCAAAACAGCAACCTGGTGATGACGCTCACTACCGAGCACACCGAGACGCTGGTCA
AAAAACTGGATTTGCGCGAGATAGATTTGGCGCTGACGCTACAGCCGGTGCAGCAGGGAGAGATCCTGACCACCCTGATT
GCCGAAGTACCGCTGGTGTACATCGACCGTCATTATCGTCAGGGGGCGGTGGAGATCGACCAGATCGACCAGCAGCGCTG
GATCTCGCCGGGACCGCACTCGCTCTCTGCCGCCATCGCCACCCGTCGCGACTTTTCCACCACCCGGCTAAACGTCCAGA
CCTACTATATGGCCACCGAGTTCGTGAAGCGCGGCATGGGCTGCAGCATCACTGATATCTTTTCCGCCCAGCACAACCTG
GCCCCGGAGATGATCCATCCCATTACGCCGCCGATGGCGATTAACCTCTGTCTGTTACGCCGGGCCGACGTTTCCCTGAG
CCCGATGGCGCAAAAGTTCGTCGATTTTCTCTGCCAGCGTCTGCGCCAGCAGCTCAAGGAGATTAACCTGCGGTTATACC
CTGACCATAAAAAGTCAATTGCGCCGCTGGGGTAA

Upstream 100 bases:

>100_bases
GATGTAACCAATGCGCTGATTGGTGATTAAATCTATGTTAACTTAGTGTTAGTAGAAAATGACTTTTTATCGGTAGGCTA
TAACCCTGAGTTAACTGTTC

Downstream 100 bases:

>100_bases
ATGCTTTGACATAACCCGATAAATTTATCAGCGGTGGATATATCGGGTTATGAACAAACGCATTGTCATTATCGGCGGCG
GCGTGGTCGGTCTGGCCACG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKLRHLEIFYAVMTCGSLSRAAEALNISQPAASKALKSAEMKLGFTLFQRVRGKLLPTSEAITLFEKAQSIYQDLDNLRL
LADNLARDPRAKITLGCLPSLGLSLVPELVTDFYQQNSNLVMTLTTEHTETLVKKLDLREIDLALTLQPVQQGEILTTLI
AEVPLVYIDRHYRQGAVEIDQIDQQRWISPGPHSLSAAIATRRDFSTTRLNVQTYYMATEFVKRGMGCSITDIFSAQHNL
APEMIHPITPPMAINLCLLRRADVSLSPMAQKFVDFLCQRLRQQLKEINLRLYPDHKKSIAPLG

Sequences:

>Translated_304_residues
MKLRHLEIFYAVMTCGSLSRAAEALNISQPAASKALKSAEMKLGFTLFQRVRGKLLPTSEAITLFEKAQSIYQDLDNLRL
LADNLARDPRAKITLGCLPSLGLSLVPELVTDFYQQNSNLVMTLTTEHTETLVKKLDLREIDLALTLQPVQQGEILTTLI
AEVPLVYIDRHYRQGAVEIDQIDQQRWISPGPHSLSAAIATRRDFSTTRLNVQTYYMATEFVKRGMGCSITDIFSAQHNL
APEMIHPITPPMAINLCLLRRADVSLSPMAQKFVDFLCQRLRQQLKEINLRLYPDHKKSIAPLG
>Mature_304_residues
MKLRHLEIFYAVMTCGSLSRAAEALNISQPAASKALKSAEMKLGFTLFQRVRGKLLPTSEAITLFEKAQSIYQDLDNLRL
LADNLARDPRAKITLGCLPSLGLSLVPELVTDFYQQNSNLVMTLTTEHTETLVKKLDLREIDLALTLQPVQQGEILTTLI
AEVPLVYIDRHYRQGAVEIDQIDQQRWISPGPHSLSAAIATRRDFSTTRLNVQTYYMATEFVKRGMGCSITDIFSAQHNL
APEMIHPITPPMAINLCLLRRADVSLSPMAQKFVDFLCQRLRQQLKEINLRLYPDHKKSIAPLG

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=146, Percent_Identity=36.3013698630137, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788887, Length=294, Percent_Identity=24.8299319727891, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081904, Length=152, Percent_Identity=30.9210526315789, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790399, Length=165, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI157672245, Length=156, Percent_Identity=28.2051282051282, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787601, Length=207, Percent_Identity=26.5700483091787, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786401, Length=301, Percent_Identity=22.9235880398671, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34231; Mature: 34231

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLRHLEIFYAVMTCGSLSRAAEALNISQPAASKALKSAEMKLGFTLFQRVRGKLLPTSE
CCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AITLFEKAQSIYQDLDNLRLLADNLARDPRAKITLGCLPSLGLSLVPELVTDFYQQNSNL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHCHHHHHHHHHHHHHHCCCCE
VMTLTTEHTETLVKKLDLREIDLALTLQPVQQGEILTTLIAEVPLVYIDRHYRQGAVEID
EEEEECHHHHHHHHHCCHHHCCEEEEECCCCCCHHHHHHHHHCCHHEEEHHHCCCCCCHH
QIDQQRWISPGPHSLSAAIATRRDFSTTRLNVQTYYMATEFVKRGMGCSITDIFSAQHNL
HHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHCC
APEMIHPITPPMAINLCLLRRADVSLSPMAQKFVDFLCQRLRQQLKEINLRLYPDHKKSI
CHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCC
APLG
CCCC
>Mature Secondary Structure
MKLRHLEIFYAVMTCGSLSRAAEALNISQPAASKALKSAEMKLGFTLFQRVRGKLLPTSE
CCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AITLFEKAQSIYQDLDNLRLLADNLARDPRAKITLGCLPSLGLSLVPELVTDFYQQNSNL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHCHHHHHHHHHHHHHHCCCCE
VMTLTTEHTETLVKKLDLREIDLALTLQPVQQGEILTTLIAEVPLVYIDRHYRQGAVEID
EEEEECHHHHHHHHHCCHHHCCEEEEECCCCCCHHHHHHHHHCCHHEEEHHHCCCCCCHH
QIDQQRWISPGPHSLSAAIATRRDFSTTRLNVQTYYMATEFVKRGMGCSITDIFSAQHNL
HHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHCC
APEMIHPITPPMAINLCLLRRADVSLSPMAQKFVDFLCQRLRQQLKEINLRLYPDHKKSI
CHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCC
APLG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]