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The map label for this gene is mhpR [H]

Identifier: 152970672

GI number: 152970672

Start: 2326771

End: 2327583

Strand: Direct

Name: mhpR [H]

Synonym: KPN_02123

Alternate gene names: 152970672

Gene position: 2326771-2327583 (Clockwise)

Preceding gene: 152970663

Following gene: 152970673

Centisome position: 43.78

GC content: 63.84

Gene sequence:

>813_bases
ATGCGTGACGATGAGTCCGCAGCGTACAAAACGGTGCGCGGATTAAGCCGGGGTTTATTGTTATTGAAATTGTTAAATAA
ATTCGACGGCGGCGCGACGCCGGGCCTGCTGGCGGAGTTTAGCGGCCTGCATCGCACCACCGTGCGCCGGCTGCTGGAGA
CGCTGCAGGAGGAGGGTTTTGTCCGCCGCAGCCGCTCCGATGACAGCTTCCGGTTGACCATTAACGTCCGCCAGCTGAGC
GATGGATTTCGTGACGAACATTGGATTTCTGCCCTCGCCACGCCGCTGCTCGGCGAGCTGCTGCGCGAGGTGCAGTGGCC
AACGGACATCACCACCCTCGACGTCGACGCCATGGTGGTGCGCGAGACTACCCACCGCTTCAGCCGACTGTCGTTTCACC
GCGCGATGGTCGGACGGCGGCTGCCGCTGCTGCTCACCGCCTCCGGACTGACGTGGCTGGCCTTTGCCCCCGACGCGGAA
CGCGACGCCGTCGTCAGCATGCTGGCCGCCCGTCCGGAAGCTGAGTATCAGCTGGCCCGCGAACCGGAACGGCTGGCGGC
GATCCTCGCCCGCACCCGCCAGAACGGCTATGGCGAAAACTTCCGCGGCTGGCGGCAGGAGGAGAAAATCGCCTCGATCG
CCGTGCCGGTCTGCAGTCAGCAGCGGGTTATCGGCTGCCTGAACCTGGTCTATATCGCCAGCGCGATGACCATTGAGCAG
GCGGCGCAGAAGCATCTCCCTGCGCTGCAGAGGGTGGCGAGGCAGATAGAAGCCCGCATGGAAGAGGAAGAAGTGTGGTA
CGAAATGCCCTGA

Upstream 100 bases:

>100_bases
GGGCTGAGTATAGGGCGGGGGTTTTCGGCTACAATCAAAACATCATCGAATGTGCACCAGGTGCACAACACTGTTTTTAA
AGCATTTTAATGGAGGATTT

Downstream 100 bases:

>100_bases
TCGTGATGAGGATAAATGCGATCAACCATTGCGCCCGGCTTCGTTATATAATTTAATACACAACGAATTTTCACGCCATT
CGGGCCACACCATGTCAAAA

Product: DNA-binding transcriptional activator MhpR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGLHRTTVRRLLETLQEEGFVRRSRSDDSFRLTINVRQLS
DGFRDEHWISALATPLLGELLREVQWPTDITTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLLTASGLTWLAFAPDAE
RDAVVSMLAARPEAEYQLAREPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRVIGCLNLVYIASAMTIEQ
AAQKHLPALQRVARQIEARMEEEEVWYEMP

Sequences:

>Translated_270_residues
MRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGLHRTTVRRLLETLQEEGFVRRSRSDDSFRLTINVRQLS
DGFRDEHWISALATPLLGELLREVQWPTDITTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLLTASGLTWLAFAPDAE
RDAVVSMLAARPEAEYQLAREPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRVIGCLNLVYIASAMTIEQ
AAQKHLPALQRVARQIEARMEEEEVWYEMP
>Mature_270_residues
MRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGLHRTTVRRLLETLQEEGFVRRSRSDDSFRLTINVRQLS
DGFRDEHWISALATPLLGELLREVQWPTDITTLDVDAMVVRETTHRFSRLSFHRAMVGRRLPLLLTASGLTWLAFAPDAE
RDAVVSMLAARPEAEYQLAREPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRVIGCLNLVYIASAMTIEQ
AAQKHLPALQRVARQIEARMEEEEVWYEMP

Specific function: Activator of the mhpRABCDEF operon coding for components of the 3-hydroxyphenylpropionate degradation pathway [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI145693096, Length=265, Percent_Identity=77.3584905660377, Blast_Score=407, Evalue=1e-115,
Organism=Escherichia coli, GI1786468, Length=218, Percent_Identity=27.5229357798165, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788131, Length=225, Percent_Identity=28, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 30674; Mature: 30674

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGLHRTTVRRLLETLQEEGF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHCCH
VRRSRSDDSFRLTINVRQLSDGFRDEHWISALATPLLGELLREVQWPTDITTLDVDAMVV
HHCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHH
RETTHRFSRLSFHRAMVGRRLPLLLTASGLTWLAFAPDAERDAVVSMLAARPEAEYQLAR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHC
EPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRVIGCLNLVYIASAMTIEQ
CHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AAQKHLPALQRVARQIEARMEEEEVWYEMP
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure
MRDDESAAYKTVRGLSRGLLLLKLLNKFDGGATPGLLAEFSGLHRTTVRRLLETLQEEGF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCHHHHHHHHHHHHHHHCCH
VRRSRSDDSFRLTINVRQLSDGFRDEHWISALATPLLGELLREVQWPTDITTLDVDAMVV
HHCCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHH
RETTHRFSRLSFHRAMVGRRLPLLLTASGLTWLAFAPDAERDAVVSMLAARPEAEYQLAR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHC
EPERLAAILARTRQNGYGENFRGWRQEEKIASIAVPVCSQQRVIGCLNLVYIASAMTIEQ
CHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AAQKHLPALQRVARQIEARMEEEEVWYEMP
HHHHHHHHHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]