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The map label for this gene is ywrD [H]

Identifier: 152970320

GI number: 152970320

Start: 1949985

End: 1951571

Strand: Direct

Name: ywrD [H]

Synonym: KPN_01768

Alternate gene names: 152970320

Gene position: 1949985-1951571 (Clockwise)

Preceding gene: 152970312

Following gene: 152970321

Centisome position: 36.69

GC content: 68.3

Gene sequence:

>1587_bases
ATGCACAGTAGCAACGTTTCGACCCACGGCATGGCGGTGGCCCCCCACCACCTCGCCAGTCAGAGCGCGCTGGCGATCCT
GCGCGAGGGCGGCAGCGCCATTGAAGCGATGGTGGCTGCCGCGGCGGCCATCGCCGTCGTCTATCCCCATATGAATGGCC
TCGGCGGCGATGGCTTCTGGCTGATCGTGCCGCCTGAGGGAGACCCAATCGCCATTGACGCCAGCGGGGCCGCCGGATCG
CTGGCGACCCTCGAGGCCTACGCCGGACAGCGGCATATTCCCAACCGGGGACCGCAGGCCGCGCTGACCGTCGCCGGCAC
CGTCAGCGGCTGGGTCGAGGCGCTGCGTATTTCACGGGACTTAACCGGCCGCGCGCTGCCGGTGGCCCGCCTGCTGGCCG
ATGCGATCGGCTATGCCGAAGACGGCATTCCGGTCACTGCCTCGCAGGCCCACGCCACCGCCAGCAAACTGGAAGAGCTG
CGCCATCAGCCGGGCTTCAGCGAAACCTGGCTGGTAGCGGGCGAGGCCCCGCGGCCCGGCAGCCGCTTCCGCCAGCCCGC
CCTCGCCGGTACCCTGCGCATGCTGGCCAGCGACGGTCTCGACAGCTTTTATCGCGGGCCGCTGGCCGAGCGTCTCGCGC
AGGGTATGGCCGCGCTGGGGATGCCGATCACCCTCGGCGACCTGCAGGCCCACCGCGCCCGGCGTCCGGGGCCGCTGACG
CTCCAGCACCAGCAGGGCACGCTGTGGAATCTTGCCCCACCCACGCAGGGGCTGGTGTCGCTGGCGATCCTTGGCATCAC
CGACCGTCTGAAGATGGCCGATGCCGACGACGCGCAAACGGTGCACCGTATCGTCGAAGCCACCAAGCGGGCATTTGCCC
TGCGCGATGCGCATATCACCGATCCGCGCCATCTGGATGTGGATGTACAGCAGTTGCTCACCCCGGAAGCCCTGCAGCCG
CTGGCCGACAGCATCGACGACGCCAGCGCTTCCCCCTGGGGCGGCGGCAAAGGCCCGGGCGATACCGTCTGGATGGGCGT
CGTGGATAACAGCGGACTGGCAGTGTCGTTTATTCAGAGTATCTATCACGAGTTCGGCAGCGGCGTGGTACTCCCGGACA
CCGGGATCGTCTGGCAAAACCGCGGGGCGGCCTTCAGCCTCGATCCGCAGCATCTCCTGGCGCTGGCCCCTGGCAAACAG
CCATTCCATACCCTCAACCCTGCCGCCGCCCGCCTGAACGATGGCCGGGTGATGGTCTATGGCTCGATGGGCGGCGACGG
TCAGCCGCAAACGCAGGCGGCGCTGTTTACTCGCTATATCCTGCAGGGGGTACCGTTGCAGGAGAGCATCTCCCGTCCGC
GCTGGCTTCTGGGCCGCACCTGGGGCCAGTCCTCCGACTCACTGAAGCTGGAGGGACGCTTTGCCCCCGCCTGTATCGCG
CGCCTGCGCGAGCTGGGGCACGACGTAGAAGTGCTGGCCGATTTCAGCGAAGCGATGGGCCACGCCGGGGCCATTGTCCG
CCATCCCAACGGTCTGCTTGAAGGGGCGACCGATCCACGCAGCAACGGCGCCGCCGCCGGGTACTAA

Upstream 100 bases:

>100_bases
GGAAAATTCTGGTCATCGTTTTTATCAATGAAACGAAACGTTCAGAGATGGAACAGCTTTTGCAGTGTTCTGCGGGTGAT
TCGTTCAGAAAGGATAATTT

Downstream 100 bases:

>100_bases
GGAGCAGACCATGACCACACAGCCAGACTGGAGCGAGTATCTGACGCAGATGACTCACCTGTTGGATATGGAGCTGGATG
CGCCGCGCCGTAAGGAGCTG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFWLIVPPEGDPIAIDASGAAGS
LATLEAYAGQRHIPNRGPQAALTVAGTVSGWVEALRISRDLTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEEL
RHQPGFSETWLVAGEAPRPGSRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
LQHQQGTLWNLAPPTQGLVSLAILGITDRLKMADADDAQTVHRIVEATKRAFALRDAHITDPRHLDVDVQQLLTPEALQP
LADSIDDASASPWGGGKGPGDTVWMGVVDNSGLAVSFIQSIYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQ
PFHTLNPAAARLNDGRVMVYGSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY

Sequences:

>Translated_528_residues
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFWLIVPPEGDPIAIDASGAAGS
LATLEAYAGQRHIPNRGPQAALTVAGTVSGWVEALRISRDLTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEEL
RHQPGFSETWLVAGEAPRPGSRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
LQHQQGTLWNLAPPTQGLVSLAILGITDRLKMADADDAQTVHRIVEATKRAFALRDAHITDPRHLDVDVQQLLTPEALQP
LADSIDDASASPWGGGKGPGDTVWMGVVDNSGLAVSFIQSIYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQ
PFHTLNPAAARLNDGRVMVYGSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY
>Mature_528_residues
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFWLIVPPEGDPIAIDASGAAGS
LATLEAYAGQRHIPNRGPQAALTVAGTVSGWVEALRISRDLTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEEL
RHQPGFSETWLVAGEAPRPGSRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
LQHQQGTLWNLAPPTQGLVSLAILGITDRLKMADADDAQTVHRIVEATKRAFALRDAHITDPRHLDVDVQQLLTPEALQP
LADSIDDASASPWGGGKGPGDTVWMGVVDNSGLAVSFIQSIYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQ
PFHTLNPAAARLNDGRVMVYGSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=555, Percent_Identity=29.3693693693694, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI73915090, Length=555, Percent_Identity=29.3693693693694, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI73915096, Length=555, Percent_Identity=29.3693693693694, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI73915094, Length=555, Percent_Identity=29.3693693693694, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI113429324, Length=529, Percent_Identity=28.9224952741021, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI113429326, Length=534, Percent_Identity=28.6516853932584, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI109148539, Length=442, Percent_Identity=28.0542986425339, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI153266885, Length=401, Percent_Identity=27.1820448877805, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI153266901, Length=401, Percent_Identity=27.1820448877805, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI153266907, Length=385, Percent_Identity=26.7532467532467, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1789856, Length=550, Percent_Identity=29.6363636363636, Blast_Score=192, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17542894, Length=483, Percent_Identity=25.2587991718427, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI193208247, Length=481, Percent_Identity=25.1559251559252, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193208245, Length=481, Percent_Identity=25.1559251559252, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI72000294, Length=459, Percent_Identity=26.1437908496732, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI212646519, Length=459, Percent_Identity=26.1437908496732, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17506189, Length=447, Percent_Identity=26.3982102908277, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161077878, Length=556, Percent_Identity=26.0791366906475, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI161077880, Length=556, Percent_Identity=26.0791366906475, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI45551474, Length=556, Percent_Identity=26.0791366906475, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24642670, Length=556, Percent_Identity=26.0791366906475, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642666, Length=556, Percent_Identity=26.0791366906475, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859893, Length=511, Percent_Identity=26.614481409002, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55543; Mature: 55543

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFW
CCCCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEE
LIVPPEGDPIAIDASGAAGSLATLEAYAGQRHIPNRGPQAALTVAGTVSGWVEALRISRD
EEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHC
LTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEELRHQPGFSETWLVAGEAPRPG
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH
SRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
HHHCCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCCEEECCHHHHHCCCCCCEE
LQHQQGTLWNLAPPTQGLVSLAILGITDRLKMADADDAQTVHRIVEATKRAFALRDAHIT
EEECCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
DPRHLDVDVQQLLTPEALQPLADSIDDASASPWGGGKGPGDTVWMGVVDNSGLAVSFIQS
CCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
IYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQPFHTLNPAAARLNDGRVMVY
HHHHHCCCEEECCCCEEECCCCCEEEECHHHHEEECCCCCCCCCCCHHHHEECCCEEEEE
GSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
ECCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCEEECCCCCHHHHH
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY
HHHHCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHSSNVSTHGMAVAPHHLASQSALAILREGGSAIEAMVAAAAAIAVVYPHMNGLGGDGFW
CCCCCCCCCCEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEECCCCCCCCCEEE
LIVPPEGDPIAIDASGAAGSLATLEAYAGQRHIPNRGPQAALTVAGTVSGWVEALRISRD
EEECCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHC
LTGRALPVARLLADAIGYAEDGIPVTASQAHATASKLEELRHQPGFSETWLVAGEAPRPG
CCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH
SRFRQPALAGTLRMLASDGLDSFYRGPLAERLAQGMAALGMPITLGDLQAHRARRPGPLT
HHHCCHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHCCCEEECCHHHHHCCCCCCEE
LQHQQGTLWNLAPPTQGLVSLAILGITDRLKMADADDAQTVHRIVEATKRAFALRDAHIT
EEECCCCEEECCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
DPRHLDVDVQQLLTPEALQPLADSIDDASASPWGGGKGPGDTVWMGVVDNSGLAVSFIQS
CCCCCCCCHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHH
IYHEFGSGVVLPDTGIVWQNRGAAFSLDPQHLLALAPGKQPFHTLNPAAARLNDGRVMVY
HHHHHCCCEEECCCCEEECCCCCEEEECHHHHEEECCCCCCCCCCCHHHHEECCCEEEEE
GSMGGDGQPQTQAALFTRYILQGVPLQESISRPRWLLGRTWGQSSDSLKLEGRFAPACIA
ECCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCEEECCCCCHHHHH
RLRELGHDVEVLADFSEAMGHAGAIVRHPNGLLEGATDPRSNGAAAGY
HHHHCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]