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The map label for this gene is cycA [H]

Identifier: 152970050

GI number: 152970050

Start: 1665292

End: 1666722

Strand: Direct

Name: cycA [H]

Synonym: KPN_01498

Alternate gene names: 152970050

Gene position: 1665292-1666722 (Clockwise)

Preceding gene: 152970049

Following gene: 152970052

Centisome position: 31.33

GC content: 61.64

Gene sequence:

>1431_bases
ATGACTGAACATCAACATCAGGCGTCACCTGCCGCCGGAGGTGAAGGCGCGTCACAGCTTAAGCGCGGGCTCAGCGCCCG
CCATATCCAGATGATTGCCCTCGGGGGCGCCATCGGCACCGGACTGTTTATGGGGGCGGGGCGCAACATCGCCGTCGCCG
GCACCTCGATCCTGGTTATCTATGTGCTGGTCGGGTTCTTTACCTATATGGTGATGCGGGCGATGGGCGAGCTGCTGCTC
ACCCGCCATGACTACCGCTCGTTTGCCGACTTTGTCGGCGAGTATCTCGGGCCGCAGGCCAGCTTTTACCTCGGCTGGAC
CTACTGGCTAAGCTGGGTGGTAACCTGTATCGCCGACGTAGTGGTCTGCGGGAGCTATATGCAGTACTGGTTCCCGGAAC
TGTCGGCGTGGATGCCGGCCCTCAGCATGCTGGCGATTCTGTTCCTGCTTAACCTGCTGTCGGTGAAAATGTTCGGTGAG
GCGGAGTTCTGGTTCGCCCTGATCAAGGTGATCACCATTATCGCCCTGATCGGCACCGGCGGCTGGATGATTGCCACCGG
CTGGACCTCCCCGGACGGCGTGACGGCCTCCCTCAGCCATCTCACCGACCCGACGGCCTTTATGCCCCACGGCATCACCG
GCTTTTTCGCCGGCTTCCAGATAGCGATCTTCTCCTTTACCGGCATTGAGCTGCTGGGCACCATGACGGCGGAGACCCGC
GATCCGCAGCGCATTTTGCCCAAGGCGATCAATGCTCTGCCGCTGCGGATTATTATCTTCTATCTGCTGTCGATGGTGGT
GATCATCGCTGTCGCCTCGTGGCCGGGGGTGTCGGCGGAGACCAGCCCCTTCGTGACGCTGTTCGCCAAGGCCGGGCTGC
CTGCCGCCGCGGCGGTGATTAACTTTGTGGCGCTGACCTCGGCGATGTCCTCGGCCAACAGCGGGGTCTTCTCCAGCACC
CGCATGCTGTACGGCCTGTCGGTGGAGAAGCATGCGCACTGGCAGTTTCGTATCCTGTCGCGCAGTACCCGCATTCCGGT
GCGCAGCCTGCTGTTCTCCTGCTTCTGCATGCTGATCGGCACGCTGTTGCTGTTTCTGGTGCCGAACGTGATGACCCTGT
TCACCATCGTCTCGACCCTGGCGGCGATTATGGTGGTGTTCAGCTGGGGGATGATCCTCGTGGCCTATCTGGTTTACCGC
CGTCAGCGTCCGGACCTGCACGCCGGGTCGATCTTTAAGATGCCCGCCGGGGTGGTGATGAGCTGGGTGAGCCTGCTGTT
CTTCGCGTTCGCTATCTTCATCATGATCTTTGACCCGGACACGCTGCTGGCGCTGTTGGCTTCTCCGCTGTGGTTTATCG
CGCTGTGGGGCTTCTGGAAGCTGAAGCAGCGGCGCGAGGGGCAGCTTCAGCTGGACAACCAGAGCGCCTGA

Upstream 100 bases:

>100_bases
TATCCTCTTTCCCAACGCCGGGGTCGCCACCGGCCAGCGCGCCGGGCTGTTGCTCCGCGCCGCTGCCCTTCGTCTCCCGC
AACCAGCCTGAGGAAACACC

Downstream 100 bases:

>100_bases
CACCCGCCGGTCCTGGCGGCCGGCTAAGCAGGGGGGAAGACTTGACGCCTGTTTGTGCCCGGTGACGGCTGGCGCCTTAC
CGGGCCTACATGCTTACCGG

Product: D-alanine/D-serine/glycine transport protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTEHQHQASPAAGGEGASQLKRGLSARHIQMIALGGAIGTGLFMGAGRNIAVAGTSILVIYVLVGFFTYMVMRAMGELLL
TRHDYRSFADFVGEYLGPQASFYLGWTYWLSWVVTCIADVVVCGSYMQYWFPELSAWMPALSMLAILFLLNLLSVKMFGE
AEFWFALIKVITIIALIGTGGWMIATGWTSPDGVTASLSHLTDPTAFMPHGITGFFAGFQIAIFSFTGIELLGTMTAETR
DPQRILPKAINALPLRIIIFYLLSMVVIIAVASWPGVSAETSPFVTLFAKAGLPAAAAVINFVALTSAMSSANSGVFSST
RMLYGLSVEKHAHWQFRILSRSTRIPVRSLLFSCFCMLIGTLLLFLVPNVMTLFTIVSTLAAIMVVFSWGMILVAYLVYR
RQRPDLHAGSIFKMPAGVVMSWVSLLFFAFAIFIMIFDPDTLLALLASPLWFIALWGFWKLKQRREGQLQLDNQSA

Sequences:

>Translated_476_residues
MTEHQHQASPAAGGEGASQLKRGLSARHIQMIALGGAIGTGLFMGAGRNIAVAGTSILVIYVLVGFFTYMVMRAMGELLL
TRHDYRSFADFVGEYLGPQASFYLGWTYWLSWVVTCIADVVVCGSYMQYWFPELSAWMPALSMLAILFLLNLLSVKMFGE
AEFWFALIKVITIIALIGTGGWMIATGWTSPDGVTASLSHLTDPTAFMPHGITGFFAGFQIAIFSFTGIELLGTMTAETR
DPQRILPKAINALPLRIIIFYLLSMVVIIAVASWPGVSAETSPFVTLFAKAGLPAAAAVINFVALTSAMSSANSGVFSST
RMLYGLSVEKHAHWQFRILSRSTRIPVRSLLFSCFCMLIGTLLLFLVPNVMTLFTIVSTLAAIMVVFSWGMILVAYLVYR
RQRPDLHAGSIFKMPAGVVMSWVSLLFFAFAIFIMIFDPDTLLALLASPLWFIALWGFWKLKQRREGQLQLDNQSA
>Mature_475_residues
TEHQHQASPAAGGEGASQLKRGLSARHIQMIALGGAIGTGLFMGAGRNIAVAGTSILVIYVLVGFFTYMVMRAMGELLLT
RHDYRSFADFVGEYLGPQASFYLGWTYWLSWVVTCIADVVVCGSYMQYWFPELSAWMPALSMLAILFLLNLLSVKMFGEA
EFWFALIKVITIIALIGTGGWMIATGWTSPDGVTASLSHLTDPTAFMPHGITGFFAGFQIAIFSFTGIELLGTMTAETRD
PQRILPKAINALPLRIIIFYLLSMVVIIAVASWPGVSAETSPFVTLFAKAGLPAAAAVINFVALTSAMSSANSGVFSSTR
MLYGLSVEKHAHWQFRILSRSTRIPVRSLLFSCFCMLIGTLLLFLVPNVMTLFTIVSTLAAIMVVFSWGMILVAYLVYRR
QRPDLHAGSIFKMPAGVVMSWVSLLFFAFAIFIMIFDPDTLLALLASPLWFIALWGFWKLKQRREGQLQLDNQSA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI33286428, Length=492, Percent_Identity=21.9512195121951, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790653, Length=454, Percent_Identity=52.6431718061674, Blast_Score=497, Evalue=1e-142,
Organism=Escherichia coli, GI1786302, Length=454, Percent_Identity=37.2246696035242, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1786789, Length=465, Percent_Identity=35.6989247311828, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1786602, Length=466, Percent_Identity=36.480686695279, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI48994972, Length=458, Percent_Identity=36.2445414847162, Blast_Score=285, Evalue=6e-78,
Organism=Escherichia coli, GI87081915, Length=473, Percent_Identity=34.8837209302326, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI87081708, Length=469, Percent_Identity=34.5415778251599, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788480, Length=343, Percent_Identity=38.4839650145773, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1789017, Length=437, Percent_Identity=30.8924485125858, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI87081869, Length=241, Percent_Identity=23.6514522821577, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=367, Percent_Identity=21.7983651226158, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=347, Percent_Identity=33.4293948126801, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324990, Length=416, Percent_Identity=27.6442307692308, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324924, Length=499, Percent_Identity=28.6573146292585, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6324061, Length=402, Percent_Identity=30.0995024875622, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=401, Percent_Identity=29.925187032419, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322892, Length=441, Percent_Identity=29.7052154195011, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319824, Length=411, Percent_Identity=27.007299270073, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324059, Length=375, Percent_Identity=32.2666666666667, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=26.1194029850746, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320717, Length=415, Percent_Identity=24.578313253012, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321629, Length=427, Percent_Identity=26.463700234192, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319542, Length=398, Percent_Identity=25.8793969849246, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6322967, Length=436, Percent_Identity=27.2935779816514, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319608, Length=444, Percent_Identity=22.5225225225225, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319543, Length=408, Percent_Identity=27.2058823529412, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6324981, Length=438, Percent_Identity=27.1689497716895, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321053, Length=391, Percent_Identity=23.5294117647059, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320364, Length=465, Percent_Identity=23.010752688172, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45550968, Length=418, Percent_Identity=27.9904306220096, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921172, Length=418, Percent_Identity=27.9904306220096, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221331183, Length=417, Percent_Identity=23.2613908872902, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17647653, Length=417, Percent_Identity=23.2613908872902, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24664379, Length=417, Percent_Identity=23.2613908872902, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357367, Length=495, Percent_Identity=24.8484848484848, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 52357; Mature: 52226

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHQHQASPAAGGEGASQLKRGLSARHIQMIALGGAIGTGLFMGAGRNIAVAGTSILVI
CCCCCCCCCCCCCCCCHHHHHHCCCHHHEEHEEECCHHHHHHHHCCCCEEEEHHHHHHHH
YVLVGFFTYMVMRAMGELLLTRHDYRSFADFVGEYLGPQASFYLGWTYWLSWVVTCIADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
VVCGSYMQYWFPELSAWMPALSMLAILFLLNLLSVKMFGEAEFWFALIKVITIIALIGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
GWMIATGWTSPDGVTASLSHLTDPTAFMPHGITGFFAGFQIAIFSFTGIELLGTMTAETR
CEEEEECCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DPQRILPKAINALPLRIIIFYLLSMVVIIAVASWPGVSAETSPFVTLFAKAGLPAAAAVI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHH
NFVALTSAMSSANSGVFSSTRMLYGLSVEKHAHWQFRILSRSTRIPVRSLLFSCFCMLIG
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
TLLLFLVPNVMTLFTIVSTLAAIMVVFSWGMILVAYLVYRRQRPDLHAGSIFKMPAGVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHH
SWVSLLFFAFAIFIMIFDPDTLLALLASPLWFIALWGFWKLKQRREGQLQLDNQSA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCC
>Mature Secondary Structure 
TEHQHQASPAAGGEGASQLKRGLSARHIQMIALGGAIGTGLFMGAGRNIAVAGTSILVI
CCCCCCCCCCCCCCCHHHHHHCCCHHHEEHEEECCHHHHHHHHCCCCEEEEHHHHHHHH
YVLVGFFTYMVMRAMGELLLTRHDYRSFADFVGEYLGPQASFYLGWTYWLSWVVTCIADV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHH
VVCGSYMQYWFPELSAWMPALSMLAILFLLNLLSVKMFGEAEFWFALIKVITIIALIGTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCC
GWMIATGWTSPDGVTASLSHLTDPTAFMPHGITGFFAGFQIAIFSFTGIELLGTMTAETR
CEEEEECCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DPQRILPKAINALPLRIIIFYLLSMVVIIAVASWPGVSAETSPFVTLFAKAGLPAAAAVI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHHHHH
NFVALTSAMSSANSGVFSSTRMLYGLSVEKHAHWQFRILSRSTRIPVRSLLFSCFCMLIG
HHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
TLLLFLVPNVMTLFTIVSTLAAIMVVFSWGMILVAYLVYRRQRPDLHAGSIFKMPAGVVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHH
SWVSLLFFAFAIFIMIFDPDTLLALLASPLWFIALWGFWKLKQRREGQLQLDNQSA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]