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The map label for this gene is umuC [H]

Identifier: 152969992

GI number: 152969992

Start: 1596110

End: 1597198

Strand: Direct

Name: umuC [H]

Synonym: KPN_01439

Alternate gene names: 152969992

Gene position: 1596110-1597198 (Clockwise)

Preceding gene: 152969991

Following gene: 152970000

Centisome position: 30.03

GC content: 53.63

Gene sequence:

>1089_bases
ATGTTTCGCCGGCACGGTATTATCGCGTTTAGCAGCAACTATGAGCTTTATGCCGATATGTCCAACCGAGTGATGACAAC
ACTGGAGGAACTCTCTCCACGCTGCGAAATTTACAGTATTGATGAGGCATTTTGCGATCTTACTGGTGTGCGAAACTGTC
GCGATCTTACCGACTTTGGCAGGGAAATTCGCGAGACGGTTCTGCGCAGGACGCACCTCACGATCGGCGTCGGCATAGCC
CAGACTAAAACCCTGGCGAAGCTGGCCAATCACGCCGCGAAACAGTGGCAGCGGCAGACCGGAGGAGTGGTGGACCTGTC
TAATCTGGAAAGGCAGAGGAAGTTGATGGCTTTGCTTCCGGTGGATGAGGTCTGGGGCGTCGGGCGCCGCATCAGTAAAA
AACTGGAGGCCATGGGGATTAAAACGGTACTGCAACTGGCGGATACCGATATCCGTTTTATCCGGAAGCATTTTAATGTG
GTTCTGGAGAGAACCGTGCGGGAGCTGCGTGGCGAACCATGCCTCGGGCTGGAGGAATTCGCGCCAGTAAAGCAGGAAAT
CGTGTGCAGCCGTTCGTTCGGCGGCCGTATCACGGAATACCATGAGATGAGGCAGGCAATATGCAGCTATGCGTCGCGCG
CAGCGGAGAAACTCCGTGGCGAGCATCAATATTGCCGATTTATCTCCGCATTTGTCAAAACGAGTCCTTTCGCGCTGAAC
GAGCCGTATTACGGGAACAGTGCATCAGTAAAGCTTCTTACACCGACCCAGGATAGCCGGGACATCATCACCGCGGCGAC
AAAATGTCTCGATGCAATCTGGCGAGACGGGCATCGTTACCAGAAAGCAGGAGTAATGCTGGGAGATTTCTACAGCCAGG
GCGTAGCGCAGCTCAACCTGTTTGATGACAACGCTCCCCGGAAGGGGAGTGAGAAACTGATGGAAGTTCTCGATCATCTC
AACGCGAAAGGCGGAAGGGGAACTCTGTATTTTGCAGGGCAGGGGATCCAGACTGCCTGGCAGATGAAGCGAGAAATGCT
ATCACCACGCTATACTACGAGGTTTTGTGACCTGCTCAAAGTTAGATGA

Upstream 100 bases:

>100_bases
GGTGGTCGTTCTGTCAAACAACGACGGCTGTGTGATCGCCCGTTCGCAAGAAGCGAAGCCCTTCGTCAAAATGGGGGAGC
CTTTTTTCAAGCAAAAGGAC

Downstream 100 bases:

>100_bases
TTCGGCCATTAACGGTAGTGGTTATGCTGTTACTACAGTCCGCTTAGAGCGAGGAGCTCACATCTGCCACCTCAAAAAGA
CCGCAAATATTCAAAAATTT

Product: DNA polymerase V subunit UmuC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MFRRHGIIAFSSNYELYADMSNRVMTTLEELSPRCEIYSIDEAFCDLTGVRNCRDLTDFGREIRETVLRRTHLTIGVGIA
QTKTLAKLANHAAKQWQRQTGGVVDLSNLERQRKLMALLPVDEVWGVGRRISKKLEAMGIKTVLQLADTDIRFIRKHFNV
VLERTVRELRGEPCLGLEEFAPVKQEIVCSRSFGGRITEYHEMRQAICSYASRAAEKLRGEHQYCRFISAFVKTSPFALN
EPYYGNSASVKLLTPTQDSRDIITAATKCLDAIWRDGHRYQKAGVMLGDFYSQGVAQLNLFDDNAPRKGSEKLMEVLDHL
NAKGGRGTLYFAGQGIQTAWQMKREMLSPRYTTRFCDLLKVR

Sequences:

>Translated_362_residues
MFRRHGIIAFSSNYELYADMSNRVMTTLEELSPRCEIYSIDEAFCDLTGVRNCRDLTDFGREIRETVLRRTHLTIGVGIA
QTKTLAKLANHAAKQWQRQTGGVVDLSNLERQRKLMALLPVDEVWGVGRRISKKLEAMGIKTVLQLADTDIRFIRKHFNV
VLERTVRELRGEPCLGLEEFAPVKQEIVCSRSFGGRITEYHEMRQAICSYASRAAEKLRGEHQYCRFISAFVKTSPFALN
EPYYGNSASVKLLTPTQDSRDIITAATKCLDAIWRDGHRYQKAGVMLGDFYSQGVAQLNLFDDNAPRKGSEKLMEVLDHL
NAKGGRGTLYFAGQGIQTAWQMKREMLSPRYTTRFCDLLKVR
>Mature_362_residues
MFRRHGIIAFSSNYELYADMSNRVMTTLEELSPRCEIYSIDEAFCDLTGVRNCRDLTDFGREIRETVLRRTHLTIGVGIA
QTKTLAKLANHAAKQWQRQTGGVVDLSNLERQRKLMALLPVDEVWGVGRRISKKLEAMGIKTVLQLADTDIRFIRKHFNV
VLERTVRELRGEPCLGLEEFAPVKQEIVCSRSFGGRITEYHEMRQAICSYASRAAEKLRGEHQYCRFISAFVKTSPFALN
EPYYGNSASVKLLTPTQDSRDIITAATKCLDAIWRDGHRYQKAGVMLGDFYSQGVAQLNLFDDNAPRKGSEKLMEVLDHL
NAKGGRGTLYFAGQGIQTAWQMKREMLSPRYTTRFCDLLKVR

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=362, Percent_Identity=87.0165745856354, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI1786425, Length=150, Percent_Identity=29.3333333333333, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 41277; Mature: 41277

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRRHGIIAFSSNYELYADMSNRVMTTLEELSPRCEIYSIDEAFCDLTGVRNCRDLTDFG
CCCCCEEEEEECCCEEEECHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCHHHHHHHH
REIRETVLRRTHLTIGVGIAQTKTLAKLANHAAKQWQRQTGGVVDLSNLERQRKLMALLP
HHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCC
VDEVWGVGRRISKKLEAMGIKTVLQLADTDIRFIRKHFNVVLERTVRELRGEPCLGLEEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
APVKQEIVCSRSFGGRITEYHEMRQAICSYASRAAEKLRGEHQYCRFISAFVKTSPFALN
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
EPYYGNSASVKLLTPTQDSRDIITAATKCLDAIWRDGHRYQKAGVMLGDFYSQGVAQLNL
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCCEEEEE
FDDNAPRKGSEKLMEVLDHLNAKGGRGTLYFAGQGIQTAWQMKREMLSPRYTTRFCDLLK
ECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHH
VR
CC
>Mature Secondary Structure
MFRRHGIIAFSSNYELYADMSNRVMTTLEELSPRCEIYSIDEAFCDLTGVRNCRDLTDFG
CCCCCEEEEEECCCEEEECHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCHHHHHHHH
REIRETVLRRTHLTIGVGIAQTKTLAKLANHAAKQWQRQTGGVVDLSNLERQRKLMALLP
HHHHHHHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHCC
VDEVWGVGRRISKKLEAMGIKTVLQLADTDIRFIRKHFNVVLERTVRELRGEPCLGLEEF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
APVKQEIVCSRSFGGRITEYHEMRQAICSYASRAAEKLRGEHQYCRFISAFVKTSPFALN
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCC
EPYYGNSASVKLLTPTQDSRDIITAATKCLDAIWRDGHRYQKAGVMLGDFYSQGVAQLNL
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHCCCEEEEE
FDDNAPRKGSEKLMEVLDHLNAKGGRGTLYFAGQGIQTAWQMKREMLSPRYTTRFCDLLK
ECCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHH
VR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]