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The map label for this gene is moaE [H]

Identifier: 152969371

GI number: 152969371

Start: 908275

End: 908727

Strand: Direct

Name: moaE [H]

Synonym: KPN_00814

Alternate gene names: 152969371

Gene position: 908275-908727 (Clockwise)

Preceding gene: 152969370

Following gene: 152969372

Centisome position: 17.09

GC content: 63.58

Gene sequence:

>453_bases
ATGACGCAAACCCGTATCGTGGTCAGCCCGGCGCGCTTTAGCGTCAGTGAGGAATATCCCTGGCTGGCGGAACGCGATGA
AGACGGCGCGGTGGTCACCTTCACCGGTAAAGTGCGTAACCACAACCTCGGCGACAGCGTGAAGGCGCTGACCCTCGAGC
ACTATCCGGGGATGACTGAAAAATCGCTGGCGGAAATTGTCGAGCTGGCGCGCGAGCGCTGGCCGCTGGGCCGGGTGACG
GTTATCCATCGCATCGGCGAAATGTGGCCGGGGGAAGAGATTGTGTTTGTCGGCGTCACCAGCGCTCACCGCGGCAGCGC
CTTCGCCGCCGGCGAGTTTATTATGGATTACCTGAAAACCCGCGCGCCGTTCTGGAAGCGTGAAGCGACGCCGGATGGCG
AACGCTGGGTCGACGCCCGCGACAGCGATCGCCAGGCGGCAGAGCGCTGGTAG

Upstream 100 bases:

>100_bases
AAGCTGCTGGCGGCGGTTAACCAGACGCTAACCTCTTTCGAACATCCAGTGGCCAGCGGCGACGAAGTGGCGTTCTTCCC
ACCGGTAACGGGGGGCTGAC

Downstream 100 bases:

>100_bases
TGTGATACGCTTACAGGGTGAAACTTTGTTTATCAGGAGAGAGTCATGGACAGATATCCGCGTTCCGATTCAATAGTGCA
GGGCCGTACCGGCCTGCAGA

Product: molybdopterin guanine dinucleotide biosynthesis protein MoaE

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 150; Mature: 149

Protein sequence:

>150_residues
MTQTRIVVSPARFSVSEEYPWLAERDEDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKSLAEIVELARERWPLGRVT
VIHRIGEMWPGEEIVFVGVTSAHRGSAFAAGEFIMDYLKTRAPFWKREATPDGERWVDARDSDRQAAERW

Sequences:

>Translated_150_residues
MTQTRIVVSPARFSVSEEYPWLAERDEDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKSLAEIVELARERWPLGRVT
VIHRIGEMWPGEEIVFVGVTSAHRGSAFAAGEFIMDYLKTRAPFWKREATPDGERWVDARDSDRQAAERW
>Mature_149_residues
TQTRIVVSPARFSVSEEYPWLAERDEDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKSLAEIVELARERWPLGRVTV
IHRIGEMWPGEEIVFVGVTSAHRGSAFAAGEFIMDYLKTRAPFWKREATPDGERWVDARDSDRQAAERW

Specific function: Converts molybdopterin precursor Z to molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=108, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787003, Length=150, Percent_Identity=84.6666666666667, Blast_Score=268, Evalue=2e-73,
Organism=Drosophila melanogaster, GI21356259, Length=120, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 17089; Mature: 16958

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTRIVVSPARFSVSEEYPWLAERDEDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTE
CCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCH
KSLAEIVELARERWPLGRVTVIHRIGEMWPGEEIVFVGVTSAHRGSAFAAGEFIMDYLKT
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
RAPFWKREATPDGERWVDARDSDRQAAERW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
>Mature Secondary Structure 
TQTRIVVSPARFSVSEEYPWLAERDEDGAVVTFTGKVRNHNLGDSVKALTLEHYPGMTE
CCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCH
KSLAEIVELARERWPLGRVTVIHRIGEMWPGEEIVFVGVTSAHRGSAFAAGEFIMDYLKT
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHH
RAPFWKREATPDGERWVDARDSDRQAAERW
CCCCCCCCCCCCCCCCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8361352; 8905232; 9278503; 8514782; 11135669 [H]