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The map label for this gene is oadA [H]

Identifier: 152969322

GI number: 152969322

Start: 850358

End: 852124

Strand: Direct

Name: oadA [H]

Synonym: KPN_00765

Alternate gene names: 152969322

Gene position: 850358-852124 (Clockwise)

Preceding gene: 152969321

Following gene: 152969323

Centisome position: 16.0

GC content: 67.01

Gene sequence:

>1767_bases
ATGACCGTTGCCATTACCGATGTCGTCCTGCGCGACGCCCACCAGTCCCTGTTCGCCACCCGTCTGCGTCTCGACGATAT
GCTGCCCGTTGCCGCTCAGCTGGACGACGTCGGCTACCGCTCGCTGGAGTGCTGGGGCGGCGCCACCTTTGACGCCTGCA
TCCGCTTCCTCGGCGAGGACCCGTGGGTCCGCCTGCGCGAGCTGAAAAAGGCGATGCCCAAGACCCCGCTGCAGATGCTG
CTCCGCGGCCAGAACCTGCTCGGCTACCGCCACTACGCCGACGACGTGGTGGAGCGCTTCGTCGAGCGCGCCGTCAAAAA
CGGCATGGACGTCTTCCGCGTCTTCGATGCCATGAACGACCCGCGCAACATGCAGGCCGCCCTGCAGGCGGTCCGCCGCC
ACGGCGCCCACGCCCAGGGTACGCTTTCGTACACCACCAGCCCGGCGCACACCCTGCAGACCTGGCTCGACCTCACCGAA
CAGTTGCTGGAGACCGGCGTTGACTCCGTCGCCATCAAGGACATGTCCGGCATTCTGACGCCGCATGCCGCCTTTGAGCT
GGTCAGCGAAATCAAGAAGCGCTACGACGTCACCCTGCACCTGCACTGCCACGCCACCACCGGGATGGCGGAGATGGCCC
TGCTGAAGGCCATTGAAGCCGGGGTCGACGGCGTCGACACCGCCATCTCCTCGATGAGCGCCACCTATGGCCACCCGGCC
ACCGAGGCGCTGGTCGCCACCCTCGCCGGCACGCAATATGACACCGGGCTGGATATCCACAGGCTGGAGAGCATCGCCGC
GTACTTTCGCGAGGTGCGCAAAAAATACCACGCCTTCGAAGGCCAGCTGAAGGGCACCGACAGCCGTATCCTGGTGGCCC
AGGTGCCGGGCGGGATGCTCACCAACCTCGAAGGCCAGCTGAAGCAGCAGAGCGCCGCCCACCGTCTGGATGAAGTGCTG
GCGGAAATCCCCCGCGTGCGCGAGGACCTCGGCTTCATCCCGCTGGTGACCCCGACCTCGCAGATTGTCGGCACCCAGGC
GGTGCTCAACGTGCTGGGCGGCGAGCGCTACAAAACCATTGCGAAGGAGACTGCCGGTATCCTGAAGGGCGAGTACGGCC
GCACCCCGGCCCCGGTGAACGCCGCCCTGCAGGCGCGGGTGCTCAACGGCGCCGACCCGGTGACCTGCCGCCCGGCCGAC
CTGCTGAAGCCGGAGCTGGCGCAGCTGGAAGCGGATGTGAAACGCCAGGCACAGGAGAAGGGCATCACGCTTGCCGAAAA
CGCCATCGACGACGTGCTCACCGTGGCGCTGTTCCCGCAAATCGGCCTGAAGTTCCTCGAAAACCGCCACAACCCGGCGG
CCTTTGAGCCGGTACCGCAGGCGGAAGCCGCGCAGCCAGTGGCAAAAGCAGAAAAACCTGCCGCCTCCGGCGTCTACACC
GTGGAGGTGGAAGGCAAAGCCTTCGTGGTCAAAGTCAGCGACGGCGGCGACGTCAGCCAGCTGACGGCGGCTGCTCCTGC
TCCTGGCTCTGCACCCGCCGCTCCGGCCGGCGCCGGCACCCCGGTGACCGCCCCGCTGGCGGGCACTATCTGGAAGGTGC
TGGCCAGCGAAGGCCAGACGGTGGCCGCAGGCGAGGTGCTGCTGATTCTGGAAGCCATGAAGATGGAAACCGAAATCCGT
GCCGCGCAGGCCGGGACCGTGCGCGGTATCGCGGTGAAAGCCGGCGACGCGGTGGCGGTCGGCGATACCCTGATGACTCT
GGCGTAA

Upstream 100 bases:

>100_bases
CGCCGTCGCGCCCGCCGACGATTTCGCCCGCCTGAAGCCGGCGATTGTCGCCGCCATTCACCACCATCGCCGTCTTCACC
CTTAATTCACGGAGGAATTC

Downstream 100 bases:

>100_bases
GGATGAGGAGCGGAAATGGAAAGTCTGAACGCCCTGATTCAGGGCATGGGGCTGATGCACCTCGGCGCCGGCCAGGCGGT
GATGCTGCTGGTCAGCCTGC

Product: oxaloacetate decarboxylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MTVAITDVVLRDAHQSLFATRLRLDDMLPVAAQLDDVGYRSLECWGGATFDACIRFLGEDPWVRLRELKKAMPKTPLQML
LRGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMNDPRNMQAALQAVRRHGAHAQGTLSYTTSPAHTLQTWLDLTE
QLLETGVDSVAIKDMSGILTPHAAFELVSEIKKRYDVTLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYGHPA
TEALVATLAGTQYDTGLDIHRLESIAAYFREVRKKYHAFEGQLKGTDSRILVAQVPGGMLTNLEGQLKQQSAAHRLDEVL
AEIPRVREDLGFIPLVTPTSQIVGTQAVLNVLGGERYKTIAKETAGILKGEYGRTPAPVNAALQARVLNGADPVTCRPAD
LLKPELAQLEADVKRQAQEKGITLAENAIDDVLTVALFPQIGLKFLENRHNPAAFEPVPQAEAAQPVAKAEKPAASGVYT
VEVEGKAFVVKVSDGGDVSQLTAAAPAPGSAPAAPAGAGTPVTAPLAGTIWKVLASEGQTVAAGEVLLILEAMKMETEIR
AAQAGTVRGIAVKAGDAVAVGDTLMTLA

Sequences:

>Translated_588_residues
MTVAITDVVLRDAHQSLFATRLRLDDMLPVAAQLDDVGYRSLECWGGATFDACIRFLGEDPWVRLRELKKAMPKTPLQML
LRGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMNDPRNMQAALQAVRRHGAHAQGTLSYTTSPAHTLQTWLDLTE
QLLETGVDSVAIKDMSGILTPHAAFELVSEIKKRYDVTLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYGHPA
TEALVATLAGTQYDTGLDIHRLESIAAYFREVRKKYHAFEGQLKGTDSRILVAQVPGGMLTNLEGQLKQQSAAHRLDEVL
AEIPRVREDLGFIPLVTPTSQIVGTQAVLNVLGGERYKTIAKETAGILKGEYGRTPAPVNAALQARVLNGADPVTCRPAD
LLKPELAQLEADVKRQAQEKGITLAENAIDDVLTVALFPQIGLKFLENRHNPAAFEPVPQAEAAQPVAKAEKPAASGVYT
VEVEGKAFVVKVSDGGDVSQLTAAAPAPGSAPAAPAGAGTPVTAPLAGTIWKVLASEGQTVAAGEVLLILEAMKMETEIR
AAQAGTVRGIAVKAGDAVAVGDTLMTLA
>Mature_587_residues
TVAITDVVLRDAHQSLFATRLRLDDMLPVAAQLDDVGYRSLECWGGATFDACIRFLGEDPWVRLRELKKAMPKTPLQMLL
RGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMNDPRNMQAALQAVRRHGAHAQGTLSYTTSPAHTLQTWLDLTEQ
LLETGVDSVAIKDMSGILTPHAAFELVSEIKKRYDVTLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYGHPAT
EALVATLAGTQYDTGLDIHRLESIAAYFREVRKKYHAFEGQLKGTDSRILVAQVPGGMLTNLEGQLKQQSAAHRLDEVLA
EIPRVREDLGFIPLVTPTSQIVGTQAVLNVLGGERYKTIAKETAGILKGEYGRTPAPVNAALQARVLNGADPVTCRPADL
LKPELAQLEADVKRQAQEKGITLAENAIDDVLTVALFPQIGLKFLENRHNPAAFEPVPQAEAAQPVAKAEKPAASGVYTV
EVEGKAFVVKVSDGGDVSQLTAAAPAPGSAPAAPAGAGTPVTAPLAGTIWKVLASEGQTVAAGEVLLILEAMKMETEIRA
AQAGTVRGIAVKAGDAVAVGDTLMTLA

Specific function: Lyase and sodium transporter [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=624, Percent_Identity=33.3333333333333, Blast_Score=282, Evalue=7e-76,
Organism=Homo sapiens, GI106049295, Length=624, Percent_Identity=33.3333333333333, Blast_Score=282, Evalue=7e-76,
Organism=Homo sapiens, GI106049292, Length=624, Percent_Identity=33.3333333333333, Blast_Score=282, Evalue=7e-76,
Organism=Caenorhabditis elegans, GI17562816, Length=624, Percent_Identity=33.974358974359, Blast_Score=313, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319695, Length=633, Percent_Identity=32.7014218009479, Blast_Score=306, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6321376, Length=632, Percent_Identity=31.4873417721519, Blast_Score=296, Evalue=6e-81,
Organism=Drosophila melanogaster, GI281363050, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24652224, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24652222, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24652220, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24652218, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24652212, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24652210, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24652214, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI19921944, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24652216, Length=627, Percent_Identity=31.4194577352472, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =4.1.1.3 [H]

Molecular weight: Translated: 62876; Mature: 62745

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAITDVVLRDAHQSLFATRLRLDDMLPVAAQLDDVGYRSLECWGGATFDACIRFLGED
CEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCC
PWVRLRELKKAMPKTPLQMLLRGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMND
CHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
PRNMQAALQAVRRHGAHAQGTLSYTTSPAHTLQTWLDLTEQLLETGVDSVAIKDMSGILT
CHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCC
PHAAFELVSEIKKRYDVTLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYGHPA
HHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCH
TEALVATLAGTQYDTGLDIHRLESIAAYFREVRKKYHAFEGQLKGTDSRILVAQVPGGML
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHH
TNLEGQLKQQSAAHRLDEVLAEIPRVREDLGFIPLVTPTSQIVGTQAVLNVLGGERYKTI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCHHHHHH
AKETAGILKGEYGRTPAPVNAALQARVLNGADPVTCRPADLLKPELAQLEADVKRQAQEK
HHHHHHHHCCCCCCCCCCHHHHHHHHEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHC
GITLAENAIDDVLTVALFPQIGLKFLENRHNPAAFEPVPQAEAAQPVAKAEKPAASGVYT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHCCCCCCCEEE
VEVEGKAFVVKVSDGGDVSQLTAAAPAPGSAPAAPAGAGTPVTAPLAGTIWKVLASEGQT
EEECCEEEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
VAAGEVLLILEAMKMETEIRAAQAGTVRGIAVKAGDAVAVGDTLMTLA
EECCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCHHHHCC
>Mature Secondary Structure 
TVAITDVVLRDAHQSLFATRLRLDDMLPVAAQLDDVGYRSLECWGGATFDACIRFLGED
EEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCC
PWVRLRELKKAMPKTPLQMLLRGQNLLGYRHYADDVVERFVERAVKNGMDVFRVFDAMND
CHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
PRNMQAALQAVRRHGAHAQGTLSYTTSPAHTLQTWLDLTEQLLETGVDSVAIKDMSGILT
CHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHCCC
PHAAFELVSEIKKRYDVTLHLHCHATTGMAEMALLKAIEAGVDGVDTAISSMSATYGHPA
HHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCH
TEALVATLAGTQYDTGLDIHRLESIAAYFREVRKKYHAFEGQLKGTDSRILVAQVPGGML
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHH
TNLEGQLKQQSAAHRLDEVLAEIPRVREDLGFIPLVTPTSQIVGTQAVLNVLGGERYKTI
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHCCHHHHHH
AKETAGILKGEYGRTPAPVNAALQARVLNGADPVTCRPADLLKPELAQLEADVKRQAQEK
HHHHHHHHCCCCCCCCCCHHHHHHHHEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHC
GITLAENAIDDVLTVALFPQIGLKFLENRHNPAAFEPVPQAEAAQPVAKAEKPAASGVYT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHCCCCCCCEEE
VEVEGKAFVVKVSDGGDVSQLTAAAPAPGSAPAAPAGAGTPVTAPLAGTIWKVLASEGQT
EEECCEEEEEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCE
VAAGEVLLILEAMKMETEIRAAQAGTVRGIAVKAGDAVAVGDTLMTLA
EECCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454915 [H]