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The map label for this gene is pheP [H]

Identifier: 152969108

GI number: 152969108

Start: 601082

End: 602458

Strand: Direct

Name: pheP [H]

Synonym: KPN_00537

Alternate gene names: 152969108

Gene position: 601082-602458 (Clockwise)

Preceding gene: 152969107

Following gene: 152969109

Centisome position: 11.31

GC content: 59.62

Gene sequence:

>1377_bases
GTGAAAGACGCGTCAACGTCGTCGGAGACCGTCACGGAAAGTGGCCCGACGCTTCATCGCGGTTTACAGAACCGACACAT
TCAACTTATCGCCCTTGGCGGCGCGATTGGCACCGGCCTGTTTCTCGGCATTGGTCCCGCTATCCAGATGGCCGGTCCGG
CGGTCTTACTGGGCTACGCCGTGGCCGGGATTGTCGCTTTTCTGATCATGCGCCAGCTGGGCGAAATGGTGGTGGAAGAG
CCAGTATCCGGTTCCTTTGCCCACTTTGCCTATAAGTACTGGGGGCCGTTCGCCGGCTTTCTCTCCGGCTGGAACTACTG
GGTGATGTTCGTGCTGGTAGGGATGGCGGAGCTGACCGCCGCCGGGATCTATATGCAGTACTGGCTTCCCGACGTGCCCA
CCTGGGTTTGGGCGGCGGCTTTCTTCATCATTATTAACGCCGTCAACCTGGTCAACGTACGCTTGTATGGCGAAGCGGAG
TTCTGGTTCGCGCTGATCAAGGTGCTGGCGATTATCGGCATGATTGCCTTCGGCCTGTGGATGCTGTTCGGCGGCCACGG
CGGCAGCAAAGCCGGGTTCGACAATCTGTGGAAACACGGCGGCTTCCTCGCCACCGGCTGGCACGGACTTATTCTGTCGC
TGGCGGTGATCATGTTCTCCTTCGGCGGGCTGGAGCTTATCGGCATCACCGCCGCCGAAGCGCAAAACCCGGAAAAGAGT
ATTCCCAAAGCGGTCAATCAGGTGGTCTATCGTATCCTGCTGTTCTATATCGGTTCGCTGGTGGTGCTGCTGGCGCTCTA
CCCGTGGGTGGAGATCAAATCCGACAGCAGCCCGTTTGTGATGATTTTCCATAATCTGGACAGCAACCTGGTGGCCTCCG
CGCTGAACTTCGTCATTCTGGTGGCCTCGCTGTCGGTGTATAACAGCGGCGTGTACTCCAACAGCCGGATGCTGTTCGGC
CTGTCGGTGCAGGGTAATGCGCCGAAATTTCTCGCCCGCGTCAGCAAGCGCGGCGTGCCGGTGAACTCCCTGCTGCTCTC
CGGGATTATCACTTCGCTGGTGGTGGTGCTGAACTACCTGCTGCCGCATGAAGCGCTGGGGCTGCTGATGGCCCTGGTGG
TGGCGACGTTGCTGCTGAACTGGATCATGATCTGTATGGCGCACCTGAAGTTCCGCGCCGCCCAGCGCCGCAAAGGGCGC
GAATCGAAGTTCAAAGCGCTGCTGGCGCCCGCCAGCAACTACTTCTGCATTGCTTTCCTTGGGCTGATCCTGGCGCTGAT
GTGCACTATCGACGGCATGCGTCTGTCGGCGATCCTGCTGCCGGTGTGGATCCTGTTCCTGTTTATCGCCTTCAAACTGC
TGCGCCGCCCGGCGTAA

Upstream 100 bases:

>100_bases
AAAAGCGGGGCGGGCGGCTGACGCTCGCCCCACGCAACTTGCGACAATCCCCCCTAAGTGATAAAAGGTGCCCCTTCACA
AAAACACACAGGGGAACGAC

Downstream 100 bases:

>100_bases
GCGAGATGCCCCGCCGTCCGGCGGGGCTGCCTGCCTTTTTATTGTGATCCTCTTCGCAGGCGGCGCATTTGCCTGGCGAT
CTTCTTTTTGTAATCGATTA

Product: phenylalanine transporter

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYAVAGIVAFLIMRQLGEMVVEE
PVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWLPDVPTWVWAAAFFIIINAVNLVNVRLYGEAE
FWFALIKVLAIIGMIAFGLWMLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGITAAEAQNPEKS
IPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSNLVASALNFVILVASLSVYNSGVYSNSRMLFG
LSVQGNAPKFLARVSKRGVPVNSLLLSGIITSLVVVLNYLLPHEALGLLMALVVATLLLNWIMICMAHLKFRAAQRRKGR
ESKFKALLAPASNYFCIAFLGLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA

Sequences:

>Translated_458_residues
MKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYAVAGIVAFLIMRQLGEMVVEE
PVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWLPDVPTWVWAAAFFIIINAVNLVNVRLYGEAE
FWFALIKVLAIIGMIAFGLWMLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGITAAEAQNPEKS
IPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSNLVASALNFVILVASLSVYNSGVYSNSRMLFG
LSVQGNAPKFLARVSKRGVPVNSLLLSGIITSLVVVLNYLLPHEALGLLMALVVATLLLNWIMICMAHLKFRAAQRRKGR
ESKFKALLAPASNYFCIAFLGLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA
>Mature_458_residues
MKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYAVAGIVAFLIMRQLGEMVVEE
PVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWLPDVPTWVWAAAFFIIINAVNLVNVRLYGEAE
FWFALIKVLAIIGMIAFGLWMLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGITAAEAQNPEKS
IPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSNLVASALNFVILVASLSVYNSGVYSNSRMLFG
LSVQGNAPKFLARVSKRGVPVNSLLLSGIITSLVVVLNYLLPHEALGLLMALVVATLLLNWIMICMAHLKFRAAQRRKGR
ESKFKALLAPASNYFCIAFLGLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=433, Percent_Identity=25.635103926097, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI110347453, Length=281, Percent_Identity=27.0462633451957, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI258645169, Length=428, Percent_Identity=22.196261682243, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4507047, Length=425, Percent_Identity=22.3529411764706, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786789, Length=457, Percent_Identity=87.746170678337, Blast_Score=811, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=446, Percent_Identity=62.780269058296, Blast_Score=592, Evalue=1e-170,
Organism=Escherichia coli, GI48994972, Length=430, Percent_Identity=43.4883720930233, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1786602, Length=450, Percent_Identity=44, Blast_Score=347, Evalue=8e-97,
Organism=Escherichia coli, GI1790653, Length=436, Percent_Identity=39.2201834862385, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI87081915, Length=404, Percent_Identity=38.3663366336634, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87081708, Length=447, Percent_Identity=35.5704697986577, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1788480, Length=404, Percent_Identity=37.8712871287129, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI1789017, Length=421, Percent_Identity=35.6294536817102, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87081869, Length=344, Percent_Identity=25.5813953488372, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87082023, Length=388, Percent_Identity=22.680412371134, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI2367353, Length=386, Percent_Identity=22.5388601036269, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=371, Percent_Identity=21.0242587601078, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=482, Percent_Identity=34.4398340248963, Blast_Score=255, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6324061, Length=446, Percent_Identity=34.7533632286996, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6324059, Length=445, Percent_Identity=35.0561797752809, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324990, Length=485, Percent_Identity=32.5773195876289, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6319824, Length=428, Percent_Identity=31.7757009345794, Blast_Score=209, Evalue=8e-55,
Organism=Saccharomyces cerevisiae, GI6324924, Length=451, Percent_Identity=31.7073170731707, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321629, Length=415, Percent_Identity=31.0843373493976, Blast_Score=199, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6322892, Length=415, Percent_Identity=33.7349397590361, Blast_Score=199, Evalue=8e-52,
Organism=Saccharomyces cerevisiae, GI6324553, Length=392, Percent_Identity=32.1428571428571, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320717, Length=483, Percent_Identity=28.1573498964803, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6319543, Length=410, Percent_Identity=30.9756097560976, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6321053, Length=446, Percent_Identity=30.9417040358744, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322967, Length=399, Percent_Identity=29.3233082706767, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320251, Length=475, Percent_Identity=26.3157894736842, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6319608, Length=402, Percent_Identity=29.6019900497512, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=477, Percent_Identity=25.7861635220126, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324981, Length=430, Percent_Identity=30.9302325581395, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320364, Length=494, Percent_Identity=25.7085020242915, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=22.6190476190476, Blast_Score=86, Evalue=8e-17,
Organism=Drosophila melanogaster, GI221512776, Length=420, Percent_Identity=22.6190476190476, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24667468, Length=428, Percent_Identity=24.7663551401869, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161077963, Length=428, Percent_Identity=23.1308411214953, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50002; Mature: 50002

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYA
CCCCCCCCCHHHCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCHHHHHCCHHHHHHHH
VAGIVAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AGIYMQYWLPDVPTWVWAAAFFIIINAVNLVNVRLYGEAEFWFALIKVLAIIGMIAFGLW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
MLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGITAAEAQNPEKS
HHHCCCCCCCCCHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCCHHH
IPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSNLVASALNFVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHH
VASLSVYNSGVYSNSRMLFGLSVQGNAPKFLARVSKRGVPVNSLLLSGIITSLVVVLNYL
HHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LPHEALGLLMALVVATLLLNWIMICMAHLKFRAAQRRKGRESKFKALLAPASNYFCIAFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHH
GLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKDASTSSETVTESGPTLHRGLQNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYA
CCCCCCCCCHHHCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCHHHHHCCHHHHHHHH
VAGIVAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
AGIYMQYWLPDVPTWVWAAAFFIIINAVNLVNVRLYGEAEFWFALIKVLAIIGMIAFGLW
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
MLFGGHGGSKAGFDNLWKHGGFLATGWHGLILSLAVIMFSFGGLELIGITAAEAQNPEKS
HHHCCCCCCCCCHHHHHHCCCEEEECHHHHHHHHHHHHHHCCCEEEEEEEHHHCCCCHHH
IPKAVNQVVYRILLFYIGSLVVLLALYPWVEIKSDSSPFVMIFHNLDSNLVASALNFVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHH
VASLSVYNSGVYSNSRMLFGLSVQGNAPKFLARVSKRGVPVNSLLLSGIITSLVVVLNYL
HHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LPHEALGLLMALVVATLLLNWIMICMAHLKFRAAQRRKGRESKFKALLAPASNYFCIAFL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHH
GLILALMCTIDGMRLSAILLPVWILFLFIAFKLLRRPA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1711024; 8905232; 9278503; 8626334 [H]