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The map label for this gene is hdaH [H]

Identifier: 152969101

GI number: 152969101

Start: 590348

End: 591463

Strand: Direct

Name: hdaH [H]

Synonym: KPN_00530

Alternate gene names: 152969101

Gene position: 590348-591463 (Clockwise)

Preceding gene: 152969100

Following gene: 152969106

Centisome position: 11.11

GC content: 63.53

Gene sequence:

>1116_bases
GTGAAAAGAAAAACCGGTTTCTTTTTTGATGAACGTTGTTTCTGGCACAGTACCGGTCTGCACGCGGTGACGCTGCCGGT
GGGCGGGTGGGTACAGCCGCCCGCCGGCGGCGGTCATGCTGAATCGCCAGAGACCAAACGGCGGATGAAAAACCTGATGG
ATGTCTCCGGGCTGACGCCGCAGCTGGCGCTGCGCAGCGCGGCGCCGGCGAGCCTTGAGGACCTGCGGCGGATCCACCCC
GACAGCTATCTGGAGCGCTTCAAGGCGATAAGCGATAACGGCGGCGGCATGCTCGGCAAAGAGGCGCCGCTGGGGCCGGG
CAGTTATGAAATCGCCTGTCTTTCCGCCGGGCTGGCCTGTGCGGCGGTGGAAGCGGTGCTGAAGGGGGAGCTGGATAACG
CCTATTCGCTGTCGCGCCCGCCCGGACACCACTGCCTGCCGGACCAGTCGATGGGATTTTGTTTCCTCGCCAATATTCCC
ATTGCCGTCGAGCGAGCGAAAGCGCAGCTGGGGCTGGGCAAGGTGGCGATCATTGACTGGGATGTTCACCACGGCAACGG
CACCCAGCATATCTACCTGCAGCGCGACGACGTACTGACTATCTCCTTGCATCAGGACGGCTGCTTCCCGCCGGGCTACG
CCGGCGAGGACGATCGCGGCGTGGGCGCGGGCGAAGGTTACAACATCAATATTCCGCTGTTGGCCGGGGCGGGGGATGAC
AGCTGGCGCTATGCGCTGGAAACTATCGTTATTCCGGCGCTGGCGCGTTTTGAGCCGGAGCTGATCATCATCGCCTGCGG
CTATGACGCCAACGCCATGGATCCATTAGCGCGGATGCAGCTGCACAGCGATAGCTTCCGGGCGATGACCGAACAGGTCC
AGCAGGCGGCGGATCGCCTGTGCGGCGGGAAACTGGTGATGGTGCACGAGGGCGGCTACGCCGAATCCTACGTGCCGTTC
TGCGGCCTGGCGGTGATGGAAGCCCTGAGCGGCATCCGCACCGAGGTCCAGGATCCGCTGCTGGAATTTATTCAGCAGCA
GCAGCCGCGCGCCGCATTCGCGCAGTTCCAGCGCGAGGCCATCGATCGGCTGGCGCAGCAGTTTGGTCTGCTATAA

Upstream 100 bases:

>100_bases
GACCCGCTGCTGGCGGCGGCAGGCGTATGCGCGCTGCTGTCACTGATTTTAATTGTGGCGGCATCCGCCGCCGGGAAGGC
TTAGCCCACGGGAGGATAGA

Downstream 100 bases:

>100_bases
ACCACCTCAGCTTCCCCGCGGTGATGGCGGGGAAGTCAATGCTTTCTCTTCTGCGATTTCACCGCGCATCCACTGACTTA
CCGCCTGATTAACCATCGCC

Product: putative deacetylase

Products: NA

Alternate protein names: HDAC-like amidohydrolase; HDAH [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKRKTGFFFDERCFWHSTGLHAVTLPVGGWVQPPAGGGHAESPETKRRMKNLMDVSGLTPQLALRSAAPASLEDLRRIHP
DSYLERFKAISDNGGGMLGKEAPLGPGSYEIACLSAGLACAAVEAVLKGELDNAYSLSRPPGHHCLPDQSMGFCFLANIP
IAVERAKAQLGLGKVAIIDWDVHHGNGTQHIYLQRDDVLTISLHQDGCFPPGYAGEDDRGVGAGEGYNINIPLLAGAGDD
SWRYALETIVIPALARFEPELIIIACGYDANAMDPLARMQLHSDSFRAMTEQVQQAADRLCGGKLVMVHEGGYAESYVPF
CGLAVMEALSGIRTEVQDPLLEFIQQQQPRAAFAQFQREAIDRLAQQFGLL

Sequences:

>Translated_371_residues
MKRKTGFFFDERCFWHSTGLHAVTLPVGGWVQPPAGGGHAESPETKRRMKNLMDVSGLTPQLALRSAAPASLEDLRRIHP
DSYLERFKAISDNGGGMLGKEAPLGPGSYEIACLSAGLACAAVEAVLKGELDNAYSLSRPPGHHCLPDQSMGFCFLANIP
IAVERAKAQLGLGKVAIIDWDVHHGNGTQHIYLQRDDVLTISLHQDGCFPPGYAGEDDRGVGAGEGYNINIPLLAGAGDD
SWRYALETIVIPALARFEPELIIIACGYDANAMDPLARMQLHSDSFRAMTEQVQQAADRLCGGKLVMVHEGGYAESYVPF
CGLAVMEALSGIRTEVQDPLLEFIQQQQPRAAFAQFQREAIDRLAQQFGLL
>Mature_371_residues
MKRKTGFFFDERCFWHSTGLHAVTLPVGGWVQPPAGGGHAESPETKRRMKNLMDVSGLTPQLALRSAAPASLEDLRRIHP
DSYLERFKAISDNGGGMLGKEAPLGPGSYEIACLSAGLACAAVEAVLKGELDNAYSLSRPPGHHCLPDQSMGFCFLANIP
IAVERAKAQLGLGKVAIIDWDVHHGNGTQHIYLQRDDVLTISLHQDGCFPPGYAGEDDRGVGAGEGYNINIPLLAGAGDD
SWRYALETIVIPALARFEPELIIIACGYDANAMDPLARMQLHSDSFRAMTEQVQQAADRLCGGKLVMVHEGGYAESYVPF
CGLAVMEALSGIRTEVQDPLLEFIQQQQPRAAFAQFQREAIDRLAQQFGLL

Specific function: Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiat

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI153085395, Length=248, Percent_Identity=35.4838709677419, Blast_Score=151, Evalue=9e-37,
Organism=Homo sapiens, GI148539870, Length=348, Percent_Identity=31.8965517241379, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI169234807, Length=348, Percent_Identity=31.8965517241379, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI13128864, Length=287, Percent_Identity=32.0557491289199, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI17158039, Length=246, Percent_Identity=35.7723577235772, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI30795204, Length=246, Percent_Identity=35.7723577235772, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI30795202, Length=246, Percent_Identity=35.7723577235772, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI62750349, Length=232, Percent_Identity=36.2068965517241, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI62750347, Length=232, Percent_Identity=36.2068965517241, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI20070354, Length=289, Percent_Identity=32.1799307958478, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI13128860, Length=315, Percent_Identity=26.6666666666667, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI293336691, Length=256, Percent_Identity=27.34375, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI226529806, Length=289, Percent_Identity=30.1038062283737, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI8923769, Length=251, Percent_Identity=25.0996015936255, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI13128862, Length=311, Percent_Identity=26.6881028938907, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI262073092, Length=223, Percent_Identity=26.0089686098655, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI262073088, Length=181, Percent_Identity=26.5193370165746, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17540334, Length=309, Percent_Identity=32.6860841423948, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17540332, Length=309, Percent_Identity=32.6860841423948, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI193206283, Length=309, Percent_Identity=32.6860841423948, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI193209491, Length=293, Percent_Identity=31.740614334471, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17508561, Length=350, Percent_Identity=29.7142857142857, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17561978, Length=300, Percent_Identity=30.6666666666667, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17534739, Length=263, Percent_Identity=28.8973384030418, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17537347, Length=216, Percent_Identity=32.8703703703704, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI25154020, Length=214, Percent_Identity=28.5046728971963, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25154022, Length=214, Percent_Identity=28.0373831775701, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6324307, Length=363, Percent_Identity=31.129476584022, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323999, Length=358, Percent_Identity=24.8603351955307, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321244, Length=294, Percent_Identity=26.1904761904762, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325325, Length=200, Percent_Identity=26.5, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281360899, Length=342, Percent_Identity=31.8713450292398, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24642142, Length=342, Percent_Identity=31.8713450292398, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24642146, Length=342, Percent_Identity=31.8713450292398, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24642144, Length=342, Percent_Identity=31.8713450292398, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281360799, Length=211, Percent_Identity=36.9668246445498, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI24641720, Length=211, Percent_Identity=36.9668246445498, Blast_Score=137, Evalue=9e-33,
Organism=Drosophila melanogaster, GI281360801, Length=211, Percent_Identity=36.9668246445498, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24657891, Length=297, Percent_Identity=28.6195286195286, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24644244, Length=263, Percent_Identity=25.4752851711027, Blast_Score=92, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 40242; Mature: 40242

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKTGFFFDERCFWHSTGLHAVTLPVGGWVQPPAGGGHAESPETKRRMKNLMDVSGLTP
CCCCCCCEECCCEEEECCCCEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCH
QLALRSAAPASLEDLRRIHPDSYLERFKAISDNGGGMLGKEAPLGPGSYEIACLSAGLAC
HHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHH
AAVEAVLKGELDNAYSLSRPPGHHCLPDQSMGFCFLANIPIAVERAKAQLGLGKVAIIDW
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCEEEEECCCEEEHHHHHHCCCCEEEEEEE
DVHHGNGTQHIYLQRDDVLTISLHQDGCFPPGYAGEDDRGVGAGEGYNINIPLLAGAGDD
EEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCC
SWRYALETIVIPALARFEPELIIIACGYDANAMDPLARMQLHSDSFRAMTEQVQQAADRL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
CGGKLVMVHEGGYAESYVPFCGLAVMEALSGIRTEVQDPLLEFIQQQQPRAAFAQFQREA
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IDRLAQQFGLL
HHHHHHHHCCC
>Mature Secondary Structure
MKRKTGFFFDERCFWHSTGLHAVTLPVGGWVQPPAGGGHAESPETKRRMKNLMDVSGLTP
CCCCCCCEECCCEEEECCCCEEEEECCCCEECCCCCCCCCCCCHHHHHHHHHHHHCCCCH
QLALRSAAPASLEDLRRIHPDSYLERFKAISDNGGGMLGKEAPLGPGSYEIACLSAGLAC
HHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHH
AAVEAVLKGELDNAYSLSRPPGHHCLPDQSMGFCFLANIPIAVERAKAQLGLGKVAIIDW
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCEEEEECCCEEEHHHHHHCCCCEEEEEEE
DVHHGNGTQHIYLQRDDVLTISLHQDGCFPPGYAGEDDRGVGAGEGYNINIPLLAGAGDD
EEECCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCC
SWRYALETIVIPALARFEPELIIIACGYDANAMDPLARMQLHSDSFRAMTEQVQQAADRL
HHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
CGGKLVMVHEGGYAESYVPFCGLAVMEALSGIRTEVQDPLLEFIQQQQPRAAFAQFQREA
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
IDRLAQQFGLL
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA