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The map label for this gene is yedX [H]

Identifier: 152969059

GI number: 152969059

Start: 533067

End: 533468

Strand: Direct

Name: yedX [H]

Synonym: KPN_00488

Alternate gene names: 152969059

Gene position: 533067-533468 (Clockwise)

Preceding gene: 152969058

Following gene: 152969060

Centisome position: 10.03

GC content: 50.75

Gene sequence:

>402_bases
ATGAAATTAGTTATCGCCTCCGTAATTTCTCTGCTCAGCTTCAGCGCGCTGGCGGCGCCAGAGGGGACGCTCAGCGTACA
CATTCTTAATCAGCAAACCGGGCTCCCTTCACCGGGGGTGCAGATTGAGCTGGATAAACAGCAGGGGGAGAGCTGGCAGC
ATATCGCCACCGGTAAAACGGATGCCGATGGGCGGATTAAATCGCTCTATCCGCAGGCGGAGAATATGGAGCCGGGGGTG
TATAAAGTGACGTTTAAAACCGGTGACTATTTTAAAAGCCAAAATATGAATACGTTCTTCCCGGTGATTCCGGTTATTTT
CAATGTCACAAAGCAAAATCAAAAACTGCATATCCCGCTGCTGCTCAGTCAGTACGGATACTCTACCTACCGCGGCAGCT
GA

Upstream 100 bases:

>100_bases
AGTACCCATCAACTCAAACTGATAACAAAAAGTTTAATTTTTTTCCCCGCCGCGCTGACTATAGTTAGGGCACTTTCACT
TGCCCAATAAGGTCACGATT

Downstream 100 bases:

>100_bases
TGACCCAAGCCGCTATCCAGCCAACGCCTGCGCGGCTTCCGCAGGCGTCACACTTTTCTCGCACCACGATGTCCACGCCT
AACGCTCGGTCTCTTTCTCT

Product: hypothetical protein

Products: NA

Alternate protein names: HIU hydrolase; HIUHase; Transthyretin-like protein; TLP [H]

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MKLVIASVISLLSFSALAAPEGTLSVHILNQQTGLPSPGVQIELDKQQGESWQHIATGKTDADGRIKSLYPQAENMEPGV
YKVTFKTGDYFKSQNMNTFFPVIPVIFNVTKQNQKLHIPLLLSQYGYSTYRGS

Sequences:

>Translated_133_residues
MKLVIASVISLLSFSALAAPEGTLSVHILNQQTGLPSPGVQIELDKQQGESWQHIATGKTDADGRIKSLYPQAENMEPGV
YKVTFKTGDYFKSQNMNTFFPVIPVIFNVTKQNQKLHIPLLLSQYGYSTYRGS
>Mature_133_residues
MKLVIASVISLLSFSALAAPEGTLSVHILNQQTGLPSPGVQIELDKQQGESWQHIATGKTDADGRIKSLYPQAENMEPGV
YKVTFKTGDYFKSQNMNTFFPVIPVIFNVTKQNQKLHIPLLLSQYGYSTYRGS

Specific function: Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) [H]

COG id: COG2351

COG function: function code R; Transthyretin-like protein

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788281, Length=133, Percent_Identity=53.3834586466165, Blast_Score=145, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI115532920, Length=133, Percent_Identity=36.0902255639098, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115532922, Length=122, Percent_Identity=36.8852459016393, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI115534555, Length=133, Percent_Identity=34.5864661654135, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24652571, Length=111, Percent_Identity=37.8378378378378, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014306
- InterPro:   IPR000895 [H]

Pfam domain/function: PF00576 Transthyretin [H]

EC number: =3.5.2.17 [H]

Molecular weight: Translated: 14719; Mature: 14719

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVIASVISLLSFSALAAPEGTLSVHILNQQTGLPSPGVQIELDKQQGESWQHIATGKT
CEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCEEEEECCCC
DADGRIKSLYPQAENMEPGVYKVTFKTGDYFKSQNMNTFFPVIPVIFNVTKQNQKLHIPL
CCCCCEEECCCCCCCCCCCEEEEEEECCCEECCCCCCCHHHHHHHHHCCCCCCCEEEEEE
LLSQYGYSTYRGS
EEECCCCCCCCCC
>Mature Secondary Structure
MKLVIASVISLLSFSALAAPEGTLSVHILNQQTGLPSPGVQIELDKQQGESWQHIATGKT
CEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCEEEEECCCC
DADGRIKSLYPQAENMEPGVYKVTFKTGDYFKSQNMNTFFPVIPVIFNVTKQNQKLHIPL
CCCCCEEECCCCCCCCCCCEEEEEEECCCEECCCCCCCHHHHHHHHHCCCCCCCEEEEEE
LLSQYGYSTYRGS
EEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]