| Definition | Klebsiella pneumoniae subsp. pneumoniae MGH 78578 chromosome, complete genome. |
|---|---|
| Accession | NC_009648 |
| Length | 5,315,120 |
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The map label for this gene is lon [H]
Identifier: 152968974
GI number: 152968974
Start: 442588
End: 444942
Strand: Direct
Name: lon [H]
Synonym: KPN_00401
Alternate gene names: 152968974
Gene position: 442588-444942 (Clockwise)
Preceding gene: 152968973
Following gene: 152968975
Centisome position: 8.33
GC content: 55.97
Gene sequence:
>2355_bases ATGAATCCTGAGCGTTCTGAACGCATTGAAATCCCCGTATTGCCATTGCGCGATGTGGTGGTTTATCCGCACATGGTCAT ACCCCTGTTCGTAGGGCGGGAAAAATCTATCCGTTGCCTCGAAGCGGCCATGGACCATGATAAAAAAATCATGCTGGTTG CGCAGAAAGAAGCGTCGACGGATGAGCCGGGTGTAAACGATCTTTTCACCGTTGGAACCGTGGCGTCTATTTTGCAGATG CTGAAGCTGCCGGACGGCACCGTGAAGGTGCTGGTCGAAGGGCTGCAGCGTGCTCGCATTTCTGCGCTGTCTGATAATGG CGAGCATTTCTCGGCGAAAGCGGAGTATCTCGACTCGCCGGCGATTGACGAACGCGAGCAGGAAGTGCTGGTTCGCACCG CTATCAGCCAGTTTGAAGGCTATATCAAGCTGAACAAGAAGATCCCACCGGAAGTGCTGACGTCGCTGAACAGCATCGAC GATCCGGCGCGCCTGGCGGATACCATCGCGGCGCACATGCCGCTGAAGCTGGCTGACAAGCAGTCTGTGCTTGAGATGTC CGACGTTAACGAACGTCTGGAATATCTGATGGCGATGATGGAATCGGAAATCGATCTGCTGCAGGTTGAGAAGCGCATTC GCAACCGCGTCAAAAAGCAGATGGAGAAATCCCAGCGCGAGTACTATCTGAACGAGCAAATGAAAGCGATTCAGAAAGAA CTCGGCGAGATGGACGACGCCCCGGACGAAAACGAAGCGCTGAAGCGTAAGATCGACGCGGCGAAAATGCCGAAAGAGGC GAAAGAAAAAACCGAAGCGGAACTGCAGAAGCTGAAGATGATGTCGCCGATGTCTGCGGAAGCGACCGTCGTGCGTGGCT ACATCGACTGGATGGTGCAGGTGCCGTGGAATGCGCGCAGTAAGGTCAAAAAAGACCTGCGTCAGGCCCAGGAGATCCTC GATACCGATCACTATGGCCTGGAGCGCGTGAAGGATCGCATCCTTGAATATCTCGCGGTGCAGAGCCGGGTGAACAAAAT CAAGGGGCCAATCCTTTGTCTGGTGGGACCGCCGGGGGTAGGTAAAACCTCGCTGGGTCAATCCATCGCCAAAGCGACCG GACGGAAATACGTTCGTATGGCGCTTGGCGGCGTGCGCGATGAAGCGGAAATCCGCGGTCATCGTCGGACCTACATTGGC TCGATGCCGGGCAAACTGATCCAGAAAATGGCGAAAGTGGGTGTCAAAAACCCGCTGTTCCTGTTGGACGAGATCGACAA AATGTCTTCCGACATGCGCGGCGATCCGGCTTCCGCGTTGCTTGAGGTGCTGGATCCGGAACAGAACGTGGCCTTTAACG ACCACTACCTGGAAGTGGATTACGATCTCAGCGACGTGATGTTCGTGGCGACTTCCAACTCCATGAACATTCCGGCGCCG CTGCTGGACCGTATGGAAGTGATTCGTCTCTCCGGCTATACCGAAGATGAAAAACTGAACATCGCCAAACGTCATCTGCT GCCGAAGCAGATCGAACGTAACGCGCTGAAGAAAGGCGAGCTGACCGTCGACGATAGCGCCATTATCGGCATTATTCGTT ACTACACGCGGGAAGCGGGGGTACGTAGCCTGGAGCGTGAAATCTCCAAGCTGTGCCGCAAGGCCGTTAAGCAACTGCTG CTGGATAAATCGCTGAAACACATCGAAATTAACGGTGAGAATCTGCATGATTATCTCGGCGTACAGCGCTTCGACTATGG CCGCGCCGATAGTGAGAACCGCGTCGGTCAGGTGACCGGTCTGGCGTGGACGGAAGTGGGCGGCGATCTGCTGACCATCG AAACCGCCTGCGTGCCGGGCAAAGGCAAGCTGACCTACACCGGCTCGCTTGGCGAGGTGATGCAGGAGTCGATTCAGGCT GCGCTGACGGTGGTACGTTCGCGGGCTGACAAGCTGGGCATTAACGCCGACTTCTACGAGAAGCGTGACATTCACGTGCA CGTGCCGGAAGGGGCGACGCCTAAGGATGGTCCGAGCGCGGGTATTGCCATGTGCACGGCGCTGGTCTCCTGCCTGACCG GCAACCCGGTACGCGCTGATGTGGCGATGACCGGTGAAATCACTCTGCGTGGTCAGGTGCTGCCGATCGGCGGTCTGAAG GAAAAACTGCTGGCGGCGCATCGCGGCGGCATTAAGACTGTTCTGATTCCTGATGAGAACAAACGCGACCTTGAAGAAAT TCCGGATAACGTTATCGCCGATTTGGATATCCATCCGGTGAAACGAATCGAGGAAGTTCTGACACTTGCGCTGCAGAACG AACCGTTCGGCATGCAGGTTGTGACCGCGAAATAG
Upstream 100 bases:
>100_bases GTGGAATACATCCCCATATACTGGATTACATATTAACGACGATGCAGTGGAGTGTGGCGTCGTCGGCTACCTGGCGGACT TTAAACTAAGAGAGAGCTCT
Downstream 100 bases:
>100_bases TGATTCTGCGCAAATTGCGCTAATAAAAATAGGGCTGGTAAGTCATTTCGGACTTGCCAGCCTTTTTTTGTGTAGCTAAC TTAGATCGCTGGCAGGGGGG
Product: DNA-binding ATP-dependent protease La
Products: NA
Alternate protein names: ATP-dependent protease La [H]
Number of amino acids: Translated: 784; Mature: 784
Protein sequence:
>784_residues MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQM LKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSID DPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE LGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEIL DTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIG SMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLL LDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA ALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK EKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPFGMQVVTAK
Sequences:
>Translated_784_residues MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQM LKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSID DPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE LGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEIL DTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIG SMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLL LDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA ALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK EKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPFGMQVVTAK >Mature_784_residues MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEASTDEPGVNDLFTVGTVASILQM LKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSPAIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSID DPARLADTIAAHMPLKLADKQSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE LGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPMSAEATVVRGYIDWMVQVPWNARSKVKKDLRQAQEIL DTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGVGKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIG SMPGKLIQKMAKVGVKNPLFLLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAGVRSLEREISKLCRKAVKQLL LDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTGLAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQA ALTVVRSRADKLGINADFYEKRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK EKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPFGMQVVTAK
Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced
COG id: COG0466
COG function: function code O; ATP-dependent Lon protease, bacterial type
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Lon domain [H]
Homologues:
Organism=Homo sapiens, GI31377667, Length=563, Percent_Identity=46.7140319715808, Blast_Score=514, Evalue=1e-145, Organism=Homo sapiens, GI21396489, Length=627, Percent_Identity=41.6267942583732, Blast_Score=513, Evalue=1e-145, Organism=Escherichia coli, GI1786643, Length=784, Percent_Identity=98.469387755102, Blast_Score=1571, Evalue=0.0, Organism=Caenorhabditis elegans, GI17505831, Length=663, Percent_Identity=40.8748114630468, Blast_Score=499, Evalue=1e-141, Organism=Caenorhabditis elegans, GI17556486, Length=794, Percent_Identity=33.2493702770781, Blast_Score=429, Evalue=1e-120, Organism=Saccharomyces cerevisiae, GI6319449, Length=706, Percent_Identity=39.943342776204, Blast_Score=488, Evalue=1e-138, Organism=Drosophila melanogaster, GI221513036, Length=628, Percent_Identity=44.5859872611465, Blast_Score=535, Evalue=1e-152, Organism=Drosophila melanogaster, GI24666867, Length=628, Percent_Identity=44.5859872611465, Blast_Score=534, Evalue=1e-152,
Paralogues:
None
Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003593 - InterPro: IPR003959 - InterPro: IPR008269 - InterPro: IPR004815 - InterPro: IPR003111 - InterPro: IPR008268 - InterPro: IPR001984 - InterPro: IPR015947 - InterPro: IPR020568 [H]
Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]
EC number: =3.4.21.53 [H]
Molecular weight: Translated: 87473; Mature: 87473
Theoretical pI: Translated: 6.21; Mature: 6.21
Prosite motif: PS01046 LON_SER ; PS00178 AA_TRNA_LIGASE_I
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.8 %Met (Translated Protein) 4.6 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.8 %Met (Mature Protein) 4.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEAST CCCCCCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCC DEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSP CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC AIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADK CCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEECCH QSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPMSAEATVVRGYIDWMVQ HCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEE VPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGV CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC GKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLF CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH LLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHH LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAG HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH VRSLEREISKLCRKAVKQLLLDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTG HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEEC LAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRSRADKLGINADFYE EEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHH EKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPFGMQV HHHHHHHCCCEEEEEECCCCCHHHHHCCHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEE VTAK EECC >Mature Secondary Structure MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEAST CCCCCCCEEECCCCCHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCC DEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLDSP CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCC AIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADK CCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEECCH QSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH LGEMDDAPDENEALKRKIDAAKMPKEAKEKTEAELQKLKMMSPMSAEATVVRGYIDWMVQ HCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEE VPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGV CCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC GKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLF CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHCCCCCCHH LLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEECCCEEEEECCCCCEEEEEECCCCCCCHH LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAG HHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHH VRSLEREISKLCRKAVKQLLLDKSLKHIEINGENLHDYLGVQRFDYGRADSENRVGQVTG HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHCCCCCCCCCCCCEEEEC LAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRSRADKLGINADFYE EEHHHCCCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEEEEEEEECCCHH EKLLAAHRGGIKTVLIPDENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPFGMQV HHHHHHHCCCEEEEEECCCCCHHHHHCCHHHEECCCCCHHHHHHHHHHHHHCCCCCCEEE VTAK EECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA