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The map label for this gene is rtn [H]

Identifier: 152968842

GI number: 152968842

Start: 302470

End: 303981

Strand: Direct

Name: rtn [H]

Synonym: KPN_00268

Alternate gene names: 152968842

Gene position: 302470-303981 (Clockwise)

Preceding gene: 152968835

Following gene: 152968843

Centisome position: 5.69

GC content: 47.88

Gene sequence:

>1512_bases
ATGATGATTACGTTAGCACTGCTGGTCAGTGTCCTGCAGTTTAAACAGGATGTCGCCCTGAGTGCGAAAACCTTATTACG
TTTTAGTGAAGATGTCTCAACTGCTTCGTGGCGGGTCACCGGGCAAGCCGTAAAATTAGCGGACAGGCCCTGCGCTGAAA
TTTTGTCGGAGCTTAACCGTACCCGCGCCTTTACTCCTTATATTCGTGATATTGGTTTGCTGGAAAAGGGCAATCTGCTC
TGTTCCTTTGTTAGCAGAGAGCAGGCGCATCCTTTTCCTCTGCCACCAGGTAAAACGCTCCCAACGCCGCTACCTGCCAG
GTGGGTTCGCTCATTTAGCTGGATGGCCGGTGGGCCTGGCAGGCCCGCGGTGGTTTACACACAGCAAGTCGCGGCGGATA
AAGCGGCGTTTGTTATCGTCGATTCTCGGTATGTCCAGGAGCTGATGGATGTACTCTCAGAAGAGAGAGAGGCCGTTTTC
AGCCTGAGATTTGGCAAAGGCGATGCCATTATCAGTCAACCAGCACAGTATGATCGAATAGTGATGACCCAGAATTACGT
CACTGACGACGGAAAGATTTCTCTTACCGTCGCTGCGCCTCTTGGCACATTGACGGCAGTTTGGATGAAATCTCTGCTCA
TTTTTATCCCTCTCTCGTTTTGCTTCTCATTTTTGACCCTGGTACTTTACCGGCATTGGTCGAAAATGCGGATGTCCATG
GCGCGAGAAATTATCCGCGGTATGAAAAATGCGCAGTTCACGGTGCATTATCAACCAGTATTTAACGTCAACCGCGGTAA
TTGTGGTGGGGTAGAGGCATTAATGCGTTGGCCTCTTCCCGATGGTCGTTTTATTACACCCGACATTTTCATCACCGCCG
CAGAAAACGAAGGTATGATCGTTCCGCTTTCGCGGCATCTGTTTAAGCTCATCGCCGAGGATGTCGAAAGGTGGCAGGTC
GCCGAAGGCTTTTATATCAGTGTTAATATTTCGCCTGAACACTTGGTGCATGAGAGCTTTATTGAAGACGTTGAGTTGTT
ACAGGCAAGATTAGGCAATCTGCGTCTGATGCTGGAGCTCACCGAACGCAGCCTCATTGTACAACCAGCACTTGTGTCAG
ATAAGCTGATACGGCTACGTGAGAAAGGCATATTGATAGCGATAGACGATTTTGGTACCGGCTACTGTTCGCTTTCTTAC
CTCCAGCAGCTACCCGTTGATTATCTGAAAATCGATCGTACTTTTGTCGATACGATTGATACCAGCGGTAGCGACGTGCC
CATTCTGGATACCATTATCATGCTTAGCCGTAAACTCGGTCTTAATATCGTTGCGGAAGGCGTGAGTTCAGAACATCAAT
TGAGCTATATTCTCGATCATAACGTAGGATTTATACAGGGCTATCTTTACGCAAAGCCTATGTGTTCATCTGATTTTACG
CGCTGGCTTGATACGCGTGCCAATGAGCAAAATGACAGGATTAAATGCAAAAAATGTTCAATAAATCAGTAA

Upstream 100 bases:

>100_bases
CGGTCAGCTATACCACCGCACATCCATTCGTGAATGAGAGGCGAAACCAGTGAAGCTAAAACTATCGTATATAATTTGTG
CAGTGCTGGTGCCGCTGGTC

Downstream 100 bases:

>100_bases
CCACTGAGGTAACATAATGGTTTAACCTGAACGACGCATTCTTAACAGAAGGTCTTATGAGTAAGAAAAAATACCTAATT
GATAAGAAAGTCATTCTTGA

Product: diguanylate cyclase/phosphodiesterase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MMITLALLVSVLQFKQDVALSAKTLLRFSEDVSTASWRVTGQAVKLADRPCAEILSELNRTRAFTPYIRDIGLLEKGNLL
CSFVSREQAHPFPLPPGKTLPTPLPARWVRSFSWMAGGPGRPAVVYTQQVAADKAAFVIVDSRYVQELMDVLSEEREAVF
SLRFGKGDAIISQPAQYDRIVMTQNYVTDDGKISLTVAAPLGTLTAVWMKSLLIFIPLSFCFSFLTLVLYRHWSKMRMSM
AREIIRGMKNAQFTVHYQPVFNVNRGNCGGVEALMRWPLPDGRFITPDIFITAAENEGMIVPLSRHLFKLIAEDVERWQV
AEGFYISVNISPEHLVHESFIEDVELLQARLGNLRLMLELTERSLIVQPALVSDKLIRLREKGILIAIDDFGTGYCSLSY
LQQLPVDYLKIDRTFVDTIDTSGSDVPILDTIIMLSRKLGLNIVAEGVSSEHQLSYILDHNVGFIQGYLYAKPMCSSDFT
RWLDTRANEQNDRIKCKKCSINQ

Sequences:

>Translated_503_residues
MMITLALLVSVLQFKQDVALSAKTLLRFSEDVSTASWRVTGQAVKLADRPCAEILSELNRTRAFTPYIRDIGLLEKGNLL
CSFVSREQAHPFPLPPGKTLPTPLPARWVRSFSWMAGGPGRPAVVYTQQVAADKAAFVIVDSRYVQELMDVLSEEREAVF
SLRFGKGDAIISQPAQYDRIVMTQNYVTDDGKISLTVAAPLGTLTAVWMKSLLIFIPLSFCFSFLTLVLYRHWSKMRMSM
AREIIRGMKNAQFTVHYQPVFNVNRGNCGGVEALMRWPLPDGRFITPDIFITAAENEGMIVPLSRHLFKLIAEDVERWQV
AEGFYISVNISPEHLVHESFIEDVELLQARLGNLRLMLELTERSLIVQPALVSDKLIRLREKGILIAIDDFGTGYCSLSY
LQQLPVDYLKIDRTFVDTIDTSGSDVPILDTIIMLSRKLGLNIVAEGVSSEHQLSYILDHNVGFIQGYLYAKPMCSSDFT
RWLDTRANEQNDRIKCKKCSINQ
>Mature_503_residues
MMITLALLVSVLQFKQDVALSAKTLLRFSEDVSTASWRVTGQAVKLADRPCAEILSELNRTRAFTPYIRDIGLLEKGNLL
CSFVSREQAHPFPLPPGKTLPTPLPARWVRSFSWMAGGPGRPAVVYTQQVAADKAAFVIVDSRYVQELMDVLSEEREAVF
SLRFGKGDAIISQPAQYDRIVMTQNYVTDDGKISLTVAAPLGTLTAVWMKSLLIFIPLSFCFSFLTLVLYRHWSKMRMSM
AREIIRGMKNAQFTVHYQPVFNVNRGNCGGVEALMRWPLPDGRFITPDIFITAAENEGMIVPLSRHLFKLIAEDVERWQV
AEGFYISVNISPEHLVHESFIEDVELLQARLGNLRLMLELTERSLIVQPALVSDKLIRLREKGILIAIDDFGTGYCSLSY
LQQLPVDYLKIDRTFVDTIDTSGSDVPILDTIIMLSRKLGLNIVAEGVSSEHQLSYILDHNVGFIQGYLYAKPMCSSDFT
RWLDTRANEQNDRIKCKKCSINQ

Specific function: Involved in resistance to phages N4 and lambda [H]

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI1788502, Length=509, Percent_Identity=30.2554027504912, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI87081845, Length=484, Percent_Identity=30.9917355371901, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI87081980, Length=453, Percent_Identity=30.242825607064, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081743, Length=495, Percent_Identity=27.0707070707071, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1786507, Length=242, Percent_Identity=37.1900826446281, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI1790496, Length=250, Percent_Identity=31.6, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1787541, Length=240, Percent_Identity=32.5, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI226510982, Length=248, Percent_Identity=33.8709677419355, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI87081921, Length=256, Percent_Identity=28.90625, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1787055, Length=249, Percent_Identity=30.9236947791165, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788849, Length=245, Percent_Identity=29.3877551020408, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87082096, Length=239, Percent_Identity=27.1966527196653, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787410, Length=151, Percent_Identity=28.476821192053, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: NA

Molecular weight: Translated: 56741; Mature: 56741

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMITLALLVSVLQFKQDVALSAKTLLRFSEDVSTASWRVTGQAVKLADRPCAEILSELNR
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCHHHHHHHHHH
TRAFTPYIRDIGLLEKGNLLCSFVSREQAHPFPLPPGKTLPTPLPARWVRSFSWMAGGPG
CCCCCCHHHHCCCCCCCCHHEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
RPAVVYTQQVAADKAAFVIVDSRYVQELMDVLSEEREAVFSLRFGKGDAIISQPAQYDRI
CCEEEEEHHHCCCCEEEEEECHHHHHHHHHHHHHHHHEEEEEEECCCCCEECCCCCCCEE
VMTQNYVTDDGKISLTVAAPLGTLTAVWMKSLLIFIPLSFCFSFLTLVLYRHWSKMRMSM
EEECCEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AREIIRGMKNAQFTVHYQPVFNVNRGNCGGVEALMRWPLPDGRFITPDIFITAAENEGMI
HHHHHHCCCCCEEEEEEEEEEECCCCCCCCHHHHHHCCCCCCCEECCEEEEEEECCCCEE
VPLSRHLFKLIAEDVERWQVAEGFYISVNISPEHLVHESFIEDVELLQARLGNLRLMLEL
EEHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
TERSLIVQPALVSDKLIRLREKGILIAIDDFGTGYCSLSYLQQLPVDYLKIDRTFVDTID
CCCCEEECCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCHHHHHHCHHHHHHCC
TSGSDVPILDTIIMLSRKLGLNIVAEGVSSEHQLSYILDHNVGFIQGYLYAKPMCSSDFT
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCEEHEEEECCCCCHHHH
RWLDTRANEQNDRIKCKKCSINQ
HHHHHCCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MMITLALLVSVLQFKQDVALSAKTLLRFSEDVSTASWRVTGQAVKLADRPCAEILSELNR
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEECCCCHHHHHHHHHH
TRAFTPYIRDIGLLEKGNLLCSFVSREQAHPFPLPPGKTLPTPLPARWVRSFSWMAGGPG
CCCCCCHHHHCCCCCCCCHHEEEHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCC
RPAVVYTQQVAADKAAFVIVDSRYVQELMDVLSEEREAVFSLRFGKGDAIISQPAQYDRI
CCEEEEEHHHCCCCEEEEEECHHHHHHHHHHHHHHHHEEEEEEECCCCCEECCCCCCCEE
VMTQNYVTDDGKISLTVAAPLGTLTAVWMKSLLIFIPLSFCFSFLTLVLYRHWSKMRMSM
EEECCEECCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AREIIRGMKNAQFTVHYQPVFNVNRGNCGGVEALMRWPLPDGRFITPDIFITAAENEGMI
HHHHHHCCCCCEEEEEEEEEEECCCCCCCCHHHHHHCCCCCCCEECCEEEEEEECCCCEE
VPLSRHLFKLIAEDVERWQVAEGFYISVNISPEHLVHESFIEDVELLQARLGNLRLMLEL
EEHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCEEEEEEE
TERSLIVQPALVSDKLIRLREKGILIAIDDFGTGYCSLSYLQQLPVDYLKIDRTFVDTID
CCCCEEECCHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHCCHHHHHHCHHHHHHCC
TSGSDVPILDTIIMLSRKLGLNIVAEGVSSEHQLSYILDHNVGFIQGYLYAKPMCSSDFT
CCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCCEEHEEEECCCCCHHHH
RWLDTRANEQNDRIKCKKCSINQ
HHHHHCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 9079933 [H]