Click here to switch to the map view.

The map label for this gene is lpxB [H]

Identifier: 152968776

GI number: 152968776

Start: 229114

End: 230265

Strand: Direct

Name: lpxB [H]

Synonym: KPN_00195

Alternate gene names: 152968776

Gene position: 229114-230265 (Clockwise)

Preceding gene: 152968775

Following gene: 152968777

Centisome position: 4.31

GC content: 60.07

Gene sequence:

>1152_bases
ATGGCTGAACAGCGTCCCCTGACGATTGCCCTGGTCGCCGGAGAAACCTCCGGCGATATTCTAGGCGCTGGTCTCATCCG
CGCGCTTAAAGCACGCATCCCGAATGCGCGCTTTGTCGGCGTGGCGGGGCCGCTAATGCAGGCGGAAGGGTGCGAAGCCT
GGTATGAAATGGAAGAGCTGGCGGTGATGGGCATTGTTGAAGTGCTCGGTCGCCTGCGTCGCTTACTCCATATTCGCGCC
GATTTGACCCGCCGCTTCGGCGAGCTGCGTCCCGATGTCTTCGTCGGCATCGACGCCCCTGACTTTAATATCACCCTCGA
AGGAAATCTGAAAAAGCAGGGCATCAAAACCATTCACTACGTCAGCCCGTCGGTCTGGGCCTGGCGACAAAAACGCGTTT
TCAAAATCGGCAGATCCACCGATCTGGTGCTGGCCTTTCTGCCTTTCGAAAAGGCGTTTTATGACAAATTTAACGTCCCC
TGCCGCTTTATTGGCCATACCATGGCGGATGCGATGCCGCTGGATCCTGACAAAGGCGCTGCGCGCGACCGGTTAGGGAT
CCCGCACAGCGTGCGCTGCCTCGCTCTGCTACCCGGCAGCCGCGGCGCGGAAGTCGAAATGCTTAGCGCCGACTTCCTGA
AAACCGCGCAGCTTCTGCGCGCCACCTATCCCGATCTGCAGGTGGTGGTGCCGCTGGTTAATGCTAAACGGCGGGAGCAG
TTTGAGCGTATTAAAGCTGAGACGGCGCCGGATATGATCGTGCATATGCTGGACGGTCAGGCGCGCGATGCGATGATCGC
CAGCGACGCCGCGCTGCTGGCCTCCGGGACGGCAGCGCTGGAGTGTATGCTGGCGAAATGCCCGATGGTGGTTGGCTACC
GGATGAAGCCGTTCACCTTCTGGCTGGCGAAGCGGTTGGTAAAAACCGACTATGTCTCGTTACCGAACCTGCTGGCCGGT
CGCGAACTGGTTAAAGAGCTGCTGCAGGATGAGTGCGAGCCCCAGGCGCTGGCAGCCGCTCTGCAGCCGCTGCTGGCCGA
TGGCAAAACCAGCCATGAGATGCATGAGACGTTCCGCGCCCTGCATCAGCAGATCCGCTGCAACGCCGATGAGCAGGCGG
CGGACGCCGTACTGGAGTTAGCAAAACAATGA

Upstream 100 bases:

>100_bases
AAGAAGCCAAGCCGGAAATTGCCGAACTGGCTGCTCAGCATCCTGAGGTTCAGCCGTTTGTCGATTTCTTCGCTCGTTCT
ACCCGCGGCTTGATTCGTTA

Downstream 100 bases:

>100_bases
TGGAGTTCGTCTATCCGCATACCCATCTGGTTGCCGGCGTCGATGAGGTCGGGCGTGGCCCCCTGGTTGGCGCGGTGGTG
ACCGCGGCGGTGATCCTCGA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MAEQRPLTIALVAGETSGDILGAGLIRALKARIPNARFVGVAGPLMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRA
DLTRRFGELRPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRSTDLVLAFLPFEKAFYDKFNVP
CRFIGHTMADAMPLDPDKGAARDRLGIPHSVRCLALLPGSRGAEVEMLSADFLKTAQLLRATYPDLQVVVPLVNAKRREQ
FERIKAETAPDMIVHMLDGQARDAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAG
RELVKELLQDECEPQALAAALQPLLADGKTSHEMHETFRALHQQIRCNADEQAADAVLELAKQ

Sequences:

>Translated_383_residues
MAEQRPLTIALVAGETSGDILGAGLIRALKARIPNARFVGVAGPLMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRA
DLTRRFGELRPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRSTDLVLAFLPFEKAFYDKFNVP
CRFIGHTMADAMPLDPDKGAARDRLGIPHSVRCLALLPGSRGAEVEMLSADFLKTAQLLRATYPDLQVVVPLVNAKRREQ
FERIKAETAPDMIVHMLDGQARDAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAG
RELVKELLQDECEPQALAAALQPLLADGKTSHEMHETFRALHQQIRCNADEQAADAVLELAKQ
>Mature_382_residues
AEQRPLTIALVAGETSGDILGAGLIRALKARIPNARFVGVAGPLMQAEGCEAWYEMEELAVMGIVEVLGRLRRLLHIRAD
LTRRFGELRPDVFVGIDAPDFNITLEGNLKKQGIKTIHYVSPSVWAWRQKRVFKIGRSTDLVLAFLPFEKAFYDKFNVPC
RFIGHTMADAMPLDPDKGAARDRLGIPHSVRCLALLPGSRGAEVEMLSADFLKTAQLLRATYPDLQVVVPLVNAKRREQF
ERIKAETAPDMIVHMLDGQARDAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTFWLAKRLVKTDYVSLPNLLAGR
ELVKELLQDECEPQALAAALQPLLADGKTSHEMHETFRALHQQIRCNADEQAADAVLELAKQ

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=382, Percent_Identity=91.0994764397906, Blast_Score=704, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 42437; Mature: 42306

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQRPLTIALVAGETSGDILGAGLIRALKARIPNARFVGVAGPLMQAEGCEAWYEMEEL
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHH
AVMGIVEVLGRLRRLLHIRADLTRRFGELRPDVFVGIDAPDFNITLEGNLKKQGIKTIHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEE
VSPSVWAWRQKRVFKIGRSTDLVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKGA
CCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
ARDRLGIPHSVRCLALLPGSRGAEVEMLSADFLKTAQLLRATYPDLQVVVPLVNAKRREQ
CCCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEEHHCCHHHHH
FERIKAETAPDMIVHMLDGQARDAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTF
HHHHHHCCCHHHHHHHHCCCCCHHHHHCCHHHHHCCHHHHHHHHHHCCHHHCCCCCHHHH
WLAKRLVKTDYVSLPNLLAGRELVKELLQDECEPQALAAALQPLLADGKTSHEMHETFRA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LHQQIRCNADEQAADAVLELAKQ
HHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AEQRPLTIALVAGETSGDILGAGLIRALKARIPNARFVGVAGPLMQAEGCEAWYEMEEL
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHH
AVMGIVEVLGRLRRLLHIRADLTRRFGELRPDVFVGIDAPDFNITLEGNLKKQGIKTIHY
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEE
VSPSVWAWRQKRVFKIGRSTDLVLAFLPFEKAFYDKFNVPCRFIGHTMADAMPLDPDKGA
CCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
ARDRLGIPHSVRCLALLPGSRGAEVEMLSADFLKTAQLLRATYPDLQVVVPLVNAKRREQ
CCCCCCCCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEEHHCCHHHHH
FERIKAETAPDMIVHMLDGQARDAMIASDAALLASGTAALECMLAKCPMVVGYRMKPFTF
HHHHHHCCCHHHHHHHHCCCCCHHHHHCCHHHHHCCHHHHHHHHHHCCHHHCCCCCHHHH
WLAKRLVKTDYVSLPNLLAGRELVKELLQDECEPQALAAALQPLLADGKTSHEMHETFRA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LHQQIRCNADEQAADAVLELAKQ
HHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA