Click here to switch to the map view.

The map label for this gene is hisIE

Identifier: 151222782

GI number: 151222782

Start: 2839708

End: 2840340

Strand: Reverse

Name: hisIE

Synonym: NWMN_2570

Alternate gene names: 151222782

Gene position: 2840340-2839708 (Counterclockwise)

Preceding gene: 151222783

Following gene: 151222781

Centisome position: 98.66

GC content: 34.76

Gene sequence:

>633_bases
ATGACCAAATATAAAATTGATTTTAGCAAAGGTTTAGTGCCAGCAATTTTACAAGATAATCAAACAAAACAAGTATTGAT
GTTGGGTTATATGAACCAAGAAGCTTTTGATAAAACGATAGAAGATGGTGTGGTATGTTTCTATTCGCGGTCGAAACAAC
GGCTATGGACAAAAGGTGAAACATCTGGTCATACGCAACGTGTTAAAGATATTCATGTAGATTGCGACAATGACACTATT
TTAATTGATGTCATACCAAATGGACCAACATGTCATACAGGCAGTCAAAGTTGTTTCAACACAGAAGTTCCATTTTCAGT
GCAAACATTAGCGCAGACAGTTCAAGATAGTGCCCAATCCAATAATGAAAAGTCATATACAAAATATTTATTAACAGAAG
GTATAGAAAAGATTACAAAAAAATACGGTGAAGAAGCTTTTGAAGTCGTAATTGAAGCAATTAAAGGTGACAAAAAAGCA
TTTGTAAGTGAAGTAGCAGATGAACTTTATCATTTATTTGTCTTGATGCATGCGCTTGGCGTCGATTTTTCAGAAATTGA
GGCGGAATTAGCGCGTAGACATCATAAGCGCAATAACTTTAAAGGTGAACGACAAAATATCGAACAGTGGTAA

Upstream 100 bases:

>100_bases
CGGATGTTTCTGCAGGTTTAGCTGCAAGTATATTACATGATCGAGAAACGACGGTTCAATCTATTAAAGAAGTGATACGG
CAAGGGGGTATAGCAGTAAG

Downstream 100 bases:

>100_bases
AGCAAGTATGGACTAAGATATAAGGAAAAGGATCATGGCTTATACACTTACAAATATTGTGGAAAACGTGACATTTTCAA
GTTTAAAATACGACACCAAC

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MTKYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIHVDCDNDTI
LIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKA
FVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW

Sequences:

>Translated_210_residues
MTKYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIHVDCDNDTI
LIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKA
FVSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW
>Mature_209_residues
TKYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGETSGHTQRVKDIHVDCDNDTIL
IDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQSNNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAF
VSEVADELYHLFVLMHALGVDFSEIEAELARRHHKRNNFKGERQNIEQW

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=197, Percent_Identity=43.1472081218274, Blast_Score=168, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319819, Length=204, Percent_Identity=32.3529411764706, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23987; Mature: 23856

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGE
CCEEEECCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCHHHCCCCC
TSGHTQRVKDIHVDCDNDTILIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQS
CCCCHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
NNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAFVSEVADELYHLFVLMHALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
VDFSEIEAELARRHHKRNNFKGERQNIEQW
CCHHHHHHHHHHHHHHHCCCCCCHHCCCCC
>Mature Secondary Structure 
TKYKIDFSKGLVPAILQDNQTKQVLMLGYMNQEAFDKTIEDGVVCFYSRSKQRLWTKGE
CEEEECCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCHHHCCCCC
TSGHTQRVKDIHVDCDNDTILIDVIPNGPTCHTGSQSCFNTEVPFSVQTLAQTVQDSAQS
CCCCHHHHHEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
NNEKSYTKYLLTEGIEKITKKYGEEAFEVVIEAIKGDKKAFVSEVADELYHLFVLMHALG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
VDFSEIEAELARRHHKRNNFKGERQNIEQW
CCHHHHHHHHHHHHHHHCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA