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The map label for this gene is gabT [H]

Identifier: 151222713

GI number: 151222713

Start: 2747006

End: 2748379

Strand: Reverse

Name: gabT [H]

Synonym: NWMN_2501

Alternate gene names: 151222713

Gene position: 2748379-2747006 (Counterclockwise)

Preceding gene: 151222716

Following gene: 151222711

Centisome position: 95.47

GC content: 37.99

Gene sequence:

>1374_bases
TTGCACATTAATACTGTCAATGGGAGGGGAATGTATATGAGTAAAGCACATCAATTAATTCAAGAGGATGAACATTATTT
TGCGAAATCAGGACGTATTAAATATTATCCGTTAGTGATTGATCATGGATATGGAGCAACATTGGTTGATATTGAGGGGA
AGACATATATCGATTTGTTATCGAGTGCGAGTTCTCAAAACGTAGGTCATGCACCTAGAGAAGTAACAGAAGCGATAAAG
GCACAAGTTGATAAATTTATTCATTATACACCAGCATATATGTATCATGAACCGTTGGTACGTTTAGCTAAGAAGCTTTG
TGAGATTGCACCTGGAGATTTTGAAAAAAGAGTGACCTTCGGATTAACCGGATCAGACGCAAATGATGGCATCATTAAAT
TTGCCAGAGCATATACAGGGCGTCCTTATATCATTAGTTTCACTAATGCATATCATGGTTCAACTTTTGGCTCATTGTCT
ATGTCAGCTATTAGTTTAAATATGCGCAAACATTATGGTCCGTTATTGAATGGTTTTTATCATATTCCGTTTCCAGATAA
ATATCGTGGTATGTACGAGCAGCCACAAGCTAATTCAGTAGAAGAATATTTAGCACCCTTAAAAGAAATGTTTGCGAAGT
ATGTACCTGCTGACGAAGTAGCATGTATTGTTATTGAAACGATACAAGGCGATGGTGGACTTTTAGAACCAGTTCCAGGG
TATTTTGAAGCGTTAGAAAAGATTTGTCGTGAACATGGTATTTTAATCGCTGTCGATGATATTCAACAAGGTTTTGGGAG
AACAGGTACATGGAGTTCAGTCTCGCATTTTAATTTTACGCCTGATTTAATCACTTTCGGAAAATCCTTAGCAGGTGGTA
TGCCTATGTCAGCAATTGTTGGACGCAAAGAGATTATGAATTGTTTAGAAGCACCAGCACATTTATTTACAACAGGTGCT
AATCCAGTTAGTTGTGAAGCTGCATTAGCCACAATTCAAATGATTGAAGATCAGTCGCTTCTTCAGGCTAGTGCGGAAAA
AGGGGAATATGTTAGGAAACGAATGGATCAATGGGTATCTAAATACAATAGTGTAGGCGATGTTAGAGGTAAAGGTCTGA
GCATTGGTATTGATATTGTTTCCGACAAAAAACTCAAAACACGTGATGCCAGTGCGGCACTTAAAATTTGTAATTACTGC
TTTGAGCATGGCGTAGTTATTATAGCTGTAGCAGGAAATGTGTTGCGATTCCAACCGCCATTGGTAATAACATATGAGCA
ATTAGACACGGCGTTAAACACTATAGAAGATGCACTGACTGCTTTGGAAGCAGGTAACTTAGATCAATATGACATATCTG
GACAAGGTTGGTAA

Upstream 100 bases:

>100_bases
AATTTTATTAGTATATTGGATAGTATTCATAGAGGCATGACGGTATTTGAGCAGGATTTTAAATCGGATTTTATAATCGA
TTTAAGAGAGGCCACTTTGC

Downstream 100 bases:

>100_bases
TAGCGATTATCTTAATATAAAATAAAAAATCATTTCCACATCTGGATGTTAATCAGATGGGAAATGATTTTTTTTATTTT
TTATTTTGGTGGGTGGTATT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MHINTVNGRGMYMSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAPREVTEAIK
AQVDKFIHYTPAYMYHEPLVRLAKKLCEIAPGDFEKRVTFGLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLS
MSAISLNMRKHYGPLLNGFYHIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPG
YFEALEKICREHGILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAPAHLFTTGA
NPVSCEAALATIQMIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYC
FEHGVVIIAVAGNVLRFQPPLVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW

Sequences:

>Translated_457_residues
MHINTVNGRGMYMSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAPREVTEAIK
AQVDKFIHYTPAYMYHEPLVRLAKKLCEIAPGDFEKRVTFGLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLS
MSAISLNMRKHYGPLLNGFYHIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPG
YFEALEKICREHGILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAPAHLFTTGA
NPVSCEAALATIQMIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYC
FEHGVVIIAVAGNVLRFQPPLVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW
>Mature_457_residues
MHINTVNGRGMYMSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLLSSASSQNVGHAPREVTEAIK
AQVDKFIHYTPAYMYHEPLVRLAKKLCEIAPGDFEKRVTFGLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLS
MSAISLNMRKHYGPLLNGFYHIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPG
YFEALEKICREHGILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIVGRKEIMNCLEAPAHLFTTGA
NPVSCEAALATIQMIEDQSLLQASAEKGEYVRKRMDQWVSKYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYC
FEHGVVIIAVAGNVLRFQPPLVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=417, Percent_Identity=29.7362110311751, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=30, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI4557809, Length=427, Percent_Identity=29.7423887587822, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=30.5912596401028, Blast_Score=175, Evalue=8e-44,
Organism=Homo sapiens, GI24119277, Length=422, Percent_Identity=28.436018957346, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI13994255, Length=428, Percent_Identity=28.2710280373832, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI284507298, Length=331, Percent_Identity=28.7009063444109, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI188536080, Length=470, Percent_Identity=25.531914893617, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI38679950, Length=470, Percent_Identity=25.531914893617, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI38679946, Length=470, Percent_Identity=25.531914893617, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1789016, Length=427, Percent_Identity=31.3817330210773, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1787560, Length=398, Percent_Identity=32.1608040201005, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI145693181, Length=463, Percent_Identity=31.5334773218143, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=29.4117647058824, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=28.7841191066998, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1786991, Length=431, Percent_Identity=27.1461716937355, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786349, Length=305, Percent_Identity=28.1967213114754, Blast_Score=122, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=30.1149425287356, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144271, Length=453, Percent_Identity=25.3863134657837, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71992977, Length=426, Percent_Identity=27.9342723004695, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI25144274, Length=439, Percent_Identity=24.373576309795, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17541228, Length=440, Percent_Identity=25.2272727272727, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=442, Percent_Identity=29.4117647058824, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=27.4231678486998, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324386, Length=354, Percent_Identity=26.271186440678, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6321456, Length=455, Percent_Identity=25.0549450549451, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI161085790, Length=425, Percent_Identity=33.4117647058824, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI28574759, Length=426, Percent_Identity=33.0985915492958, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI21356575, Length=450, Percent_Identity=30, Blast_Score=188, Evalue=8e-48,
Organism=Drosophila melanogaster, GI21357415, Length=434, Percent_Identity=27.4193548387097, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI281366494, Length=438, Percent_Identity=24.2009132420091, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24667139, Length=438, Percent_Identity=24.2009132420091, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24667143, Length=438, Percent_Identity=24.2009132420091, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 50457; Mature: 50457

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHINTVNGRGMYMSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLL
CEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCHHHHHH
SSASSQNVGHAPREVTEAIKAQVDKFIHYTPAYMYHEPLVRLAKKLCEIAPGDFEKRVTF
HCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
GLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLSMSAISLNMRKHYGPLLNGFY
EECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHEEEHHHHHCCHHHCCEE
HIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPG
ECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCH
YFEALEKICREHGILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIV
HHHHHHHHHHHCCEEEEEECHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHH
GRKEIMNCLEAPAHLFTTGANPVSCEAALATIQMIEDQSLLQASAEKGEYVRKRMDQWVS
HHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYCFEHGVVIIAVAGNVLRFQPP
HHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCEEEECCC
LVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW
EEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MHINTVNGRGMYMSKAHQLIQEDEHYFAKSGRIKYYPLVIDHGYGATLVDIEGKTYIDLL
CEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCHHHHHH
SSASSQNVGHAPREVTEAIKAQVDKFIHYTPAYMYHEPLVRLAKKLCEIAPGDFEKRVTF
HCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
GLTGSDANDGIIKFARAYTGRPYIISFTNAYHGSTFGSLSMSAISLNMRKHYGPLLNGFY
EECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEHHEEEHHHHHCCHHHCCEE
HIPFPDKYRGMYEQPQANSVEEYLAPLKEMFAKYVPADEVACIVIETIQGDGGLLEPVPG
ECCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCH
YFEALEKICREHGILIAVDDIQQGFGRTGTWSSVSHFNFTPDLITFGKSLAGGMPMSAIV
HHHHHHHHHHHCCEEEEEECHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHH
GRKEIMNCLEAPAHLFTTGANPVSCEAALATIQMIEDQSLLQASAEKGEYVRKRMDQWVS
HHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYNSVGDVRGKGLSIGIDIVSDKKLKTRDASAALKICNYCFEHGVVIIAVAGNVLRFQPP
HHCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCEEEECCC
LVITYEQLDTALNTIEDALTALEAGNLDQYDISGQGW
EEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]