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The map label for this gene is panB

Identifier: 151222708

GI number: 151222708

Start: 2741011

End: 2741829

Strand: Reverse

Name: panB

Synonym: NWMN_2496

Alternate gene names: 151222708

Gene position: 2741829-2741011 (Counterclockwise)

Preceding gene: 151222710

Following gene: 151222707

Centisome position: 95.24

GC content: 36.14

Gene sequence:

>819_bases
TTGAAAACAGTAAGTCAATTAATAGATATGAAACAAAAGCAAACTAAAATTTCTATGGTAACAGCTTATGATTTTCCAAG
TGCTAAACAAGTGGAAGCAGCGGGTATTGATATGATTCTTGTTGGGGATTCACTTGGTATGACTGTATTAGGTTATGAAA
GTATCGTACAAGTGACGTTAGCAGATATGATTCATCACGGTCGTGCAGTAAGAAGAGGCGCACCAAATACATTTGTAGTT
GTTGATATGCCGATTGGTGCAGTAGGCATCTCTATGACACAAGACTTAAATCATGCTCTAAAGCTTTATCAGGAGACGAA
TGCAAATGCAATTAAAGCAGAAGGAGCGCATATTACACCATTTATTGAAAAAGCAACGGCAATTGGTATTCCTGTTGTTG
CACATTTAGGATTAACACCTCAAAGTGTTGGCGTTATGGGGTATAAATTACAAGGTGCAACGAAAGAAGCAGCGGAGCAA
CTTATTTTAGACGCGAAAAATGTAGAACAAGCTGGTGCAGTTGCGTTAGTACTTGAAGCAATTCCAAATGATTTAGCAGA
AGAAATTAGCAAGCACTTAACAATTCCAGTCATTGGTATTGGTGCAGGAAAAGGTACAGATGGTCAAGTATTGGTTTATC
ACGATATGTTAAATTATGGTGTTGAACATAAAGCGAAATTTGTGAAGCAATTTGCTGATTTTAGTGTTGGTGTGGATGGT
TTAAAACAATACGATCAAGAAGTTAAATCTGGTGCATTTCCATCAGAAGAATATACGTATAAAAAGAAAATTATGAATGA
GGTTAATAACAATGACTAA

Upstream 100 bases:

>100_bases
CTGGGCCGATAATCGCAACTGATAACATCTTCTTCTTTCCTTTCTATAAAAGATTCATTATACTATTTCTAATAATACTG
CAAAAAGAGGTTGAATAACA

Downstream 100 bases:

>100_bases
GCTGATTACTACGGTAAAAGAGATGCAACACATTGTTAAAGCAGCCAAACGCTCAGGCACAACGATTGGTTTTATCCCAA
CAATGGGTGCCTTACATGAT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MKTVSQLIDMKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESIVQVTLADMIHHGRAVRRGAPNTFVV
VDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQ
LILDAKNVEQAGAVALVLEAIPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDG
LKQYDQEVKSGAFPSEEYTYKKKIMNEVNNND

Sequences:

>Translated_272_residues
MKTVSQLIDMKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESIVQVTLADMIHHGRAVRRGAPNTFVV
VDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQ
LILDAKNVEQAGAVALVLEAIPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDG
LKQYDQEVKSGAFPSEEYTYKKKIMNEVNNND
>Mature_272_residues
MKTVSQLIDMKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESIVQVTLADMIHHGRAVRRGAPNTFVV
VDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITPFIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQ
LILDAKNVEQAGAVALVLEAIPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDG
LKQYDQEVKSGAFPSEEYTYKKKIMNEVNNND

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=264, Percent_Identity=43.9393939393939, Blast_Score=201, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6319653, Length=266, Percent_Identity=37.218045112782, Blast_Score=174, Evalue=2e-44,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 29268; Mature: 29268

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVSQLIDMKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESIVQVTL
CCHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHCCCEEEEECCCCCEEEECHHHHHHHHH
ADMIHHGRAVRRGAPNTFVVVDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITP
HHHHHCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCH
FIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVEQAGAVALVLEA
HHHHHHHCCCHHHHHCCCCCHHCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
IPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDG
HCHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCHHH
LKQYDQEVKSGAFPSEEYTYKKKIMNEVNNND
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTVSQLIDMKQKQTKISMVTAYDFPSAKQVEAAGIDMILVGDSLGMTVLGYESIVQVTL
CCHHHHHHHHHHHHHEEEEEEEECCCCCCCHHHCCCEEEEECCCCCEEEECHHHHHHHHH
ADMIHHGRAVRRGAPNTFVVVDMPIGAVGISMTQDLNHALKLYQETNANAIKAEGAHITP
HHHHHCCHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCCCH
FIEKATAIGIPVVAHLGLTPQSVGVMGYKLQGATKEAAEQLILDAKNVEQAGAVALVLEA
HHHHHHHCCCHHHHHCCCCCHHCCEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
IPNDLAEEISKHLTIPVIGIGAGKGTDGQVLVYHDMLNYGVEHKAKFVKQFADFSVGVDG
HCHHHHHHHHHCCEEEEEEECCCCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHHHCCHHH
LKQYDQEVKSGAFPSEEYTYKKKIMNEVNNND
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA