Click here to switch to the map view.

The map label for this gene is fmhB

Identifier: 151222375

GI number: 151222375

Start: 2388162

End: 2389427

Strand: Reverse

Name: fmhB

Synonym: NWMN_2163

Alternate gene names: 151222375

Gene position: 2389427-2388162 (Counterclockwise)

Preceding gene: 151222376

Following gene: 151222374

Centisome position: 83.0

GC content: 33.97

Gene sequence:

>1266_bases
ATGGAAAAGATGCATATCACTAATCAGGAACATGACGCATTTGTTAAATCCCACCCAAATGGAGATTTATTACAATTAAC
GAAATGGGCAGAAACAAAGAAATTAACTGGATGGTACGCGCGAAGAATCGCTGTAGGTCGTGACGGTGAAGTTCAGGGTG
TTGCGCAGTTACTTTTTAAAAAAGTACCTAAATTACCTTATACGCTATGTTATATTTCGCGTGGTTTTGTTGTTGATTAT
AGTAATAAAGAAGCGTTAAATGCATTGTTAGACAGTGCAAAAGAAATTGCTAAAGCTGAGAAAGCGTATGCAATTAAAAT
CGATCCTGATGTTGAAGTTGATAAAGGTACAGATGCTTTGCAAAATTTGAAAGCGCTTGGTTTTAAACATAAAGGATTTA
AAGAAGGTTTATCAAAAGACTACATCCAACCACGTATGACTATGATTACACCAATTGATAAAAATGATGATGAGTTATTA
AATAGTTTTGAACGCCGAAATCGTTCAAAAGTGCGCTTGGCTTTAAAGCGAGGTACGACAGTAGAACGATCTGATAGAGA
AGGTTTAAAAACATTTGCTGAGTTAATGAAAATCACTGGGGAACGCGATGGCTTCTTAACGCGTGATATTAGTTACTTTG
AAAATATTTATGATGCGTTGCATGAAGATGGAGATGCTGAACTATTTTTAGTAAAGTTGGATCCAAAAGAAAATATAGCG
AAAGTAAATCAAGAATTGAATGAACTTCATGCCGAAATTGCTAAATGGCAGCAGAAGATGAAAACATCTGAAAAGCAAGC
TAAAAAAGCGCAAAATATGATTAATGATGCGCAAAATAAAATTGCTAAAAATGAAGATTTAAAACGAGACCTAGAAGCTT
TAGAAAAGGAACATCCTGAAGGTATTTATCTTTCTGGTGCACTATTAATGTTTGCTGGCTCAAAATCATATTACTTATAT
GGTGCGTCTTCTAATGAATTTAGAGATTTTTTACCAAATCATCATATGCAGTATACGATGATGAAGTATGCACGTGAACA
TGGTGCAACAACTTACGATTTCGGTGGTACAGATAATGATCCAGATAAAGACTCAGAACATTATGGATTATGGGCATTTA
AAAAAGTGTGGGGAACATACTTAAGTGAAAAGATTGGTGAATTTGATTATGTATTGAATCAGCCATTGTACCAATTAATT
GAGCAAGTTAAACCGCGTTTAACAAAAGCTAAAATTAAAATATCTCGTAAATTAAAACGAAAATAG

Upstream 100 bases:

>100_bases
AAAATAAGAGTTCAAATCTTACACAAGCTCTGAATCGACACTATAAGATACAAACTGTATAATTAAAGGTATTGTTAAAT
AGAAGGAGATATCATAAATC

Downstream 100 bases:

>100_bases
ATTAACGACTGAAATCTGAACGCTCATAAGACTGTCATTTGCGTTCAGATTTTTTTACACAATATAGAATGGTTGAGTAA
AATATTTTTGAATATAGTGA

Product: peptidoglycan pentaglycine interpeptide biosynthesis protein

Products: NA

Alternate protein names: Factor essential for expression of methicillin resistance X

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDY
SNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELL
NSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
KVNQELNELHAEIAKWQQKMKTSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLY
GASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLI
EQVKPRLTKAKIKISRKLKRK

Sequences:

>Translated_421_residues
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDY
SNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELL
NSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
KVNQELNELHAEIAKWQQKMKTSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLY
GASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLI
EQVKPRLTKAKIKISRKLKRK
>Mature_421_residues
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFKKVPKLPYTLCYISRGFVVDY
SNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDALQNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELL
NSFERRNRSKVRLALKRGTTVERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
KVNQELNELHAEIAKWQQKMKTSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPEGIYLSGALLMFAGSKSYYLY
GASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDNDPDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLI
EQVKPRLTKAKIKISRKLKRK

Specific function: Catalyzes the incorporation of the first glycine of the pentaglycine interpeptide bridge, which is characteristic of the S.aureus peptidoglycan. This glycine is added to the epsilon-amino group of the L-lysine of the membrane-bound lipid II intermediate (

COG id: COG2348

COG function: function code V; Uncharacterized protein involved in methicillin resistance

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the femABX family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FEMX_STAA3 (Q2FEM9)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_494849.1
- ProteinModelPortal:   Q2FEM9
- SMR:   Q2FEM9
- STRING:   Q2FEM9
- EnsemblBacteria:   EBSTAT00000038226
- GeneID:   3914487
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_2214
- eggNOG:   COG2348
- GeneTree:   EBGT00050000023974
- HOGENOM:   HBG475713
- OMA:   TWYETAK
- ProtClustDB:   CLSK885847
- GO:   GO:0005737
- InterPro:   IPR016181
- InterPro:   IPR003447
- Gene3D:   G3DSA:3.40.630.30

Pfam domain/function: PF02388 FemAB; SSF55729 Acyl_CoA_acyltransferase

EC number: NA

Molecular weight: Translated: 48522; Mature: 48522

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS51191 FEMABX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFK
CCCCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDAL
HCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHH
QNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTT
HHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCHHEEEHHHCCCC
VERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
KVNQELNELHAEIAKWQQKMKTSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDND
CEEEECEEEEEECCCCEEEEECCCCHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCCCC
PDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C
>Mature Secondary Structure
MEKMHITNQEHDAFVKSHPNGDLLQLTKWAETKKLTGWYARRIAVGRDGEVQGVAQLLFK
CCCCCCCCCHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
KVPKLPYTLCYISRGFVVDYSNKEALNALLDSAKEIAKAEKAYAIKIDPDVEVDKGTDAL
HCCCCCEEEEEEECCEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHH
QNLKALGFKHKGFKEGLSKDYIQPRMTMITPIDKNDDELLNSFERRNRSKVRLALKRGTT
HHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCHHEEEHHHCCCC
VERSDREGLKTFAELMKITGERDGFLTRDISYFENIYDALHEDGDAELFLVKLDPKENIA
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHH
KVNQELNELHAEIAKWQQKMKTSEKQAKKAQNMINDAQNKIAKNEDLKRDLEALEKEHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
GIYLSGALLMFAGSKSYYLYGASSNEFRDFLPNHHMQYTMMKYAREHGATTYDFGGTDND
CEEEECEEEEEECCCCEEEEECCCCHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCCCC
PDKDSEHYGLWAFKKVWGTYLSEKIGEFDYVLNQPLYQLIEQVKPRLTKAKIKISRKLKR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA