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The map label for this gene is dut [H]

Identifier: 151222116

GI number: 151222116

Start: 2116565

End: 2117107

Strand: Reverse

Name: dut [H]

Synonym: NWMN_1904

Alternate gene names: 151222116

Gene position: 2117107-2116565 (Counterclockwise)

Preceding gene: 151222117

Following gene: 151222115

Centisome position: 73.54

GC content: 38.86

Gene sequence:

>543_bases
ATGACTAACACATTACAAGTAAGGCTATTATCAGAAAATGCTAGAATGCCCGAACGAAATCATAAGACGGATGCAGGTTA
TGACATATTCTCAGCTGAAACTGTCGTACTTGAGCCACAAGAAAAGGCAGTGATTAAAACAGATGTAGCTGTAAGCATAC
CAGAGGGCTATGTCGGGCTATTAACTAGCCGTAGTGGTGTAAGTAGTAAAACACATTTAGTGATTGAAACAGGCAAGATA
GACGCCGGATATCACGGCAATTTAGGGATTAATATTAAGAATGATGAAGAACGTGATGGAATACCCTTTTTATATGATGA
TATAGACGCTGAATTAGAAGATGGATTAATAAGCATTTTAGATATAAAAGGTAACTATGTACAAGATGGAAGAGGCATAA
GAAGAATTTACCAAATCAACAAAGGCGACAAACTAGCACAACTGGTTATCGTGCCTATATGGACACCTGAACTAAAGCAA
GTGGAGGAATTCGAGAGTGTTTCAGAACGTGGAGCAAAAGGCTTCGGAAGTAGCGGAGTGTAA

Upstream 100 bases:

>100_bases
GATATTAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTT
AATCAAGGAGGAGCAGGAAA

Downstream 100 bases:

>100_bases
AGACATCTTAGATCGAGTCAAGGAGGTTTTGGGGAAGTGACACAATACTTAGTCACAACATTCAAAGATTCAACAGGACG
TAAACATACACACATAACTA

Product: phage dUTP pyrophosphatase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MTNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKTHLVIETGKI
DAGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISILDIKGNYVQDGRGIRRIYQINKGDKLAQLVIVPIWTPELKQ
VEEFESVSERGAKGFGSSGV

Sequences:

>Translated_180_residues
MTNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKTHLVIETGKI
DAGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISILDIKGNYVQDGRGIRRIYQINKGDKLAQLVIVPIWTPELKQ
VEEFESVSERGAKGFGSSGV
>Mature_179_residues
TNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGLLTSRSGVSSKTHLVIETGKID
AGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISILDIKGNYVQDGRGIRRIYQINKGDKLAQLVIVPIWTPELKQV
EEFESVSERGAKGFGSSGV

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=177, Percent_Identity=31.0734463276836, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI4503423, Length=177, Percent_Identity=31.0734463276836, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI70906441, Length=177, Percent_Identity=31.0734463276836, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71988561, Length=176, Percent_Identity=29.5454545454545, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319729, Length=176, Percent_Identity=26.1363636363636, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24583610, Length=179, Percent_Identity=31.8435754189944, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19921126, Length=179, Percent_Identity=31.8435754189944, Blast_Score=90, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 19818; Mature: 19686

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGL
CCCEEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEECCCCCEEEEECEEEECCCCEEEE
LTSRSGVSSKTHLVIETGKIDAGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISIL
EECCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCHHCCCEEEEE
DIKGNYVQDGRGIRRIYQINKGDKLAQLVIVPIWTPELKQVEEFESVSERGAKGFGSSGV
EECCCEEECCCCEEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TNTLQVRLLSENARMPERNHKTDAGYDIFSAETVVLEPQEKAVIKTDVAVSIPEGYVGL
CCEEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEECCCCCEEEEECEEEECCCCEEEE
LTSRSGVSSKTHLVIETGKIDAGYHGNLGINIKNDEERDGIPFLYDDIDAELEDGLISIL
EECCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCEEECCCCCHHCCCEEEEE
DIKGNYVQDGRGIRRIYQINKGDKLAQLVIVPIWTPELKQVEEFESVSERGAKGFGSSGV
EECCCEEECCCCEEEEEEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]