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The map label for this gene is hemN

Identifier: 151221698

GI number: 151221698

Start: 1653049

End: 1654173

Strand: Reverse

Name: hemN

Synonym: NWMN_1486

Alternate gene names: 151221698

Gene position: 1654173-1653049 (Counterclockwise)

Preceding gene: 151221699

Following gene: 151221697

Centisome position: 57.46

GC content: 32.62

Gene sequence:

>1125_bases
ATGACGGTACAAAGTGCATATATACATATTCCATTTTGTGTAAGAATATGTACATATTGTGATTTCAATAAATATTTTAT
ACAGAATCAACCTGTAGATGAGTACTTAGATGCACTAATCACAGAAATGTCTACAGCAAAATATAGGATCTTAAAGACCA
TGTATGTAGGTGGCGGCACACCAACGGCCCTTTCTATTAATCAGTTGGAAAGATTACTTAAAGCAATACGTGATACGTTT
ACAATCACAGGCGAGTATACATTTGAAGCAAATCCTGATGAGTTAACTAAAGAGAAAGTCCAACTATTAGAGAAATATGG
AGTAAAAAGGATTTCAATGGGCGTTCAAACATTCAAGCCGGAGTTATTGTCTGTTTTAGGTAGAACGCACAATACTGAAG
ATATTTACACTTCGGTGTTAAATGCTAAAAACGCAGGTATTAAATCAATCAGTTTAGATTTAATGTATCATTTACCGAAA
CAGACGATTGAAGATTTTGAACAAAGTTTAGATCTAGCTTTAGATATGGATATTCAACATATTTCGAGTTACGGCTTAAT
ACTTGAACCTAAAACCCAATTTTATAATATGTATAGAAAAGGCTTGCTCAAACTTCCTAATGAGGATTTAGGTGCTGACA
TGTATCAGTTGCTGATGTCTAAGATAGAACAATCTCCTTTCCATCAATACGAAATATCTAATTTTGCATTAGATGGCCAT
GAATCAGAACATAATAAGGTTTACTGGTTTAATGAGGAATATTATGGATTTGGAGCAGGTGCAAGTGGTTATGTAGATGG
TGTGCGTTATACGAATATCAATCCAGTGAATCATTATATCAAAGCTATAAATAAAGAAAGTAAAGCAATTTTAGTATCAA
ATAAACCTTCTTTGACTGAGAGAATGGAAGAAGAAATGTTTCTTGGGTTGCGTTTAAATGAAGGTGTGAGTAGTAGTAGG
TTCAAAAAGAAGTTTGACCAATCTATTGAAAGTGTCTTTGGTCAAACAATAAATAATTTAAAAGAGAAGGAATTAATTGT
AGAAAAGAACGATGTGATTGCACTTACAAATAGAGGGAAAGTCATAGGTAATGAGGTTTTTGAAGCTTTCCTAATAAATG
ATTAA

Upstream 100 bases:

>100_bases
AATCATTGATTAAACGTTAAAGTTAAAAGTAAGAATAATTGCAGATAGTCCAACAGGATATAGCCGATTGGATAAAAAGT
CTGAGAAGCGGGGCATTAAA

Downstream 100 bases:

>100_bases
AAAAAATTGAAATTTCGAGTCTTTAACATTGACTTACTTTGACCAATTTGATAAATTATAATTAGCACTTGAGATAAGTG
AGTGCTAATGAGGTGAAAAC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRILKTMYVGGGTPTALSINQLERLLKAIRDTF
TITGEYTFEANPDELTKEKVQLLEKYGVKRISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPK
QTIEDFEQSLDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQYEISNFALDGH
ESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTERMEEEMFLGLRLNEGVSSSR
FKKKFDQSIESVFGQTINNLKEKELIVEKNDVIALTNRGKVIGNEVFEAFLIND

Sequences:

>Translated_374_residues
MTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRILKTMYVGGGTPTALSINQLERLLKAIRDTF
TITGEYTFEANPDELTKEKVQLLEKYGVKRISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPK
QTIEDFEQSLDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQYEISNFALDGH
ESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTERMEEEMFLGLRLNEGVSSSR
FKKKFDQSIESVFGQTINNLKEKELIVEKNDVIALTNRGKVIGNEVFEAFLIND
>Mature_373_residues
TVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRILKTMYVGGGTPTALSINQLERLLKAIRDTFT
ITGEYTFEANPDELTKEKVQLLEKYGVKRISMGVQTFKPELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQ
TIEDFEQSLDLALDMDIQHISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQYEISNFALDGHE
SEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTERMEEEMFLGLRLNEGVSSSRF
KKKFDQSIESVFGQTINNLKEKELIVEKNDVIALTNRGKVIGNEVFEAFLIND

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=263, Percent_Identity=33.4600760456274, Blast_Score=164, Evalue=2e-40,
Organism=Escherichia coli, GI1789325, Length=381, Percent_Identity=31.758530183727, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI87082341, Length=388, Percent_Identity=25.2577319587629, Blast_Score=121, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42867; Mature: 42736

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRILKTMYVGGGT
CCCCCEEEEHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCC
PTALSINQLERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVKRISMGVQTFKP
CCEEEHHHHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQTIEDFEQSLDLALDMDIQH
HHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHCCHHHHHHHHHHHCCEECCCHHH
ISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQYEISNFALDGH
HHCCCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCEEECCC
ESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTE
CCCCCEEEEECCCEEECCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCEEEEECCCHHHH
RMEEEMFLGLRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEKNDVIALTNRGK
HHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCC
VIGNEVFEAFLIND
CHHHHHHHHHHCCC
>Mature Secondary Structure 
TVQSAYIHIPFCVRICTYCDFNKYFIQNQPVDEYLDALITEMSTAKYRILKTMYVGGGT
CCCCEEEEHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCC
PTALSINQLERLLKAIRDTFTITGEYTFEANPDELTKEKVQLLEKYGVKRISMGVQTFKP
CCEEEHHHHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ELLSVLGRTHNTEDIYTSVLNAKNAGIKSISLDLMYHLPKQTIEDFEQSLDLALDMDIQH
HHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEHHHHHHCCHHHHHHHHHHHCCEECCCHHH
ISSYGLILEPKTQFYNMYRKGLLKLPNEDLGADMYQLLMSKIEQSPFHQYEISNFALDGH
HHCCCEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCEEECCC
ESEHNKVYWFNEEYYGFGAGASGYVDGVRYTNINPVNHYIKAINKESKAILVSNKPSLTE
CCCCCEEEEECCCEEECCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCEEEEECCCHHHH
RMEEEMFLGLRLNEGVSSSRFKKKFDQSIESVFGQTINNLKEKELIVEKNDVIALTNRGK
HHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCEEEEECCCC
VIGNEVFEAFLIND
CHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]