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The map label for this gene is moeA [C]

Identifier: 150401882

GI number: 150401882

Start: 1520205

End: 1521425

Strand: Direct

Name: moeA [C]

Synonym: Maeo_1460

Alternate gene names: 150401882

Gene position: 1520205-1521425 (Clockwise)

Preceding gene: 150401881

Following gene: 150401883

Centisome position: 96.86

GC content: 30.06

Gene sequence:

>1221_bases
ATGGAACTATTAAAAAACCTAATAAGCTACCATGATGCTAAAAATATTGTATTTAATAATCTCGATAAATTAATAAATTC
AAAATACAAAACAATCAGCGTTTTAAATTCATTAAATAAAATATCTTTTGAAGATATTAAAGCTCCAACAGATTTGCCCA
TGTTCAATAAGTCTGCAATGGACGGATATGCAATAATAGCAGAGGATACATTTGGAGCTTCGGAAAATAATCCTATTATT
TTAAATTTGGTGGAAGGAGACGAAATAAGCTCGGAAGAGTGTATAAAGGTATGCACTGGAATGCCCATTCCAAAAGGTGC
TAATGCCGTGGTAATGAAAGAATATTGTAATGAAGAAGATAATTTTTTAGAGGTAAGGTGGAGCTCCTATCCAAATGAAA
ATATTTCAAGAATTGGAGAGGATATAAAAAAAGGAGAAACAATATTAAAAAAAGGAGAAACAATCAACCCATATCACATT
GCTTTATTGCTGTCATTGGGCATAAAAGATATAAAAGTAATGGATTTAAAAATTGGTTTGATATCTACGGGGGATGAATT
AATAGATATTGAGGATTTAAAAGATATACAACAATTAAAAAATCAACACAAAATAGTAAATTCAAATACTCCTATGCTAT
CTGCACTAATTAATGAAACTGGATTAACACCAAATATTTACAAATTGGTAAAAGATAATGAGGAAGAAATAAAAAATATA
TTATTAAATGCACTAAATGAAAATGACATAATATTTACTACGGGAGGAACTTCTGTTGGAGATAGGGATTACACAATAAA
AGTAATTAATGATTTGTGTAGTATGGAGCTCCACGGAGTGCAGATTAGACCAGGAAAACCATTTGGATTTGCAAAATATA
AAACCAACGAAGGAGAGGAAAAGCTAATATTTATATTATCGGGCTATCCCGTTGCTGGTGCCGTGCAATTTGAATTATTT
TTTAGAAATTATTTTAAACCACGAAAATATTTATATTTGCCATTAAATAGAAATATAGCTTCTACACTTGGTAGAACTGA
CATATTAAGGTTAAAATTCGTAGAAACAAACAATAACAACAAAAAATCAGCCGTAGAACCACTTAAAATAACAGGTAGCG
GGGTGCTGTCTTCAATAGCAAAGGCAGATTGCTATACAATTATAGGGGAAAATATTGAAGGCTATGAAAAAGGGGAAGTT
ATTAAAGTATATATATTATAA

Upstream 100 bases:

>100_bases
AATTCATAATTCATATTTATTATTTTATTTAATGAAATTTCTCTATTTTTTTACTATTGGACGCATAATTATCTATTTAT
TTTAACTATTCGGTGTTAAT

Downstream 100 bases:

>100_bases
ATTATAACGGTCATATTATAAAAATAAATAGATATATTGAGTATATATAAATAAATATTAATAATTTTTTCTCAATCGAT
ATTATTGTGATATAATGATT

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MELLKNLISYHDAKNIVFNNLDKLINSKYKTISVLNSLNKISFEDIKAPTDLPMFNKSAMDGYAIIAEDTFGASENNPII
LNLVEGDEISSEECIKVCTGMPIPKGANAVVMKEYCNEEDNFLEVRWSSYPNENISRIGEDIKKGETILKKGETINPYHI
ALLLSLGIKDIKVMDLKIGLISTGDELIDIEDLKDIQQLKNQHKIVNSNTPMLSALINETGLTPNIYKLVKDNEEEIKNI
LLNALNENDIIFTTGGTSVGDRDYTIKVINDLCSMELHGVQIRPGKPFGFAKYKTNEGEEKLIFILSGYPVAGAVQFELF
FRNYFKPRKYLYLPLNRNIASTLGRTDILRLKFVETNNNNKKSAVEPLKITGSGVLSSIAKADCYTIIGENIEGYEKGEV
IKVYIL

Sequences:

>Translated_406_residues
MELLKNLISYHDAKNIVFNNLDKLINSKYKTISVLNSLNKISFEDIKAPTDLPMFNKSAMDGYAIIAEDTFGASENNPII
LNLVEGDEISSEECIKVCTGMPIPKGANAVVMKEYCNEEDNFLEVRWSSYPNENISRIGEDIKKGETILKKGETINPYHI
ALLLSLGIKDIKVMDLKIGLISTGDELIDIEDLKDIQQLKNQHKIVNSNTPMLSALINETGLTPNIYKLVKDNEEEIKNI
LLNALNENDIIFTTGGTSVGDRDYTIKVINDLCSMELHGVQIRPGKPFGFAKYKTNEGEEKLIFILSGYPVAGAVQFELF
FRNYFKPRKYLYLPLNRNIASTLGRTDILRLKFVETNNNNKKSAVEPLKITGSGVLSSIAKADCYTIIGENIEGYEKGEV
IKVYIL
>Mature_406_residues
MELLKNLISYHDAKNIVFNNLDKLINSKYKTISVLNSLNKISFEDIKAPTDLPMFNKSAMDGYAIIAEDTFGASENNPII
LNLVEGDEISSEECIKVCTGMPIPKGANAVVMKEYCNEEDNFLEVRWSSYPNENISRIGEDIKKGETILKKGETINPYHI
ALLLSLGIKDIKVMDLKIGLISTGDELIDIEDLKDIQQLKNQHKIVNSNTPMLSALINETGLTPNIYKLVKDNEEEIKNI
LLNALNENDIIFTTGGTSVGDRDYTIKVINDLCSMELHGVQIRPGKPFGFAKYKTNEGEEKLIFILSGYPVAGAVQFELF
FRNYFKPRKYLYLPLNRNIASTLGRTDILRLKFVETNNNNKKSAVEPLKITGSGVLSSIAKADCYTIIGENIEGYEKGEV
IKVYIL

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=301, Percent_Identity=33.8870431893688, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI10880983, Length=301, Percent_Identity=33.8870431893688, Blast_Score=138, Evalue=7e-33,
Organism=Escherichia coli, GI1787049, Length=410, Percent_Identity=26.5853658536585, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25147659, Length=339, Percent_Identity=28.6135693215339, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17562606, Length=252, Percent_Identity=26.5873015873016, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136978, Length=331, Percent_Identity=28.7009063444109, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24638841, Length=331, Percent_Identity=28.7009063444109, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45493; Mature: 45493

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLKNLISYHDAKNIVFNNLDKLINSKYKTISVLNSLNKISFEDIKAPTDLPMFNKSAM
CHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCC
DGYAIIAEDTFGASENNPIILNLVEGDEISSEECIKVCTGMPIPKGANAVVMKEYCNEED
CCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCEEEEHHHCCCCC
NFLEVRWSSYPNENISRIGEDIKKGETILKKGETINPYHIALLLSLGIKDIKVMDLKIGL
CEEEEEECCCCCHHHHHHHHHHHHCHHHHHCCCCCCHHHEEHHHHCCCCCEEEEEEEEEE
ISTGDELIDIEDLKDIQQLKNQHKIVNSNTPMLSALINETGLTPNIYKLVKDNEEEIKNI
EECCCCEEEHHHHHHHHHHHHHCEEECCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHH
LLNALNENDIIFTTGGTSVGDRDYTIKVINDLCSMELHGVQIRPGKPFGFAKYKTNEGEE
HHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCEECCEEECCCCCCCEEEEECCCCCC
KLIFILSGYPVAGAVQFELFFRNYFKPRKYLYLPLNRNIASTLGRTDILRLKFVETNNNN
EEEEEEECCCCCCEEEEEEHHHHHCCCCEEEEEECCCCHHHHCCCCEEEEEEEEEECCCC
KKSAVEPLKITGSGVLSSIAKADCYTIIGENIEGYEKGEVIKVYIL
CCCCCCCEEEECCHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MELLKNLISYHDAKNIVFNNLDKLINSKYKTISVLNSLNKISFEDIKAPTDLPMFNKSAM
CHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCC
DGYAIIAEDTFGASENNPIILNLVEGDEISSEECIKVCTGMPIPKGANAVVMKEYCNEED
CCEEEEEECCCCCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCEEEEHHHCCCCC
NFLEVRWSSYPNENISRIGEDIKKGETILKKGETINPYHIALLLSLGIKDIKVMDLKIGL
CEEEEEECCCCCHHHHHHHHHHHHCHHHHHCCCCCCHHHEEHHHHCCCCCEEEEEEEEEE
ISTGDELIDIEDLKDIQQLKNQHKIVNSNTPMLSALINETGLTPNIYKLVKDNEEEIKNI
EECCCCEEEHHHHHHHHHHHHHCEEECCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHH
LLNALNENDIIFTTGGTSVGDRDYTIKVINDLCSMELHGVQIRPGKPFGFAKYKTNEGEE
HHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCEECCEEECCCCCCCEEEEECCCCCC
KLIFILSGYPVAGAVQFELFFRNYFKPRKYLYLPLNRNIASTLGRTDILRLKFVETNNNN
EEEEEEECCCCCCEEEEEEHHHHHCCCCEEEEEECCCCHHHHCCCCEEEEEEEEEECCCC
KKSAVEPLKITGSGVLSSIAKADCYTIIGENIEGYEKGEVIKVYIL
CCCCCCCEEEECCHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]