Click here to switch to the map view.

The map label for this gene is rtcA [H]

Identifier: 150401880

GI number: 150401880

Start: 1516675

End: 1517694

Strand: Direct

Name: rtcA [H]

Synonym: Maeo_1458

Alternate gene names: 150401880

Gene position: 1516675-1517694 (Clockwise)

Preceding gene: 150401879

Following gene: 150401881

Centisome position: 96.63

GC content: 30.29

Gene sequence:

>1020_bases
ATGGAAATAATAACAATAGATGGGAGTTATGGCGAAGGAGGAGGTCAAATTATTAGAACCGCTGTTTCATTGAGTGCCAT
TACTCAAAAGCCCATAAAAATAATAAATATACGAAAAAATAGAAAAAATAAAGGGCTATCTCACCAGCATATAGCCTGTG
TAAATGCCATTAAAAAACTGTGTAATGCAAAGGTAGAAGGACTTTTTAAAGGTTCTGAAACGATGGAATTTTATCCGAAT
AAACTGTCTCCAAAAGATTTTACTATGGATATTGGAACTGCTGGAAGTATTTCTCTGGTTATTCAGTCAATTCTACCGGT
TGGGTTATTTATTGATAAAGATGTTACAATTAACATTAAAGGGGGAACTAATGTAAAAAATTCTCCCACTATTGATTATA
TTAAATATATTACTATGGATATTTTAAATAAAATGGGGTATGATGGACAGGTTGAAATAATTAAAAGGGGATTTTATCCA
GAAGGTGGCGGAGAGGTTAAATTACATATAAAACATTCCAAATTAAATAAAATTATTGATTTGGTGGAATTAAATAAGAA
TAATAATGTAGTTGAAGGAATAATATTTAATCAAAATTTAGATGCTCAAATTTCTAAAAGAATTCGGAGCTCCGCAACAA
ACCTAATTATGAAGCATGGATTTATACCAAATATAAAAATAGAAAATATAAAAGGGAGCTCCTCGGGAGTTGGAATATTT
TTAAAATATGGTAGTTTAGGGAGCTCCATGCTTGGAGAAAAAGGATTAAGGGCTGAAATTGTTGGGGCCAGTGCAGTCGA
AAATCTTTTAAAAGAAATAAACTCAGGAATGGCACTTGATAAATATATGGGAGACCAAATAATCCCATTTTTACCATTTT
ATGGTGGTTCTGTTGGAGTTTCTAAAATTACCGACCATACCTTATCCAACATATTCGTAGTCGAAAAATTGTTAAATGTT
AAATTTAATGTTGAAAAATATAAAAATAATAATTGCAATGGTTTTTTAATAACATGTTAA

Upstream 100 bases:

>100_bases
CCATTTTTTATAGCTAAAATTAGAAAAATACAATAAATTAAACATGAATAATATTATTATATAATATTTATATGATATTA
ATAATAATATGGGGAAAATA

Downstream 100 bases:

>100_bases
AATAGGGAGCTCCGCGGAGCTCCCATTTATATAAATTTTAGTTTTATATGTTTATCATAGAATTGCATATTAATTTATAA
AAACATTAAAAACATTTAAT

Product: RNA 3'-terminal-phosphate cyclase

Products: NA

Alternate protein names: RNA cyclase; RNA-3'-phosphate cyclase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MEIITIDGSYGEGGGQIIRTAVSLSAITQKPIKIINIRKNRKNKGLSHQHIACVNAIKKLCNAKVEGLFKGSETMEFYPN
KLSPKDFTMDIGTAGSISLVIQSILPVGLFIDKDVTINIKGGTNVKNSPTIDYIKYITMDILNKMGYDGQVEIIKRGFYP
EGGGEVKLHIKHSKLNKIIDLVELNKNNNVVEGIIFNQNLDAQISKRIRSSATNLIMKHGFIPNIKIENIKGSSSGVGIF
LKYGSLGSSMLGEKGLRAEIVGASAVENLLKEINSGMALDKYMGDQIIPFLPFYGGSVGVSKITDHTLSNIFVVEKLLNV
KFNVEKYKNNNCNGFLITC

Sequences:

>Translated_339_residues
MEIITIDGSYGEGGGQIIRTAVSLSAITQKPIKIINIRKNRKNKGLSHQHIACVNAIKKLCNAKVEGLFKGSETMEFYPN
KLSPKDFTMDIGTAGSISLVIQSILPVGLFIDKDVTINIKGGTNVKNSPTIDYIKYITMDILNKMGYDGQVEIIKRGFYP
EGGGEVKLHIKHSKLNKIIDLVELNKNNNVVEGIIFNQNLDAQISKRIRSSATNLIMKHGFIPNIKIENIKGSSSGVGIF
LKYGSLGSSMLGEKGLRAEIVGASAVENLLKEINSGMALDKYMGDQIIPFLPFYGGSVGVSKITDHTLSNIFVVEKLLNV
KFNVEKYKNNNCNGFLITC
>Mature_339_residues
MEIITIDGSYGEGGGQIIRTAVSLSAITQKPIKIINIRKNRKNKGLSHQHIACVNAIKKLCNAKVEGLFKGSETMEFYPN
KLSPKDFTMDIGTAGSISLVIQSILPVGLFIDKDVTINIKGGTNVKNSPTIDYIKYITMDILNKMGYDGQVEIIKRGFYP
EGGGEVKLHIKHSKLNKIIDLVELNKNNNVVEGIIFNQNLDAQISKRIRSSATNLIMKHGFIPNIKIENIKGSSSGVGIF
LKYGSLGSSMLGEKGLRAEIVGASAVENLLKEINSGMALDKYMGDQIIPFLPFYGGSVGVSKITDHTLSNIFVVEKLLNV
KFNVEKYKNNNCNGFLITC

Specific function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A;

COG id: COG0430

COG function: function code A; RNA 3'-terminal phosphate cyclase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4506589, Length=340, Percent_Identity=30.5882352941176, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI195927044, Length=353, Percent_Identity=29.7450424929178, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI157426877, Length=342, Percent_Identity=25.4385964912281, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI48994937, Length=327, Percent_Identity=32.1100917431193, Blast_Score=181, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI32564710, Length=346, Percent_Identity=23.9884393063584, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324564, Length=328, Percent_Identity=23.780487804878, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI18543269, Length=336, Percent_Identity=32.4404761904762, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI18860065, Length=241, Percent_Identity=24.0663900414938, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000228
- InterPro:   IPR020719
- InterPro:   IPR013796
- InterPro:   IPR020723
- InterPro:   IPR017770
- InterPro:   IPR013792 [H]

Pfam domain/function: PF01137 RTC; PF05189 RTC_insert [H]

EC number: =6.5.1.4 [H]

Molecular weight: Translated: 37130; Mature: 37130

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS01287 RTC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIITIDGSYGEGGGQIIRTAVSLSAITQKPIKIINIRKNRKNKGLSHQHIACVNAIKKL
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
CNAKVEGLFKGSETMEFYPNKLSPKDFTMDIGTAGSISLVIQSILPVGLFIDKDVTINIK
HCCHHHEEECCCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEECCCEEEEEC
GGTNVKNSPTIDYIKYITMDILNKMGYDGQVEIIKRGFYPEGGGEVKLHIKHSKLNKIID
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEHHHHHHHHH
LVELNKNNNVVEGIIFNQNLDAQISKRIRSSATNLIMKHGFIPNIKIENIKGSSSGVGIF
HEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEE
LKYGSLGSSMLGEKGLRAEIVGASAVENLLKEINSGMALDKYMGDQIIPFLPFYGGSVGV
EEECCCCCHHHCCCCCEEEEECHHHHHHHHHHHHCCCEEHHHCCCCCCEECCCCCCCCCH
SKITDHTLSNIFVVEKLLNVKFNVEKYKNNNCNGFLITC
HHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEC
>Mature Secondary Structure
MEIITIDGSYGEGGGQIIRTAVSLSAITQKPIKIINIRKNRKNKGLSHQHIACVNAIKKL
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHH
CNAKVEGLFKGSETMEFYPNKLSPKDFTMDIGTAGSISLVIQSILPVGLFIDKDVTINIK
HCCHHHEEECCCCCEEECCCCCCCCCEEEECCCCCHHHHHHHHHHCCCEEECCCEEEEEC
GGTNVKNSPTIDYIKYITMDILNKMGYDGQVEIIKRGFYPEGGGEVKLHIKHSKLNKIID
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEHHHHHHHHH
LVELNKNNNVVEGIIFNQNLDAQISKRIRSSATNLIMKHGFIPNIKIENIKGSSSGVGIF
HEEECCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEE
LKYGSLGSSMLGEKGLRAEIVGASAVENLLKEINSGMALDKYMGDQIIPFLPFYGGSVGV
EEECCCCCHHHCCCCCEEEEECHHHHHHHHHHHHCCCEEHHHCCCCCCEECCCCCCCCCH
SKITDHTLSNIFVVEKLLNVKFNVEKYKNNNCNGFLITC
HHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]