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The map label for this gene is purC [H]

Identifier: 150401867

GI number: 150401867

Start: 1502027

End: 1502755

Strand: Reverse

Name: purC [H]

Synonym: Maeo_1445

Alternate gene names: 150401867

Gene position: 1502755-1502027 (Counterclockwise)

Preceding gene: 150401872

Following gene: 150401866

Centisome position: 95.75

GC content: 30.73

Gene sequence:

>729_bases
ATGGATATAAATGTAAAAGAGATAATGAAAAATGAACCATTATACAGTGGAAAGGCAAAATCGATATATAAAATAGATGA
TGAAAAAGTATTAATTGATTTTAGAGATGATATAACTGCTGGAAATGGAGAAATGCACGATGTAAAGTCTGGAAAAGGAT
ATTTAAATGCCTTGATATCCTCGAAATTATTTGAAGTGTTGGAACAACAAGGAGCTCCCACTCACTTTATAGAATACATA
AAACCAAACCAGATGATAGCAAAAAATGTTGAAATAATCCCGATAGAAGTAATAGTTAGGAATATTGCAACAGGTAGTTT
GTGCAGAAGATTCCCGTTCGAAGATGGAACAGTATTAGAAAATCCAATAGTTCAGTTTGATTATAAAAACGATGATTATG
GAGACCCAATGTTAAATGACGACATAGCCCTTGCTTTAAAAATTGCTACAAAGGAAGAATTAAAACAATTAAAACAATTG
GGTTTAAAAGTAAATGAAATATTATATAAATACTTTGATGAAATAGGAATTACCCTCGTAGATTTTAAAATTGAAATCGG
GAAAACAACAGACGGAAAATTAGTAATTGCCGACGAAGTTAGCCCAGATACCATGAGATTATGGGATAAAGAAACAAAAG
AAGCTATGGACAAAGATGTTTATAGAAAAAGTATGGGAGATGTTGTTGGAAAATACGAAATAGTTGCTAAAAAAATGGGA
TGTTTATAA

Upstream 100 bases:

>100_bases
AACCAAAATATAATAATATAATATTATAAATAATTATTAAATATTATTTAAAATATTATCTAATATATAAAAATAAATAA
AATAAATATAAGGTGACAGT

Downstream 100 bases:

>100_bases
TCCCAAACGATGTATTTTGCAGGGAGCTCCCTGCGCAATTTAAATCATATTATTTTAAAATTTTTTTATTATCGACTTAT
TTTTATTTTAAAAATAGGCC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MDINVKEIMKNEPLYSGKAKSIYKIDDEKVLIDFRDDITAGNGEMHDVKSGKGYLNALISSKLFEVLEQQGAPTHFIEYI
KPNQMIAKNVEIIPIEVIVRNIATGSLCRRFPFEDGTVLENPIVQFDYKNDDYGDPMLNDDIALALKIATKEELKQLKQL
GLKVNEILYKYFDEIGITLVDFKIEIGKTTDGKLVIADEVSPDTMRLWDKETKEAMDKDVYRKSMGDVVGKYEIVAKKMG
CL

Sequences:

>Translated_242_residues
MDINVKEIMKNEPLYSGKAKSIYKIDDEKVLIDFRDDITAGNGEMHDVKSGKGYLNALISSKLFEVLEQQGAPTHFIEYI
KPNQMIAKNVEIIPIEVIVRNIATGSLCRRFPFEDGTVLENPIVQFDYKNDDYGDPMLNDDIALALKIATKEELKQLKQL
GLKVNEILYKYFDEIGITLVDFKIEIGKTTDGKLVIADEVSPDTMRLWDKETKEAMDKDVYRKSMGDVVGKYEIVAKKMG
CL
>Mature_242_residues
MDINVKEIMKNEPLYSGKAKSIYKIDDEKVLIDFRDDITAGNGEMHDVKSGKGYLNALISSKLFEVLEQQGAPTHFIEYI
KPNQMIAKNVEIIPIEVIVRNIATGSLCRRFPFEDGTVLENPIVQFDYKNDDYGDPMLNDDIALALKIATKEELKQLKQL
GLKVNEILYKYFDEIGITLVDFKIEIGKTTDGKLVIADEVSPDTMRLWDKETKEAMDKDVYRKSMGDVVGKYEIVAKKMG
CL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=220, Percent_Identity=33.6363636363636, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI5453539, Length=220, Percent_Identity=33.6363636363636, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI119220559, Length=227, Percent_Identity=32.15859030837, Blast_Score=100, Evalue=8e-22,
Organism=Escherichia coli, GI1788820, Length=234, Percent_Identity=38.4615384615385, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17531275, Length=222, Percent_Identity=32.8828828828829, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18860083, Length=217, Percent_Identity=29.9539170506912, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24583917, Length=218, Percent_Identity=29.3577981651376, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27482; Mature: 27482

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDINVKEIMKNEPLYSGKAKSIYKIDDEKVLIDFRDDITAGNGEMHDVKSGKGYLNALIS
CCCCHHHHHCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
SKLFEVLEQQGAPTHFIEYIKPNQMIAKNVEIIPIEVIVRNIATGSLCRRFPFEDGTVLE
HHHHHHHHHCCCCHHHHHHCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEC
NPIVQFDYKNDDYGDPMLNDDIALALKIATKEELKQLKQLGLKVNEILYKYFDEIGITLV
CCEEEEECCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHCCEEE
DFKIEIGKTTDGKLVIADEVSPDTMRLWDKETKEAMDKDVYRKSMGDVVGKYEIVAKKMG
EEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
CL
CC
>Mature Secondary Structure
MDINVKEIMKNEPLYSGKAKSIYKIDDEKVLIDFRDDITAGNGEMHDVKSGKGYLNALIS
CCCCHHHHHCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHH
SKLFEVLEQQGAPTHFIEYIKPNQMIAKNVEIIPIEVIVRNIATGSLCRRFPFEDGTVLE
HHHHHHHHHCCCCHHHHHHCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCEEC
NPIVQFDYKNDDYGDPMLNDDIALALKIATKEELKQLKQLGLKVNEILYKYFDEIGITLV
CCEEEEECCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHCCEEE
DFKIEIGKTTDGKLVIADEVSPDTMRLWDKETKEAMDKDVYRKSMGDVVGKYEIVAKKMG
EEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
CL
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]