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The map label for this gene is bioF [C]

Identifier: 150401841

GI number: 150401841

Start: 1473990

End: 1475135

Strand: Reverse

Name: bioF [C]

Synonym: Maeo_1419

Alternate gene names: 150401841

Gene position: 1475135-1473990 (Counterclockwise)

Preceding gene: 150401842

Following gene: 150401840

Centisome position: 93.99

GC content: 30.02

Gene sequence:

>1146_bases
ATGCTAAAATCACAGCTTCAACAACAATTAAAAAAATTAAAAGATAATAATTTATACAGATTTTTAAGAAAAAATAATTC
ATACAATAACAAAAATTATTTAGATTTTTCTTCAAATGATTATTTATGTTTATCAACCAATAAGGAAATAATAGATGCCA
TAAAAGAGGGAGGATTAAAATATGGTTTTGGTTCAACGGGTTCAAGATTAACGGCGGGAGATATAAACCATCAATTATTA
GAGCATAAGATAGCTGAATTTAAAGGAACAGAAAGAAGTTTAATTTATTCTTCAGGTTATGCCACAAATGTTGGGGTAAT
TAGTGCATTATGTAAAAAGGGAGATTTGATTTTAAGCGATAAATTAAATCATGCCTCCATAATAGACGGGTGCAAATTAA
GTAAATCAGCCGTTTTAATTTATAACCACTGCGATATGGATAATTTAATTGATTTAATTGAAAAGAATAGGAGCTCCTAC
AATAATTTATTCATCATCACAGATGGAGTATTTTCCATGGATGGAGATATTGCTCCACTGGATAAATTAAAAAAGATTGC
CGATGAATACAATGGGATATTGATAATAGACGACGCTCACGGCACTGGGGTTTTAGGAAATGGAAAAGGCTCGTTAAAAC
ATTTTAATTTAAAACCATCAGATAATATAATCCAAATAGGAACGATGTCAAAGGCTGTTGGTGGATTGGGGGGTTTTGTG
TGTGGTATTGAGGAAGTGATTGAATACCTTATAAATACTTCCAGAAGTTTTATATATTCTACTTCCCTTCCGCCGTCTGT
TGTTAGTGGATGTATTAAAAGTTTTGAGCTCATAGAAGAAGGAGCTCCAACAAAAAAATTGCAAAAAAATATAGGGCTTG
CAAATAAAATTTTTAAAGAACATAATTTAATAGAGGAAAATAATTTAACGCCTATTTATCCGTTCATTTTTAAAGAAAAA
ACTATGGATATTGCAGAACAATTAATAAAAAATAATATCTTCTGTGTAGGAATTAGATATCCAACAGTTCCAAAAGGTAT
GGAGAGGTTAAGAGTTAGTATAACCGTTGGACATAGTGAGGAGGATTTTAGGGTTTTGTGTGAAAGAATAAATTTAATTA
TTAAAAAGAAATTCAAAGGCATATAA

Upstream 100 bases:

>100_bases
TTTTTTGTTAAAAATGATACAAATATTGAGGATTTAATTTATAAATTGGAAAATAAACCATATATTATTAAATAATTAAA
AGCGGACATAGGGAAAAATC

Downstream 100 bases:

>100_bases
TAATAAATAATATTTATAAATTCTTATTTTATTTTTTTCGATATATATGTACTTTCAAAGCATATATCACTTTAAAAATA
GTATAAAATAAAAAACTATT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MLKSQLQQQLKKLKDNNLYRFLRKNNSYNNKNYLDFSSNDYLCLSTNKEIIDAIKEGGLKYGFGSTGSRLTAGDINHQLL
EHKIAEFKGTERSLIYSSGYATNVGVISALCKKGDLILSDKLNHASIIDGCKLSKSAVLIYNHCDMDNLIDLIEKNRSSY
NNLFIITDGVFSMDGDIAPLDKLKKIADEYNGILIIDDAHGTGVLGNGKGSLKHFNLKPSDNIIQIGTMSKAVGGLGGFV
CGIEEVIEYLINTSRSFIYSTSLPPSVVSGCIKSFELIEEGAPTKKLQKNIGLANKIFKEHNLIEENNLTPIYPFIFKEK
TMDIAEQLIKNNIFCVGIRYPTVPKGMERLRVSITVGHSEEDFRVLCERINLIIKKKFKGI

Sequences:

>Translated_381_residues
MLKSQLQQQLKKLKDNNLYRFLRKNNSYNNKNYLDFSSNDYLCLSTNKEIIDAIKEGGLKYGFGSTGSRLTAGDINHQLL
EHKIAEFKGTERSLIYSSGYATNVGVISALCKKGDLILSDKLNHASIIDGCKLSKSAVLIYNHCDMDNLIDLIEKNRSSY
NNLFIITDGVFSMDGDIAPLDKLKKIADEYNGILIIDDAHGTGVLGNGKGSLKHFNLKPSDNIIQIGTMSKAVGGLGGFV
CGIEEVIEYLINTSRSFIYSTSLPPSVVSGCIKSFELIEEGAPTKKLQKNIGLANKIFKEHNLIEENNLTPIYPFIFKEK
TMDIAEQLIKNNIFCVGIRYPTVPKGMERLRVSITVGHSEEDFRVLCERINLIIKKKFKGI
>Mature_381_residues
MLKSQLQQQLKKLKDNNLYRFLRKNNSYNNKNYLDFSSNDYLCLSTNKEIIDAIKEGGLKYGFGSTGSRLTAGDINHQLL
EHKIAEFKGTERSLIYSSGYATNVGVISALCKKGDLILSDKLNHASIIDGCKLSKSAVLIYNHCDMDNLIDLIEKNRSSY
NNLFIITDGVFSMDGDIAPLDKLKKIADEYNGILIIDDAHGTGVLGNGKGSLKHFNLKPSDNIIQIGTMSKAVGGLGGFV
CGIEEVIEYLINTSRSFIYSTSLPPSVVSGCIKSFELIEEGAPTKKLQKNIGLANKIFKEHNLIEENNLTPIYPFIFKEK
TMDIAEQLIKNNIFCVGIRYPTVPKGMERLRVSITVGHSEEDFRVLCERINLIIKKKFKGI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Homo sapiens, GI7657118, Length=340, Percent_Identity=35.2941176470588, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI284448556, Length=340, Percent_Identity=35.2941176470588, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI4758668, Length=350, Percent_Identity=31.7142857142857, Blast_Score=182, Evalue=6e-46,
Organism=Homo sapiens, GI119220554, Length=363, Percent_Identity=28.099173553719, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI83977442, Length=358, Percent_Identity=30.4469273743017, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI83977444, Length=358, Percent_Identity=30.4469273743017, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI83977440, Length=358, Percent_Identity=30.4469273743017, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4502025, Length=356, Percent_Identity=29.7752808988764, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI40316939, Length=356, Percent_Identity=29.7752808988764, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI5454084, Length=391, Percent_Identity=27.1099744245524, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=36.3112391930836, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1790046, Length=358, Percent_Identity=34.6368715083799, Blast_Score=206, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71994529, Length=356, Percent_Identity=36.5168539325843, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI32566772, Length=363, Percent_Identity=29.4765840220386, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17560914, Length=362, Percent_Identity=28.1767955801105, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560912, Length=362, Percent_Identity=28.1767955801105, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982617, Length=284, Percent_Identity=29.2253521126761, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71982625, Length=284, Percent_Identity=29.2253521126761, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320438, Length=358, Percent_Identity=31.8435754189944, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320267, Length=363, Percent_Identity=29.2011019283747, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=30.9701492537313, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24662918, Length=377, Percent_Identity=33.6870026525199, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI17137420, Length=386, Percent_Identity=29.7927461139896, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17136286, Length=365, Percent_Identity=27.3972602739726, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24653280, Length=267, Percent_Identity=29.2134831460674, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24653276, Length=267, Percent_Identity=29.2134831460674, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI24653278, Length=267, Percent_Identity=29.2134831460674, Blast_Score=124, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIKB_META3 (A6UWX3)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325607.1
- ProteinModelPortal:   A6UWX3
- STRING:   A6UWX3
- GeneID:   5326505
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_1419
- eggNOG:   arNOG04128
- HOGENOM:   HBG649839
- OMA:   NTSRSFI
- ProtClustDB:   CLSK876517
- BioCyc:   MAEO419665:MAEO_1419-MONOMER
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.29; =2.3.1.47

Molecular weight: Translated: 42478; Mature: 42478

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 20-20 BINDING 124-124 BINDING 172-172 BINDING 342-342

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSQLQQQLKKLKDNNLYRFLRKNNSYNNKNYLDFSSNDYLCLSTNKEIIDAIKEGGLK
CCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHCCEE
YGFGSTGSRLTAGDINHQLLEHKIAEFKGTERSLIYSSGYATNVGVISALCKKGDLILSD
ECCCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEC
KLNHASIIDGCKLSKSAVLIYNHCDMDNLIDLIEKNRSSYNNLFIITDGVFSMDGDIAPL
CCCCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCEECCCCCCCH
DKLKKIADEYNGILIIDDAHGTGVLGNGKGSLKHFNLKPSDNIIQIGTMSKAVGGLGGFV
HHHHHHHHHHCCEEEEECCCCCCEEECCCCCCEEECCCCCCCEEEEECHHHHHHHHHHHH
CGIEEVIEYLINTSRSFIYSTSLPPSVVSGCIKSFELIEEGAPTKKLQKNIGLANKIFKE
HHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHH
HNLIEENNLTPIYPFIFKEKTMDIAEQLIKNNIFCVGIRYPTVPKGMERLRVSITVGHSE
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHEEEEEEEECCCC
EDFRVLCERINLIIKKKFKGI
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLKSQLQQQLKKLKDNNLYRFLRKNNSYNNKNYLDFSSNDYLCLSTNKEIIDAIKEGGLK
CCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHCCEE
YGFGSTGSRLTAGDINHQLLEHKIAEFKGTERSLIYSSGYATNVGVISALCKKGDLILSD
ECCCCCCCEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEC
KLNHASIIDGCKLSKSAVLIYNHCDMDNLIDLIEKNRSSYNNLFIITDGVFSMDGDIAPL
CCCCHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCEECCCCCCCH
DKLKKIADEYNGILIIDDAHGTGVLGNGKGSLKHFNLKPSDNIIQIGTMSKAVGGLGGFV
HHHHHHHHHHCCEEEEECCCCCCEEECCCCCCEEECCCCCCCEEEEECHHHHHHHHHHHH
CGIEEVIEYLINTSRSFIYSTSLPPSVVSGCIKSFELIEEGAPTKKLQKNIGLANKIFKE
HHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHH
HNLIEENNLTPIYPFIFKEKTMDIAEQLIKNNIFCVGIRYPTVPKGMERLRVSITVGHSE
CCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHEEEEEEEECCCC
EDFRVLCERINLIIKKKFKGI
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA