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The map label for this gene is pcm

Identifier: 150401739

GI number: 150401739

Start: 1380070

End: 1380720

Strand: Reverse

Name: pcm

Synonym: Maeo_1317

Alternate gene names: 150401739

Gene position: 1380720-1380070 (Counterclockwise)

Preceding gene: 150401740

Following gene: 150401738

Centisome position: 87.97

GC content: 34.41

Gene sequence:

>651_bases
ATGACAATAAAAAAAATGGAAGCAATTGTTAAAGGATTAATAAACGCAGGATATTTAAAAAATAAAATGGTTTCAAAAGC
ACTTTTAACAGTTCCAAGGCATGAATTTATTCCTGCGGAGCTCCATGATTATGCATATGTTGACACACCATTAAATATCG
GGCATGGTCAAACAATTTCAGCAATTCATATGGTTGCCATAATATGTGATGCCCTTGATTTAAAAGAAGGCGATAAAGTT
CTTGAAATTGGAACGGGCTCTGGCTATCATGCCGCAGTCGTTGCTGAAATTGTCGGAAAAAATGGGCAGGTAATTACAAT
AGAAAGAATTCCAGAACTTGCCGAAAAAGCTGAAAGTACATTAAAAAAACTGGGATATACAAATGTTAAGGTAATTTGTG
GTAATGGAACTTTGGGGAGCTCCGAGTTTGCACCATATGATAAAATATATCTGACTGCATCGGGACCCGACATACCTAAC
TCATTAATTGAACAGTTGAAAAAAGGGGGAAAATTGGTGGCACCTGTTGGTCTATATATTCAAGATTTAATATTATTGGA
AAAAAAGAATGGAAATATAATTAAAAAAAATTTGGGTGCTGTTGCATTTGTTCCACTCATAGGTAAAAATGGATGGCATA
ATGAATATTAA

Upstream 100 bases:

>100_bases
ATCTTGCAATAGTAAAAGAAGATAAAAAGAAAATAGAAAGAAGAGATAGAAAATAATATTAATATATATAATATCTATAA
TCTAAAAGAGAGTATATATT

Downstream 100 bases:

>100_bases
TTTTCGATAATATTAAATATATAAAAAATATATTAAAAACATATTAAAAGTCATAATTAATAAGGTGTGTTTATATGCTG
TGTGTTAGGGGCTATTTATA

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTIKKMEAIVKGLINAGYLKNKMVSKALLTVPRHEFIPAELHDYAYVDTPLNIGHGQTISAIHMVAIICDALDLKEGDKV
LEIGTGSGYHAAVVAEIVGKNGQVITIERIPELAEKAESTLKKLGYTNVKVICGNGTLGSSEFAPYDKIYLTASGPDIPN
SLIEQLKKGGKLVAPVGLYIQDLILLEKKNGNIIKKNLGAVAFVPLIGKNGWHNEY

Sequences:

>Translated_216_residues
MTIKKMEAIVKGLINAGYLKNKMVSKALLTVPRHEFIPAELHDYAYVDTPLNIGHGQTISAIHMVAIICDALDLKEGDKV
LEIGTGSGYHAAVVAEIVGKNGQVITIERIPELAEKAESTLKKLGYTNVKVICGNGTLGSSEFAPYDKIYLTASGPDIPN
SLIEQLKKGGKLVAPVGLYIQDLILLEKKNGNIIKKNLGAVAFVPLIGKNGWHNEY
>Mature_215_residues
TIKKMEAIVKGLINAGYLKNKMVSKALLTVPRHEFIPAELHDYAYVDTPLNIGHGQTISAIHMVAIICDALDLKEGDKVL
EIGTGSGYHAAVVAEIVGKNGQVITIERIPELAEKAESTLKKLGYTNVKVICGNGTLGSSEFAPYDKIYLTASGPDIPNS
LIEQLKKGGKLVAPVGLYIQDLILLEKKNGNIIKKNLGAVAFVPLIGKNGWHNEY

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=212, Percent_Identity=35.377358490566, Blast_Score=114, Evalue=6e-26,
Organism=Escherichia coli, GI1789100, Length=207, Percent_Identity=39.1304347826087, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71983477, Length=210, Percent_Identity=34.7619047619048, Blast_Score=114, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193207222, Length=208, Percent_Identity=32.6923076923077, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI17981723, Length=217, Percent_Identity=31.7972350230415, Blast_Score=97, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_META3 (A6UWM1)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325505.1
- ProteinModelPortal:   A6UWM1
- SMR:   A6UWM1
- STRING:   A6UWM1
- GeneID:   5327324
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_1317
- eggNOG:   arNOG08853
- HOGENOM:   HBG699907
- OMA:   GYHAAVV
- ProtClustDB:   PRK13942
- BioCyc:   MAEO419665:MAEO_1317-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 23319; Mature: 23187

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKKMEAIVKGLINAGYLKNKMVSKALLTVPRHEFIPAELHDYAYVDTPLNIGHGQTIS
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHCCCEEECCCCCCCCCCHHH
AIHMVAIICDALDLKEGDKVLEIGTGSGYHAAVVAEIVGKNGQVITIERIPELAEKAEST
HHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
LKKLGYTNVKVICGNGTLGSSEFAPYDKIYLTASGPDIPNSLIEQLKKGGKLVAPVGLYI
HHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEHHHHHH
QDLILLEKKNGNIIKKNLGAVAFVPLIGKNGWHNEY
HHHHEEECCCCCEEEECCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure 
TIKKMEAIVKGLINAGYLKNKMVSKALLTVPRHEFIPAELHDYAYVDTPLNIGHGQTIS
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHCCCEEECCCCCCCCCCHHH
AIHMVAIICDALDLKEGDKVLEIGTGSGYHAAVVAEIVGKNGQVITIERIPELAEKAEST
HHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
LKKLGYTNVKVICGNGTLGSSEFAPYDKIYLTASGPDIPNSLIEQLKKGGKLVAPVGLYI
HHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEHHHHHH
QDLILLEKKNGNIIKKNLGAVAFVPLIGKNGWHNEY
HHHHEEECCCCCEEEECCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA