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The map label for this gene is rfcS [H]

Identifier: 150401734

GI number: 150401734

Start: 1371310

End: 1374132

Strand: Reverse

Name: rfcS [H]

Synonym: Maeo_1312

Alternate gene names: 150401734

Gene position: 1374132-1371310 (Counterclockwise)

Preceding gene: 150401735

Following gene: 150401733

Centisome position: 87.55

GC content: 30.75

Gene sequence:

>2823_bases
ATGGAAAAACCATGGGTTGAAAAATACCGTCCAAAAACATTGAATGAGATTACAGGACATGATGCCATTATAACCCGCCT
TAAAAATTATGTAGAAAAAGAATCCCTCCCACATATGCTATTCAGTGGTCCGCCGGGTTTAGGCAAAACGACATCTGCAT
TGTGCCTTGCAAAGGATTTATACGGCGATACTTGGAAAGATAATTTTTTGGAACTCAACAGTTCCGACGAAAGAGGTATT
GATGTGGTGAGAACAAAAGTAAAAAACTTTGCAAGAACAAAACCTATTGGAGATGCACCATTTAAAATAATATTTTTGGA
TGAAAGTGATGCCCTAACAAGTGATGCCCAAAATGCCCTTAGAAGAACTATGGAAAAATATTCGGATATATGTAGGTTTA
TATTGAGTTGTTTAACTGAAAATGCTAAAATATACACTGCTGACGAGAGAGAGCTAAAAATCAGTGATTATTTAAAACTA
TTCGAAGAAAGAAAAATTAAAACTGTTTTAAATAGAAATGGGGAAGACTTGGTTTTAGCAGGAGTTAAATACAACTCAGA
AATGGTCGGACATCCAGTATATAAAATCACTCTTGAAAGTGGTAGAACCATCGAAGCAACAGAAGACCATAAATTTTTAA
CAAATAACAGATGGATGAAAATATCTCAATTAAATGAAGGAGATGAGCTTCTAATATACCCTACACTTGAAGGGGTTGAA
TATAAGGAGGACAGTAGAAAAATAATAAATCTTAAAGATTTCTACAATTTCCTTGAAGAAATTGAATTGCAGGGCAACTA
TAAGAGATTAGGAGAAGCGGATGAATTTAGCCAATTAACCACAAAGGATAAAGAAGTAATATTAAATAGAGCTCTGGAAC
TTTATGCAAAATTACATGAAGGGCTAACCGATAGAGAATGTGAAATATTAAATTCAATTCCAGAGGAGGGTATAAGTAGG
GAGGAGCTCCAAAAAACAGTTGGTCTTTCAAGAGGTAGGTTAAATCAAATATTGCAGAACATTGAAAATAAAAAGTATAT
CAACAGGAACATAAATAAATCCAAAAAAACTCAATTCATAAAAAATACCTCTAAAAACTCACCAATAATCCTAAGAAATA
TAATGGATATTAAACGAATAATTGAAAGAGAGCATAATATAAAAATAAGCTATACTGCATTTAAAAAATTATTAAATCAT
GGAGTTAAAGGCTTTGCACAAAACCATATAAAAAATATCAAAGAAAGAAACTGGGACAGTATAACCTATGATAGCAAGAA
CGCAGGAATGTTTGCAAGATTAGTTGGTTTTATAATTGGAGATGGGCACTTAGCAAAAACTGAGGAAAAAAGAATTGTAA
TTACCTCAACTAATAATGAGTTGAAACAAATAATAAACGATTTAACAGAGCTCAATATCAAATGCTCAGGAATAATAGAA
AAAGAAATAACCAATAAAATAGGTGAAAGAACAGTTCAAGGCATTACCTCTTCAATATATATTGATAACAGAACACTTTA
TTTATTGTTAATGTATTGGGGTATTGAAATAGGCAATAAAACAAAAATTGGATATAAAGTCCCAGAATGGATAAAAGAAG
GAAATAAATTTGTAAAGAGGGAATTTATTAGGGGATTGTTTGGTGCCGATGGAACCAAACCCAACATAAAAAAATACAAC
GCAAACTGTATAAAGTTATCGTTAAGATGTGAAAAAGAAGCACTGAATAAAACAAAGATGTTCTTTGAAGATATTAAATG
CATGTTGAAAGAATTTGATATTGATTCAAAAATAAATGAAAGAACCATTGATAATAAATATTTAATTGAGTTAATAGTTG
CACCAAATGATGAAAATTACATTAAATACCTATCCAAAATATCCTATGCCTATGAAAAGGACAATTTTGCACGGATTGTT
GGAGAATATCTCAGAATAAAAAGTTATTATAAAAATAACATATTAAAAGAAATAGGAAATAATGCAATAAATGAGATAAA
AACAACTGGAAACAGCATTCGAAAAACTGCAAAAAAATATGAGGTATCGGTTGATTTTGTATTAAATCAGATGAAAGGCA
AAAAAATAGGTTTGCCAAGAGACTATATGACTTATGAACAGTTTATAGATAAAGTAGTAGATAATAAATATGTATCGGAG
AAAATAATAAAAAAAGAATACATTGGACACAAGGATGTTTATGATATTACCTGTCATAATGACCATTCATTTATTGCCAA
TGGATTTGTATCCCATAATTGCAACTATCCGAGCCGAATAATCCCCCCAATTCAATCAAGATGTGCCATATTCAGGTTTT
CACCATTGAAAAGAGAAGATATCGTAAAAAAACTAACTGAAATAGCCCAAAATGAAAATATTGTTATAAAAGATAGTGGT
ATAGATGCCATAATTTATGTATCAGAAGGAGATTTAAGAAAAGCCATAAATGTTCTACAAACTGCATCAACAGTTTCAAC
CACAATAGACGAAGAGATAGTTTATAAAGTATCCTTTAAAGCAAGACCCGATGAAATTAGAAAAATGATTCAATTATCTT
TAAAAGGTAAATTTATGGAAGCCCGGGAGCTCCTATATAGTTTAATGATAGATTGGGGAATGAGTGGAGAAGATATTGTT
GTGCAGATATTTAGGGAGCTCCCTAATTTAGATATTGAAGAAAAAAATAAGGTAGTTCTTGCAGAATATATTGGAGAATG
TGATTTTAGAATGGTAGAAGGAGCAAATGAAAGAATACAATTAAGTGCTTTATTGGCCAAAATTGGGATACTTGATGAAA
ATGCCCATAGTTATAAAATATAA

Upstream 100 bases:

>100_bases
AAAATCAAGAATGGGAGAAATTTTAAATTATGTTAATAAATAATATACACAGCAAAAACAGAGGATAATAAATATAATAT
ATCTGTTATTCGGTGAAAAT

Downstream 100 bases:

>100_bases
ATAATAAATGATATAAATAATAAATGATAATACATATATGCATAACAATCTGTATGGAGGAATGGAAATTGCCAGGATTA
AGAAGAATCGTATTAGATGT

Product: replication factor C small subunit

Products: N Pyrophosphate; DNA(N). [C]

Alternate protein names: RFC small subunit; Clamp loader small subunit; PabRFC small subunit [H]

Number of amino acids: Translated: 940; Mature: 940

Protein sequence:

>940_residues
MEKPWVEKYRPKTLNEITGHDAIITRLKNYVEKESLPHMLFSGPPGLGKTTSALCLAKDLYGDTWKDNFLELNSSDERGI
DVVRTKVKNFARTKPIGDAPFKIIFLDESDALTSDAQNALRRTMEKYSDICRFILSCLTENAKIYTADERELKISDYLKL
FEERKIKTVLNRNGEDLVLAGVKYNSEMVGHPVYKITLESGRTIEATEDHKFLTNNRWMKISQLNEGDELLIYPTLEGVE
YKEDSRKIINLKDFYNFLEEIELQGNYKRLGEADEFSQLTTKDKEVILNRALELYAKLHEGLTDRECEILNSIPEEGISR
EELQKTVGLSRGRLNQILQNIENKKYINRNINKSKKTQFIKNTSKNSPIILRNIMDIKRIIEREHNIKISYTAFKKLLNH
GVKGFAQNHIKNIKERNWDSITYDSKNAGMFARLVGFIIGDGHLAKTEEKRIVITSTNNELKQIINDLTELNIKCSGIIE
KEITNKIGERTVQGITSSIYIDNRTLYLLLMYWGIEIGNKTKIGYKVPEWIKEGNKFVKREFIRGLFGADGTKPNIKKYN
ANCIKLSLRCEKEALNKTKMFFEDIKCMLKEFDIDSKINERTIDNKYLIELIVAPNDENYIKYLSKISYAYEKDNFARIV
GEYLRIKSYYKNNILKEIGNNAINEIKTTGNSIRKTAKKYEVSVDFVLNQMKGKKIGLPRDYMTYEQFIDKVVDNKYVSE
KIIKKEYIGHKDVYDITCHNDHSFIANGFVSHNCNYPSRIIPPIQSRCAIFRFSPLKREDIVKKLTEIAQNENIVIKDSG
IDAIIYVSEGDLRKAINVLQTASTVSTTIDEEIVYKVSFKARPDEIRKMIQLSLKGKFMEARELLYSLMIDWGMSGEDIV
VQIFRELPNLDIEEKNKVVLAEYIGECDFRMVEGANERIQLSALLAKIGILDENAHSYKI

Sequences:

>Translated_940_residues
MEKPWVEKYRPKTLNEITGHDAIITRLKNYVEKESLPHMLFSGPPGLGKTTSALCLAKDLYGDTWKDNFLELNSSDERGI
DVVRTKVKNFARTKPIGDAPFKIIFLDESDALTSDAQNALRRTMEKYSDICRFILSCLTENAKIYTADERELKISDYLKL
FEERKIKTVLNRNGEDLVLAGVKYNSEMVGHPVYKITLESGRTIEATEDHKFLTNNRWMKISQLNEGDELLIYPTLEGVE
YKEDSRKIINLKDFYNFLEEIELQGNYKRLGEADEFSQLTTKDKEVILNRALELYAKLHEGLTDRECEILNSIPEEGISR
EELQKTVGLSRGRLNQILQNIENKKYINRNINKSKKTQFIKNTSKNSPIILRNIMDIKRIIEREHNIKISYTAFKKLLNH
GVKGFAQNHIKNIKERNWDSITYDSKNAGMFARLVGFIIGDGHLAKTEEKRIVITSTNNELKQIINDLTELNIKCSGIIE
KEITNKIGERTVQGITSSIYIDNRTLYLLLMYWGIEIGNKTKIGYKVPEWIKEGNKFVKREFIRGLFGADGTKPNIKKYN
ANCIKLSLRCEKEALNKTKMFFEDIKCMLKEFDIDSKINERTIDNKYLIELIVAPNDENYIKYLSKISYAYEKDNFARIV
GEYLRIKSYYKNNILKEIGNNAINEIKTTGNSIRKTAKKYEVSVDFVLNQMKGKKIGLPRDYMTYEQFIDKVVDNKYVSE
KIIKKEYIGHKDVYDITCHNDHSFIANGFVSHNCNYPSRIIPPIQSRCAIFRFSPLKREDIVKKLTEIAQNENIVIKDSG
IDAIIYVSEGDLRKAINVLQTASTVSTTIDEEIVYKVSFKARPDEIRKMIQLSLKGKFMEARELLYSLMIDWGMSGEDIV
VQIFRELPNLDIEEKNKVVLAEYIGECDFRMVEGANERIQLSALLAKIGILDENAHSYKI
>Mature_940_residues
MEKPWVEKYRPKTLNEITGHDAIITRLKNYVEKESLPHMLFSGPPGLGKTTSALCLAKDLYGDTWKDNFLELNSSDERGI
DVVRTKVKNFARTKPIGDAPFKIIFLDESDALTSDAQNALRRTMEKYSDICRFILSCLTENAKIYTADERELKISDYLKL
FEERKIKTVLNRNGEDLVLAGVKYNSEMVGHPVYKITLESGRTIEATEDHKFLTNNRWMKISQLNEGDELLIYPTLEGVE
YKEDSRKIINLKDFYNFLEEIELQGNYKRLGEADEFSQLTTKDKEVILNRALELYAKLHEGLTDRECEILNSIPEEGISR
EELQKTVGLSRGRLNQILQNIENKKYINRNINKSKKTQFIKNTSKNSPIILRNIMDIKRIIEREHNIKISYTAFKKLLNH
GVKGFAQNHIKNIKERNWDSITYDSKNAGMFARLVGFIIGDGHLAKTEEKRIVITSTNNELKQIINDLTELNIKCSGIIE
KEITNKIGERTVQGITSSIYIDNRTLYLLLMYWGIEIGNKTKIGYKVPEWIKEGNKFVKREFIRGLFGADGTKPNIKKYN
ANCIKLSLRCEKEALNKTKMFFEDIKCMLKEFDIDSKINERTIDNKYLIELIVAPNDENYIKYLSKISYAYEKDNFARIV
GEYLRIKSYYKNNILKEIGNNAINEIKTTGNSIRKTAKKYEVSVDFVLNQMKGKKIGLPRDYMTYEQFIDKVVDNKYVSE
KIIKKEYIGHKDVYDITCHNDHSFIANGFVSHNCNYPSRIIPPIQSRCAIFRFSPLKREDIVKKLTEIAQNENIVIKDSG
IDAIIYVSEGDLRKAINVLQTASTVSTTIDEEIVYKVSFKARPDEIRKMIQLSLKGKFMEARELLYSLMIDWGMSGEDIV
VQIFRELPNLDIEEKNKVVLAEYIGECDFRMVEGANERIQLSALLAKIGILDENAHSYKI

Specific function: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. The complex possesses DNA-independent ATPase activity [H]

COG id: COG1372

COG function: function code L; Intein/homing endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 DOD-type homing endonuclease domains [H]

Homologues:

Organism=Homo sapiens, GI31563534, Length=173, Percent_Identity=47.3988439306358, Blast_Score=156, Evalue=9e-38,
Organism=Homo sapiens, GI6677723, Length=135, Percent_Identity=49.6296296296296, Blast_Score=151, Evalue=3e-36,
Organism=Homo sapiens, GI4506491, Length=142, Percent_Identity=51.4084507042254, Blast_Score=148, Evalue=3e-35,
Organism=Homo sapiens, GI31881687, Length=142, Percent_Identity=51.4084507042254, Blast_Score=148, Evalue=3e-35,
Organism=Homo sapiens, GI194306571, Length=134, Percent_Identity=48.5074626865672, Blast_Score=144, Evalue=6e-34,
Organism=Homo sapiens, GI194306567, Length=134, Percent_Identity=48.5074626865672, Blast_Score=144, Evalue=6e-34,
Organism=Homo sapiens, GI28882049, Length=170, Percent_Identity=36.4705882352941, Blast_Score=111, Evalue=4e-24,
Organism=Homo sapiens, GI194306569, Length=177, Percent_Identity=31.638418079096, Blast_Score=108, Evalue=3e-23,
Organism=Homo sapiens, GI4506489, Length=162, Percent_Identity=36.4197530864198, Blast_Score=103, Evalue=8e-22,
Organism=Homo sapiens, GI108773789, Length=162, Percent_Identity=36.4197530864198, Blast_Score=100, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71986063, Length=144, Percent_Identity=52.0833333333333, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17541988, Length=158, Percent_Identity=50, Blast_Score=156, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17554730, Length=140, Percent_Identity=47.1428571428571, Blast_Score=135, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541990, Length=164, Percent_Identity=37.1951219512195, Blast_Score=97, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6322528, Length=147, Percent_Identity=56.4625850340136, Blast_Score=168, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6324478, Length=173, Percent_Identity=47.3988439306358, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324039, Length=138, Percent_Identity=51.4492753623188, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI18859927, Length=285, Percent_Identity=35.7894736842105, Blast_Score=154, Evalue=3e-37,
Organism=Drosophila melanogaster, GI19921076, Length=135, Percent_Identity=51.1111111111111, Blast_Score=154, Evalue=4e-37,
Organism=Drosophila melanogaster, GI17647857, Length=139, Percent_Identity=51.0791366906475, Blast_Score=148, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19921136, Length=161, Percent_Identity=37.888198757764, Blast_Score=103, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003959
- InterPro:   IPR008824
- InterPro:   IPR008921
- InterPro:   IPR003586
- InterPro:   IPR003587
- InterPro:   IPR001387
- InterPro:   IPR006142
- InterPro:   IPR004042
- InterPro:   IPR006141
- InterPro:   IPR010982
- InterPro:   IPR013748
- InterPro:   IPR002831
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00004 AAA; PF01381 HTH_3; PF08542 Rep_fac_C; PF05496 RuvB_N; PF01978 TrmB [H]

EC number: 2.7.7.7 [C]

Molecular weight: Translated: 108649; Mature: 108649

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS50817 INTEIN_N_TER ; PS50818 INTEIN_C_TER ; PS50819 INTEIN_ENDONUCLEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPWVEKYRPKTLNEITGHDAIITRLKNYVEKESLPHMLFSGPPGLGKTTSALCLAKDL
CCCCCCHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHH
YGDTWKDNFLELNSSDERGIDVVRTKVKNFARTKPIGDAPFKIIFLDESDALTSDAQNAL
CCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHH
RRTMEKYSDICRFILSCLTENAKIYTADERELKISDYLKLFEERKIKTVLNRNGEDLVLA
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEEE
GVKYNSEMVGHPVYKITLESGRTIEATEDHKFLTNNRWMKISQLNEGDELLIYPTLEGVE
EEEECCCCCCCCEEEEEECCCCEEECCCCCCEECCCCEEEEEECCCCCCEEEEECCCCCC
YKEDSRKIINLKDFYNFLEEIELQGNYKRLGEADEFSQLTTKDKEVILNRALELYAKLHE
CCCCCCCEEEHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLTDRECEILNSIPEEGISREELQKTVGLSRGRLNQILQNIENKKYINRNINKSKKTQFI
CCCCCHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
KNTSKNSPIILRNIMDIKRIIEREHNIKISYTAFKKLLNHGVKGFAQNHIKNIKERNWDS
HCCCCCCCEEHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ITYDSKNAGMFARLVGFIIGDGHLAKTEEKRIVITSTNNELKQIINDLTELNIKCSGIIE
EEECCCCCCHHHHHHHHHHCCCCEECCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEHH
KEITNKIGERTVQGITSSIYIDNRTLYLLLMYWGIEIGNKTKIGYKVPEWIKEGNKFVKR
HHHHHHHHHHHHHHCHHEEEECCCHHHHEEEHHHHEECCCCCCCCCCHHHHHHHHHHHHH
EFIRGLFGADGTKPNIKKYNANCIKLSLRCEKEALNKTKMFFEDIKCMLKEFDIDSKINE
HHHHHHHCCCCCCCCCEECCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
RTIDNKYLIELIVAPNDENYIKYLSKISYAYEKDNFARIVGEYLRIKSYYKNNILKEIGN
HCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
NAINEIKTTGNSIRKTAKKYEVSVDFVLNQMKGKKIGLPRDYMTYEQFIDKVVDNKYVSE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHH
KIIKKEYIGHKDVYDITCHNDHSFIANGFVSHNCNYPSRIIPPIQSRCAIFRFSPLKRED
HHHHHHHCCCCCCEEEEECCCCCHHHCCCCCCCCCCCCCCCCCHHHCCEEEECCCCCHHH
IVKKLTEIAQNENIVIKDSGIDAIIYVSEGDLRKAINVLQTASTVSTTIDEEIVYKVSFK
HHHHHHHHHCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
ARPDEIRKMIQLSLKGKFMEARELLYSLMIDWGMSGEDIVVQIFRELPNLDIEEKNKVVL
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEH
AEYIGECDFRMVEGANERIQLSALLAKIGILDENAHSYKI
HHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEKPWVEKYRPKTLNEITGHDAIITRLKNYVEKESLPHMLFSGPPGLGKTTSALCLAKDL
CCCCCCHHCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCHHHHHHHHHH
YGDTWKDNFLELNSSDERGIDVVRTKVKNFARTKPIGDAPFKIIFLDESDALTSDAQNAL
CCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHH
RRTMEKYSDICRFILSCLTENAKIYTADERELKISDYLKLFEERKIKTVLNRNGEDLVLA
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHCCCCCEEEEE
GVKYNSEMVGHPVYKITLESGRTIEATEDHKFLTNNRWMKISQLNEGDELLIYPTLEGVE
EEEECCCCCCCCEEEEEECCCCEEECCCCCCEECCCCEEEEEECCCCCCEEEEECCCCCC
YKEDSRKIINLKDFYNFLEEIELQGNYKRLGEADEFSQLTTKDKEVILNRALELYAKLHE
CCCCCCCEEEHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLTDRECEILNSIPEEGISREELQKTVGLSRGRLNQILQNIENKKYINRNINKSKKTQFI
CCCCCHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
KNTSKNSPIILRNIMDIKRIIEREHNIKISYTAFKKLLNHGVKGFAQNHIKNIKERNWDS
HCCCCCCCEEHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ITYDSKNAGMFARLVGFIIGDGHLAKTEEKRIVITSTNNELKQIINDLTELNIKCSGIIE
EEECCCCCCHHHHHHHHHHCCCCEECCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEHH
KEITNKIGERTVQGITSSIYIDNRTLYLLLMYWGIEIGNKTKIGYKVPEWIKEGNKFVKR
HHHHHHHHHHHHHHCHHEEEECCCHHHHEEEHHHHEECCCCCCCCCCHHHHHHHHHHHHH
EFIRGLFGADGTKPNIKKYNANCIKLSLRCEKEALNKTKMFFEDIKCMLKEFDIDSKINE
HHHHHHHCCCCCCCCCEECCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
RTIDNKYLIELIVAPNDENYIKYLSKISYAYEKDNFARIVGEYLRIKSYYKNNILKEIGN
HCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
NAINEIKTTGNSIRKTAKKYEVSVDFVLNQMKGKKIGLPRDYMTYEQFIDKVVDNKYVSE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHH
KIIKKEYIGHKDVYDITCHNDHSFIANGFVSHNCNYPSRIIPPIQSRCAIFRFSPLKRED
HHHHHHHCCCCCCEEEEECCCCCHHHCCCCCCCCCCCCCCCCCHHHCCEEEECCCCCHHH
IVKKLTEIAQNENIVIKDSGIDAIIYVSEGDLRKAINVLQTASTVSTTIDEEIVYKVSFK
HHHHHHHHHCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
ARPDEIRKMIQLSLKGKFMEARELLYSLMIDWGMSGEDIVVQIFRELPNLDIEEKNKVVL
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCEEH
AEYIGECDFRMVEGANERIQLSALLAKIGILDENAHSYKI
HHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Dimethyl sulfoxide epsilon,; Polymerase alpha accessory factors; Proliferating cell nuclear antigen; Replication factor A; Replication factor C; Thiol [C]

Metal ions: K+; Mg2+; Mn2+; Na+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.0063 {dATP}} [C]

Substrates: N Deoxynucleoside Triphosphate; DNA [C]

Specific reaction: N Deoxynucleoside Triphosphate = N Pyrophosphate + DNA(N). Protein + DNA = Protein-DNA [C]

General reaction: Nucleotidyl group transfer [C]

Inhibitor: 1, 10-Phenanthroline; 2', 3'-Dideoxythymidine5'-triphosphate polymerase beta, gamma, delta, epsilon; Aphidicolin polymerase alpha; Ara-ATP; Ara-CTP; Benzyl oxycarbonyl -Leu-Leu-al; Carbonyl diphosphonate delta, alpha,; Dideoxynucleoside 5'-triphosphate;

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]