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The map label for this gene is trpC [H]

Identifier: 150401538

GI number: 150401538

Start: 1160278

End: 1160964

Strand: Direct

Name: trpC [H]

Synonym: Maeo_1115

Alternate gene names: 150401538

Gene position: 1160278-1160964 (Clockwise)

Preceding gene: 150401537

Following gene: 150401539

Centisome position: 73.93

GC content: 32.17

Gene sequence:

>687_bases
ATGAAAATGGTTAAATCAATATTAAACACAAAAAATAACAACAAGAACCCAATAATTGCAGAAATAAAAGTTCATTCTCC
AAAATATGGGGATATGATTAATAGAAGAGATGAAATGGATATTTTAAAAATATATGAAAATGCAGGAGCATCGGGAATAT
CATACATCACAGATAAAGAACATTTTAACGGAGATTTTGAAATGTACAAAAAAATATGTAAAAACACGGAGCTCCCTGTT
TTAAGAAAAGACTTTATAACTACAAAGGATGAAATTGAAAAAACCGCAGAAGTTGAAGGGGGGGCAATATTATTAATAGC
ACGACTATTAAAGGAAGAAACAGCTGAATTTGTAGATTATGCCCTTGAACACGGATTAGATACGCTTGTTGAAGTCCATA
ATAAAGAGGAGATAGATATAGCTAAGGAAACAAACAGCACAATGATAGGAGTAAATAACAGGGACATTACAAAATTAGAG
TTGGACGATGGAACTGTATCCCTTACGGAACAGCTTGCCCCATTGATTCCAAAAAATATGGTTTTTGTTAGTGAAAGTGG
AATAGGAACAATCGAGGATTTAAGAATGGCATTGAAATATGCCGATGCCGCACTAATTGGAACAAGTTTTATGAAAGCTA
AAAATATTGAAGAATTTGTTAAATCATTTGTAGATGCGAAATTATAG

Upstream 100 bases:

>100_bases
ATATTATAATTTAATATTATGCTAATTATATTTATTAACTCATATATTTATGTATTATAATACATTCTATTATTAATTAA
AATATTGTATCGGTGATATT

Downstream 100 bases:

>100_bases
TTAATCTTCAATAGCTGTCCCTTATCCGTCCTATTGTTATTAAACAAAATCCTTTTAGGATTTTATACAAAATCGAAGAT
TTTGTAAATAAATCTTGTAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKMVKSILNTKNNNKNPIIAEIKVHSPKYGDMINRRDEMDILKIYENAGASGISYITDKEHFNGDFEMYKKICKNTELPV
LRKDFITTKDEIEKTAEVEGGAILLIARLLKEETAEFVDYALEHGLDTLVEVHNKEEIDIAKETNSTMIGVNNRDITKLE
LDDGTVSLTEQLAPLIPKNMVFVSESGIGTIEDLRMALKYADAALIGTSFMKAKNIEEFVKSFVDAKL

Sequences:

>Translated_228_residues
MKMVKSILNTKNNNKNPIIAEIKVHSPKYGDMINRRDEMDILKIYENAGASGISYITDKEHFNGDFEMYKKICKNTELPV
LRKDFITTKDEIEKTAEVEGGAILLIARLLKEETAEFVDYALEHGLDTLVEVHNKEEIDIAKETNSTMIGVNNRDITKLE
LDDGTVSLTEQLAPLIPKNMVFVSESGIGTIEDLRMALKYADAALIGTSFMKAKNIEEFVKSFVDAKL
>Mature_228_residues
MKMVKSILNTKNNNKNPIIAEIKVHSPKYGDMINRRDEMDILKIYENAGASGISYITDKEHFNGDFEMYKKICKNTELPV
LRKDFITTKDEIEKTAEVEGGAILLIARLLKEETAEFVDYALEHGLDTLVEVHNKEEIDIAKETNSTMIGVNNRDITKLE
LDDGTVSLTEQLAPLIPKNMVFVSESGIGTIEDLRMALKYADAALIGTSFMKAKNIEEFVKSFVDAKL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=210, Percent_Identity=31.4285714285714, Blast_Score=95, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322638, Length=221, Percent_Identity=30.316742081448, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 25650; Mature: 25650

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMVKSILNTKNNNKNPIIAEIKVHSPKYGDMINRRDEMDILKIYENAGASGISYITDKE
CHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHCCCCHHHHHHHHHCCCCCCCEECCCHH
HFNGDFEMYKKICKNTELPVLRKDFITTKDEIEKTAEVEGGAILLIARLLKEETAEFVDY
HCCCCHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALEHGLDTLVEVHNKEEIDIAKETNSTMIGVNNRDITKLELDDGTVSLTEQLAPLIPKNM
HHHHCHHHHHHHCCCCCCEEEECCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCE
VFVSESGIGTIEDLRMALKYADAALIGTSFMKAKNIEEFVKSFVDAKL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKMVKSILNTKNNNKNPIIAEIKVHSPKYGDMINRRDEMDILKIYENAGASGISYITDKE
CHHHHHHHCCCCCCCCCEEEEEEECCCCHHHHHCCCCHHHHHHHHHCCCCCCCEECCCHH
HFNGDFEMYKKICKNTELPVLRKDFITTKDEIEKTAEVEGGAILLIARLLKEETAEFVDY
HCCCCHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
ALEHGLDTLVEVHNKEEIDIAKETNSTMIGVNNRDITKLELDDGTVSLTEQLAPLIPKNM
HHHHCHHHHHHHCCCCCCEEEECCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCE
VFVSESGIGTIEDLRMALKYADAALIGTSFMKAKNIEEFVKSFVDAKL
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]