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The map label for this gene is comC [H]

Identifier: 150401439

GI number: 150401439

Start: 1041419

End: 1042456

Strand: Direct

Name: comC [H]

Synonym: Maeo_1015

Alternate gene names: 150401439

Gene position: 1041419-1042456 (Clockwise)

Preceding gene: 150401438

Following gene: 150401440

Centisome position: 66.35

GC content: 34.59

Gene sequence:

>1038_bases
ATGAAAATTACAATAGATAATAAAAAGAAATTAATTAAGGACATATTAATGAAGTATGGCATAAATGAAAAAGATGCAGA
AACTACGGCGAAGATATATGTTGAAGCTGATTTGAAAGGGTTTTCATCCCATGGTACGGGTAGATTCCCGCAAACTGTCG
TAGGTCTTGAAAATGGAAATATAAATCCAAATCCAAATATTTCATTAATAAAAGAAAGTCCAGCAACAGCAACAGTTGAT
GGGGATATGGGTCTTGGGTATGTAATAGGAGAATATGCTATGAATTTAGCAATTGAAAAGGCAAAAAATATTGGAATAGG
TGCAGTAGCTACTGTTAATGCAAATCATTTTGGAATTACCGGATATTATTCAGAAATGGCACTAAACCATGATTTAATAG
GGATAGTGATAACCAATACAGAACCAGCCATGGCCCCATTTGGAGGGACTGAAAAAATATTGGGAACAAACCCAATAGCA
ATAGCAATTAAAGGAAAGAAATATTCGTATTCTCTTGATATGGCTACTGCATCACTTGCAAGAGGAAAACTGCTTGAAGC
CGTGAGACTTGGAAAAGAAATTCCAGAGGGGTGCGTAGTAGATAAAGAAGGAAATATAACCACAGACCCTGCTAAGGGAT
TAGAAGGATGTATATTGCCATTTGGGGGTCCAAAAGGTTATGGACTTGCACTTGCCATTGAAATTCTTTCGGCATTGGGC
GGTGCTGAAATGGGAACCAATGTTAAAGGAACTGCCAATCCATTAGATAAATGCACAAAAGGAGACTTTTTCGTAGCCAT
AAATCCAGAATTTTTTGGAGATAAGGAAGTATTTATGGAAAAAGTAGATGCCCTAATAGAAGAATTGAAAAACTCAAAAC
CGGCGGAAGGATTTTCCATATTAATCCCCGGAGAAATTGAAAAAATGAACTCTGAAAAAAATAAATCAGGTTTTGAAATT
GATACGGTTTTATATAACAAATTAAAAGATATTTGTGATAAAAAAGAGATAGATTTAAATGAATATATGATTAAGTAA

Upstream 100 bases:

>100_bases
ATCCTCCGTTATATGATTGGCACCTATAATCTAGTCAATCTTCGGACTTTTGTCATAAATATATTGGTAAAATAAATTTA
ATACAGTGAGAGGTGAATCA

Downstream 100 bases:

>100_bases
TATATCTATGTAATTATACCCTGTAATTATACCATATCATGTTTTATATTGTGGTGTGTTCAAAACTATTATTGTAATAA
AATACCACAACTAATTACGC

Product: (R)-2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: (R)-2-hydroxyacid dehydrogenase; (R)-sulfolactate dehydrogenase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKITIDNKKKLIKDILMKYGINEKDAETTAKIYVEADLKGFSSHGTGRFPQTVVGLENGNINPNPNISLIKESPATATVD
GDMGLGYVIGEYAMNLAIEKAKNIGIGAVATVNANHFGITGYYSEMALNHDLIGIVITNTEPAMAPFGGTEKILGTNPIA
IAIKGKKYSYSLDMATASLARGKLLEAVRLGKEIPEGCVVDKEGNITTDPAKGLEGCILPFGGPKGYGLALAIEILSALG
GAEMGTNVKGTANPLDKCTKGDFFVAINPEFFGDKEVFMEKVDALIEELKNSKPAEGFSILIPGEIEKMNSEKNKSGFEI
DTVLYNKLKDICDKKEIDLNEYMIK

Sequences:

>Translated_345_residues
MKITIDNKKKLIKDILMKYGINEKDAETTAKIYVEADLKGFSSHGTGRFPQTVVGLENGNINPNPNISLIKESPATATVD
GDMGLGYVIGEYAMNLAIEKAKNIGIGAVATVNANHFGITGYYSEMALNHDLIGIVITNTEPAMAPFGGTEKILGTNPIA
IAIKGKKYSYSLDMATASLARGKLLEAVRLGKEIPEGCVVDKEGNITTDPAKGLEGCILPFGGPKGYGLALAIEILSALG
GAEMGTNVKGTANPLDKCTKGDFFVAINPEFFGDKEVFMEKVDALIEELKNSKPAEGFSILIPGEIEKMNSEKNKSGFEI
DTVLYNKLKDICDKKEIDLNEYMIK
>Mature_345_residues
MKITIDNKKKLIKDILMKYGINEKDAETTAKIYVEADLKGFSSHGTGRFPQTVVGLENGNINPNPNISLIKESPATATVD
GDMGLGYVIGEYAMNLAIEKAKNIGIGAVATVNANHFGITGYYSEMALNHDLIGIVITNTEPAMAPFGGTEKILGTNPIA
IAIKGKKYSYSLDMATASLARGKLLEAVRLGKEIPEGCVVDKEGNITTDPAKGLEGCILPFGGPKGYGLALAIEILSALG
GAEMGTNVKGTANPLDKCTKGDFFVAINPEFFGDKEVFMEKVDALIEELKNSKPAEGFSILIPGEIEKMNSEKNKSGFEI
DTVLYNKLKDICDKKEIDLNEYMIK

Specific function: Catalyzes the reduction of sulfopyruvate to (R)- sulfolactate much more efficiently than the reverse reaction. Also catalyzes the reduction of oxaloacetate, alpha-ketoglutarate, and to a much lower extent, KHTCA, but not pyruvate. Involved in the biosynth

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=333, Percent_Identity=33.3333333333333, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1787020, Length=348, Percent_Identity=33.0459770114943, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1790000, Length=337, Percent_Identity=29.673590504451, Blast_Score=137, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI17507179, Length=350, Percent_Identity=33.1428571428571, Blast_Score=165, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17536633, Length=317, Percent_Identity=34.384858044164, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24667904, Length=351, Percent_Identity=34.1880341880342, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24667908, Length=351, Percent_Identity=34.1880341880342, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI45553211, Length=351, Percent_Identity=34.1880341880342, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24667912, Length=351, Percent_Identity=34.1880341880342, Blast_Score=178, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24658010, Length=337, Percent_Identity=30.2670623145401, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24648360, Length=343, Percent_Identity=27.1137026239067, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.272 [H]

Molecular weight: Translated: 37053; Mature: 37053

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITIDNKKKLIKDILMKYGINEKDAETTAKIYVEADLKGFSSHGTGRFPQTVVGLENGN
CEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEECCCC
INPNPNISLIKESPATATVDGDMGLGYVIGEYAMNLAIEKAKNIGIGAVATVNANHFGIT
CCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEE
GYYSEMALNHDLIGIVITNTEPAMAPFGGTEKILGTNPIAIAIKGKKYSYSLDMATASLA
EEHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEHHHHHHHH
RGKLLEAVRLGKEIPEGCVVDKEGNITTDPAKGLEGCILPFGGPKGYGLALAIEILSALG
HHHHHHHHHHHHCCCCCCEEECCCCEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHC
GAEMGTNVKGTANPLDKCTKGDFFVAINPEFFGDKEVFMEKVDALIEELKNSKPAEGFSI
CCCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEE
LIPGEIEKMNSEKNKSGFEIDTVLYNKLKDICDKKEIDLNEYMIK
EECCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCC
>Mature Secondary Structure
MKITIDNKKKLIKDILMKYGINEKDAETTAKIYVEADLKGFSSHGTGRFPQTVVGLENGN
CEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEECCCC
INPNPNISLIKESPATATVDGDMGLGYVIGEYAMNLAIEKAKNIGIGAVATVNANHFGIT
CCCCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEE
GYYSEMALNHDLIGIVITNTEPAMAPFGGTEKILGTNPIAIAIKGKKYSYSLDMATASLA
EEHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEHHHHHHHH
RGKLLEAVRLGKEIPEGCVVDKEGNITTDPAKGLEGCILPFGGPKGYGLALAIEILSALG
HHHHHHHHHHHHCCCCCCEEECCCCEECCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHC
GAEMGTNVKGTANPLDKCTKGDFFVAINPEFFGDKEVFMEKVDALIEELKNSKPAEGFSI
CCCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEE
LIPGEIEKMNSEKNKSGFEIDTVLYNKLKDICDKKEIDLNEYMIK
EECCHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10850983 [H]