Click here to switch to the map view.

The map label for this gene is 150401381

Identifier: 150401381

GI number: 150401381

Start: 983255

End: 984055

Strand: Reverse

Name: 150401381

Synonym: Maeo_0957

Alternate gene names: NA

Gene position: 984055-983255 (Counterclockwise)

Preceding gene: 150401382

Following gene: 150401380

Centisome position: 62.7

GC content: 35.58

Gene sequence:

>801_bases
ATGAAAGCTACATTTATATACCACAAAGGAAACCAGAGAATGGAGAAATTTTATAAAAATCTACTGAATGAACCAGATTT
TTGTAGAATCTGTGAGGATTGTTATAACTGTCGAGGGGATTGGTCGTATAAAGACGATGTAAAGGCTGTGGTTTTGGACG
CTATTGATGATGATGAATTTATAGAGGATGCTTCCGATTACATACCGGAGCTCCCGGAGGGTGATGTGGCAGTTGCCCAA
CTTCATGAGGATTTATTGTATGAGCTCCCAAACATGCTTGCGGAAAAAAATTACAAATTGTTAATTGTGCCATCAGAAAC
ACCATCTGATTTATCAATAGCTATGAGAAACAGCTTAAAAGAAATGTGTGAAAAGAATGGAATGGATTTTGAAAATCCAA
AGCCATTTTGTGCTTTAAAAAAGAGACATAATAGAAAAGTTTTAAATGAGTTTATAAATTACTTTAAAATAGGATTTCCA
CAGGTTGAAATTAAATCATCAGATGGACATAAAATAGACGACGATGTTAAGGTGATTATATCGGCACCATGTGGTGAAAC
TCACTATATGTCCAAAAGGATTAAAGGAAAAATCATAAACGAATTAAAGGACAAGATAGCAAACGCTCACCACAACTACC
CATGTTTGGGAAGTATGGAATATGATAAGGAGCTGGAAGATACCATGCTTCACGAAGCAGGATATATTGCATTAGATGCC
GTAAAGAAAGCACTTTTGCCATACAAATGTAAAAATAAATTTTGCGGTAGATGTGGGATTTTCGGGCAGAGCTCCTTATA
A

Upstream 100 bases:

>100_bases
ATGTATTGAACGCTCATTAAAATATATAAAATAACTTTTTTAAAGTGATTTGAGCTAAATCCTGTGGGTTTTGTAGCTCA
CTCACTTGTTAGGTGATATT

Downstream 100 bases:

>100_bases
TAAATTTTTTTATAATAAATTCCTCTAACATTTCAAATATATTTTTGGTGAAACTATGGATAAGCTCCAAATATTAAGAA
AAATATCTCAAACAGCATTT

Product: hypothetical protein

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKATFIYHKGNQRMEKFYKNLLNEPDFCRICEDCYNCRGDWSYKDDVKAVVLDAIDDDEFIEDASDYIPELPEGDVAVAQ
LHEDLLYELPNMLAEKNYKLLIVPSETPSDLSIAMRNSLKEMCEKNGMDFENPKPFCALKKRHNRKVLNEFINYFKIGFP
QVEIKSSDGHKIDDDVKVIISAPCGETHYMSKRIKGKIINELKDKIANAHHNYPCLGSMEYDKELEDTMLHEAGYIALDA
VKKALLPYKCKNKFCGRCGIFGQSSL

Sequences:

>Translated_266_residues
MKATFIYHKGNQRMEKFYKNLLNEPDFCRICEDCYNCRGDWSYKDDVKAVVLDAIDDDEFIEDASDYIPELPEGDVAVAQ
LHEDLLYELPNMLAEKNYKLLIVPSETPSDLSIAMRNSLKEMCEKNGMDFENPKPFCALKKRHNRKVLNEFINYFKIGFP
QVEIKSSDGHKIDDDVKVIISAPCGETHYMSKRIKGKIINELKDKIANAHHNYPCLGSMEYDKELEDTMLHEAGYIALDA
VKKALLPYKCKNKFCGRCGIFGQSSL
>Mature_266_residues
MKATFIYHKGNQRMEKFYKNLLNEPDFCRICEDCYNCRGDWSYKDDVKAVVLDAIDDDEFIEDASDYIPELPEGDVAVAQ
LHEDLLYELPNMLAEKNYKLLIVPSETPSDLSIAMRNSLKEMCEKNGMDFENPKPFCALKKRHNRKVLNEFINYFKIGFP
QVEIKSSDGHKIDDDVKVIISAPCGETHYMSKRIKGKIINELKDKIANAHHNYPCLGSMEYDKELEDTMLHEAGYIALDA
VKKALLPYKCKNKFCGRCGIFGQSSL

Specific function: Is able to catalyze the biosynthesis of dTMP using dUMP, tetrahydrofolate and formaldehyde in vitro, i.e. a reaction equivalent to that catalyzed by bacterial thymidylate synthases (EC 2.1.1.45). However, M.jannaschii like most methanogenic Archaea lacks

COG id: COG1810

COG function: function code S; Uncharacterized protein conserved in archaea

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003745 [H]

Pfam domain/function: PF02593 DUF166 [H]

EC number: NA

Molecular weight: Translated: 30573; Mature: 30573

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKATFIYHKGNQRMEKFYKNLLNEPDFCRICEDCYNCRGDWSYKDDVKAVVLDAIDDDEF
CCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHH
IEDASDYIPELPEGDVAVAQLHEDLLYELPNMLAEKNYKLLIVPSETPSDLSIAMRNSLK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
EMCEKNGMDFENPKPFCALKKRHNRKVLNEFINYFKIGFPQVEIKSSDGHKIDDDVKVII
HHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEE
SAPCGETHYMSKRIKGKIINELKDKIANAHHNYPCLGSMEYDKELEDTMLHEAGYIALDA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
VKKALLPYKCKNKFCGRCGIFGQSSL
HHHHHCCHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKATFIYHKGNQRMEKFYKNLLNEPDFCRICEDCYNCRGDWSYKDDVKAVVLDAIDDDEF
CCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHH
IEDASDYIPELPEGDVAVAQLHEDLLYELPNMLAEKNYKLLIVPSETPSDLSIAMRNSLK
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
EMCEKNGMDFENPKPFCALKKRHNRKVLNEFINYFKIGFPQVEIKSSDGHKIDDDVKVII
HHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEE
SAPCGETHYMSKRIKGKIINELKDKIANAHHNYPCLGSMEYDKELEDTMLHEAGYIALDA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHH
VKKALLPYKCKNKFCGRCGIFGQSSL
HHHHHCCHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]