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The map label for this gene is xapA [C]

Identifier: 150401353

GI number: 150401353

Start: 948635

End: 949393

Strand: Direct

Name: xapA [C]

Synonym: Maeo_0926

Alternate gene names: 150401353

Gene position: 948635-949393 (Clockwise)

Preceding gene: 150401349

Following gene: 150401360

Centisome position: 60.44

GC content: 33.07

Gene sequence:

>759_bases
TTGATAGGCATAATCGGAGGAACTGGAATATCTACAATATTAAATAAAGGCAGAGAGGAAATAATAAACACAAAATATGG
AAATGCAAAGGTATTAATTGATAAAGAAAGCGATGTAGTTTTATTATTTAGGCACGGCATACGCCATAACACCCCACCAC
ACAAAATAAATTATAGGGCCAATATTATGGCACTTAAACAGCTTGGTGTCGATAAAATTTTAGCAATAAATGCCGTAGGT
TCATTAAAAGAAGAAATAACTCCGGGAAGTTTTGTAGTGGCAAATGATTTTATAGAATTCACAAAAGAAAGGAAAAGCAC
ATTTTACGATGGAGAAAATGGCGAAGTTGTGCATATTGATGTTTCAGAGCCTTATTGCCCACAAATGACAGAATTAATAA
AATGTTTATTGAATAATAGGGGCTACAAATATTGCGAAGGCACCTATGTATGCACAGAAGGGCCAAGATTTGAAACTAAG
GCAGAAATAAATTTCTATAAAACAATAGGAGATATTGTGGGCATGACGGCATACCCCGAAGTAGTTCTTGCTAGGGAGCT
CCAACTATGCTATGGTTCTATATGCACAGTCTCCAACTATTGCACAGGAATATCTAAAAGTAGATTAACTATATCAGAAG
TATATGAAACAATAAATGAAATGGAAAATGAAATATTGAATATTGTGGAGGATATAATAAATTATAAACGGGACCAATGT
AGTTATTGTAAAAATATACTAAATGATGCTAAAATGTAA

Upstream 100 bases:

>100_bases
TTTAATAAATAAGTTATGATGGAATAAAAAAATAAATACAATAACTACAAAAACATTGAAGTCCCCAATAATATTTAAAA
ATTAAAAAATAGGTGGTATT

Downstream 100 bases:

>100_bases
TATAATAATTATTTGTGTGAATTACCCCTCCCTTACGGAAGGAGCTCCCTGACTCATAGGGGATACTTGCCCAGAGATTA
CCTTTATGTAAGGTATAATT

Product: purine phosphorylase family 2

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MIGIIGGTGISTILNKGREEIINTKYGNAKVLIDKESDVVLLFRHGIRHNTPPHKINYRANIMALKQLGVDKILAINAVG
SLKEEITPGSFVVANDFIEFTKERKSTFYDGENGEVVHIDVSEPYCPQMTELIKCLLNNRGYKYCEGTYVCTEGPRFETK
AEINFYKTIGDIVGMTAYPEVVLARELQLCYGSICTVSNYCTGISKSRLTISEVYETINEMENEILNIVEDIINYKRDQC
SYCKNILNDAKM

Sequences:

>Translated_252_residues
MIGIIGGTGISTILNKGREEIINTKYGNAKVLIDKESDVVLLFRHGIRHNTPPHKINYRANIMALKQLGVDKILAINAVG
SLKEEITPGSFVVANDFIEFTKERKSTFYDGENGEVVHIDVSEPYCPQMTELIKCLLNNRGYKYCEGTYVCTEGPRFETK
AEINFYKTIGDIVGMTAYPEVVLARELQLCYGSICTVSNYCTGISKSRLTISEVYETINEMENEILNIVEDIINYKRDQC
SYCKNILNDAKM
>Mature_252_residues
MIGIIGGTGISTILNKGREEIINTKYGNAKVLIDKESDVVLLFRHGIRHNTPPHKINYRANIMALKQLGVDKILAINAVG
SLKEEITPGSFVVANDFIEFTKERKSTFYDGENGEVVHIDVSEPYCPQMTELIKCLLNNRGYKYCEGTYVCTEGPRFETK
AEINFYKTIGDIVGMTAYPEVVLARELQLCYGSICTVSNYCTGISKSRLTISEVYETINEMENEILNIVEDIINYKRDQC
SYCKNILNDAKM

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=240, Percent_Identity=39.1666666666667, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1788746, Length=169, Percent_Identity=27.2189349112426, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71980569, Length=229, Percent_Identity=34.9344978165939, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323045, Length=223, Percent_Identity=33.1838565022422, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI20130079, Length=278, Percent_Identity=35.9712230215827, Blast_Score=146, Evalue=1e-35,
Organism=Drosophila melanogaster, GI221459247, Length=225, Percent_Identity=34.2222222222222, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 28396; Mature: 28396

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIIGGTGISTILNKGREEIINTKYGNAKVLIDKESDVVLLFRHGIRHNTPPHKINYRA
CEEEECCCCHHHHHHCCHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEECHH
NIMALKQLGVDKILAINAVGSLKEEITPGSFVVANDFIEFTKERKSTFYDGENGEVVHID
HHHHHHHCCCHHEEEHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEE
VSEPYCPQMTELIKCLLNNRGYKYCEGTYVCTEGPRFETKAEINFYKTIGDIVGMTAYPE
CCCCCCHHHHHHHHHHHCCCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHH
VVLARELQLCYGSICTVSNYCTGISKSRLTISEVYETINEMENEILNIVEDIINYKRDQC
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SYCKNILNDAKM
HHHHHHHHHCCC
>Mature Secondary Structure
MIGIIGGTGISTILNKGREEIINTKYGNAKVLIDKESDVVLLFRHGIRHNTPPHKINYRA
CEEEECCCCHHHHHHCCHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEECHH
NIMALKQLGVDKILAINAVGSLKEEITPGSFVVANDFIEFTKERKSTFYDGENGEVVHID
HHHHHHHCCCHHEEEHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCEEEEE
VSEPYCPQMTELIKCLLNNRGYKYCEGTYVCTEGPRFETKAEINFYKTIGDIVGMTAYPE
CCCCCCHHHHHHHHHHHCCCCCEEECCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCHH
VVLARELQLCYGSICTVSNYCTGISKSRLTISEVYETINEMENEILNIVEDIINYKRDQC
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SYCKNILNDAKM
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]