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The map label for this gene is dapA

Identifier: 150401335

GI number: 150401335

Start: 933242

End: 934108

Strand: Reverse

Name: dapA

Synonym: Maeo_0908

Alternate gene names: 150401335

Gene position: 934108-933242 (Counterclockwise)

Preceding gene: 150401336

Following gene: 150401334

Centisome position: 59.52

GC content: 33.1

Gene sequence:

>867_bases
ATGCAAGGAGTGTTTCCTGCAATTATTACTCCATTTAAAAATGGGGGAGTAGATTACGAAGGTTTAGAACAAAACATAAA
CTTTTTAATCGATAATGGAGTTAATGGCATAGTATCAGTTGGAACAACTGGCGAATCTCCTACTTTATCCCATGATGAAC
ACAAAAAGATTATTGAAAAATCCGTTAGTGTATGTGATGGAAAGGTGGATGTTATAGCTGGTGCTGGTTCAAACTCAACA
GAAGAGGCGATTGCACTTTCTCAATTTGCGGAAGATGTTGGTGCTGATTCTGTGCTATTAATAACTCCTTACTATAATAA
ACCCACCCAGGAAGGATTAAAACAGCATTTCTCTAAAATAGCGGAATCAATAAATATTCCGATAGTATTATATAATGTTC
CTTCTAGAACAGCTGTAAATCTCCAACCTGAAACTATAAAATATCTATATGAGGAATACAGCAACATTACAACTGTTAAA
GAAGCAAATCCAGATTTATCCCATATATCGGATGTTATAAATTCATGTGATATATCTGTGCTTTCTGGAAATGATGAATT
AACCTTGCCCGTAATATCTCTCGGAGGTAATGGGGTTATTAGTGTTGTTGCCAACATAGTTCCAAATGAATTTGTCCAAA
TGGTAAATTATGCTAATGAAGGCAAATTTAAAGAGGCTCGTGAAATACATTATAAATTATTTAATCTTATGAAGTCCTTA
TTTATTGAAACTAATCCTGTGCCAATAAAAACCGCAATGAATTTATTAAATATGCCTGCTGGTGATTTACGACTTCCATT
ATGTAAAATGGAAGAAGAAAATAAATTTAAATTAGAAACAGCACTAAAAGAGTATGGGTTGTTATAA

Upstream 100 bases:

>100_bases
CAAAAGACTTAGAAATAGGGTTGCAGGATATGTAACTAAAAAAATGAAAAAAGTCGATGCATAATCAGTATGGTAGGTAT
ATGTCTTAATTGGTGATTTT

Downstream 100 bases:

>100_bases
ATAATACGGCCATACAAAAATTATAAATAGTTATAAATATATTATGGTATATTATAATTTATTTATGTGGTTTTTATGAT
AGATATTGAAAAAATACAAA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MQGVFPAIITPFKNGGVDYEGLEQNINFLIDNGVNGIVSVGTTGESPTLSHDEHKKIIEKSVSVCDGKVDVIAGAGSNST
EEAIALSQFAEDVGADSVLLITPYYNKPTQEGLKQHFSKIAESINIPIVLYNVPSRTAVNLQPETIKYLYEEYSNITTVK
EANPDLSHISDVINSCDISVLSGNDELTLPVISLGGNGVISVVANIVPNEFVQMVNYANEGKFKEAREIHYKLFNLMKSL
FIETNPVPIKTAMNLLNMPAGDLRLPLCKMEEENKFKLETALKEYGLL

Sequences:

>Translated_288_residues
MQGVFPAIITPFKNGGVDYEGLEQNINFLIDNGVNGIVSVGTTGESPTLSHDEHKKIIEKSVSVCDGKVDVIAGAGSNST
EEAIALSQFAEDVGADSVLLITPYYNKPTQEGLKQHFSKIAESINIPIVLYNVPSRTAVNLQPETIKYLYEEYSNITTVK
EANPDLSHISDVINSCDISVLSGNDELTLPVISLGGNGVISVVANIVPNEFVQMVNYANEGKFKEAREIHYKLFNLMKSL
FIETNPVPIKTAMNLLNMPAGDLRLPLCKMEEENKFKLETALKEYGLL
>Mature_288_residues
MQGVFPAIITPFKNGGVDYEGLEQNINFLIDNGVNGIVSVGTTGESPTLSHDEHKKIIEKSVSVCDGKVDVIAGAGSNST
EEAIALSQFAEDVGADSVLLITPYYNKPTQEGLKQHFSKIAESINIPIVLYNVPSRTAVNLQPETIKYLYEEYSNITTVK
EANPDLSHISDVINSCDISVLSGNDELTLPVISLGGNGVISVVANIVPNEFVQMVNYANEGKFKEAREIHYKLFNLMKSL
FIETNPVPIKTAMNLLNMPAGDLRLPLCKMEEENKFKLETALKEYGLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=285, Percent_Identity=25.2631578947368, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI13540533, Length=301, Percent_Identity=26.9102990033223, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1788823, Length=290, Percent_Identity=44.4827586206897, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=32.4324324324324, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1786463, Length=271, Percent_Identity=31.3653136531365, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789620, Length=273, Percent_Identity=26.7399267399267, Blast_Score=100, Evalue=8e-23,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_META3 (A6UVG7)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001325101.1
- ProteinModelPortal:   A6UVG7
- SMR:   A6UVG7
- STRING:   A6UVG7
- GeneID:   5327440
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0908
- eggNOG:   arNOG05039
- HOGENOM:   HBG358848
- OMA:   PAIITPF
- ProtClustDB:   PRK03170
- BioCyc:   MAEO419665:MAEO_0908-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31495; Mature: 31495

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 160-160 BINDING 104-104

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGVFPAIITPFKNGGVDYEGLEQNINFLIDNGVNGIVSVGTTGESPTLSHDEHKKIIEK
CCCCCCHHHCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHH
SVSVCDGKVDVIAGAGSNSTEEAIALSQFAEDVGADSVLLITPYYNKPTQEGLKQHFSKI
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH
AESINIPIVLYNVPSRTAVNLQPETIKYLYEEYSNITTVKEANPDLSHISDVINSCDISV
HHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCEEE
LSGNDELTLPVISLGGNGVISVVANIVPNEFVQMVNYANEGKFKEAREIHYKLFNLMKSL
EECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
FIETNPVPIKTAMNLLNMPAGDLRLPLCKMEEENKFKLETALKEYGLL
HHCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MQGVFPAIITPFKNGGVDYEGLEQNINFLIDNGVNGIVSVGTTGESPTLSHDEHKKIIEK
CCCCCCHHHCCCCCCCCCHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHH
SVSVCDGKVDVIAGAGSNSTEEAIALSQFAEDVGADSVLLITPYYNKPTQEGLKQHFSKI
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHH
AESINIPIVLYNVPSRTAVNLQPETIKYLYEEYSNITTVKEANPDLSHISDVINSCDISV
HHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCEEE
LSGNDELTLPVISLGGNGVISVVANIVPNEFVQMVNYANEGKFKEAREIHYKLFNLMKSL
EECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
FIETNPVPIKTAMNLLNMPAGDLRLPLCKMEEENKFKLETALKEYGLL
HHCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA