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The map label for this gene is purM [H]

Identifier: 150401239

GI number: 150401239

Start: 838565

End: 839620

Strand: Reverse

Name: purM [H]

Synonym: Maeo_0810

Alternate gene names: 150401239

Gene position: 839620-838565 (Counterclockwise)

Preceding gene: 150401240

Following gene: 150401236

Centisome position: 53.5

GC content: 32.77

Gene sequence:

>1056_bases
ATGATAACATATAAGGATGCAGGAGTAGATATTTACAAAGAAGATAAAATAATAAAGGCATTGGTATCACAAATAAAATT
TAAAAGAACAGACGACATAAAACCGGCCGAGGAATTGGCAGGACATTATGCTGGTGCAATTGAATTTGGGAATTATTATC
TTGTGCTATGTACCGATGGAGTAGGTAGTAAAATGATAGTGGCAGAAATGGCAGATAAATTTGATACTGTGCCTATTGAT
ATGATAGCTATGAATGTGAATGATGCTATTTGTATTGGGGCCGAGCCTGTTGCTCTTGTGGATTATATGGCTGTTGAGGA
CATTACAGAGGACATGGCAAAACAAATTGGAAAAGGATTAAATGAAGGATTAAAAGAATCAAATATAAATATAATTGGTG
GAGAAACTGCCTCACTTCCCGATATGGTAAAAGGTGTTGATATAGCTGGAACAGTTCTTGCCATTGCTGAAAAAGGTAAA
TTGATATTGGGTAAAGATATTAAAAAGGGAGATGTGATAGTTGGGCTTAGTAGTGCGGGAATACACAGTAATGGATTATC
CCTTGCAAGAAAAGTTTTATTCGATATTGCTGGTTTGGGTATAAATGATAAATTGTCATATGGAAAAACTGTTGCCGAGG
AGCTCCTAACTCCTACAAGAATATATGTAAAACCAGTAATGGAAATGATTAATTCCGAGGTTTTCGTTAAAGGATTGGCA
CATATTACCGGAGGCGGATTTAGAAAAATAATAAGATTAAACAAAAATATAGTTTATTTGATTGATAATTTGCCTGAACC
ATTGCCTATATTTAAAGAAATACAAAATATTGGAAATGTGAAAGACGAGGAAATGTTTAAAACATTTAATATGGGAATTG
GGTTCTGTGTTGTTGTAGATGAAAAAGATGCCGAAGAAATTATAAAAATATCTGAAAAGTATAATATTTCTGCTTCAATA
ATTGGAAAAATAGAGGACGAAGTAGAGGTAAATGGTAAAGTGGTTAAAAATACTGTTGTAGTTGATTATAATGGTAAAAA
AATGATAATGGAATAA

Upstream 100 bases:

>100_bases
ATAAATTAATAGTAAAATAGAATTATTAAGCAATTATAGTCAATCAACGAACACTTGGCATAATAGAACTATTACTATAA
AATACAATTTTGGTGAGAAA

Downstream 100 bases:

>100_bases
TAATTATAATATAGTCAATCTTCGGACAATTTCACTAAACCCCCTCTCATATTAAAATGCAAAATAACCATAAAATTAGC
AAAAATAAAACAATATTATA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MITYKDAGVDIYKEDKIIKALVSQIKFKRTDDIKPAEELAGHYAGAIEFGNYYLVLCTDGVGSKMIVAEMADKFDTVPID
MIAMNVNDAICIGAEPVALVDYMAVEDITEDMAKQIGKGLNEGLKESNINIIGGETASLPDMVKGVDIAGTVLAIAEKGK
LILGKDIKKGDVIVGLSSAGIHSNGLSLARKVLFDIAGLGINDKLSYGKTVAEELLTPTRIYVKPVMEMINSEVFVKGLA
HITGGGFRKIIRLNKNIVYLIDNLPEPLPIFKEIQNIGNVKDEEMFKTFNMGIGFCVVVDEKDAEEIIKISEKYNISASI
IGKIEDEVEVNGKVVKNTVVVDYNGKKMIME

Sequences:

>Translated_351_residues
MITYKDAGVDIYKEDKIIKALVSQIKFKRTDDIKPAEELAGHYAGAIEFGNYYLVLCTDGVGSKMIVAEMADKFDTVPID
MIAMNVNDAICIGAEPVALVDYMAVEDITEDMAKQIGKGLNEGLKESNINIIGGETASLPDMVKGVDIAGTVLAIAEKGK
LILGKDIKKGDVIVGLSSAGIHSNGLSLARKVLFDIAGLGINDKLSYGKTVAEELLTPTRIYVKPVMEMINSEVFVKGLA
HITGGGFRKIIRLNKNIVYLIDNLPEPLPIFKEIQNIGNVKDEEMFKTFNMGIGFCVVVDEKDAEEIIKISEKYNISASI
IGKIEDEVEVNGKVVKNTVVVDYNGKKMIME
>Mature_351_residues
MITYKDAGVDIYKEDKIIKALVSQIKFKRTDDIKPAEELAGHYAGAIEFGNYYLVLCTDGVGSKMIVAEMADKFDTVPID
MIAMNVNDAICIGAEPVALVDYMAVEDITEDMAKQIGKGLNEGLKESNINIIGGETASLPDMVKGVDIAGTVLAIAEKGK
LILGKDIKKGDVIVGLSSAGIHSNGLSLARKVLFDIAGLGINDKLSYGKTVAEELLTPTRIYVKPVMEMINSEVFVKGLA
HITGGGFRKIIRLNKNIVYLIDNLPEPLPIFKEIQNIGNVKDEEMFKTFNMGIGFCVVVDEKDAEEIIKISEKYNISASI
IGKIEDEVEVNGKVVKNTVVVDYNGKKMIME

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=384, Percent_Identity=31.25, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI209869995, Length=384, Percent_Identity=31.25, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI209869993, Length=384, Percent_Identity=31.25, Blast_Score=174, Evalue=9e-44,
Organism=Escherichia coli, GI1788845, Length=333, Percent_Identity=36.036036036036, Blast_Score=191, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17567511, Length=358, Percent_Identity=35.195530726257, Blast_Score=172, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321203, Length=367, Percent_Identity=30.5177111716621, Blast_Score=161, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24582400, Length=309, Percent_Identity=36.8932038834951, Blast_Score=184, Evalue=9e-47,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38229; Mature: 38229

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITYKDAGVDIYKEDKIIKALVSQIKFKRTDDIKPAEELAGHYAGAIEFGNYYLVLCTDG
CCEEECCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCEEEECCEEEEEEECC
VGSKMIVAEMADKFDTVPIDMIAMNVNDAICIGAEPVALVDYMAVEDITEDMAKQIGKGL
CCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
NEGLKESNINIIGGETASLPDMVKGVDIAGTVLAIAEKGKLILGKDIKKGDVIVGLSSAG
HHHHHHCCCEEECCCCCCCHHHHCCCCHHHHEEEEECCCCEEEECCCCCCCEEEEEECCC
IHSNGLSLARKVLFDIAGLGINDKLSYGKTVAEELLTPTRIYVKPVMEMINSEVFVKGLA
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
HITGGGFRKIIRLNKNIVYLIDNLPEPLPIFKEIQNIGNVKDEEMFKTFNMGIGFCVVVD
HHCCCHHHHHHEECCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEC
EKDAEEIIKISEKYNISASIIGKIEDEVEVNGKVVKNTVVVDYNGKKMIME
CCCHHHHHHHHHCCCCEEEEEECCCCCEECCCEEEEEEEEEEECCCEECCC
>Mature Secondary Structure
MITYKDAGVDIYKEDKIIKALVSQIKFKRTDDIKPAEELAGHYAGAIEFGNYYLVLCTDG
CCEEECCCCEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCEEEECCEEEEEEECC
VGSKMIVAEMADKFDTVPIDMIAMNVNDAICIGAEPVALVDYMAVEDITEDMAKQIGKGL
CCCHHHHHHHHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
NEGLKESNINIIGGETASLPDMVKGVDIAGTVLAIAEKGKLILGKDIKKGDVIVGLSSAG
HHHHHHCCCEEECCCCCCCHHHHCCCCHHHHEEEEECCCCEEEECCCCCCCEEEEEECCC
IHSNGLSLARKVLFDIAGLGINDKLSYGKTVAEELLTPTRIYVKPVMEMINSEVFVKGLA
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHH
HITGGGFRKIIRLNKNIVYLIDNLPEPLPIFKEIQNIGNVKDEEMFKTFNMGIGFCVVVD
HHCCCHHHHHHEECCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEC
EKDAEEIIKISEKYNISASIIGKIEDEVEVNGKVVKNTVVVDYNGKKMIME
CCCHHHHHHHHHCCCCEEEEEECCCCCEECCCEEEEEEEEEEECCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA