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The map label for this gene is flpA

Identifier: 150401190

GI number: 150401190

Start: 783184

End: 783879

Strand: Direct

Name: flpA

Synonym: Maeo_0761

Alternate gene names: 150401190

Gene position: 783184-783879 (Clockwise)

Preceding gene: 150401189

Following gene: 150401191

Centisome position: 49.9

GC content: 31.9

Gene sequence:

>696_bases
ATGGAAAAAGTAAAACTTAAAGAAATATTTAATAATATTTATGAATTAAAGTCAGATGATGGATTGAAAAGAATAGCCAC
AAAATCGTTGGTCCCGTCAAAAAGAATATACGGGGAAAAATTAATTACTGGCGAAGATAATTTAGAATATAGAATATGGA
ACCCAAATAGAAGTAAATTGGGTGCTGCAATAGTAAATGGATTAAAAACAATGCCAATAAAAAAAGGCTCAAAAGTGCTG
TATTTGGGAGTATCCGCAGGAACAACACCATCGCATGTTGCAGATATAACCGAAAATTCCCCAGTTTACTCAGTAGAATT
TGCACCGAGAATTATGAGAGAATTTTTAGATGTCTCCAAAGATAGAAAAAATTTAATCCCAATACTTGGAGATGCTACAA
ACCCAGTTGAATATTCAAATGTAGTTGAGGAAGTTGATGTGATTTTTGAAGATGTAGCACAACCAAAACAGGCCGAAATT
CTTGTAAATAATGCAAAATGGTTTTTAAAAGAGGGCGGCTATGGAATGATTTCAATTAAAGCGAGAAGTGTTGATGTACT
AAGAAACCCCAAAGAAATATTTGAAGAACAAAAACAAATATTAATAGAAGGGGGTTTTGAAATAGTAGATGAAGTGAATA
TTGAGCCTTTTGAAAAAGACCATATATTATTTGTTGGGATTTGGAATAAACAATAA

Upstream 100 bases:

>100_bases
AAAAAGATAAAAAAGATAAAAAAGTTAAAACTGAAAGAAAAATCATAGGCAAAACTTCATCAAAATATTAATAAATTTAC
ATAACTTAGAGGTTAAAAAA

Downstream 100 bases:

>100_bases
ATTTTAAGCAAATGTTCGCCGATTTACCCCCCCTATTTTTTTAAATATTTTTGGTGATATAATGAACAATAATTTAAATC
CTAAAAAAATAATTGAAATG

Product: fibrillarin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MEKVKLKEIFNNIYELKSDDGLKRIATKSLVPSKRIYGEKLITGEDNLEYRIWNPNRSKLGAAIVNGLKTMPIKKGSKVL
YLGVSAGTTPSHVADITENSPVYSVEFAPRIMREFLDVSKDRKNLIPILGDATNPVEYSNVVEEVDVIFEDVAQPKQAEI
LVNNAKWFLKEGGYGMISIKARSVDVLRNPKEIFEEQKQILIEGGFEIVDEVNIEPFEKDHILFVGIWNKQ

Sequences:

>Translated_231_residues
MEKVKLKEIFNNIYELKSDDGLKRIATKSLVPSKRIYGEKLITGEDNLEYRIWNPNRSKLGAAIVNGLKTMPIKKGSKVL
YLGVSAGTTPSHVADITENSPVYSVEFAPRIMREFLDVSKDRKNLIPILGDATNPVEYSNVVEEVDVIFEDVAQPKQAEI
LVNNAKWFLKEGGYGMISIKARSVDVLRNPKEIFEEQKQILIEGGFEIVDEVNIEPFEKDHILFVGIWNKQ
>Mature_231_residues
MEKVKLKEIFNNIYELKSDDGLKRIATKSLVPSKRIYGEKLITGEDNLEYRIWNPNRSKLGAAIVNGLKTMPIKKGSKVL
YLGVSAGTTPSHVADITENSPVYSVEFAPRIMREFLDVSKDRKNLIPILGDATNPVEYSNVVEEVDVIFEDVAQPKQAEI
LVNNAKWFLKEGGYGMISIKARSVDVLRNPKEIFEEQKQILIEGGFEIVDEVNIEPFEKDHILFVGIWNKQ

Specific function: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the sub

COG id: COG1889

COG function: function code J; Fibrillarin-like rRNA methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Fibrillarin family

Homologues:

Organism=Homo sapiens, GI12056465, Length=208, Percent_Identity=43.2692307692308, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17563672, Length=208, Percent_Identity=44.7115384615385, Blast_Score=186, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6320190, Length=217, Percent_Identity=40.5529953917051, Blast_Score=170, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17647425, Length=208, Percent_Identity=43.2692307692308, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24646406, Length=221, Percent_Identity=31.6742081447964, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FLPA_META3 (A6UV22)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324956.1
- ProteinModelPortal:   A6UV22
- SMR:   A6UV22
- STRING:   A6UV22
- GeneID:   5326418
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0761
- eggNOG:   arNOG06356
- HOGENOM:   HBG297404
- OMA:   VNIEPFE
- ProtClustDB:   PRK04266
- BioCyc:   MAEO419665:MAEO_0761-MONOMER
- HAMAP:   MF_00351
- InterPro:   IPR000692
- InterPro:   IPR020813
- PANTHER:   PTHR10335
- PIRSF:   PIRSF006540
- PRINTS:   PR00052

Pfam domain/function: PF01269 Fibrillarin

EC number: NA

Molecular weight: Translated: 26166; Mature: 26166

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00566 FIBRILLARIN

Important sites: BINDING 59-59 BINDING 151-151

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVKLKEIFNNIYELKSDDGLKRIATKSLVPSKRIYGEKLITGEDNLEYRIWNPNRSKL
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHCCCEEECCCCCCEEEEECCCHHHH
GAAIVNGLKTMPIKKGSKVLYLGVSAGTTPSHVADITENSPVYSVEFAPRIMREFLDVSK
HHHHHCCHHCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCC
DRKNLIPILGDATNPVEYSNVVEEVDVIFEDVAQPKQAEILVNNAKWFLKEGGYGMISIK
CCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCEEEEEEE
ARSVDVLRNPKEIFEEQKQILIEGGFEIVDEVNIEPFEKDHILFVGIWNKQ
ECCCHHHCCHHHHHHHHHHEEHHCCCEEEECCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MEKVKLKEIFNNIYELKSDDGLKRIATKSLVPSKRIYGEKLITGEDNLEYRIWNPNRSKL
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHCCCEEECCCCCCEEEEECCCHHHH
GAAIVNGLKTMPIKKGSKVLYLGVSAGTTPSHVADITENSPVYSVEFAPRIMREFLDVSK
HHHHHCCHHCCCCCCCCEEEEEEECCCCCHHHHHHCCCCCCEEEEEHHHHHHHHHHHCCC
DRKNLIPILGDATNPVEYSNVVEEVDVIFEDVAQPKQAEILVNNAKWFLKEGGYGMISIK
CCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECCCEEEEEEE
ARSVDVLRNPKEIFEEQKQILIEGGFEIVDEVNIEPFEKDHILFVGIWNKQ
ECCCHHHCCHHHHHHHHHHEEHHCCCEEEECCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA