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The map label for this gene is pcn

Identifier: 150401128

GI number: 150401128

Start: 718385

End: 719128

Strand: Direct

Name: pcn

Synonym: Maeo_0699

Alternate gene names: 150401128

Gene position: 718385-719128 (Clockwise)

Preceding gene: 150401127

Following gene: 150401129

Centisome position: 45.77

GC content: 27.69

Gene sequence:

>744_bases
ATGTTTAAAGCAGTAATGAATGCAAAAAATTTTAAAAAAATAATAGATTCCATAAGCAATTTAGTAGATGAAATTTGTTT
TGAAGTTGATGAACTAGGTATTAAAGCAAATGCCATGGATCCCTCTCATGTGGCATTAATTAGTGTAAATATACCAAAAG
AATCATTTGACGAATATGTTTCAGATACTCATGACATAGGCGTTGATTTAGAAGCCCTTAAAAAAATAATGAACAGGGCA
AAACCCAATGAAAAATTAATGTTAGAACTGGATATGGAAAAAAATAAATTAGATATCATATTAAAAAATGAAGGCACAAG
AAAATTTTCAATTTCATTGTATGATGTATCATCTTCAAATGTAAAAGTTCCAGAAATAGGATACCCCAATGAAGTTATGA
TTAAAGCGGGAACGATTGTTGAATCTTTAAAGGATGCAGAACTTGTAAATGACCATGTTAGTTTAAAAATTACAGAAGAT
GGTAAATTTATAATTTATTCCAAAGGAGATATTAACACAAATGAAACAGTTTTAGATAGGGATAACGAATCAATTATTGA
GTTAAAAATATCAGAATCCTCAAAAAGCACCTATAATTTAGCATATTTAAAAGATATAACAAAGGCAACTTCCTCAGAAG
ATATTTTGCATATTCATCTTGGCACAGATATGCCCGTAAAAATAGAATATATAATAGGAGATACAAAATTAATATATTTA
TTAGCTCCTAGAATAGAATCTTAA

Upstream 100 bases:

>100_bases
TATAAAGATAATTATTAATATATGTTGGTATTAATACTGTCATATGATAATTTACATATATCTCTTTTTATGGTTAAATT
AACATTATTTGGTGAAATAA

Downstream 100 bases:

>100_bases
ATCATAATTCAACATTATATATTATTTTATATATCATTAGAATATAGTAAATCTTCGAACTGTTTCACCCCGTTTATGCA
AATAAGACTATATTATATAA

Product: proliferating cell nuclear antigen PcnA

Products: NA

Alternate protein names: Proliferating cell nuclear antigen homolog; PCNA

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MFKAVMNAKNFKKIIDSISNLVDEICFEVDELGIKANAMDPSHVALISVNIPKESFDEYVSDTHDIGVDLEALKKIMNRA
KPNEKLMLELDMEKNKLDIILKNEGTRKFSISLYDVSSSNVKVPEIGYPNEVMIKAGTIVESLKDAELVNDHVSLKITED
GKFIIYSKGDINTNETVLDRDNESIIELKISESSKSTYNLAYLKDITKATSSEDILHIHLGTDMPVKIEYIIGDTKLIYL
LAPRIES

Sequences:

>Translated_247_residues
MFKAVMNAKNFKKIIDSISNLVDEICFEVDELGIKANAMDPSHVALISVNIPKESFDEYVSDTHDIGVDLEALKKIMNRA
KPNEKLMLELDMEKNKLDIILKNEGTRKFSISLYDVSSSNVKVPEIGYPNEVMIKAGTIVESLKDAELVNDHVSLKITED
GKFIIYSKGDINTNETVLDRDNESIIELKISESSKSTYNLAYLKDITKATSSEDILHIHLGTDMPVKIEYIIGDTKLIYL
LAPRIES
>Mature_247_residues
MFKAVMNAKNFKKIIDSISNLVDEICFEVDELGIKANAMDPSHVALISVNIPKESFDEYVSDTHDIGVDLEALKKIMNRA
KPNEKLMLELDMEKNKLDIILKNEGTRKFSISLYDVSSSNVKVPEIGYPNEVMIKAGTIVESLKDAELVNDHVSLKITED
GKFIIYSKGDINTNETVLDRDNESIIELKISESSKSTYNLAYLKDITKATSSEDILHIHLGTDMPVKIEYIIGDTKLIYL
LAPRIES

Specific function: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication

COG id: COG0592

COG function: function code L; DNA polymerase sliding clamp subunit (PCNA homolog)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PCNA family

Homologues:

Organism=Homo sapiens, GI33239451, Length=257, Percent_Identity=27.2373540856031, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI4505641, Length=257, Percent_Identity=27.2373540856031, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71995072, Length=223, Percent_Identity=27.8026905829596, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319564, Length=251, Percent_Identity=29.4820717131474, Blast_Score=93, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136790, Length=259, Percent_Identity=27.7992277992278, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45552759, Length=259, Percent_Identity=27.7992277992278, Blast_Score=98, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24585303, Length=241, Percent_Identity=21.9917012448133, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCNA_META3 (A6UUW0)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324894.1
- ProteinModelPortal:   A6UUW0
- SMR:   A6UUW0
- STRING:   A6UUW0
- GeneID:   5326566
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0699
- eggNOG:   arNOG05779
- HOGENOM:   HBG553564
- OMA:   ICRDLSQ
- ProtClustDB:   PRK01115
- BioCyc:   MAEO419665:MAEO_0699-MONOMER
- HAMAP:   MF_00317
- InterPro:   IPR000730
- InterPro:   IPR022649
- InterPro:   IPR022659
- InterPro:   IPR022648
- PANTHER:   PTHR11352
- PRINTS:   PR00339
- TIGRFAMs:   TIGR00590

Pfam domain/function: PF02747 PCNA_C; PF00705 PCNA_N

EC number: NA

Molecular weight: Translated: 27743; Mature: 27743

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS01251 PCNA_1; PS00293 PCNA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKAVMNAKNFKKIIDSISNLVDEICFEVDELGIKANAMDPSHVALISVNIPKESFDEYV
CCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEEECCHHHHHHHH
SDTHDIGVDLEALKKIMNRAKPNEKLMLELDMEKNKLDIILKNEGTRKFSISLYDVSSSN
CCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEEEEEECCCC
VKVPEIGYPNEVMIKAGTIVESLKDAELVNDHVSLKITEDGKFIIYSKGDINTNETVLDR
EECCCCCCCCEEEEEECHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEEC
DNESIIELKISESSKSTYNLAYLKDITKATSSEDILHIHLGTDMPVKIEYIIGDTKLIYL
CCCEEEEEEEECCCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCEEEEE
LAPRIES
ECCCCCC
>Mature Secondary Structure
MFKAVMNAKNFKKIIDSISNLVDEICFEVDELGIKANAMDPSHVALISVNIPKESFDEYV
CCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEEEEECCHHHHHHHH
SDTHDIGVDLEALKKIMNRAKPNEKLMLELDMEKNKLDIILKNEGTRKFSISLYDVSSSN
CCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEECCCCEEEEEEEEEECCCC
VKVPEIGYPNEVMIKAGTIVESLKDAELVNDHVSLKITEDGKFIIYSKGDINTNETVLDR
EECCCCCCCCEEEEEECHHHHHHHHHHHCCCCEEEEEECCCCEEEEECCCCCCCCEEEEC
DNESIIELKISESSKSTYNLAYLKDITKATSSEDILHIHLGTDMPVKIEYIIGDTKLIYL
CCCEEEEEEEECCCCCEEEEHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEECCCEEEEE
LAPRIES
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA