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The map label for this gene is argG [H]

Identifier: 150401052

GI number: 150401052

Start: 640492

End: 641697

Strand: Reverse

Name: argG [H]

Synonym: Maeo_0622

Alternate gene names: 150401052

Gene position: 641697-640492 (Counterclockwise)

Preceding gene: 150401053

Following gene: 150401051

Centisome position: 40.89

GC content: 33.5

Gene sequence:

>1206_bases
ATGACAAACGAAAACAAAGAAAAAATAGCAGTTTTGGCATATTCTGGTGGATTAGACACAAGTTGTTGTTTAAAACTATT
GGAAGAAAATTATAATTATAAGGTAGTAACTGCCTGTGTAGATGTGGGACAACCAGAGGAGGAAATAACAAAACCAGTGG
AAAAAGCAAAAGAATACGGAGTATTTGCCCATTATACCATAGATGCTAAGGAGGAATTTGCAAAAGAATATATATTCAGA
GCAATTAAAGCAAATGCAATATATGAAGGATACCCACTATCAACAGCACTTGCAAGACCCCTTATAGGTTTAAAATTAGT
AGAATTGGCAAAAGAATTAAATGCAGAGGCAATATCTCATGGTTGCACCGGAAAAGGAAATGACCAATTTAGATTTGAAT
CAATTATGAGGGCAAAAGCACCAGAAGTTAAAATAATTGCTCCAATTAGGGATTTAAACCTTACAAGAAGTGAAGAAATA
GAATATGCTAAAAAACACGGAATACCAATCCCAACAGAAAGCAAAAAATATAGTATTGACGAAAACCTTTGGGGAAGAAG
TGTGGAGGGGGGAGAATTAGAAGACCCAATGTTTGAAACACCAGAGGAAGCTTATGGTTGGACTAAAAATCCAATGGAAT
GCACAGGGCCAGAATATGTTGAGATAGAATTTGAAAATGGTATTCCGGTAAAAATAAATAATAAAGAATATGATGCAGTG
GAATTAATAAGGGAAGCTAATAAAATTGCTGGAAGAAATGGGGTAGGTAGAGTAGATATAATTGAGGATAGGATTTTAGG
ATTAAAATCAAGAGAAAACTACGAATGTCCGGGGGCTATAATGCTTATTACGGCACATAAGGCACTTGAACAATTAACAC
TAACCAGAGAAGAGATTAAATTTAAAGAAATAGTAGATTCCACTTATGCAGATTTAATATATAAAGGATTATGGCATGAA
CCACTTAGGTTGGATTTAGATGCTTTCATTGATAAAACACAGGAAAGAGTAAGTGGAAAAGTGGTTGTAAAATTATATGC
TGGTTCAATCAGAGTTGTAGGAAAAGAAAGCAATTATGCACTATTTAGCCAAGAATTAGTTTCATTTGAGGATAAAGAAA
TAGACCAAAGAGAAACAATAGGGGCTGTTAAATTCCATGGATTACAAGCTTCAATATATGAATCTGTGAAAAATAAAAAT
AAATAA

Upstream 100 bases:

>100_bases
AAAAAAGGTGAAGTAAATCAAAGATTAGATGAAATCCTGCGGATTTCATTGCTTGACCTATCGGTCGATTTACTAAACCA
AAAAAAGAAATGGTGAGATA

Downstream 100 bases:

>100_bases
AAATATACATTTTAACATACTATTTTTTAACTTTTTTAAATTTAAAATCCTGTCTTTTTTTCAAGTTATTCAATTACTAT
TATATTATAAAATTATAAAA

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTNENKEKIAVLAYSGGLDTSCCLKLLEENYNYKVVTACVDVGQPEEEITKPVEKAKEYGVFAHYTIDAKEEFAKEYIFR
AIKANAIYEGYPLSTALARPLIGLKLVELAKELNAEAISHGCTGKGNDQFRFESIMRAKAPEVKIIAPIRDLNLTRSEEI
EYAKKHGIPIPTESKKYSIDENLWGRSVEGGELEDPMFETPEEAYGWTKNPMECTGPEYVEIEFENGIPVKINNKEYDAV
ELIREANKIAGRNGVGRVDIIEDRILGLKSRENYECPGAIMLITAHKALEQLTLTREEIKFKEIVDSTYADLIYKGLWHE
PLRLDLDAFIDKTQERVSGKVVVKLYAGSIRVVGKESNYALFSQELVSFEDKEIDQRETIGAVKFHGLQASIYESVKNKN
K

Sequences:

>Translated_401_residues
MTNENKEKIAVLAYSGGLDTSCCLKLLEENYNYKVVTACVDVGQPEEEITKPVEKAKEYGVFAHYTIDAKEEFAKEYIFR
AIKANAIYEGYPLSTALARPLIGLKLVELAKELNAEAISHGCTGKGNDQFRFESIMRAKAPEVKIIAPIRDLNLTRSEEI
EYAKKHGIPIPTESKKYSIDENLWGRSVEGGELEDPMFETPEEAYGWTKNPMECTGPEYVEIEFENGIPVKINNKEYDAV
ELIREANKIAGRNGVGRVDIIEDRILGLKSRENYECPGAIMLITAHKALEQLTLTREEIKFKEIVDSTYADLIYKGLWHE
PLRLDLDAFIDKTQERVSGKVVVKLYAGSIRVVGKESNYALFSQELVSFEDKEIDQRETIGAVKFHGLQASIYESVKNKN
K
>Mature_400_residues
TNENKEKIAVLAYSGGLDTSCCLKLLEENYNYKVVTACVDVGQPEEEITKPVEKAKEYGVFAHYTIDAKEEFAKEYIFRA
IKANAIYEGYPLSTALARPLIGLKLVELAKELNAEAISHGCTGKGNDQFRFESIMRAKAPEVKIIAPIRDLNLTRSEEIE
YAKKHGIPIPTESKKYSIDENLWGRSVEGGELEDPMFETPEEAYGWTKNPMECTGPEYVEIEFENGIPVKINNKEYDAVE
LIREANKIAGRNGVGRVDIIEDRILGLKSRENYECPGAIMLITAHKALEQLTLTREEIKFKEIVDSTYADLIYKGLWHEP
LRLDLDAFIDKTQERVSGKVVVKLYAGSIRVVGKESNYALFSQELVSFEDKEIDQRETIGAVKFHGLQASIYESVKNKNK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=405, Percent_Identity=40.7407407407407, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI16950633, Length=405, Percent_Identity=40.7407407407407, Blast_Score=274, Evalue=9e-74,
Organism=Escherichia coli, GI1789563, Length=360, Percent_Identity=30.2777777777778, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6324514, Length=364, Percent_Identity=39.2857142857143, Blast_Score=225, Evalue=9e-60,
Organism=Drosophila melanogaster, GI21358151, Length=377, Percent_Identity=38.7267904509284, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 45280; Mature: 45149

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNENKEKIAVLAYSGGLDTSCCLKLLEENYNYKVVTACVDVGQPEEEITKPVEKAKEYG
CCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCC
VFAHYTIDAKEEFAKEYIFRAIKANAIYEGYPLSTALARPLIGLKLVELAKELNAEAISH
EEEEEEECCHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHC
GCTGKGNDQFRFESIMRAKAPEVKIIAPIRDLNLTRSEEIEYAKKHGIPIPTESKKYSID
CCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEECC
ENLWGRSVEGGELEDPMFETPEEAYGWTKNPMECTGPEYVEIEFENGIPVKINNKEYDAV
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCHHHH
ELIREANKIAGRNGVGRVDIIEDRILGLKSRENYECPGAIMLITAHKALEQLTLTREEIK
HHHHHHHHHCCCCCCCCEEEEHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHH
FKEIVDSTYADLIYKGLWHEPLRLDLDAFIDKTQERVSGKVVVKLYAGSIRVVGKESNYA
HHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHCCCEEEEEEEECEEEEEECCCCCH
LFSQELVSFEDKEIDQRETIGAVKFHGLQASIYESVKNKNK
HHHHHHHCCCCCCCCHHHHCCCEEECCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TNENKEKIAVLAYSGGLDTSCCLKLLEENYNYKVVTACVDVGQPEEEITKPVEKAKEYG
CCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCC
VFAHYTIDAKEEFAKEYIFRAIKANAIYEGYPLSTALARPLIGLKLVELAKELNAEAISH
EEEEEEECCHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHC
GCTGKGNDQFRFESIMRAKAPEVKIIAPIRDLNLTRSEEIEYAKKHGIPIPTESKKYSID
CCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCEECC
ENLWGRSVEGGELEDPMFETPEEAYGWTKNPMECTGPEYVEIEFENGIPVKINNKEYDAV
CCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCHHHH
ELIREANKIAGRNGVGRVDIIEDRILGLKSRENYECPGAIMLITAHKALEQLTLTREEIK
HHHHHHHHHCCCCCCCCEEEEHHHHHCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHH
FKEIVDSTYADLIYKGLWHEPLRLDLDAFIDKTQERVSGKVVVKLYAGSIRVVGKESNYA
HHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHCCCEEEEEEEECEEEEEECCCCCH
LFSQELVSFEDKEIDQRETIGAVKFHGLQASIYESVKNKNK
HHHHHHHCCCCCCCCHHHHCCCEEECCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA