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The map label for this gene is tmk

Identifier: 150400777

GI number: 150400777

Start: 364699

End: 365289

Strand: Reverse

Name: tmk

Synonym: Maeo_0344

Alternate gene names: 150400777

Gene position: 365289-364699 (Counterclockwise)

Preceding gene: 150400778

Following gene: 150400775

Centisome position: 23.27

GC content: 27.07

Gene sequence:

>591_bases
ATGAACAAATTTATAGTGTTTGAAGGAATTGATGGAAGCGGAAAAACCACTCAGGCAAAATTATTAGCCGATTATTTAAA
TGGAATTTATACCTGCGAACCTACAAATGGAGAAATAGGTCAATTAATTAGAAAGGTGTTGGGCGGTAAAAACTGCGAAA
AGGAATCGTTGGCTTTACTTTTTGCAGGAGATAGGGTGGAACATATTAAAGAAATAGAGCACAAATTGATAGAAAATATG
GTAATTTGTGATAGATATGTTTATTCCTCCATGGTTTATCAATCGATTCAAGGTATTGATATTGATTTTATTGCAAGTAT
AAACAGATTTGCAAAAATACCTGATGTTTTAATATATTTAGATGTTTCTATTGAAGAATCATTAAAAAGAATGGGGGATA
GGGACAGTAAAGAAATATTTGAAAATAAAGAAATATTGCAAAAAGTAAATAAAAAATATATGAATATTATAAATGAAAGA
TTATTTGAACCAAAAAACGGATATATTTTAATAAATACAGACAATAAAACAGTTGAGGAAGTCCATAAAGAGATAATTAA
AAAATTAATGGATAAAAAAATAATTCTTTAA

Upstream 100 bases:

>100_bases
AGATATTATTAATATTATTCATTATAATTTACTTTTTTTTATTGTTGGTGTTATTACGAAATTAATATGATTATTTGTTA
TTGTTGTTTTTGGTGTTATT

Downstream 100 bases:

>100_bases
AAACCGAAGGATTTTACATTTATTTATTATTTGCAGTCAATCTTCGGACGATTTCTCGTAATACCATAATTAAAAAGGAC
AAAATCCTCATATATTATAC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MNKFIVFEGIDGSGKTTQAKLLADYLNGIYTCEPTNGEIGQLIRKVLGGKNCEKESLALLFAGDRVEHIKEIEHKLIENM
VICDRYVYSSMVYQSIQGIDIDFIASINRFAKIPDVLIYLDVSIEESLKRMGDRDSKEIFENKEILQKVNKKYMNIINER
LFEPKNGYILINTDNKTVEEVHKEIIKKLMDKKIIL

Sequences:

>Translated_196_residues
MNKFIVFEGIDGSGKTTQAKLLADYLNGIYTCEPTNGEIGQLIRKVLGGKNCEKESLALLFAGDRVEHIKEIEHKLIENM
VICDRYVYSSMVYQSIQGIDIDFIASINRFAKIPDVLIYLDVSIEESLKRMGDRDSKEIFENKEILQKVNKKYMNIINER
LFEPKNGYILINTDNKTVEEVHKEIIKKLMDKKIIL
>Mature_196_residues
MNKFIVFEGIDGSGKTTQAKLLADYLNGIYTCEPTNGEIGQLIRKVLGGKNCEKESLALLFAGDRVEHIKEIEHKLIENM
VICDRYVYSSMVYQSIQGIDIDFIASINRFAKIPDVLIYLDVSIEESLKRMGDRDSKEIFENKEILQKVNKKYMNIINER
LFEPKNGYILINTDNKTVEEVHKEIIKKLMDKKIIL

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Caenorhabditis elegans, GI17535647, Length=163, Percent_Identity=33.1288343558282, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322517, Length=195, Percent_Identity=25.6410256410256, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573735, Length=192, Percent_Identity=32.2916666666667, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_META3 (A6UTV9)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324543.1
- ProteinModelPortal:   A6UTV9
- STRING:   A6UTV9
- GeneID:   5327176
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0344
- eggNOG:   arNOG06813
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- ProtClustDB:   PRK13975
- BioCyc:   MAEO419665:MAEO_0344-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22596; Mature: 22596

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFIVFEGIDGSGKTTQAKLLADYLNGIYTCEPTNGEIGQLIRKVLGGKNCEKESLALL
CCCEEEEECCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCHHHEEEE
FAGDRVEHIKEIEHKLIENMVICDRYVYSSMVYQSIQGIDIDFIASINRFAKIPDVLIYL
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEE
DVSIEESLKRMGDRDSKEIFENKEILQKVNKKYMNIINERLFEPKNGYILINTDNKTVEE
ECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
VHKEIIKKLMDKKIIL
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKFIVFEGIDGSGKTTQAKLLADYLNGIYTCEPTNGEIGQLIRKVLGGKNCEKESLALL
CCCEEEEECCCCCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCHHHEEEE
FAGDRVEHIKEIEHKLIENMVICDRYVYSSMVYQSIQGIDIDFIASINRFAKIPDVLIYL
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEE
DVSIEESLKRMGDRDSKEIFENKEILQKVNKKYMNIINERLFEPKNGYILINTDNKTVEE
ECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
VHKEIIKKLMDKKIIL
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA