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The map label for this gene is lysA [H]

Identifier: 150400645

GI number: 150400645

Start: 221176

End: 222483

Strand: Direct

Name: lysA [H]

Synonym: Maeo_0207

Alternate gene names: 150400645

Gene position: 221176-222483 (Clockwise)

Preceding gene: 150400642

Following gene: 150400648

Centisome position: 14.09

GC content: 32.65

Gene sequence:

>1308_bases
GTGTTTTTAGGAAATGAAATGATTACAGTGGAAAATAATAAATTAAAAATAGATGGATTTGATGTATCAGAATTAGCTGA
ACAGCATGGCACACCATTATATGTAATGAGTGAAAGTCAAATAGTAAAAAACTTTACAAGATATACCGAGGCATTTAAAG
AATATTCAGAAAAAACAGGAAAAGAATTTATAGTATCATATGCCTACAAAGCTAACTCTAATTTAGCAGTATTAAAAATA
TTAACAAATTTAGGTTGCGGTGCTGATGTTGTAAGTGGGGGGGAGCTCTACACAGCAAAAATGGTATCCGTTGATTCCTC
AAAAATAGTATTTAATGGAAATTGTAAATTAGAGGAAGAAATAATAATGGGAATTGAAACAAATATAAGAGCTTTTAATG
TAGATAGTATTAGCGAATTAGAATTAATAAACGAAGTGGCTGGAAAATTGGGAAAAGTTGCAAATGTGGCTTTCAGAATT
AACCCAAATGTAAATCCAAAAACCCACCCAAAAATATCAACAGGATTAAAAAGTAATAAATTTGGTTTAGATGTTGAAGC
AGGAATTGCCTTAAAAGCAATTAAAATGGCAAAAGAAATGAAAAATGTAAAAATTGTTGGTATCCACTGTCATATTGGCT
CCCAATTAACAGATATTAGTCCATTTGTTGAAGAAACTAAAAAAGTTATGGACTTTGTAGTATCATTAAAAGAACAAGGT
ATAAAAATTGAAGATGTTAATATTGGTGGAGGATTAGGAGTTCCATACGATAAAAACACAGAAATACCTGTTCAAAAAGA
TTTGGCAAATGCCGTAATAAATACCATGTTGGAATATGCCGATAAAGTGGAGCTCCCCAACTTAATCATAGAGCCGGGAA
GAAGTTTAGTAGCTACGGCTGGTGTGTTGTTGGGAAAAGTTCACCATATAAAAGAAACACCATCTGCAAAATGGATTATG
ATTGATGCAGGAATGAATGATATGATGAGGCCTGCAATTTATGAGGCATATCATGAAATTACACCCTGCACCATAAGGGA
TGAAAAAGAAGTTGTAAATATTGCAGGAGGATTATGTGAAAGCTCCGATGTATTTGGTAAAGAAAGGGAGCTCCCTAAAA
TAGAAGTAAAAGACACAATTGCAATATTGGATGTTGGGGCATATGGTATAAGTATGGCCAACAATTACAACGCAAGAGGA
ATTTCTAAAATGATTTTAACAAGTGAAGATGGGGCGTATACAATAAGAGAAAGAGAAACCTATGCAGATTTACTTTCTAA
AGACATTATTCCTCCTAAGTATTTGTAA

Upstream 100 bases:

>100_bases
TTTATACTTAATATAAACTAATATTATAATAGTATGCAATAATTATATACAATTATAAATAAAATATAAAATTTATTTAT
ACAATATTTTTGGTGAAATT

Downstream 100 bases:

>100_bases
TCGTGATGGTCGTTGAATAACTAATAAAAAAAGTAGAGATAATATTTTTTATTTTTTATTTTTTTAATAATTCATCTTTA
TGATTTCTTCTTATCTATTT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MFLGNEMITVENNKLKIDGFDVSELAEQHGTPLYVMSESQIVKNFTRYTEAFKEYSEKTGKEFIVSYAYKANSNLAVLKI
LTNLGCGADVVSGGELYTAKMVSVDSSKIVFNGNCKLEEEIIMGIETNIRAFNVDSISELELINEVAGKLGKVANVAFRI
NPNVNPKTHPKISTGLKSNKFGLDVEAGIALKAIKMAKEMKNVKIVGIHCHIGSQLTDISPFVEETKKVMDFVVSLKEQG
IKIEDVNIGGGLGVPYDKNTEIPVQKDLANAVINTMLEYADKVELPNLIIEPGRSLVATAGVLLGKVHHIKETPSAKWIM
IDAGMNDMMRPAIYEAYHEITPCTIRDEKEVVNIAGGLCESSDVFGKERELPKIEVKDTIAILDVGAYGISMANNYNARG
ISKMILTSEDGAYTIRERETYADLLSKDIIPPKYL

Sequences:

>Translated_435_residues
MFLGNEMITVENNKLKIDGFDVSELAEQHGTPLYVMSESQIVKNFTRYTEAFKEYSEKTGKEFIVSYAYKANSNLAVLKI
LTNLGCGADVVSGGELYTAKMVSVDSSKIVFNGNCKLEEEIIMGIETNIRAFNVDSISELELINEVAGKLGKVANVAFRI
NPNVNPKTHPKISTGLKSNKFGLDVEAGIALKAIKMAKEMKNVKIVGIHCHIGSQLTDISPFVEETKKVMDFVVSLKEQG
IKIEDVNIGGGLGVPYDKNTEIPVQKDLANAVINTMLEYADKVELPNLIIEPGRSLVATAGVLLGKVHHIKETPSAKWIM
IDAGMNDMMRPAIYEAYHEITPCTIRDEKEVVNIAGGLCESSDVFGKERELPKIEVKDTIAILDVGAYGISMANNYNARG
ISKMILTSEDGAYTIRERETYADLLSKDIIPPKYL
>Mature_435_residues
MFLGNEMITVENNKLKIDGFDVSELAEQHGTPLYVMSESQIVKNFTRYTEAFKEYSEKTGKEFIVSYAYKANSNLAVLKI
LTNLGCGADVVSGGELYTAKMVSVDSSKIVFNGNCKLEEEIIMGIETNIRAFNVDSISELELINEVAGKLGKVANVAFRI
NPNVNPKTHPKISTGLKSNKFGLDVEAGIALKAIKMAKEMKNVKIVGIHCHIGSQLTDISPFVEETKKVMDFVVSLKEQG
IKIEDVNIGGGLGVPYDKNTEIPVQKDLANAVINTMLEYADKVELPNLIIEPGRSLVATAGVLLGKVHHIKETPSAKWIM
IDAGMNDMMRPAIYEAYHEITPCTIRDEKEVVNIAGGLCESSDVFGKERELPKIEVKDTIAILDVGAYGISMANNYNARG
ISKMILTSEDGAYTIRERETYADLLSKDIIPPKYL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=389, Percent_Identity=25.1928020565553, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789203, Length=422, Percent_Identity=31.042654028436, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1789307, Length=336, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562780, Length=370, Percent_Identity=26.7567567567568, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24586472, Length=355, Percent_Identity=23.0985915492958, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586474, Length=347, Percent_Identity=25.0720461095101, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47824; Mature: 47824

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLGNEMITVENNKLKIDGFDVSELAEQHGTPLYVMSESQIVKNFTRYTEAFKEYSEKTG
CCCCCEEEEEECCEEEECCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC
KEFIVSYAYKANSNLAVLKILTNLGCGADVVSGGELYTAKMVSVDSSKIVFNGNCKLEEE
CEEEEEEEEECCCCEEEEEEHHHCCCCCCCCCCCCEEEEEEEEECCCEEEECCCCCCCHH
IIMGIETNIRAFNVDSISELELINEVAGKLGKVANVAFRINPNVNPKTHPKISTGLKSNK
EEEEEECCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHCCCCCCC
FGLDVEAGIALKAIKMAKEMKNVKIVGIHCHIGSQLTDISPFVEETKKVMDFVVSLKEQG
CCCEECCCHHHHHHHHHHHHCCEEEEEEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHCC
IKIEDVNIGGGLGVPYDKNTEIPVQKDLANAVINTMLEYADKVELPNLIIEPGRSLVATA
CEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHH
GVLLGKVHHIKETPSAKWIMIDAGMNDMMRPAIYEAYHEITPCTIRDEKEVVNIAGGLCE
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCCCC
SSDVFGKERELPKIEVKDTIAILDVGAYGISMANNYNARGISKMILTSEDGAYTIRERET
CCCCCCCCCCCCEEEECCEEEEEEECCHHEEECCCCCCCCEEEEEEECCCCCEEEEHHHH
YADLLSKDIIPPKYL
HHHHHHHCCCCCCCC
>Mature Secondary Structure
MFLGNEMITVENNKLKIDGFDVSELAEQHGTPLYVMSESQIVKNFTRYTEAFKEYSEKTG
CCCCCEEEEEECCEEEECCCCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCC
KEFIVSYAYKANSNLAVLKILTNLGCGADVVSGGELYTAKMVSVDSSKIVFNGNCKLEEE
CEEEEEEEEECCCCEEEEEEHHHCCCCCCCCCCCCEEEEEEEEECCCEEEECCCCCCCHH
IIMGIETNIRAFNVDSISELELINEVAGKLGKVANVAFRINPNVNPKTHPKISTGLKSNK
EEEEEECCCEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHCCCCCCC
FGLDVEAGIALKAIKMAKEMKNVKIVGIHCHIGSQLTDISPFVEETKKVMDFVVSLKEQG
CCCEECCCHHHHHHHHHHHHCCEEEEEEEEECCCCCHHCHHHHHHHHHHHHHHHHHHHCC
IKIEDVNIGGGLGVPYDKNTEIPVQKDLANAVINTMLEYADKVELPNLIIEPGRSLVATA
CEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHH
GVLLGKVHHIKETPSAKWIMIDAGMNDMMRPAIYEAYHEITPCTIRDEKEVVNIAGGLCE
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEECCCHHHHHHHCCCCC
SSDVFGKERELPKIEVKDTIAILDVGAYGISMANNYNARGISKMILTSEDGAYTIRERET
CCCCCCCCCCCCEEEECCEEEEEEECCHHEEECCCCCCCCEEEEEEECCCCCEEEEHHHH
YADLLSKDIIPPKYL
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]