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The map label for this gene is hisG

Identifier: 150400575

GI number: 150400575

Start: 154454

End: 155320

Strand: Reverse

Name: hisG

Synonym: Maeo_0137

Alternate gene names: 150400575

Gene position: 155320-154454 (Counterclockwise)

Preceding gene: 150400581

Following gene: 150400571

Centisome position: 9.9

GC content: 31.14

Gene sequence:

>867_bases
TTGATTTTATTAGCACTACCAAATAAAGGAAGAATTTCCGAACCAATTAATAAAATATTGGACAAAGCAGGCTTAAAAAT
ATCAGCACGGGGGCGAAGCTTATTTGCAAAAACTGTTGATGAGGAAATAGAAGTAATGTTTGCAAGGGCTAGAGACATTC
CAGAATTTGTTGCAGACGGTGTTGCAGATGTTGGAATTACTGGCTATGATTTAATCTGTGAAAGAGATACAGAAAACTCA
GTGGAATTTTTATTAGATTTCAATTTTGGAAAGGCTAATTTAGTAATAGCATCTCCCGAAGATTCAGATATTAATTCAAT
CAATGATTTAAAAAATGGCATGAAAATAGCCACAGAATTTCCCCATATTACAAAAAAATATTTGGAAAGTAAAAATCTTG
ATTTAGAAATTATAGAGTTAAGCGGGGCAACAGAAATTGCACCATTTATAGGAGTTGCAGACCTTATAAGCGATTTAACT
TCAACTGGAACAACGCTAAAATTAAACAGATTAAAACAAATAGATACAATAGTAAAATCCACCACACGACTAATAGCCAA
TAAAAAAAGCATGGTAGACGAAAATAAACGATTAAAAATAAATCAAATTACATCGGGAATAAAAAGTGTTCTTTATGCCC
AGACAAAACGATTAATTATGATGAATGCCCCAAAGGATAAAGTAAATGAAATTAAACAAATTATTCCAGGCATGAGCGGA
CCTACAATATCAGAGGTATTATCAAATGATAAAGTAGTTGCCGTTAATGTTGTAGTTGATGAAAAACAGGTATTTAAAAT
AGTTTCAGAATTAGAATTAATAGGAGCAAAAGATATACTTGTGCTACCAATTGAAAGAATTTTATAA

Upstream 100 bases:

>100_bases
ATTTGTTATGTATATATGTTATATATCATATTAATTTATTATTAGTTTATTAATTAATTTATAAGTTATTTAATTAGTTT
ATAATTTTATCGGTGATATA

Downstream 100 bases:

>100_bases
TATATTATTTTATTATTATTTTATTTTTTATTCAAAATATCAGCCAAATATTTTAAAATCTCCCCTGGAACATCTGCAAA
ATTCATAATTCCCCTAAATT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MILLALPNKGRISEPINKILDKAGLKISARGRSLFAKTVDEEIEVMFARARDIPEFVADGVADVGITGYDLICERDTENS
VEFLLDFNFGKANLVIASPEDSDINSINDLKNGMKIATEFPHITKKYLESKNLDLEIIELSGATEIAPFIGVADLISDLT
STGTTLKLNRLKQIDTIVKSTTRLIANKKSMVDENKRLKINQITSGIKSVLYAQTKRLIMMNAPKDKVNEIKQIIPGMSG
PTISEVLSNDKVVAVNVVVDEKQVFKIVSELELIGAKDILVLPIERIL

Sequences:

>Translated_288_residues
MILLALPNKGRISEPINKILDKAGLKISARGRSLFAKTVDEEIEVMFARARDIPEFVADGVADVGITGYDLICERDTENS
VEFLLDFNFGKANLVIASPEDSDINSINDLKNGMKIATEFPHITKKYLESKNLDLEIIELSGATEIAPFIGVADLISDLT
STGTTLKLNRLKQIDTIVKSTTRLIANKKSMVDENKRLKINQITSGIKSVLYAQTKRLIMMNAPKDKVNEIKQIIPGMSG
PTISEVLSNDKVVAVNVVVDEKQVFKIVSELELIGAKDILVLPIERIL
>Mature_288_residues
MILLALPNKGRISEPINKILDKAGLKISARGRSLFAKTVDEEIEVMFARARDIPEFVADGVADVGITGYDLICERDTENS
VEFLLDFNFGKANLVIASPEDSDINSINDLKNGMKIATEFPHITKKYLESKNLDLEIIELSGATEIAPFIGVADLISDLT
STGTTLKLNRLKQIDTIVKSTTRLIANKKSMVDENKRLKINQITSGIKSVLYAQTKRLIMMNAPKDKVNEIKQIIPGMSG
PTISEVLSNDKVVAVNVVVDEKQVFKIVSELELIGAKDILVLPIERIL

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=292, Percent_Identity=33.9041095890411, Blast_Score=174, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6320896, Length=289, Percent_Identity=30.4498269896194, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_META3 (A6UTA7)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324341.1
- ProteinModelPortal:   A6UTA7
- SMR:   A6UTA7
- STRING:   A6UTA7
- GeneID:   5326854
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0137
- eggNOG:   arNOG04876
- HOGENOM:   HBG391868
- OMA:   LLMFRAE
- ProtClustDB:   PRK00489
- BioCyc:   MAEO419665:MAEO_0137-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 31749; Mature: 31749

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLALPNKGRISEPINKILDKAGLKISARGRSLFAKTVDEEIEVMFARARDIPEFVADG
CEEEEECCCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHCC
VADVGITGYDLICERDTENSVEFLLDFNFGKANLVIASPEDSDINSINDLKNGMKIATEF
HHHCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHCCCEEHHCC
PHITKKYLESKNLDLEIIELSGATEIAPFIGVADLISDLTSTGTTLKLNRLKQIDTIVKS
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
TTRLIANKKSMVDENKRLKINQITSGIKSVLYAQTKRLIMMNAPKDKVNEIKQIIPGMSG
HHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCC
PTISEVLSNDKVVAVNVVVDEKQVFKIVSELELIGAKDILVLPIERIL
CHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHCCCCCEEEECHHHHC
>Mature Secondary Structure
MILLALPNKGRISEPINKILDKAGLKISARGRSLFAKTVDEEIEVMFARARDIPEFVADG
CEEEEECCCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHCC
VADVGITGYDLICERDTENSVEFLLDFNFGKANLVIASPEDSDINSINDLKNGMKIATEF
HHHCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEECCCCCCCHHHHHHHCCCEEHHCC
PHITKKYLESKNLDLEIIELSGATEIAPFIGVADLISDLTSTGTTLKLNRLKQIDTIVKS
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHH
TTRLIANKKSMVDENKRLKINQITSGIKSVLYAQTKRLIMMNAPKDKVNEIKQIIPGMSG
HHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCC
PTISEVLSNDKVVAVNVVVDEKQVFKIVSELELIGAKDILVLPIERIL
CHHHHHHCCCCEEEEEEEECHHHHHHHHHHHHHCCCCCEEEECHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA