Click here to switch to the map view.

The map label for this gene is atpB

Identifier: 150400504

GI number: 150400504

Start: 73035

End: 74429

Strand: Direct

Name: atpB

Synonym: Maeo_0066

Alternate gene names: 150400504

Gene position: 73035-74429 (Clockwise)

Preceding gene: 150400503

Following gene: 150400505

Centisome position: 4.65

GC content: 37.13

Gene sequence:

>1395_bases
ATGTCTTCTTTGGAAAAAAATATTGAATATACATCAGTTTCAAGTATCGCTGGTCCATTGATAGTAGTTGAAGGAATTAA
AGGAGTGGCATACGGGGAAATCGTAAGTATCACCTGCCCAAGTGGTGAAAAAAGAACAGGACAGGTTTTAGAGGCAAGAG
AAGATGTTGCCGTTGTACAGGTGTTTGAAGGAACAACTGCATTAAACACAAGCGAAACAAAAATTAGATTTGTTGGAGAA
ACTGCTAAATTAGGAGTATCCACTGATATGCTTGGTAGAATATTTAACGGAGCAGGAAAACCATTAGATGGCGGTCCAGA
CATTATAGCAGAAGATAAAATTGATATTAATGGATACCCATTAAATCCAGTATCAAGACAAAGCCCAAATGATTTTGTTC
AAACAGGTATATCCACAATAGATGGAACAAATACATTGGTTAGGGGTCAAAAAATACCTATATTTTCAGGTTCAGGTCTT
CCTCACAACCTCTTAGCTGCTCAAATAGCAAGACAGGCAAAAGTTAGAGGTAGTGATGAGCAATTTGCTGTTGTATTCGC
AGCCATGGGAATTACAGCAGAGGAATCAAACTACTTTATGAACGAGTTTAAAAGAACAGGAGCTCTTGAAAATGCAGTGG
TATTTATTAACCTTGCAGACGATCCAGCTATTGAAAGAATTCTTACACCAAGAATTGCTTTAACAACAGCAGAATACCTT
GCTTATGAAAAAGGAATGCATGTTTTAGTTATTATGACAGATATTACAAATTACTGTGAAGCTCTTAGGGAAATTGCAGC
AGCAAGGAACGAGGTTCCAGGAAGAAGAGGATACCCTGGATACATGTATACAGACCTTGCTACGCTGTATGAAAGAGCTG
GAAGAGTTAAAGGTAAATCTGGAACAGTTACACAGATTCCAATTTTAACAATGCCTCATGACGATATTACTCACCCAATT
CCTGATTTGACTGGATATATTACAGAAGGACAGATAGTTCTTTCAAGAGAATTAAACAGAAAAGGTATTTACCCGCCTGT
TGATGTTCTTCCATCATTGTCAAGGTTGGCAGGTAATGGAGTTGGAGAAGGAAAAACAAGGGACGACCACTCAAAAGTTA
TTAGTCAGGTATATGCAGGATATGCAGAAGGTATTGGATTAAGAGATTTGGTTGCTGTTGTTGGGGAAGAATCATTGTCT
GAAAGAGACAGAGCATACTTAAAATTAGCTGATGTTTTCGAAAAGAAATTTGTTCAACAAGGAAAAGACGAGGACAGAAG
CATTGAAGAAACCCTTGACATAGTTTGGGACATATTAACAATTCTTCCAGAAGAAGAATTAAAGAGAGTTTCCGAAGACC
TTATTAAAAAATACCATCCAAACCATAAAAAATAA

Upstream 100 bases:

>100_bases
ATTTATTATAATTAATTTTTAAATTTTTAAAATATTATATTTTACCTATATATTATAAATGTTAAAATCATACAAAAAAT
AAAAAATAAGGAGGGTTATT

Downstream 100 bases:

>100_bases
AAATAAATATTTTTTATCTTCTATTTTTTTATTATGACATTTTACAGTAAATCGACAATTATTGTCCTTTATACGGGGTA
AAAATCAAAGATTTTTACCA

Product: V-type ATP synthase subunit B

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit B

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSSLEKNIEYTSVSSIAGPLIVVEGIKGVAYGEIVSITCPSGEKRTGQVLEAREDVAVVQVFEGTTALNTSETKIRFVGE
TAKLGVSTDMLGRIFNGAGKPLDGGPDIIAEDKIDINGYPLNPVSRQSPNDFVQTGISTIDGTNTLVRGQKIPIFSGSGL
PHNLLAAQIARQAKVRGSDEQFAVVFAAMGITAEESNYFMNEFKRTGALENAVVFINLADDPAIERILTPRIALTTAEYL
AYEKGMHVLVIMTDITNYCEALREIAAARNEVPGRRGYPGYMYTDLATLYERAGRVKGKSGTVTQIPILTMPHDDITHPI
PDLTGYITEGQIVLSRELNRKGIYPPVDVLPSLSRLAGNGVGEGKTRDDHSKVISQVYAGYAEGIGLRDLVAVVGEESLS
ERDRAYLKLADVFEKKFVQQGKDEDRSIEETLDIVWDILTILPEEELKRVSEDLIKKYHPNHKK

Sequences:

>Translated_464_residues
MSSLEKNIEYTSVSSIAGPLIVVEGIKGVAYGEIVSITCPSGEKRTGQVLEAREDVAVVQVFEGTTALNTSETKIRFVGE
TAKLGVSTDMLGRIFNGAGKPLDGGPDIIAEDKIDINGYPLNPVSRQSPNDFVQTGISTIDGTNTLVRGQKIPIFSGSGL
PHNLLAAQIARQAKVRGSDEQFAVVFAAMGITAEESNYFMNEFKRTGALENAVVFINLADDPAIERILTPRIALTTAEYL
AYEKGMHVLVIMTDITNYCEALREIAAARNEVPGRRGYPGYMYTDLATLYERAGRVKGKSGTVTQIPILTMPHDDITHPI
PDLTGYITEGQIVLSRELNRKGIYPPVDVLPSLSRLAGNGVGEGKTRDDHSKVISQVYAGYAEGIGLRDLVAVVGEESLS
ERDRAYLKLADVFEKKFVQQGKDEDRSIEETLDIVWDILTILPEEELKRVSEDLIKKYHPNHKK
>Mature_463_residues
SSLEKNIEYTSVSSIAGPLIVVEGIKGVAYGEIVSITCPSGEKRTGQVLEAREDVAVVQVFEGTTALNTSETKIRFVGET
AKLGVSTDMLGRIFNGAGKPLDGGPDIIAEDKIDINGYPLNPVSRQSPNDFVQTGISTIDGTNTLVRGQKIPIFSGSGLP
HNLLAAQIARQAKVRGSDEQFAVVFAAMGITAEESNYFMNEFKRTGALENAVVFINLADDPAIERILTPRIALTTAEYLA
YEKGMHVLVIMTDITNYCEALREIAAARNEVPGRRGYPGYMYTDLATLYERAGRVKGKSGTVTQIPILTMPHDDITHPIP
DLTGYITEGQIVLSRELNRKGIYPPVDVLPSLSRLAGNGVGEGKTRDDHSKVISQVYAGYAEGIGLRDLVAVVGEESLSE
RDRAYLKLADVFEKKFVQQGKDEDRSIEETLDIVWDILTILPEEELKRVSEDLIKKYHPNHKK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit

COG id: COG1156

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit B

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913428, Length=464, Percent_Identity=55.3879310344828, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI19913426, Length=460, Percent_Identity=55.6521739130435, Blast_Score=543, Evalue=1e-154,
Organism=Homo sapiens, GI32189394, Length=373, Percent_Identity=27.3458445040214, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI50345984, Length=354, Percent_Identity=27.4011299435028, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4757810, Length=354, Percent_Identity=27.4011299435028, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI19913424, Length=317, Percent_Identity=24.9211356466877, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788251, Length=273, Percent_Identity=32.6007326007326, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1790170, Length=329, Percent_Identity=27.0516717325228, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790172, Length=367, Percent_Identity=27.7929155313352, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=457, Percent_Identity=57.3304157549234, Blast_Score=554, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17510931, Length=468, Percent_Identity=55.5555555555556, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI25144756, Length=348, Percent_Identity=27.5862068965517, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71988080, Length=359, Percent_Identity=26.7409470752089, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71988063, Length=359, Percent_Identity=26.7409470752089, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17565854, Length=328, Percent_Identity=24.0853658536585, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71988074, Length=266, Percent_Identity=26.6917293233083, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319603, Length=465, Percent_Identity=55.0537634408602, Blast_Score=550, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322581, Length=365, Percent_Identity=29.8630136986301, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319370, Length=290, Percent_Identity=27.5862068965517, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320016, Length=232, Percent_Identity=25, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281361666, Length=469, Percent_Identity=54.3710021321962, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24646341, Length=469, Percent_Identity=54.3710021321962, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI17136796, Length=469, Percent_Identity=54.3710021321962, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24638766, Length=367, Percent_Identity=27.7929155313352, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574560, Length=349, Percent_Identity=27.7936962750716, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24658560, Length=354, Percent_Identity=26.8361581920904, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24583992, Length=315, Percent_Identity=24.7619047619048, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129479, Length=314, Percent_Identity=24.5222929936306, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24583988, Length=314, Percent_Identity=24.203821656051, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583986, Length=314, Percent_Identity=24.203821656051, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583984, Length=314, Percent_Identity=24.203821656051, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): VATB_META3 (A6UT36)

Other databases:

- EMBL:   CP000743
- RefSeq:   YP_001324270.1
- ProteinModelPortal:   A6UT36
- SMR:   A6UT36
- STRING:   A6UT36
- GeneID:   5327499
- GenomeReviews:   CP000743_GR
- KEGG:   mae:Maeo_0066
- eggNOG:   arNOG04087
- HOGENOM:   HBG565875
- OMA:   RQAKVRG
- ProtClustDB:   PRK04196
- BioCyc:   MAEO419665:MAEO_0066-MONOMER
- HAMAP:   MF_00310
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022879

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C

EC number: 3.6.3.14

Molecular weight: Translated: 50744; Mature: 50613

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLEKNIEYTSVSSIAGPLIVVEGIKGVAYGEIVSITCPSGEKRTGQVLEAREDVAVVQ
CCCHHHCCCHHHHHHHCCCEEEEECCCCCEECCEEEEECCCCCCCCHHHHHHHCCEEEEE
VFEGTTALNTSETKIRFVGETAKLGVSTDMLGRIFNGAGKPLDGGPDIIAEDKIDINGYP
EECCCEECCCCCCEEEEECCHHHCCCCHHHHHHHHCCCCCCCCCCCCCEECCEEECCCCC
LNPVSRQSPNDFVQTGISTIDGTNTLVRGQKIPIFSGSGLPHNLLAAQIARQAKVRGSDE
CCCCCCCCCHHHHHHCCHHCCCCCCEECCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCC
QFAVVFAAMGITAEESNYFMNEFKRTGALENAVVFINLADDPAIERILTPRIALTTAEYL
CEEEEEEECCCEECCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHHH
AYEKGMHVLVIMTDITNYCEALREIAAARNEVPGRRGYPGYMYTDLATLYERAGRVKGKS
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTVTQIPILTMPHDDITHPIPDLTGYITEGQIVLSRELNRKGIYPPVDVLPSLSRLAGNG
CCEEEEEEEECCCCCCCCCCCCHHCEEECCEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
VGEGKTRDDHSKVISQVYAGYAEGIGLRDLVAVVGEESLSERDRAYLKLADVFEKKFVQQ
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GKDEDRSIEETLDIVWDILTILPEEELKRVSEDLIKKYHPNHKK
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSLEKNIEYTSVSSIAGPLIVVEGIKGVAYGEIVSITCPSGEKRTGQVLEAREDVAVVQ
CCHHHCCCHHHHHHHCCCEEEEECCCCCEECCEEEEECCCCCCCCHHHHHHHCCEEEEE
VFEGTTALNTSETKIRFVGETAKLGVSTDMLGRIFNGAGKPLDGGPDIIAEDKIDINGYP
EECCCEECCCCCCEEEEECCHHHCCCCHHHHHHHHCCCCCCCCCCCCCEECCEEECCCCC
LNPVSRQSPNDFVQTGISTIDGTNTLVRGQKIPIFSGSGLPHNLLAAQIARQAKVRGSDE
CCCCCCCCCHHHHHHCCHHCCCCCCEECCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCC
QFAVVFAAMGITAEESNYFMNEFKRTGALENAVVFINLADDPAIERILTPRIALTTAEYL
CEEEEEEECCCEECCCHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHCCHHHHHHHHHH
AYEKGMHVLVIMTDITNYCEALREIAAARNEVPGRRGYPGYMYTDLATLYERAGRVKGKS
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTVTQIPILTMPHDDITHPIPDLTGYITEGQIVLSRELNRKGIYPPVDVLPSLSRLAGNG
CCEEEEEEEECCCCCCCCCCCCHHCEEECCEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
VGEGKTRDDHSKVISQVYAGYAEGIGLRDLVAVVGEESLSERDRAYLKLADVFEKKFVQQ
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHC
GKDEDRSIEETLDIVWDILTILPEEELKRVSEDLIKKYHPNHKK
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Borate; Diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines various reactions catalyzed by ATPase, analogs; Oligomycin; Quercetin; Trialkyl tinderivatives; Venturicidin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA