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The map label for this gene is mepA [H]

Identifier: 150400314

GI number: 150400314

Start: 1592737

End: 1594080

Strand: Reverse

Name: mepA [H]

Synonym: Mevan_1577

Alternate gene names: 150400314

Gene position: 1594080-1592737 (Counterclockwise)

Preceding gene: 150400315

Following gene: 150400311

Centisome position: 92.68

GC content: 33.85

Gene sequence:

>1344_bases
ATGGTTTATAAAAGTGAATTTTTAGGAATTGAGCCCGTAAAGACGTTACTTATAAAATTATCCATTCCAGCTATAATTGG
TATGCTTATTATGGCACTTTATAACGTAGTTGACGGGTTTTTTATAGGTAGATGGGTTGGAACACTTGCATTTACAGGAG
TTTCATTAATATTCCCATTTCAAATGGTAGTACTTGCTTTTGGAATTACTTTCGGAATTGGGGGTGCATCAATTTTATCA
AGAAAACTTGGTGAAGGCAATTTAAAAATTGCAAAAAAAGCTGCTGGAAATTCAATCAGTATGGTGTTAATTTTATCGTT
ATTAATAACAACACTAGGAATTTTATTTGCAGTTCCAATTTTAAATCTTTTAGGGGCTTCTGTTGAGGTATTTCCTTACG
CTAAAGATTATTATTTAATAATTCTCTATGGGACAATATTTAATAGCTACTTAATTGTTGCAAACAACCTTGTTCGCGCA
GAAGGATTGGCAAAAATTGCAATGTTTGGAATGGTTTTTCCAGCGGTTTTAAACACAATGCTTGATGTACTTTTTATTAT
CGGATTAAACATGGGTGTAAAAGGGGCTGCAATTGCAACCGTGATTTCACAAGTTGTCGGCGTAATTTATCTTACGTATT
ACCAGCTTGGGAAGCATACTAGTATTAAATACAAGGTTAATGATTTTTTAATTGATATAAAAACATGCGTAGAGATAATA
CTTATAGGTGCATCCGAATTTGCAAGAACTATCATGAGTAGCGTTCTTTTAGTACTTGGAAACAATTTACTTGGATTTTA
TGGCGGGGACATTGCAATTGCAATCTTTGGCGTAGTAAATCGAATTGCAATGCTTTTATTTATGCCAGTACACGGGATAG
TTCAAGGACTTCAGCCTATTGTTGGATATAACTATGGGAAAGGAAATTTAAAAAGAGTTAGTGAAGCAGTGAAACTTGCG
TTAATCTCGACTACAAGTCTTTGTTTCTTGGGCTTTATCTTCATAATAGCATTTCCAGAGCAATTTATCAGGATATTCAT
AACAGATAGTGAGGTAATCTCAAAGGGAATACTCCCAATAAGGATATTTTTCGGATTTTCATTCTTAATAGGGGCCCAAA
TGGTAATTAGCGGATTATATCAATCACTTGGAAAAGCATTACCTGCATTTGTTCTTTCCTGTGCAAGGCAGACTTTATTT
TTAATTCCCCCAATGATTATTCTTCCAATGTATATCGGGTTAAATGGAATATGGCTCGCAATACCGTTAGGCGACTTTTT
AGGGTTTTTACTTTCAGTAGGGCTCATATATATTGATAGAAAAATGCTAAACCTTTCATTTTAA

Upstream 100 bases:

>100_bases
GTTTAATGCACCTAAATTTGGAAAAAGAATTTGCTATAGAATTTAAAAAAAAATTAGAATATGACAATAAATTAATGTAA
AATATATTATTGTGATAAAT

Downstream 100 bases:

>100_bases
TTTTTAAAAAATTACCAGAATTTTAATTTTGAAAGGATACCTTTTTTTTCCCCTTCTTTTTTAGTTTTCTCATGAGAATC
AATATACTGATTCATTGGAA

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MVYKSEFLGIEPVKTLLIKLSIPAIIGMLIMALYNVVDGFFIGRWVGTLAFTGVSLIFPFQMVVLAFGITFGIGGASILS
RKLGEGNLKIAKKAAGNSISMVLILSLLITTLGILFAVPILNLLGASVEVFPYAKDYYLIILYGTIFNSYLIVANNLVRA
EGLAKIAMFGMVFPAVLNTMLDVLFIIGLNMGVKGAAIATVISQVVGVIYLTYYQLGKHTSIKYKVNDFLIDIKTCVEII
LIGASEFARTIMSSVLLVLGNNLLGFYGGDIAIAIFGVVNRIAMLLFMPVHGIVQGLQPIVGYNYGKGNLKRVSEAVKLA
LISTTSLCFLGFIFIIAFPEQFIRIFITDSEVISKGILPIRIFFGFSFLIGAQMVISGLYQSLGKALPAFVLSCARQTLF
LIPPMIILPMYIGLNGIWLAIPLGDFLGFLLSVGLIYIDRKMLNLSF

Sequences:

>Translated_447_residues
MVYKSEFLGIEPVKTLLIKLSIPAIIGMLIMALYNVVDGFFIGRWVGTLAFTGVSLIFPFQMVVLAFGITFGIGGASILS
RKLGEGNLKIAKKAAGNSISMVLILSLLITTLGILFAVPILNLLGASVEVFPYAKDYYLIILYGTIFNSYLIVANNLVRA
EGLAKIAMFGMVFPAVLNTMLDVLFIIGLNMGVKGAAIATVISQVVGVIYLTYYQLGKHTSIKYKVNDFLIDIKTCVEII
LIGASEFARTIMSSVLLVLGNNLLGFYGGDIAIAIFGVVNRIAMLLFMPVHGIVQGLQPIVGYNYGKGNLKRVSEAVKLA
LISTTSLCFLGFIFIIAFPEQFIRIFITDSEVISKGILPIRIFFGFSFLIGAQMVISGLYQSLGKALPAFVLSCARQTLF
LIPPMIILPMYIGLNGIWLAIPLGDFLGFLLSVGLIYIDRKMLNLSF
>Mature_447_residues
MVYKSEFLGIEPVKTLLIKLSIPAIIGMLIMALYNVVDGFFIGRWVGTLAFTGVSLIFPFQMVVLAFGITFGIGGASILS
RKLGEGNLKIAKKAAGNSISMVLILSLLITTLGILFAVPILNLLGASVEVFPYAKDYYLIILYGTIFNSYLIVANNLVRA
EGLAKIAMFGMVFPAVLNTMLDVLFIIGLNMGVKGAAIATVISQVVGVIYLTYYQLGKHTSIKYKVNDFLIDIKTCVEII
LIGASEFARTIMSSVLLVLGNNLLGFYGGDIAIAIFGVVNRIAMLLFMPVHGIVQGLQPIVGYNYGKGNLKRVSEAVKLA
LISTTSLCFLGFIFIIAFPEQFIRIFITDSEVISKGILPIRIFFGFSFLIGAQMVISGLYQSLGKALPAFVLSCARQTLF
LIPPMIILPMYIGLNGIWLAIPLGDFLGFLLSVGLIYIDRKMLNLSF

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48605; Mature: 48605

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYKSEFLGIEPVKTLLIKLSIPAIIGMLIMALYNVVDGFFIGRWVGTLAFTGVSLIFPF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMVVLAFGITFGIGGASILSRKLGEGNLKIAKKAAGNSISMVLILSLLITTLGILFAVPI
HHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LNLLGASVEVFPYAKDYYLIILYGTIFNSYLIVANNLVRAEGLAKIAMFGMVFPAVLNTM
HHHHCCCEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDVLFIIGLNMGVKGAAIATVISQVVGVIYLTYYQLGKHTSIKYKVNDFLIDIKTCVEII
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHH
LIGASEFARTIMSSVLLVLGNNLLGFYGGDIAIAIFGVVNRIAMLLFMPVHGIVQGLQPI
HHCCHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGYNYGKGNLKRVSEAVKLALISTTSLCFLGFIFIIAFPEQFIRIFITDSEVISKGILPI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHCCCHHH
RIFFGFSFLIGAQMVISGLYQSLGKALPAFVLSCARQTLFLIPPMIILPMYIGLNGIWLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEE
IPLGDFLGFLLSVGLIYIDRKMLNLSF
EEHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVYKSEFLGIEPVKTLLIKLSIPAIIGMLIMALYNVVDGFFIGRWVGTLAFTGVSLIFPF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMVVLAFGITFGIGGASILSRKLGEGNLKIAKKAAGNSISMVLILSLLITTLGILFAVPI
HHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LNLLGASVEVFPYAKDYYLIILYGTIFNSYLIVANNLVRAEGLAKIAMFGMVFPAVLNTM
HHHHCCCEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDVLFIIGLNMGVKGAAIATVISQVVGVIYLTYYQLGKHTSIKYKVNDFLIDIKTCVEII
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHH
LIGASEFARTIMSSVLLVLGNNLLGFYGGDIAIAIFGVVNRIAMLLFMPVHGIVQGLQPI
HHCCHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGYNYGKGNLKRVSEAVKLALISTTSLCFLGFIFIIAFPEQFIRIFITDSEVISKGILPI
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHCCCHHH
RIFFGFSFLIGAQMVISGLYQSLGKALPAFVLSCARQTLFLIPPMIILPMYIGLNGIWLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEE
IPLGDFLGFLLSVGLIYIDRKMLNLSF
EEHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA