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The map label for this gene is spcS [H]

Identifier: 150400206

GI number: 150400206

Start: 1489968

End: 1491278

Strand: Reverse

Name: spcS [H]

Synonym: Mevan_1467

Alternate gene names: 150400206

Gene position: 1491278-1489968 (Counterclockwise)

Preceding gene: 150400210

Following gene: 150400204

Centisome position: 86.7

GC content: 32.57

Gene sequence:

>1311_bases
ATGCTTGATTTTAATGTTAGCGGATTGATTCCAAAAAATATGGAAAAAAGAGGGGAATTGGTATTTTCCGAAAATTTAAA
GGAAATTGAAGATATATTTAACCATCGAAAAATTCCGGAAAATGGGCTTAGCAATGAAAAAATAAGACTTTTTTTACGGT
TTCTTTCAATGATGGATACAGATAAAGACCCAAAATCTATTAGAATTGGTGAAAGAGAAGCTAGAATTGTTTCAAGTGTT
CATGATGAACTATCATATGGATTCTGTCACGGGGTTGGTAGAAGCGGAAATTTAATAGATCCTCAGCCAAAAGCACCCGG
TGCAAGTATAATGTATTCGCTTACAAATAAAATCCTTGAAAGCTTCTTAAAAACGCTTGGAATAGACGTATATGGAATTT
CAACACCGGTATCTACTGGAATGTCTATTTCACTATGTTTATGTGCAGCTAGAAAAAAATATGCATCAAATGTTGTAATT
TATCCTTATGCTGCACATAAAAGTCCAATAAAAGCCGTTTCATTTGCAGGTATGAAGATGAGACTTGTTGAAACGGTTTT
AGATGGAGATAAAGTATATGTTCCGGTTGAGGAGATAGAAAGTGCGGTTAAAAAAGAAATTGAGCTAGGGAATAATCCTT
GCATTTTAAGTACACTTACATTTTTTCCGCCAAGAAATAGCGATGATATTTTAGAAATATCAAAAATTTGCGAAATTTAT
GACATTCCCCATATAGTTAATGGGGCTTACGCTTTACAGAATAATTTTTACATCGAAAAGCTGAAAAAAGCATTTAAATA
CCGAATCGATGCAGTTGTAAGTTCGAGTGATAAAAACTTACTTACCCCAATTGGCGGAGGAATTATATTTTCAAAAAATC
AGGACTTTTTAAAAGAAATTTCTCACTGCTATCCTGGAAGGGCATCTGCAACGCCAATTGTAAGTACCCTAGTTTCACTA
CTTTCGATAGGATCTAAAAATTATATCGAACTTATGAAAAATCAAAAAAGCAGTAAAAAGCTATTGGACGATTTATTGTA
TGATTTATCAAAAAAAACAGGGAATAAATTGTTAGATTCAGAAAGCCCAATTGCGTCATGTATTTCAGTAAATTCTAACC
CCGTAGAAATTGCTGCAAAACTATATAATTTAAGAGTAACGGGCCCAAGAGGCGTAACAAAAACAGACAAATTTGGAAAT
TGCTATACTGGAAACTACATCTATGATTATATTGTAATGAATGCTGCAATAGGTGTAAAAACAGAAGATGTAGTAAATGC
AGTCGATAAACTTGAAAAAATAATTTTATAA

Upstream 100 bases:

>100_bases
ATCTAAAACTATTTAATCATTCGGGTATTTAATACTAATTACAATCGAAAAAATCGCTAAGGGATATATTAATTACTCAG
TTAATTTAAAAAGTGATAGA

Downstream 100 bases:

>100_bases
TGAGTATATGTTTTGAAATATATTAAACTCGAAAAATTTAAAAGTATTTATTTATTTATTTATTTATTTATTTATTTATT
TATTTATTTATTTATTTATT

Product: soluble liver antigen/liver pancreas antigen

Products: NA

Alternate protein names: Selenocysteine synthase; Sec synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MLDFNVSGLIPKNMEKRGELVFSENLKEIEDIFNHRKIPENGLSNEKIRLFLRFLSMMDTDKDPKSIRIGEREARIVSSV
HDELSYGFCHGVGRSGNLIDPQPKAPGASIMYSLTNKILESFLKTLGIDVYGISTPVSTGMSISLCLCAARKKYASNVVI
YPYAAHKSPIKAVSFAGMKMRLVETVLDGDKVYVPVEEIESAVKKEIELGNNPCILSTLTFFPPRNSDDILEISKICEIY
DIPHIVNGAYALQNNFYIEKLKKAFKYRIDAVVSSSDKNLLTPIGGGIIFSKNQDFLKEISHCYPGRASATPIVSTLVSL
LSIGSKNYIELMKNQKSSKKLLDDLLYDLSKKTGNKLLDSESPIASCISVNSNPVEIAAKLYNLRVTGPRGVTKTDKFGN
CYTGNYIYDYIVMNAAIGVKTEDVVNAVDKLEKIIL

Sequences:

>Translated_436_residues
MLDFNVSGLIPKNMEKRGELVFSENLKEIEDIFNHRKIPENGLSNEKIRLFLRFLSMMDTDKDPKSIRIGEREARIVSSV
HDELSYGFCHGVGRSGNLIDPQPKAPGASIMYSLTNKILESFLKTLGIDVYGISTPVSTGMSISLCLCAARKKYASNVVI
YPYAAHKSPIKAVSFAGMKMRLVETVLDGDKVYVPVEEIESAVKKEIELGNNPCILSTLTFFPPRNSDDILEISKICEIY
DIPHIVNGAYALQNNFYIEKLKKAFKYRIDAVVSSSDKNLLTPIGGGIIFSKNQDFLKEISHCYPGRASATPIVSTLVSL
LSIGSKNYIELMKNQKSSKKLLDDLLYDLSKKTGNKLLDSESPIASCISVNSNPVEIAAKLYNLRVTGPRGVTKTDKFGN
CYTGNYIYDYIVMNAAIGVKTEDVVNAVDKLEKIIL
>Mature_436_residues
MLDFNVSGLIPKNMEKRGELVFSENLKEIEDIFNHRKIPENGLSNEKIRLFLRFLSMMDTDKDPKSIRIGEREARIVSSV
HDELSYGFCHGVGRSGNLIDPQPKAPGASIMYSLTNKILESFLKTLGIDVYGISTPVSTGMSISLCLCAARKKYASNVVI
YPYAAHKSPIKAVSFAGMKMRLVETVLDGDKVYVPVEEIESAVKKEIELGNNPCILSTLTFFPPRNSDDILEISKICEIY
DIPHIVNGAYALQNNFYIEKLKKAFKYRIDAVVSSSDKNLLTPIGGGIIFSKNQDFLKEISHCYPGRASATPIVSTLVSL
LSIGSKNYIELMKNQKSSKKLLDDLLYDLSKKTGNKLLDSESPIASCISVNSNPVEIAAKLYNLRVTGPRGVTKTDKFGN
CYTGNYIYDYIVMNAAIGVKTEDVVNAVDKLEKIIL

Specific function: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SepSecS family [H]

Homologues:

Organism=Homo sapiens, GI267844904, Length=422, Percent_Identity=34.1232227488152, Blast_Score=238, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17559116, Length=396, Percent_Identity=32.5757575757576, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI212646307, Length=396, Percent_Identity=32.5757575757576, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI221377925, Length=447, Percent_Identity=29.9776286353468, Blast_Score=214, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR019872
- InterPro:   IPR008829 [H]

Pfam domain/function: PF05889 SLA_LP_auto_ag [H]

EC number: =2.9.1.2 [H]

Molecular weight: Translated: 48355; Mature: 48355

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFNVSGLIPKNMEKRGELVFSENLKEIEDIFNHRKIPENGLSNEKIRLFLRFLSMMDT
CCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC
DKDPKSIRIGEREARIVSSVHDELSYGFCHGVGRSGNLIDPQPKAPGASIMYSLTNKILE
CCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SFLKTLGIDVYGISTPVSTGMSISLCLCAARKKYASNVVIYPYAAHKSPIKAVSFAGMKM
HHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHCCHHH
RLVETVLDGDKVYVPVEEIESAVKKEIELGNNPCILSTLTFFPPRNSDDILEISKICEIY
HHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHH
DIPHIVNGAYALQNNFYIEKLKKAFKYRIDAVVSSSDKNLLTPIGGGIIFSKNQDFLKEI
CCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEECCHHHHHHH
SHCYPGRASATPIVSTLVSLLSIGSKNYIELMKNQKSSKKLLDDLLYDLSKKTGNKLLDS
HHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHCCC
ESPIASCISVNSNPVEIAAKLYNLRVTGPRGVTKTDKFGNCYTGNYIYDYIVMNAAIGVK
CCCHHHHHCCCCCHHHHEEEHHEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCC
TEDVVNAVDKLEKIIL
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDFNVSGLIPKNMEKRGELVFSENLKEIEDIFNHRKIPENGLSNEKIRLFLRFLSMMDT
CCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCC
DKDPKSIRIGEREARIVSSVHDELSYGFCHGVGRSGNLIDPQPKAPGASIMYSLTNKILE
CCCCCCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
SFLKTLGIDVYGISTPVSTGMSISLCLCAARKKYASNVVIYPYAAHKSPIKAVSFAGMKM
HHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHCCHHH
RLVETVLDGDKVYVPVEEIESAVKKEIELGNNPCILSTLTFFPPRNSDDILEISKICEIY
HHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHH
DIPHIVNGAYALQNNFYIEKLKKAFKYRIDAVVSSSDKNLLTPIGGGIIFSKNQDFLKEI
CCCHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCEEEECCHHHHHHH
SHCYPGRASATPIVSTLVSLLSIGSKNYIELMKNQKSSKKLLDDLLYDLSKKTGNKLLDS
HHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHCCC
ESPIASCISVNSNPVEIAAKLYNLRVTGPRGVTKTDKFGNCYTGNYIYDYIVMNAAIGVK
CCCHHHHHCCCCCHHHHEEEHHEEEEECCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCC
TEDVVNAVDKLEKIIL
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA