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The map label for this gene is dapA

Identifier: 150400188

GI number: 150400188

Start: 1472705

End: 1473574

Strand: Reverse

Name: dapA

Synonym: Mevan_1449

Alternate gene names: 150400188

Gene position: 1473574-1472705 (Counterclockwise)

Preceding gene: 150400189

Following gene: 150400187

Centisome position: 85.67

GC content: 35.75

Gene sequence:

>870_bases
ATGCAAGGCGTATATCCTGCAATTGTTACCCCGTTCAAAGACGGTAGCGTAGATTTCGAAGGTTTACGAAAGAATATAGA
CTTTTTAATTGAAAATGGTGTTAAGGGCGTCGTTCCAGTTGGAACAACAGGTGAATCACCTACATTAACTCCAAAAGAAC
ATGAAAAGGTAATTGAAAAGGTCGTAGATTTCGTAAACGGTAGAGTCGAGGTAATTGCAGGCACTGGTTCAAACTCTACT
TTGGAAGCACTTGAATTTTCCCAATATGCTGAAGATGTAGGTGCTGATAGAGTACTACTGATAACTCCCTACTATAACAA
ACCACCTCAGGAAGGTTTGAAACGACACTTTGGAGAAGTAGCAAACTCAATAACCGTTCCTATTGTTCTATATAATGTTC
CTTCAAGAACTGCCTTGAATATAGAACCAGATACTATTAAATACTTATTTGATGAATATAGTAACATTACAGCCATTAAA
GAAGCAAATCCAAATTTATCGCAGGTTTCTGAAATATTGGATATATGTAATATCGATGTTTTGTCAGGAAATGATGAATT
AACCTTACCAATAATGTCACTTGGAGGAAAGGGAGTTATAAGCGTTATTGCAAATATTGCCCCCAAGGAATTCGTTCAGA
TGGTTGAATTCGCTGAAAAGGGCAAGTTTGATAAGGCAAAAGAAATTCACTATAAATTATTCCCACTAATGAAACTAATG
TTCATTGAAACAAATCCAATACCCATAAAAACCGCAATGAATATGCTTGGAATGCCTTCCGGTGAGTTAAGGTTACCCCT
TTGTGAAATGGCGCAAAGCAATAAATTAAAATTGCAAAATGCATTAAATACATTGGGATTACTTAAATAA

Upstream 100 bases:

>100_bases
GTTGAAGAAGTTGCAAGAATCTCAACAAAAACATTGAGAAACAGAATCGCAGGATACATTACTGCTAAAGTAAAAAAAAT
GAACGCTTAAGGTGTAATTT

Downstream 100 bases:

>100_bases
TCACGGTTTGTGATAATATGATTGATATTGAAAAAATTCAAAAACAGGCTGAAGAAATCGTTTCAAAACTCGCTGACGTT
TTAGAAAACTTTAAGTTTGA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MQGVYPAIVTPFKDGSVDFEGLRKNIDFLIENGVKGVVPVGTTGESPTLTPKEHEKVIEKVVDFVNGRVEVIAGTGSNST
LEALEFSQYAEDVGADRVLLITPYYNKPPQEGLKRHFGEVANSITVPIVLYNVPSRTALNIEPDTIKYLFDEYSNITAIK
EANPNLSQVSEILDICNIDVLSGNDELTLPIMSLGGKGVISVIANIAPKEFVQMVEFAEKGKFDKAKEIHYKLFPLMKLM
FIETNPIPIKTAMNMLGMPSGELRLPLCEMAQSNKLKLQNALNTLGLLK

Sequences:

>Translated_289_residues
MQGVYPAIVTPFKDGSVDFEGLRKNIDFLIENGVKGVVPVGTTGESPTLTPKEHEKVIEKVVDFVNGRVEVIAGTGSNST
LEALEFSQYAEDVGADRVLLITPYYNKPPQEGLKRHFGEVANSITVPIVLYNVPSRTALNIEPDTIKYLFDEYSNITAIK
EANPNLSQVSEILDICNIDVLSGNDELTLPIMSLGGKGVISVIANIAPKEFVQMVEFAEKGKFDKAKEIHYKLFPLMKLM
FIETNPIPIKTAMNMLGMPSGELRLPLCEMAQSNKLKLQNALNTLGLLK
>Mature_289_residues
MQGVYPAIVTPFKDGSVDFEGLRKNIDFLIENGVKGVVPVGTTGESPTLTPKEHEKVIEKVVDFVNGRVEVIAGTGSNST
LEALEFSQYAEDVGADRVLLITPYYNKPPQEGLKRHFGEVANSITVPIVLYNVPSRTALNIEPDTIKYLFDEYSNITAIK
EANPNLSQVSEILDICNIDVLSGNDELTLPIMSLGGKGVISVIANIAPKEFVQMVEFAEKGKFDKAKEIHYKLFPLMKLM
FIETNPIPIKTAMNMLGMPSGELRLPLCEMAQSNKLKLQNALNTLGLLK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=302, Percent_Identity=26.8211920529801, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI13540533, Length=301, Percent_Identity=26.9102990033223, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1788823, Length=290, Percent_Identity=43.448275862069, Blast_Score=234, Evalue=5e-63,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=31.7567567567568, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786463, Length=271, Percent_Identity=33.210332103321, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1789620, Length=272, Percent_Identity=25.7352941176471, Blast_Score=96, Evalue=2e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_METVS (A6US71)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323955.1
- ProteinModelPortal:   A6US71
- SMR:   A6US71
- STRING:   A6US71
- GeneID:   5324836
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1449
- eggNOG:   arNOG05039
- HOGENOM:   HBG358848
- OMA:   QKGLIEH
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31770; Mature: 31770

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 160-160 BINDING 104-104

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGVYPAIVTPFKDGSVDFEGLRKNIDFLIENGVKGVVPVGTTGESPTLTPKEHEKVIEK
CCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHH
VVDFVNGRVEVIAGTGSNSTLEALEFSQYAEDVGADRVLLITPYYNKPPQEGLKRHFGEV
HHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH
ANSITVPIVLYNVPSRTALNIEPDTIKYLFDEYSNITAIKEANPNLSQVSEILDICNIDV
HCCEEEEEEEEECCCCCEECCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCEE
LSGNDELTLPIMSLGGKGVISVIANIAPKEFVQMVEFAEKGKFDKAKEIHYKLFPLMKLM
ECCCCCEEEEHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FIETNPIPIKTAMNMLGMPSGELRLPLCEMAQSNKLKLQNALNTLGLLK
HCCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MQGVYPAIVTPFKDGSVDFEGLRKNIDFLIENGVKGVVPVGTTGESPTLTPKEHEKVIEK
CCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHH
VVDFVNGRVEVIAGTGSNSTLEALEFSQYAEDVGADRVLLITPYYNKPPQEGLKRHFGEV
HHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHH
ANSITVPIVLYNVPSRTALNIEPDTIKYLFDEYSNITAIKEANPNLSQVSEILDICNIDV
HCCEEEEEEEEECCCCCEECCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCEE
LSGNDELTLPIMSLGGKGVISVIANIAPKEFVQMVEFAEKGKFDKAKEIHYKLFPLMKLM
ECCCCCEEEEHHHCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FIETNPIPIKTAMNMLGMPSGELRLPLCEMAQSNKLKLQNALNTLGLLK
HCCCCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA