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The map label for this gene is 150400157

Identifier: 150400157

GI number: 150400157

Start: 1448514

End: 1449815

Strand: Reverse

Name: 150400157

Synonym: Mevan_1416

Alternate gene names: NA

Gene position: 1449815-1448514 (Counterclockwise)

Preceding gene: 150400160

Following gene: 150400154

Centisome position: 84.29

GC content: 32.95

Gene sequence:

>1302_bases
ATGGAACTCTATTTTAGAGGAGGGGCTTTTGAAGTTGGAAGAAGTTGTGTAGAAGTAAAATCAGATAAAAGTACAGTATT
ATTTGACTGCGGTGTAAAATTATCCCCCAAGGGAATTGAATATCCAATTTTAGATGATTTAAATGCAGATTGCGTTTTCC
CATCTCATTCACACCTTGATCACGTTGGAAGTATTCCAGTTTTAATTCGAAAAGGCATGGTTCCCGCAATTTATGCAACC
CCAATTACAAAGGCAATTACTAAAGAGCTTTTAAGGGATTCCTTAAAAATTTCACAGGTAGAAGGTCATGAACTTCCGTA
CGATAAAGAGGATTTTAACACTTCATTAAGCCTATTTAGAAAAGCAGGATATAATAAACCGAAAAAATTTAAAGATTTTG
AATTTGAACTATTTAATGCCGGCCATATTCCTGGAAGTTCAACAATTTTACTAAATTATGGAAGTAAAAAAATAGTTTAT
ACTGGAGATGTAAAAGTAAATGACACAGAACTTGTAAAGGGGGCAGATTTATCATATTCTAAGGAAAATATTGATTGTTT
GATAATTGAATCAACTTACGGGGGAAATAATCAGGAAGATCGAAAAGAAGCCGAGAAGAAGTTTGTAGAAGAAATAAAAA
AGACTGTTGAAAGAGGGGGAGTTGCATTAATACCAGTTTTTGCAGTTGACCGTAGCCAAGAAATTATTATGATGCTTAAT
AAGTACGATTTTAAAGTTCCAGTATATTTTGATGGACTGGGTAGAAAAATAACTCGAATAATGCTTGATTATCCAGAATA
CTTAAATTATCCCCATGAATTAAAAGATGCCTTTTTTAAGGTAATTGAAGTGAACCCAAAAGACAGAAAACAGATTATAA
AAGACCTGAAAAACAATGGGGGAATAGTAGTCAGTACTGCGGGAATGCTTGAAGGGGGGCCAATAATTCCATATATTTTT
GAATTTATGAAAGATAAAAAAAGTTCCCTGATTTTTACTGGCTACCAAGTAGAAGACACTGCTGGAAGATATTTACTTGA
AACTGGAAAAGTAAAAATGGGAGAACTTGATGTAACTCCTGAATTTGAAGTTATGGCGTTTCAATTTTCTGCCCATGGGG
AAATGGGCGAATTAAGGCATATCGTAAAAAAAGTAAACCCTGAAACATTAATTATTCAGCATGGAGAAGCTAGTTCACTT
GAATCTTTTAAAAACTGGGCAGTTTTAGAAGGATTTAGTGAAAATAAAGTATTTACTCCTAAAGTAGGGGATAAAATTAA
TTTAAATGAAATTTTAAGGTAA

Upstream 100 bases:

>100_bases
TTTTCTTCGTTTTTAATAACTTTCTATTTTAACTTTATTTTTACCTCTTTATATATTTTGTAAGATATAAGTTATGTAAA
ATAAGGGAGGCGGTATATGT

Downstream 100 bases:

>100_bases
TAATTCATTTAAAATCTTAAACTAATATTTTAAAATTAATTTTTAGTTTATTTTTTAAATGTTAAATACTTTTATTTAAA
AAAGAAAATATTATTCCACA

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MELYFRGGAFEVGRSCVEVKSDKSTVLFDCGVKLSPKGIEYPILDDLNADCVFPSHSHLDHVGSIPVLIRKGMVPAIYAT
PITKAITKELLRDSLKISQVEGHELPYDKEDFNTSLSLFRKAGYNKPKKFKDFEFELFNAGHIPGSSTILLNYGSKKIVY
TGDVKVNDTELVKGADLSYSKENIDCLIIESTYGGNNQEDRKEAEKKFVEEIKKTVERGGVALIPVFAVDRSQEIIMMLN
KYDFKVPVYFDGLGRKITRIMLDYPEYLNYPHELKDAFFKVIEVNPKDRKQIIKDLKNNGGIVVSTAGMLEGGPIIPYIF
EFMKDKKSSLIFTGYQVEDTAGRYLLETGKVKMGELDVTPEFEVMAFQFSAHGEMGELRHIVKKVNPETLIIQHGEASSL
ESFKNWAVLEGFSENKVFTPKVGDKINLNEILR

Sequences:

>Translated_433_residues
MELYFRGGAFEVGRSCVEVKSDKSTVLFDCGVKLSPKGIEYPILDDLNADCVFPSHSHLDHVGSIPVLIRKGMVPAIYAT
PITKAITKELLRDSLKISQVEGHELPYDKEDFNTSLSLFRKAGYNKPKKFKDFEFELFNAGHIPGSSTILLNYGSKKIVY
TGDVKVNDTELVKGADLSYSKENIDCLIIESTYGGNNQEDRKEAEKKFVEEIKKTVERGGVALIPVFAVDRSQEIIMMLN
KYDFKVPVYFDGLGRKITRIMLDYPEYLNYPHELKDAFFKVIEVNPKDRKQIIKDLKNNGGIVVSTAGMLEGGPIIPYIF
EFMKDKKSSLIFTGYQVEDTAGRYLLETGKVKMGELDVTPEFEVMAFQFSAHGEMGELRHIVKKVNPETLIIQHGEASSL
ESFKNWAVLEGFSENKVFTPKVGDKINLNEILR
>Mature_433_residues
MELYFRGGAFEVGRSCVEVKSDKSTVLFDCGVKLSPKGIEYPILDDLNADCVFPSHSHLDHVGSIPVLIRKGMVPAIYAT
PITKAITKELLRDSLKISQVEGHELPYDKEDFNTSLSLFRKAGYNKPKKFKDFEFELFNAGHIPGSSTILLNYGSKKIVY
TGDVKVNDTELVKGADLSYSKENIDCLIIESTYGGNNQEDRKEAEKKFVEEIKKTVERGGVALIPVFAVDRSQEIIMMLN
KYDFKVPVYFDGLGRKITRIMLDYPEYLNYPHELKDAFFKVIEVNPKDRKQIIKDLKNNGGIVVSTAGMLEGGPIIPYIF
EFMKDKKSSLIFTGYQVEDTAGRYLLETGKVKMGELDVTPEFEVMAFQFSAHGEMGELRHIVKKVNPETLIIQHGEASSL
ESFKNWAVLEGFSENKVFTPKVGDKINLNEILR

Specific function: Unknown

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=449, Percent_Identity=26.7260579064588, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI33300633, Length=444, Percent_Identity=27.9279279279279, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566029, Length=422, Percent_Identity=28.1990521327014, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI32564696, Length=424, Percent_Identity=27.122641509434, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6323307, Length=461, Percent_Identity=26.8980477223427, Blast_Score=164, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24648013, Length=419, Percent_Identity=26.7303102625298, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21358523, Length=431, Percent_Identity=27.6102088167053, Blast_Score=149, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 48847; Mature: 48847

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELYFRGGAFEVGRSCVEVKSDKSTVLFDCGVKLSPKGIEYPILDDLNADCVFPSHSHLD
CEEEEECCCHHHCCHHHEECCCCCEEEEECCCEECCCCCCCCCCCCCCCCEECCCCCCHH
HVGSIPVLIRKGMVPAIYATPITKAITKELLRDSLKISQVEGHELPYDKEDFNTSLSLFR
HCCCCHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHH
KAGYNKPKKFKDFEFELFNAGHIPGSSTILLNYGSKKIVYTGDVKVNDTELVKGADLSYS
HCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEECCEEECCHHEEECCCCCCC
KENIDCLIIESTYGGNNQEDRKEAEKKFVEEIKKTVERGGVALIPVFAVDRSQEIIMMLN
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEEEEEE
KYDFKVPVYFDGLGRKITRIMLDYPEYLNYPHELKDAFFKVIEVNPKDRKQIIKDLKNNG
CCCEEEEEEECCCCHHHHHHHHCCHHHCCCCHHHHHHHEEEEECCCHHHHHHHHHHHCCC
GIVVSTAGMLEGGPIIPYIFEFMKDKKSSLIFTGYQVEDTAGRYLLETGKVKMGELDVTP
CEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEECCCEEECEECCCC
EFEVMAFQFSAHGEMGELRHIVKKVNPETLIIQHGEASSLESFKNWAVLEGFSENKVFTP
CCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCEEEEECCCCCCEECC
KVGDKINLNEILR
CCCCEECHHHHCC
>Mature Secondary Structure
MELYFRGGAFEVGRSCVEVKSDKSTVLFDCGVKLSPKGIEYPILDDLNADCVFPSHSHLD
CEEEEECCCHHHCCHHHEECCCCCEEEEECCCEECCCCCCCCCCCCCCCCEECCCCCCHH
HVGSIPVLIRKGMVPAIYATPITKAITKELLRDSLKISQVEGHELPYDKEDFNTSLSLFR
HCCCCHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHHHH
KAGYNKPKKFKDFEFELFNAGHIPGSSTILLNYGSKKIVYTGDVKVNDTELVKGADLSYS
HCCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEECCEEECCHHEEECCCCCCC
KENIDCLIIESTYGGNNQEDRKEAEKKFVEEIKKTVERGGVALIPVFAVDRSQEIIMMLN
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCEEEEEEE
KYDFKVPVYFDGLGRKITRIMLDYPEYLNYPHELKDAFFKVIEVNPKDRKQIIKDLKNNG
CCCEEEEEEECCCCHHHHHHHHCCHHHCCCCHHHHHHHEEEEECCCHHHHHHHHHHHCCC
GIVVSTAGMLEGGPIIPYIFEFMKDKKSSLIFTGYQVEDTAGRYLLETGKVKMGELDVTP
CEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEECCCEEECEECCCC
EFEVMAFQFSAHGEMGELRHIVKKVNPETLIIQHGEASSLESFKNWAVLEGFSENKVFTP
CCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCEEEEECCCCCCEECC
KVGDKINLNEILR
CCCCEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]