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The map label for this gene is hemD [H]

Identifier: 150400123

GI number: 150400123

Start: 1411491

End: 1412231

Strand: Reverse

Name: hemD [H]

Synonym: Mevan_1381

Alternate gene names: 150400123

Gene position: 1412231-1411491 (Counterclockwise)

Preceding gene: 150400124

Following gene: 150400122

Centisome position: 82.1

GC content: 29.96

Gene sequence:

>741_bases
ATGAAAGTTGTAATCACCCGTCCAATTGAAAAAGGAAGTAATTTTGGAGAAATACTTAAAAAAGAAGGATTTGAGCCCAT
ATTAATACCTACTCTTGACTTGGTATTTAAAAACATAAATTTAAAAATCGACGATTATTCTTGGATTGTATTTACAAGTC
CTAGAGGTGTTGAAGGCCTTCTTAAAAATCTAAGTTTAGAGGATGTTAAAAAGGTAACTTCAAAAAAAATAGGCGTAATC
GGGATAGAAACTGCAAAAGAATTTAAAAACATTTTTGGAAAAGATGCAGATATTATTCCAAACTTATATACTGCTGAAAA
TCTTCTTTTAGCACTTAAAAAAGAAGTTAAAAGTCATGAAAAAGTTTTAATTCCGACAACGCCTTCAACAAGGGATGTAT
TAAAGGAAGGATTAAACGCAGAACTTGTTTTTGTATACTCTTCTGAAGAACCAAACGACATTGATAAAAAAATAGATGAT
TTAAAAAAGATAACTGCCAACGAAAACAAATCCGGCAGAAAAATAGTATTAACATTTACAAGTAGCCTTACTGCAAGGAA
TTTTTTCAAACATGTTGATTTAAGCTTTTTAGAGGTTTTAAAAAAACAGGAAGTCGTTTCAATTGGCCCAATAACTAAAA
AAACCGTTGATTCATTTGGTTTTGACTCTAAAATGCACCCTGAAAACTACACTACTAAAGGCATGGTTTTTGTTATTAAA
GGTTTAAGTTTAAATATCTGA

Upstream 100 bases:

>100_bases
AAAGAATAGATAACATAATTATATAACATTATTAAAAATGATTAAAAATGATTAAAAATGCATTAGTAGTTAAAAATAGA
TATTTAAGCATTGTGAAACT

Downstream 100 bases:

>100_bases
TTTTTATATTATATTTGCTTAATTTATTTTGTTGTTTAATATCGTTTATAATGGTGGTTTTTTATGAAACTTGGAATAAT
TTCGGATACTCACGATCACC

Product: uroporphyrinogen III synthase HEM4

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKVVITRPIEKGSNFGEILKKEGFEPILIPTLDLVFKNINLKIDDYSWIVFTSPRGVEGLLKNLSLEDVKKVTSKKIGVI
GIETAKEFKNIFGKDADIIPNLYTAENLLLALKKEVKSHEKVLIPTTPSTRDVLKEGLNAELVFVYSSEEPNDIDKKIDD
LKKITANENKSGRKIVLTFTSSLTARNFFKHVDLSFLEVLKKQEVVSIGPITKKTVDSFGFDSKMHPENYTTKGMVFVIK
GLSLNI

Sequences:

>Translated_246_residues
MKVVITRPIEKGSNFGEILKKEGFEPILIPTLDLVFKNINLKIDDYSWIVFTSPRGVEGLLKNLSLEDVKKVTSKKIGVI
GIETAKEFKNIFGKDADIIPNLYTAENLLLALKKEVKSHEKVLIPTTPSTRDVLKEGLNAELVFVYSSEEPNDIDKKIDD
LKKITANENKSGRKIVLTFTSSLTARNFFKHVDLSFLEVLKKQEVVSIGPITKKTVDSFGFDSKMHPENYTTKGMVFVIK
GLSLNI
>Mature_246_residues
MKVVITRPIEKGSNFGEILKKEGFEPILIPTLDLVFKNINLKIDDYSWIVFTSPRGVEGLLKNLSLEDVKKVTSKKIGVI
GIETAKEFKNIFGKDADIIPNLYTAENLLLALKKEVKSHEKVLIPTTPSTRDVLKEGLNAELVFVYSSEEPNDIDKKIDD
LKKITANENKSGRKIVLTFTSSLTARNFFKHVDLSFLEVLKKQEVVSIGPITKKTVDSFGFDSKMHPENYTTKGMVFVIK
GLSLNI

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27617; Mature: 27617

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVITRPIEKGSNFGEILKKEGFEPILIPTLDLVFKNINLKIDDYSWIVFTSPRGVEGL
CEEEEECCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHCCEEECCEEEEEEECCCCHHHH
LKNLSLEDVKKVTSKKIGVIGIETAKEFKNIFGKDADIIPNLYTAENLLLALKKEVKSHE
HHCCCHHHHHHHHHCCCCEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
KVLIPTTPSTRDVLKEGLNAELVFVYSSEEPNDIDKKIDDLKKITANENKSGRKIVLTFT
EEEEECCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEC
SSLTARNFFKHVDLSFLEVLKKQEVVSIGPITKKTVDSFGFDSKMHPENYTTKGMVFVIK
CCHHHHHHHHHCCHHHHHHHHHCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEE
GLSLNI
CCEECC
>Mature Secondary Structure
MKVVITRPIEKGSNFGEILKKEGFEPILIPTLDLVFKNINLKIDDYSWIVFTSPRGVEGL
CEEEEECCCCCCCCHHHHHHHCCCCEEEHHHHHHHHHHCCEEECCEEEEEEECCCCHHHH
LKNLSLEDVKKVTSKKIGVIGIETAKEFKNIFGKDADIIPNLYTAENLLLALKKEVKSHE
HHCCCHHHHHHHHHCCCCEEECHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
KVLIPTTPSTRDVLKEGLNAELVFVYSSEEPNDIDKKIDDLKKITANENKSGRKIVLTFT
EEEEECCCCHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEC
SSLTARNFFKHVDLSFLEVLKKQEVVSIGPITKKTVDSFGFDSKMHPENYTTKGMVFVIK
CCHHHHHHHHHCCHHHHHHHHHCCEEEECCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEE
GLSLNI
CCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]