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The map label for this gene is fixC [C]

Identifier: 150400117

GI number: 150400117

Start: 1405922

End: 1407094

Strand: Reverse

Name: fixC [C]

Synonym: Mevan_1375

Alternate gene names: 150400117

Gene position: 1407094-1405922 (Counterclockwise)

Preceding gene: 150400118

Following gene: 150400115

Centisome position: 81.81

GC content: 33.84

Gene sequence:

>1173_bases
ATGAGGGCTTTAGAAGAGAGTTATGATGTAGTTGTAGTTGGTGCGGGGCCTGCTGGTTCCATGTCATCATATAATGCATC
AAAAAACGGGGCTAAAACACTTCTAATTGAAAAAGCACAGGAAATTGGAACGCCGGTTAGATGTGCAGAAGCAATTCCAA
GAATTGAGTCTTTTGGAATCAATCCAAGTTCCGAATTTATAAGGTCGTATATTAAAGGTGCTTATTTAGTTGCACCAAAC
GGGAAAAAAATAACTGTAAAAGGCGGAAAAACAGACGGTTATGTAGTTGAAAGAAAAATATTTGATAAATTCCTTGCAAT
AAGGAGTGCTAAGGAAGGCACGAAAATTGCAGTTAAAAGTAGAGTTACAGGCCTTGAAAAAACAGAAGAAGGATATAACG
TATTTGTAAACCATCTTGGAAAGGAATATACTGTAAAAACAAAACTCGTAATTGCTGCTGACGGCGTAGAAAGTACAATT
TCAGAATATGCTGGTTTAAAATCAAAAAAGAACCATAATGAAGTGTGTTCATGTGCAGAATACGAAATGACAAATGTAAA
GCTCTTAGATAACAACATGATGGAGTTTTATTTTGGTGAAATTTGCCCAAAGGGGTACATTTGGCTGTTTCCAAAAGGCG
ATACAGTAAATGTTGGAATAGGAATAATTGAAGGAAGTAAAAAAGCTATTGAATATTTAGATGACTTTTTAAGTAACCCT
CTTTTAGAAGGGAGGTTAAAAAATGCAGTTCCAGTTGAATTTAAAGTTGGGGGTGACCCTGTTGGCGGCCCTATTAAAAA
AACATTTAAAGATAATTTAATTGTTGTTGGAGATGCAGCAGGACATGTTAGTCCATTAACTGGGGGTGGAATTTCACTTG
CAATGGATTGCGGTTTAATTGCAGGGGAAGTTTGTGCAAAAAGTATCTCTTCTAAAAATTATTCTGAGGAGTTTTTAAGT
CAGTATGAAACACGCTGGAAAGAAAAACACTATAAATTCCTTATGAATGACTTAAAATACAAAACCATACTTCAAAAATT
AAATGATAATGAGTTAAATGCAATTGCTGATTCAATTCCTGAAAATTTAGAGGAAGTTGATGTTGGAAAGCTTGCAATAA
AAATCGTTAAAAAAGCACCTTCATTATTAAAATATTTTAAAGAATTAATTTAA

Upstream 100 bases:

>100_bases
ATTGAATTAATTGAAAATAAGATTATTATTTACGACGAAAAATGTAACAACTGTAAACTGTGTGCCGTAGTGTGCCCACT
AAATGCGCTGGAGGAGTAAC

Downstream 100 bases:

>100_bases
TTCTTCTTTTCCTTTTTTTTTCTTTTTTTCTTTTTGGTAGTCATAATAACTCCAGACTAAAAATATTATCAAAAACCAGT
AGACATTTTCCTTTAAGATT

Product: geranylgeranyl reductase

Products: NA

Alternate protein names: DGGGPL reductase; 2,3-di-O-geranylgeranylglyceryl phosphate reductase; Geranylgeranyl reductase; GGR

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MRALEESYDVVVVGAGPAGSMSSYNASKNGAKTLLIEKAQEIGTPVRCAEAIPRIESFGINPSSEFIRSYIKGAYLVAPN
GKKITVKGGKTDGYVVERKIFDKFLAIRSAKEGTKIAVKSRVTGLEKTEEGYNVFVNHLGKEYTVKTKLVIAADGVESTI
SEYAGLKSKKNHNEVCSCAEYEMTNVKLLDNNMMEFYFGEICPKGYIWLFPKGDTVNVGIGIIEGSKKAIEYLDDFLSNP
LLEGRLKNAVPVEFKVGGDPVGGPIKKTFKDNLIVVGDAAGHVSPLTGGGISLAMDCGLIAGEVCAKSISSKNYSEEFLS
QYETRWKEKHYKFLMNDLKYKTILQKLNDNELNAIADSIPENLEEVDVGKLAIKIVKKAPSLLKYFKELI

Sequences:

>Translated_390_residues
MRALEESYDVVVVGAGPAGSMSSYNASKNGAKTLLIEKAQEIGTPVRCAEAIPRIESFGINPSSEFIRSYIKGAYLVAPN
GKKITVKGGKTDGYVVERKIFDKFLAIRSAKEGTKIAVKSRVTGLEKTEEGYNVFVNHLGKEYTVKTKLVIAADGVESTI
SEYAGLKSKKNHNEVCSCAEYEMTNVKLLDNNMMEFYFGEICPKGYIWLFPKGDTVNVGIGIIEGSKKAIEYLDDFLSNP
LLEGRLKNAVPVEFKVGGDPVGGPIKKTFKDNLIVVGDAAGHVSPLTGGGISLAMDCGLIAGEVCAKSISSKNYSEEFLS
QYETRWKEKHYKFLMNDLKYKTILQKLNDNELNAIADSIPENLEEVDVGKLAIKIVKKAPSLLKYFKELI
>Mature_390_residues
MRALEESYDVVVVGAGPAGSMSSYNASKNGAKTLLIEKAQEIGTPVRCAEAIPRIESFGINPSSEFIRSYIKGAYLVAPN
GKKITVKGGKTDGYVVERKIFDKFLAIRSAKEGTKIAVKSRVTGLEKTEEGYNVFVNHLGKEYTVKTKLVIAADGVESTI
SEYAGLKSKKNHNEVCSCAEYEMTNVKLLDNNMMEFYFGEICPKGYIWLFPKGDTVNVGIGIIEGSKKAIEYLDDFLSNP
LLEGRLKNAVPVEFKVGGDPVGGPIKKTFKDNLIVVGDAAGHVSPLTGGGISLAMDCGLIAGEVCAKSISSKNYSEEFLS
QYETRWKEKHYKFLMNDLKYKTILQKLNDNELNAIADSIPENLEEVDVGKLAIKIVKKAPSLLKYFKELI

Specific function: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GGR_METVS (A6US00)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323884.1
- ProteinModelPortal:   A6US00
- SMR:   A6US00
- STRING:   A6US00
- GeneID:   5324717
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1375
- eggNOG:   arNOG04976
- HOGENOM:   HBG626912
- OMA:   DCGLMAG
- ProtClustDB:   CLSK876233
- HAMAP:   MF_01287
- InterPro:   IPR004792
- InterPro:   IPR011777
- InterPro:   IPR002938
- InterPro:   IPR003042
- PRINTS:   PR00420
- TIGRFAMs:   TIGR02032

Pfam domain/function: PF01494 FAD_binding_3; PF03486 HI0933_like

EC number: NA

Molecular weight: Translated: 42743; Mature: 42743

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALEESYDVVVVGAGPAGSMSSYNASKNGAKTLLIEKAQEIGTPVRCAEAIPRIESFGI
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHHCCC
NPSSEFIRSYIKGAYLVAPNGKKITVKGGKTDGYVVERKIFDKFLAIRSAKEGTKIAVKS
CCHHHHHHHHHCCEEEECCCCCEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEHH
RVTGLEKTEEGYNVFVNHLGKEYTVKTKLVIAADGVESTISEYAGLKSKKNHNEVCSCAE
HHCCCHHCCCHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHH
YEMTNVKLLDNNMMEFYFGEICPKGYIWLFPKGDTVNVGIGIIEGSKKAIEYLDDFLSNP
CCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHCCC
LLEGRLKNAVPVEFKVGGDPVGGPIKKTFKDNLIVVGDAAGHVSPLTGGGISLAMDCGLI
HHHCCCCCCCCEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEEHHCCHH
AGEVCAKSISSKNYSEEFLSQYETRWKEKHYKFLMNDLKYKTILQKLNDNELNAIADSIP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ENLEEVDVGKLAIKIVKKAPSLLKYFKELI
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHC
>Mature Secondary Structure
MRALEESYDVVVVGAGPAGSMSSYNASKNGAKTLLIEKAQEIGTPVRCAEAIPRIESFGI
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCHHHHCCC
NPSSEFIRSYIKGAYLVAPNGKKITVKGGKTDGYVVERKIFDKFLAIRSAKEGTKIAVKS
CCHHHHHHHHHCCEEEECCCCCEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCEEEEHH
RVTGLEKTEEGYNVFVNHLGKEYTVKTKLVIAADGVESTISEYAGLKSKKNHNEVCSCAE
HHCCCHHCCCHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHH
YEMTNVKLLDNNMMEFYFGEICPKGYIWLFPKGDTVNVGIGIIEGSKKAIEYLDDFLSNP
CCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCCEEEEEEEEEECCHHHHHHHHHHHCCC
LLEGRLKNAVPVEFKVGGDPVGGPIKKTFKDNLIVVGDAAGHVSPLTGGGISLAMDCGLI
HHHCCCCCCCCEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEEHHCCHH
AGEVCAKSISSKNYSEEFLSQYETRWKEKHYKFLMNDLKYKTILQKLNDNELNAIADSIP
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
ENLEEVDVGKLAIKIVKKAPSLLKYFKELI
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a quinone or similar compound as acceptor [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA