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The map label for this gene is pyrH

Identifier: 150400114

GI number: 150400114

Start: 1403979

End: 1404656

Strand: Reverse

Name: pyrH

Synonym: Mevan_1372

Alternate gene names: 150400114

Gene position: 1404656-1403979 (Counterclockwise)

Preceding gene: 150400115

Following gene: 150400113

Centisome position: 81.66

GC content: 34.51

Gene sequence:

>678_bases
ATGGATATTGTTTTTGCACTTGGGGGATCTGTTTTGATGCCAAAAGATGGAGCATCTGCTGAAAATATCAAAAGTTATGC
ACAAGTATTTAAAAAATTAAAGGATATGGGGCATAACGTTTCCATTGTTGTCGGGGGCGGAAATACTGCAAGGGAATACA
TAAAAGTTTCAAGGGAATTTACAAATGAGTCAGTTTGTGATGAAATAGGCATTATGGCAACTAGAATGAATGCAATGCTG
TTAATCTCTGCACTTTCAAAATATTCGGTAAACTTTGTTCCAACAAATTTTAAAGATGCGGAAATGATTTTAAATTTAGG
AAAAATACTTGTAATGGGTGGAACGCACCCAGCTCACACAACCGATGCAGTTTCTGCAACTTTAGCAGAATTTACAAATG
CCGATTTACTTGTTATTGCAACAAATGTTGATGGAGTTTATACTAAAGACCCTAGAACAAATAACGATGCTAAAAAGCTT
GAAAAGATGACTACAAAAGAATTGATTGAAATTACTGGTTCAAATTCGATTAGTGCAGGCTCTTCAAGCGTTGTAGATTC
TCTTGCATCAAAAATCATTGATAGGGCAAAATTAAAAACAATTGTTGTAAAAGGAACTCCTGATGAAATTTTAAAGTCTG
TTCTTGGAGGGCATGATGGAACTATTATCATACCTTAA

Upstream 100 bases:

>100_bases
TAAACCTTTATATAATTAGTAAGTATAGTATTTTGGAAAATTATTCAAGTTTAAAATTTTTCAAGTTATTTTAAAAATTA
CAAATTTTAGAGGTTACTTC

Downstream 100 bases:

>100_bases
AAAATATTAAAATATAGTTTGGTGAAAAAAATGGAAAAACATAAACACTGCATAAATTGTGGACTTTCAATCCCTCCTGA
AGAATCACTTTGTTCTGAAA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MDIVFALGGSVLMPKDGASAENIKSYAQVFKKLKDMGHNVSIVVGGGNTAREYIKVSREFTNESVCDEIGIMATRMNAML
LISALSKYSVNFVPTNFKDAEMILNLGKILVMGGTHPAHTTDAVSATLAEFTNADLLVIATNVDGVYTKDPRTNNDAKKL
EKMTTKELIEITGSNSISAGSSSVVDSLASKIIDRAKLKTIVVKGTPDEILKSVLGGHDGTIIIP

Sequences:

>Translated_225_residues
MDIVFALGGSVLMPKDGASAENIKSYAQVFKKLKDMGHNVSIVVGGGNTAREYIKVSREFTNESVCDEIGIMATRMNAML
LISALSKYSVNFVPTNFKDAEMILNLGKILVMGGTHPAHTTDAVSATLAEFTNADLLVIATNVDGVYTKDPRTNNDAKKL
EKMTTKELIEITGSNSISAGSSSVVDSLASKIIDRAKLKTIVVKGTPDEILKSVLGGHDGTIIIP
>Mature_225_residues
MDIVFALGGSVLMPKDGASAENIKSYAQVFKKLKDMGHNVSIVVGGGNTAREYIKVSREFTNESVCDEIGIMATRMNAML
LISALSKYSVNFVPTNFKDAEMILNLGKILVMGGTHPAHTTDAVSATLAEFTNADLLVIATNVDGVYTKDPRTNNDAKKL
EKMTTKELIEITGSNSISAGSSSVVDSLASKIIDRAKLKTIVVKGTPDEILKSVLGGHDGTIIIP

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=238, Percent_Identity=28.1512605042017, Blast_Score=73, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_METVS (A6URZ7)

Other databases:

- EMBL:   CP000742
- RefSeq:   YP_001323881.1
- ProteinModelPortal:   A6URZ7
- SMR:   A6URZ7
- STRING:   A6URZ7
- GeneID:   5325159
- GenomeReviews:   CP000742_GR
- KEGG:   mvn:Mevan_1372
- eggNOG:   arNOG05927
- HOGENOM:   HBG497552
- OMA:   TRANAML
- ProtClustDB:   PRK00358
- GO:   GO:0005737
- HAMAP:   MF_01220_A
- InterPro:   IPR001048
- InterPro:   IPR001057
- InterPro:   IPR011817
- InterPro:   IPR011818
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- PRINTS:   PR00474
- TIGRFAMs:   TIGR02076

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 23963; Mature: 23963

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: BINDING 46-46 BINDING 47-47 BINDING 51-51 BINDING 67-67 BINDING 141-141 BINDING 142-142 BINDING 147-147 BINDING 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIVFALGGSVLMPKDGASAENIKSYAQVFKKLKDMGHNVSIVVGGGNTAREYIKVSREF
CEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHH
TNESVCDEIGIMATRMNAMLLISALSKYSVNFVPTNFKDAEMILNLGKILVMGGTHPAHT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCEEEECCCCCCCC
TDAVSATLAEFTNADLLVIATNVDGVYTKDPRTNNDAKKLEKMTTKELIEITGSNSISAG
HHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
SSSVVDSLASKIIDRAKLKTIVVKGTPDEILKSVLGGHDGTIIIP
CHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHCCCCCEEEEC
>Mature Secondary Structure
MDIVFALGGSVLMPKDGASAENIKSYAQVFKKLKDMGHNVSIVVGGGNTAREYIKVSREF
CEEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHH
TNESVCDEIGIMATRMNAMLLISALSKYSVNFVPTNFKDAEMILNLGKILVMGGTHPAHT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHCCCEEEECCCCCCCC
TDAVSATLAEFTNADLLVIATNVDGVYTKDPRTNNDAKKLEKMTTKELIEITGSNSISAG
HHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
SSSVVDSLASKIIDRAKLKTIVVKGTPDEILKSVLGGHDGTIIIP
CHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA