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The map label for this gene is purE [H]

Identifier: 150400035

GI number: 150400035

Start: 1319764

End: 1320234

Strand: Reverse

Name: purE [H]

Synonym: Mevan_1293

Alternate gene names: 150400035

Gene position: 1320234-1319764 (Counterclockwise)

Preceding gene: 150400036

Following gene: 150400030

Centisome position: 76.76

GC content: 36.52

Gene sequence:

>471_bases
ATGATAACAATACTAATGGGCAGTAAAAGTGACGTAGAAGTTGCAAAAAAAGCATGTTCAATTTTAAAAGATTTTGAAAT
CCCTTTTGAGGTTAGAGTAGCTCCAGCACATAGGACTCCAGAACTGGTTGAAAATATTGTAAAAAATTCAAAGTCAAAAG
TATTTATCGCAATTGCAGGTCTTGCAGCACATTTACCCGGAGTAGTTGCCTCAATGACTACAAAGCCAGTTATTGCAGTG
CCTGTTGAAAGTAAGATGGATGGACTTGATGCACTTTTAAGTTCTGTTCAAATGCCTCCAGGAATTCCTGTTGCATGTGT
TGGAATCGATAGGGGAGAAAATGCGGCGATTTTAGCTGTTCAAATGCTTTCAACGTCTGATGAGAACCTTTCAAAAAAAT
TAGCAGAATTTAGGGAAAAACAGAAAGAAAAAGTAATTTCAGACGACTCTGAAGTTTCAAAAATGTTTTAG

Upstream 100 bases:

>100_bases
TTTGTAACAAAAAAGCTATTTCTAGATGGTTAAGTAAATATAACCGGCAATACTTTAACCCTAGAATTTCAACCGCTGAA
TATATGCGTGGTGATATCAA

Downstream 100 bases:

>100_bases
ATAATGCCTAAAAAACTAAATAAAAATTTGAAGTTTTTAAATTTCCACATAGATATCTTTTCCTTTTCTCATTGCATTTT
CAAGTTCTTTACCAATTACC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 156; Mature: 156

Protein sequence:

>156_residues
MITILMGSKSDVEVAKKACSILKDFEIPFEVRVAPAHRTPELVENIVKNSKSKVFIAIAGLAAHLPGVVASMTTKPVIAV
PVESKMDGLDALLSSVQMPPGIPVACVGIDRGENAAILAVQMLSTSDENLSKKLAEFREKQKEKVISDDSEVSKMF

Sequences:

>Translated_156_residues
MITILMGSKSDVEVAKKACSILKDFEIPFEVRVAPAHRTPELVENIVKNSKSKVFIAIAGLAAHLPGVVASMTTKPVIAV
PVESKMDGLDALLSSVQMPPGIPVACVGIDRGENAAILAVQMLSTSDENLSKKLAEFREKQKEKVISDDSEVSKMF
>Mature_156_residues
MITILMGSKSDVEVAKKACSILKDFEIPFEVRVAPAHRTPELVENIVKNSKSKVFIAIAGLAAHLPGVVASMTTKPVIAV
PVESKMDGLDALLSSVQMPPGIPVACVGIDRGENAAILAVQMLSTSDENLSKKLAEFREKQKEKVISDDSEVSKMF

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=153, Percent_Identity=41.1764705882353, Blast_Score=94, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=150, Percent_Identity=50, Blast_Score=137, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16734; Mature: 16734

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITILMGSKSDVEVAKKACSILKDFEIPFEVRVAPAHRTPELVENIVKNSKSKVFIAIAG
CEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEC
LAAHLPGVVASMTTKPVIAVPVESKMDGLDALLSSVQMPPGIPVACVGIDRGENAAILAV
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEE
QMLSTSDENLSKKLAEFREKQKEKVISDDSEVSKMF
EECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
>Mature Secondary Structure
MITILMGSKSDVEVAKKACSILKDFEIPFEVRVAPAHRTPELVENIVKNSKSKVFIAIAG
CEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEEEC
LAAHLPGVVASMTTKPVIAVPVESKMDGLDALLSSVQMPPGIPVACVGIDRGENAAILAV
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEE
QMLSTSDENLSKKLAEFREKQKEKVISDDSEVSKMF
EECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]